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1. 发明授权

US09605307B2 Systems and methods for forming a nanopore in a lipid bilayer 有权
公开(公告)号：US09605307B2
公开(公告)日：2017-03-28
申请号：US12658591
申请日：2010-02-08
申请人： Roger Chen , Randy Davis
发明人： Roger Chen , Randy Davis
IPC分类号： B01D59/02 , B01D59/42 , B01D59/50 , B01D61/42 , B01D61/58 , C02F1/469 , C07K1/26 , C08F2/58 , C25B7/00 , C25B15/00 , G01F1/64 , G01L1/20 , G01L9/18 , C12Q1/68 , B82Y5/00 , G01N33/487
CPC分类号： B29C67/20 , B82Y5/00 , B82Y10/00 , B82Y40/00 , C12Q1/6869 , G01N33/48721 , Y10S977/797 , Y10S977/90 , Y10S977/942 , C12Q2565/631
摘要： Techniques for forming a nanopore in a lipid bilayer are described herein. In one example, an agitation stimulus level such as an electrical agitation stimulus is applied to a lipid bilayer wherein the agitation stimulus level tends to facilitate the formation of nanopores in the lipid bilayer. In some embodiments, a change in an electrical property of the lipid bilayer resulting from the formation of the nanopore in the lipid bilayer is detected, and a nanopore has formed in the lipid bilayer is determined based on the detected change in the lipid bilayer electrical property.

2. 发明申请

US20140080086A1 Image Navigation Integrated Dental Implant System 审中-公开
标题翻译：图像导航综合牙种植体系统
公开(公告)号：US20140080086A1
公开(公告)日：2014-03-20
申请号：US13623586
申请日：2012-09-20
申请人： Roger CHEN
发明人： Roger CHEN
IPC分类号： A61B6/14
CPC分类号： A61C9/0053 , A61B6/14 , A61B6/506 , A61C1/084 , A61C8/00 , A61C13/34
摘要： An image navigation integrated dental implant system includes a control unit for storing and transmitting data streams, a scan module electrically connected to the control unit for scanning and taking the pictures of the soft tissue and hard tissue of the parenchyma of the oral cavity of a patient and the related external skin color and transmitting the obtained data to the control unit, a design module electrically connected to the control unit for receiving the oral cavity data from the control unit and using the data to design a oral cavity simulation diagram, and a navigator module electrically connected to the control unit for receiving the oral cavity data and photographing the oral cavity and then providing a picture to guide the dentist to perform the dental implant surgery.
摘要翻译：图像导航一体化牙种植体系统包括用于存储和传输数据流的控制单元，电连接到控制单元的扫描模块，用于扫描和拍摄患者的口腔的软组织和硬组织的图片和相关的外部皮肤颜色，并将获得的数据传送到控制单元，电气连接到控制单元的设计模块，用于从控制单元接收口腔数据并使用数据设计口腔模拟图，以及导航器模块电连接到控制单元，用于接收口腔数据并拍摄口腔，然后提供图片以引导牙医进行牙科植入手术。

3. 发明申请

US20140065570A1 LIGHT GUIDE TYPE PAIN RELIEVER 有权
标题翻译：轻型指导型PAIN RELIEVER
公开(公告)号：US20140065570A1
公开(公告)日：2014-03-06
申请号：US13864856
申请日：2013-04-17
申请人： Roger CHEN
发明人： Roger CHEN , Ming-Chih TSAI
IPC分类号： A61N5/06
CPC分类号： A61H23/0254 , A61H23/02 , A61H2201/0153 , A61N5/0601 , A61N5/0603 , A61N5/0613 , A61N2005/0606 , A61N2005/063
摘要： A light guide type pain reliever includes a handle including a barrel accommodating a battery, a rear end cap and a front end cap respectively capped on two opposite ends of the barrel, a pushbutton mounted in the rear end cap and a switching connector mounted in the rear end cap and electrically connected to the battery and drivable by the pushbutton to switching on/off the battery, a holder shell connected to the front end cap and electrically coupled to the battery and having electrically connected thereto a vibrator and a light-emitting device, an adapter connected to the holder shell, and a light guide plate connected to adapter guiding out light rays emitted by the light-emitting device.
摘要翻译：导光型止痛器包括手柄，其包括容纳电池的镜筒，分别盖在镜筒的两个相对端上的后端盖和前端盖，安装在后端盖中的按钮和安装在所述后端盖中的开关连接器后端盖并且电连接到电池并且由按钮驱动以打开/关闭电池;保持壳，其连接到前端盖并电耦合到电池并且电连接到振动器和发光器件连接到保持器壳体的适配器以及连接到适配器的导光板，该导向板引导由发光装置发射的光线。

4. 发明申请

US20130341537A1 OPTOELECTRONIC DEVICE AND METHOD OF MANUFACTURE 有权
标题翻译：光电器件及其制造方法
公开(公告)号：US20130341537A1
公开(公告)日：2013-12-26
申请号：US13529843
申请日：2012-06-21
申请人： Jimmy Chee Mang Wong , Roger Chen , Shiun Dar Lee
发明人： Jimmy Chee Mang Wong , Roger Chen , Shiun Dar Lee
IPC分类号： G02B27/00 , H01R43/00
CPC分类号： H04B10/802 , Y10T29/49117
摘要： An optoelectronic device is disclosed. The optoelectronic device may be employed as a single or multi-channel opto-coupler that electrically isolates one circuit from another circuit. The opto-coupler may include one or more folded leads that establish an enhanced isolation gap. The enhanced isolation gap increases the creepage distance of the opto-coupler and increases operational voltages that can be accommodated by the opto-coupler.
摘要翻译：公开了一种光电子器件。光电子器件可以用作将一个电路与另一个电路电隔离的单通道或多通道光耦合器。光耦合器可以包括建立增强隔离间隙的一个或多个折叠引线。增强的隔离间隙增加了光耦合器的爬电距离，并增加了光耦合器可以适应的工作电压。

5. 发明授权

US08461854B2 Systems and methods for characterizing a molecule 有权
公开(公告)号：US08461854B2
公开(公告)日：2013-06-11
申请号：US13620973
申请日：2012-09-15
申请人： Roger Chen , Randy Davis
发明人： Roger Chen , Randy Davis
IPC分类号： G01R27/08
CPC分类号： C12Q1/6816 , B82Y30/00 , C12Q1/6869 , G01N27/3278 , G01N27/447 , G01N27/44791 , G01N33/48721 , G01N2015/0038 , Y10T29/49002 , Y10T29/49117 , C12Q2563/116 , C12Q2565/631
摘要： Techniques for characterizing a molecule are described herein. In one example, a portion of the molecule is trapped in a nanopore, a variable voltage is applied across the nanopore until the trapped portion of molecule is moved within the nanopore, and the molecule is characterized based on the electrical stimulus required to affect movement of at least a portion of the trapped portion of the molecule within the nanopore.

6. 发明授权

US08324914B2 Systems and methods for characterizing a molecule 有权
标题翻译：表征分子的系统和方法
公开(公告)号：US08324914B2
公开(公告)日：2012-12-04
申请号：US12658604
申请日：2010-02-08
申请人： Roger Chen , Randy Davis
发明人： Roger Chen , Randy Davis
IPC分类号： G01N27/00
CPC分类号： C12Q1/6816 , B82Y30/00 , C12Q1/6869 , G01N27/3278 , G01N27/447 , G01N27/44791 , G01N33/48721 , G01N2015/0038 , Y10T29/49002 , Y10T29/49117 , C12Q2563/116 , C12Q2565/631
摘要： Techniques for characterizing a molecule are described herein. In one example, a portion of the molecule is trapped in a nanopore, a variable voltage is applied across the nanopore until the trapped portion of molecule is moved within the nanopore, and the molecule is characterized based on the electrical stimulus required to affect movement of at least a portion of the trapped portion of the molecule within the nanopore.
摘要翻译：用于表征分子的技术在本文中描述。在一个实例中，分子的一部分被捕获在纳米孔中，跨越纳米孔施加可变电压，直到分子的被捕获部分在纳米孔内移动，并且基于影响运动所需的电刺激来表征分子纳米孔内的分子的截留部分的至少一部分。

7. 发明申请

US20120259398A1 SPRING PASSIVE LEAD ANCHOR AND METHODS AND DEVICES USING THE ANCHOR 有权
标题翻译：弹簧被动引导锚杆和使用锚杆的方法和装置
公开(公告)号：US20120259398A1
公开(公告)日：2012-10-11
申请号：US13529709
申请日：2012-06-21
申请人： Roger Chen , John Michael Barker
发明人： Roger Chen , John Michael Barker
IPC分类号： A61N1/05
CPC分类号： A61N1/0558
摘要： A lead anchor includes a body defining at least one first portion of a lead lumen, the body having a first opening and a second opening. An obstructing member is disposed within the body. The obstructing member defines a second portion of the lead lumen. A spring is disposed in the body and configured and arranged to operate on the obstructing member so that the second portion of the lead lumen is coterminous with the at least one first portion of the lead lumen and forms a continuous lead path when the spring is compressed and the second portion of the lead lumen is offset from the at least one first portion of the lead lumen when the spring is not compressed.
摘要翻译：引线锚杆包括限定引导腔的至少一个第一部分的主体，主体具有第一开口和第二开口。阻塞构件设置在主体内。阻塞构件限定引导腔的第二部分。弹簧设置在主体中，并且构造和布置成在阻塞构件上操作，使得引导腔的第二部分与引导腔的至少一个第一部分相接合，并且当弹簧被压缩时形成连续的引导路径并且当弹簧未被压缩时，引导腔的第二部分与引导腔的至少一个第一部分偏移。

8. 发明申请

US20110163712A1 SECONDARY BATTERY 失效
标题翻译：二次电池
公开(公告)号：US20110163712A1
公开(公告)日：2011-07-07
申请号：US12759386
申请日：2010-04-13
申请人： Roger Chen
发明人： Roger Chen
IPC分类号： H02J7/00
CPC分类号： H02J7/0011 , H01M10/052 , H01M10/46 , H01M10/488 , H02J2007/0062
摘要： A secondary battery includes a battery case configured subject to the configuration of a conventional 9V or 1.5V battery and a battery body and a battery charger mounted in the battery case. The battery charger controls the battery body for charging and voltage output, and provides a USB socket as charging interface and positive and negative electrodes as discharging interface. Thus, the secondary battery is connectable to a USB plug of a cell phone battery charger or computer for charging, and can be installed in an electric product like a conventional battery cell to provide DC power to the electric product. Under the provision of current detection function and voltage adjusting function, the 1.5V secondary battery can be connected in series or in parallel with one or a number of micro resistor-provided virtual batteries to output a voltage subject to its linking arrangement.
摘要翻译：二次电池包括配置为常规9V或1.5V电池的配置的电池盒和安装在电池壳体中的电池体和电池充电器。电池充电器控制电池体充电和电压输出，并提供USB插座作为充电接口，正极和负极作为放电接口。因此，二次电池可连接到手机电池充电器的USB插头或用于充电的计算机，并且可以安装在像常规电池单元的电气产品中以向电气产品提供直流电力。在提供电流检测功能和电压调整功能的情况下，1.5V二次电池可以与一个或多个微电阻提供的虚拟电池串联或并联连接，以输出受其连接布置的电压。

9. 发明申请

US20060247296A1 Methods of using and compositions comprising (+)-3-(3,4-dimethoxy-phenyl)-3-(1-oxo-1,3-dihydro-isoindol-2-yl)-propionamide 审中-公开
标题翻译：使用方法和包含（+） - 3-（3,4-二甲氧基 - 苯基）-3-（1-氧代-1,3-二氢 - 异吲哚-2-基） - 丙酰胺
公开(公告)号：US20060247296A1
公开(公告)日：2006-11-02
申请号：US10535004
申请日：2005-08-30
申请人： George Muller , Roger Chen
发明人： George Muller , Roger Chen
IPC分类号： A61K31/4035
CPC分类号： A61K31/4035 , A61K31/24 , A61K31/40 , C07C229/34 , C07C233/47 , C07D209/46
摘要： Enantiomerically pure (+)-3-(3,4-dimethoxy-phenyl)-3-(1-oxo-1,3-dihydroisoindol-2-yl)-propionamide, and pro-drugs, metabolites, polymorphs, salts, solvates (e.g. hydrates), and clathrates thereof are discussed. Methods of treating and/or preventing various diseases and disorders, such as those ameliorated by the reduction of levels of TNF-α or the inhibition of PDE4, are also disclosed.
摘要翻译：对映体纯的（+） - 3-（3,4-二甲氧基 - 苯基）-3-（1-氧代-1,3-二氢异吲哚-2-基） - 丙酰胺和前药，代谢物，多晶型物，盐，溶剂合物（例如水合物）和其包合物进行讨论。还公开了治疗和/或预防各种疾病和病症的方法，例如通过降低TNF-α水平或PDE4的抑制而改善的方法。

10. 发明申请

US20050107339A1 Diphenylethylene compounds and uses thereof 失效
公开(公告)号：US20050107339A1
公开(公告)日：2005-05-19
申请号：US10934974
申请日：2004-09-03
申请人： George Muller , Faribourz Payvandi , Ling Zhang , Michael Robarge , Roger Chen , Hon-Wah Man , Alexander Ruchelman
发明人： George Muller , Faribourz Payvandi , Ling Zhang , Michael Robarge , Roger Chen , Hon-Wah Man , Alexander Ruchelman
IPC分类号： A61K31/165 , A61K31/18 , A61K31/24 , A61K31/275 , A61K31/277 , A61K31/40 , A61K31/44 , A61K31/66 , C07F9/28
CPC分类号： C07C255/37 , C07C43/215 , C07C43/23 , C07C49/255 , C07C59/64 , C07C69/734 , C07C217/84 , C07C255/38 , C07C255/42 , C07C255/43 , C07C255/44 , C07C271/28 , C07C275/34 , C07C275/42 , C07C307/02 , C07C311/60 , C07C2601/08 , C07D207/323 , C07D207/337 , C07D209/08 , C07D317/60 , C07D319/18 , C07D319/20 , C07D321/10 , C07F9/12
摘要： The present invention relates to Diphenylethylene Compounds and compositions comprising a Diphenylethylene Compound. The present invention also relates to methods for preventing or treating various diseases and disorders by administering to a subject in need thereof one or more Diphenylethylene Compounds. In particular, the invention relates to methods for preventing or treating cancer or an inflammatory disorder by administering to a subject in need thereof one or more Diphenylethylene Compounds. The present invention further relates to articles of manufacture and kits comprising one or more Diphenylethylene Compounds.

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