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21. 发明授权

US07976560B2 Embolic filtering devices 有权
标题翻译：栓塞过滤装置
公开(公告)号：US07976560B2
公开(公告)日：2011-07-12
申请号：US11654426
申请日：2007-01-17
申请人： Andy E. Denison , William J. Harrison , Benjamin C. Huter , Scott J. Huter , John E. Papp , Steven T. Saville , Kent C. B. Stalker
发明人： Andy E. Denison , William J. Harrison , Benjamin C. Huter , Scott J. Huter , John E. Papp , Steven T. Saville , Kent C. B. Stalker
IPC分类号： A61M29/00
CPC分类号： A61F2/013 , A61F2002/015 , A61F2002/018 , A61F2230/0006 , A61F2230/008
摘要： An expandable frame for an embolic filtering device used to capture embolic debris in a body vessel includes a first half frame having a first control arm connected to a second control arm by a partial loop and a second half frame having a first control arm connected to a second control arm by a partial loop. The partial loops cooperatively form a composite loop for attachment of a filtering element which will expand in the body vessel to capture embolic debris entrained in the fluid of the vessel. The lengths and positioning of the first and second control arms of each half frame can be varied to create an expandable frame which conforms to the size and shape of the body vessel in which the filtering device is deployed. Additionally, the radius of the partial loops, along with the length of the arc of the partial loops, can be varied on each of the frames to create a composite filtering assembly that can easily adapt to the size and shape of the body vessel. Additionally, the control arms of the half frames can be disposed either proximally or distally of the composite loop to create a distinct filtering structure.
摘要翻译：用于捕获身体血管中的栓塞碎片的栓塞过滤装置的可膨胀框架包括：第一半框架，具有通过部分回路连接到第二控制臂的第一控制臂，以及具有连接到第二控制臂的第二控制臂的第二半框架第二控制臂通过部分回路。部分回路协同地形成用于附接过滤元件的复合回路，该过滤元件将在体内容器中膨胀以捕获携带在血管流体中的栓塞碎片。可以改变每个半框架的第一和第二控制臂的长度和定位，以便产生符合过滤装置展开的身体容器的尺寸和形状的可扩张框架。此外，部分回路的半径以及部分回路的圆弧的长度可以在每个框架上变化以产生可以容易地适应身体血管的尺寸和形状的复合过滤组件。此外，半框架的控制臂可以在复合环路的近侧或远端设置，以产生不同的过滤结构。

22. 发明授权

US06575996B1 Filter device for embolic protection system 有权
标题翻译：用于栓塞保护系统的过滤装置
公开(公告)号：US06575996B1
公开(公告)日：2003-06-10
申请号：US09895784
申请日：2001-06-29
申请人： Andy Denison , Benjamin C. Huter , Scott J. Huter , John D. Whitfield
发明人： Andy Denison , Benjamin C. Huter , Scott J. Huter , John D. Whitfield
IPC分类号： A61M2900
CPC分类号： A61F2/013 , A61F2002/018 , A61F2230/005 , A61F2230/0067
摘要： A system for enabling the insertion and removal of an embolic protection device, for capturing and retaining embolic debris which may be created during the performance of a therapeutic interventional procedure in a stenosed or occluded region of a blood vessel. The system, in a version of an embodiment thereof, enables the device to expand upon deployment thereof so as to seal off the inner surface of a blood vessel, to inhibit the forming of a gap therein, for inhibiting embolic material from passing therethrough. The system, in another version of the embodiment thereof, enables the device to navigate through confined spaces in tortuous anatomy.
摘要翻译：一种能够插入和移除栓塞保护装置的系统，用于捕获和保留在血管的狭窄或阻塞区域中执行治疗介入手术期间可产生的栓塞碎片。该系统在其实施例的一个实施例中使装置能够在展开时扩张，以便密封血管的内表面，以阻止其中形成间隙，以阻止栓塞材料通过。该系统在其实施例的另一个版本中使得设备能够在弯曲的解剖结构中通过密闭的空间导航。

23. 发明授权

US06706053B1 Nitinol alloy design for sheath deployable and re-sheathable vascular devices 有权
标题翻译：镍钛诺合金设计，用于护套可展开和可再包层的血管装置
公开(公告)号：US06706053B1
公开(公告)日：2004-03-16
申请号：US09561747
申请日：2000-04-28
申请人： John F. Boylan , Scott J. Huter
发明人： John F. Boylan , Scott J. Huter
IPC分类号： A61M2900
CPC分类号： A61F2/013 , A61F2002/018 , A61F2230/0006 , A61F2230/0067
摘要： An embolic protection device that employs a superelastic alloy self-expanding strut assembly with a small profile delivery system for use with interventional procedures is disclosed. The expandable strut assembly is covered with a filter element and both are compressed into a restraining sheath for delivery to a deployment site downstream and distal to the interventional procedure. Once at the desired site, the restraining sheath is retracted to deploy the embolic protection device, which captures flowing emboli generated during the interventional procedure. The expandable strut assembly is made from a superelastic alloy such as nickel-titanium or nitinol, and includes a ternary element in order to minimize the stress hysteresis of the superelastic material. The stress hysteresis is defined by the difference between the loading plateau stress and the unloading plateau stress of the superelastic material. The resulting delivery system including the restraining sheath has a small profile and has a thin wall.
摘要翻译：公开了一种栓塞保护装置，其采用具有小型轮廓输送系统的超弹性合金自扩张支架组件用于介入程序。可膨胀支柱组件被过滤元件覆盖，并且两者被压缩成约束护套，用于递送到介入过程下游和远端的部署部位。一旦在期望的位置，约束护套被缩回以部署栓塞保护装置，其捕获在介入手术期间产生的流动栓塞。可膨胀支柱组件由镍 - 钛或镍钛镍超弹性合金制成，并且包括三元元件以使超弹性材料的应力滞后最小化。应力滞后由载荷平台应力与超弹性材料的卸载平台应力之间的差异定义。所产生的包括约束鞘的输送系统具有小的轮廓并且具有薄壁。

24. 发明申请

US20110029008A1 GUIDE WIRE WITH EMBOLIC FILTERING ATTACHMENT 有权
标题翻译：导线与导线连接
公开(公告)号：US20110029008A1
公开(公告)日：2011-02-03
申请号：US12904001
申请日：2010-10-13
申请人： Douglas H. Gesswein , Wayne E. Cornish , Scott J. Huter , Benjamin C. Huter , John E. Papp
发明人： Douglas H. Gesswein , Wayne E. Cornish , Scott J. Huter , Benjamin C. Huter , John E. Papp
IPC分类号： A61F2/01
CPC分类号： A61F2/013 , A61F2002/018 , A61F2230/0006 , A61F2230/0067 , A61F2230/008
摘要： A separate deliverable embolic protection device filter that attaches to a helical coil at a distal end of a conventional guide, for use in a blood vessel when an interventional procedure is being performed to capture any embolic material which may be created and released into the bloodstream during the procedure. The device includes a filter assembly with a proximal end and a distal end, and a guide wire connector attached to the distal end of the filter assembly. The guide wire connector is able to couple with the helical coil of the guide wire. A restraining sheath placed over the filter assembly in a coaxial arrangement maintains the filter assembly in a collapsed position and delivers the filter assembly separately to the helical coil of the guide wire, and then the guide wire connector is joined to the helical coil. Alternatively, the guide wire can include a rotatable coil section forming a portion of the distal tip coil on the guide wire which is adapted to be coupled to the filter assembly. This arrangement allows the filter assembly to be rotatably mounted onto the guide wire.
摘要翻译：一种单独的可输送栓塞保护装置过滤器，其连接到常规引导件的远端处的螺旋线圈，用于血管中，当进行介入手术以捕获可能产生并释放到血流中的任何栓塞物质时步骤。该装置包括具有近端和远端的过滤器组件和连接到过滤器组件的远端的导丝连接器。导丝连接器能够与导丝的螺旋线圈耦合。以同轴布置放置在过滤器组件上方的限制护套将过滤器组件保持在折叠位置并将过滤器组件分别输送到导丝的螺旋线圈，然后导丝连接器连接到螺旋线圈。或者，引导线可以包括可旋转的线圈部分，其形成导丝上的远端尖端线圈的一部分，其适于联接到过滤器组件。这种布置允许过滤器组件可旋转地安装在导丝上。

25. 发明授权

US07331973B2 Guide wire with embolic filtering attachment 有权
标题翻译：导丝与栓塞过滤附件
公开(公告)号：US07331973B2
公开(公告)日：2008-02-19
申请号：US10260718
申请日：2002-09-30
申请人： Douglas H. Gesswein , Wayne E. Cornish , Scott J. Huter , Benjamin C. Huter , John E. Papp
发明人： Douglas H. Gesswein , Wayne E. Cornish , Scott J. Huter , Benjamin C. Huter , John E. Papp
IPC分类号： A61M29/00
CPC分类号： A61F2/013 , A61F2002/018 , A61F2230/0006 , A61F2230/0067 , A61F2230/008
摘要： A separate deliverable embolic protection device filter that attaches to a helical coil at a distal end of a conventional guide, for use in a blood vessel when an interventional procedure is being performed to capture any embolic material which may be created and released into the bloodstream during the procedure. The device includes a filter assembly with a proximal end and a distal end, and a guide wire connector attached to the distal end of the filter assembly. The guide wire connector is able to couple with the helical coil of the guide wire. A restraining sheath placed over the filter assembly in a coaxial arrangement maintains the filter assembly in a collapsed position and delivers the filter assembly separately to the helical coil of the guide wire, and then the guide wire connector is joined to the helical coil. Alternatively, the guide wire can include a rotatable coil section forming a portion of the distal tip coil on the guide wire which is adapted to be coupled to the filter assembly. This arrangement allows the filter assembly to be rotatably mounted onto the guide wire.
摘要翻译：一种单独的可输送栓塞保护装置过滤器，其连接到常规引导件的远端处的螺旋线圈，用于血管中，当进行介入手术以捕获可能产生并释放到血流中的任何栓塞物质时步骤。该装置包括具有近端和远端的过滤器组件和连接到过滤器组件的远端的导丝连接器。导丝连接器能够与导丝的螺旋线圈耦合。以同轴布置放置在过滤器组件上方的限制护套将过滤器组件保持在折叠位置并将过滤器组件分别输送到导丝的螺旋线圈，然后导丝连接器连接到螺旋线圈。或者，引导线可以包括可旋转的线圈部分，其形成导丝上的远端尖端线圈的一部分，其适于联接到过滤器组件。这种布置允许过滤器组件可旋转地安装在导丝上。

26. 发明授权

US06645220B1 Embolic protection system and method including and embolic-capturing filter 有权
标题翻译：栓塞保护系统包括栓塞过滤器的方法
公开(公告)号：US06645220B1
公开(公告)日：2003-11-11
申请号：US09475600
申请日：1999-12-30
申请人： Benjamin C. Huter , Scott J. Huter , Kent B. Stalker
发明人： Benjamin C. Huter , Scott J. Huter , Kent B. Stalker
IPC分类号： A61M2900
CPC分类号： A61F2/013 , A61F2002/018 , A61F2230/0006 , A61F2230/0067
摘要： A system used in a blood vessel when an interventional procedure is being performed in a stenosed or occluded region to capture any embolic material which may be created and released into the bloodstream during the procedure. The system includes an emboli-capturing filter which is capable of occluding a blood vessel distal to an interventional procedure site, passing the blood to enable blood to flow past the occlusion, and filtering the blood to capture and retain embolic material which may be released into the blood during a therapeutic interventional procedure. The emboli-capturing filter includes an expandable member which is capable of projecting from a guiding catheter so as to be deployed distal to the interventional procedure site to filter the blood. The expandable member is also capable of being retracted into the guiding catheter to capture and retain any released embolic material. The expandable member is further capable of being expanded distal to the area of treatment at the interventional procedure site for occluding the blood vessel. The expandable member may also include a plurality of openings for enabling blood to pass therethrough while preventing emboli from passing therethrough.
摘要翻译：当在狭窄或闭塞区域进行介入手术以捕获在手术期间可能产生和释放到血流中的任何栓塞物质时，在血管中使用的系统。该系统包括栓塞捕获过滤器，其能够封闭介入手术部位远端的血管，使血液通过血液流过闭塞，并过滤血液以捕获并保留可释放的栓塞材料治疗介入手术期间的血液。栓塞捕获过滤器包括可扩张构件，该可膨胀构件能够从引导导管突出以便远离介入手术部位展开以过滤血液。可膨胀构件还能够缩回到引导导管中以捕获和保持任何释放的栓塞材料。可扩张构件还能够在介入手术部位处远离扩张区域扩张以封闭血管。可膨胀构件还可以包括多个开口，用于使血液能够通过，同时防止栓塞通过。

27. 发明授权

US06511496B1 Embolic protection device for use in interventional procedures 有权
标题翻译：用于介入手术的栓塞保护装置
公开(公告)号：US06511496B1
公开(公告)日：2003-01-28
申请号：US09659949
申请日：2000-09-12
申请人： Benjamin C. Huter , Scott J. Huter , Christopher L. Steadham
发明人： Benjamin C. Huter , Scott J. Huter , Christopher L. Steadham
IPC分类号： A61M2900
CPC分类号： A61F2/013 , A61F2002/018 , A61F2230/0006 , A61F2230/005 , A61F2230/0067
摘要： An intravascular filter device for capturing embolic particles entrained in blood flowing in an arterial vessel during an interventional procedure. The filter includes an expandable strut assembly and a filtering medium. Each strut is coated with an elastic polymer in order to minimize trauma to an arterial lumen upon deployment of the filter and to ensure secure adhesion of the filtering medium to the struts. Attached to the coating of the strut assembly is the filtering medium which is formed from a thin elastic polymer membrane containing a plurality of holes which allow blood to pass through filter while capturing embolic particles. The filtering medium is attached to the layer of polymeric material by laser welding, ultrasonic welding or adhesive bonding.
摘要翻译：一种血管内过滤器装置，用于捕获在介入手术期间夹带在动脉血管中流动的血液中的栓塞颗粒。过滤器包括可膨胀支柱组件和过滤介质。每个支柱涂覆有弹性聚合物，以便在部署过滤器时最小化对动脉腔的创伤，并确保过滤介质与支柱的牢固粘附。附着在支柱组件的涂层上的是由包含多个孔的薄弹性聚合物膜形成的过滤介质，其允许血液在捕获栓塞颗粒的同时通过过滤器。过滤介质通过激光焊接，超声波焊接或粘合剂粘结附着在聚合物材料层上。

28. 发明授权

US06383206B1 Embolic protection system and method including filtering elements 有权
标题翻译：栓塞保护系统及方法包括过滤元件
公开(公告)号：US06383206B1
公开(公告)日：2002-05-07
申请号：US09475599
申请日：1999-12-30
申请人： Matthew J. Gillick , Scott J. Huter , Kent C. B. Stalker , Benjamin C. Huter , Anuja Patel
发明人： Matthew J. Gillick , Scott J. Huter , Kent C. B. Stalker , Benjamin C. Huter , Anuja Patel
IPC分类号： A61M2900
CPC分类号： A61F2/013 , A61F2002/018 , A61F2230/0006 , A61F2230/0067 , A61F2230/008 , A61F2230/0093
摘要： A system used in a blood vessel when an interventional procedure is being performed in a stenosed or occluded region to capture any embolic material which may be created and released into the bloodstream during the procedure. The system includes filtering elements which are capable of occluding a blood vessel distal to an interventional procedure site, while enabling the blood to flow past the occlusion and filtering the blood to capture embolic material which may be released into the blood during a therapeutic interventional procedure. The filtering elements include an expandable member which is capable of being expanded distal to the area of treatment at the interventional procedure site for occluding the blood vessel and for enabling the blood to pass therethrough while preventing emboli from passing therethrough. The system also includes a sheath movable distally and proximally to enable the filtering elements to expand into position distal to the interventional procedure site for capturing embolic material and to collapse the filtering elements to retain the captured embolic material therein.
摘要翻译：当在狭窄或闭塞区域进行介入手术以捕获在手术期间可能产生和释放到血流中的任何栓塞物质时，在血管中使用的系统。该系统包括能够封闭介入手术部位远端的血管的过滤元件，同时使血液能够流过闭塞并过滤血液以捕获在治疗介入手术过程中可释放到血液中的栓塞物质。过滤元件包括可扩张构件，该可膨胀构件能够在介入手术部位处远离扩张区域扩张，用于阻塞血管并使血液能够通过，同时防止栓塞通过。该系统还包括可向远侧和近侧移动的护套，以使得过滤元件能够扩展到介入手术部位的远端位置，用于捕获栓塞材料并使过滤元件折叠以将捕获的栓塞材料保持在其中。

29. 发明授权

US07815660B2 Guide wire with embolic filtering attachment 有权
标题翻译：导丝与栓塞过滤附件
公开(公告)号：US07815660B2
公开(公告)日：2010-10-19
申请号：US12025404
申请日：2008-02-04
申请人： Douglas H. Gesswein , Wayne E. Cornish , Scott J. Huter , Benjamin C. Huter , John E. Papp
发明人： Douglas H. Gesswein , Wayne E. Cornish , Scott J. Huter , Benjamin C. Huter , John E. Papp
IPC分类号： A61M29/00
CPC分类号： A61F2/013 , A61F2002/018 , A61F2230/0006 , A61F2230/0067 , A61F2230/008
摘要： A separate deliverable embolic protection device filter that attaches to a helical coil at a distal end of a conventional guide, for use in a blood vessel when an interventional procedure is being performed to capture any embolic material which may be created and released into the bloodstream during the procedure. The device includes a filter assembly with a proximal end and a distal end, and a guide wire connector attached to the distal end of the filter assembly. The guide wire connector is able to couple with the helical coil of the guide wire. A restraining sheath placed over the filter assembly in a coaxial arrangement maintains the filter assembly in a collapsed position and delivers the filter assembly separately to the helical coil of the guide wire, and then the guide wire connector is joined to the helical coil. Alternatively, the guide wire can include a rotatable coil section forming a portion of the distal tip coil on the guide wire which is adapted to be coupled to the filter assembly. This arrangement allows the filter assembly to be rotatably mounted onto the guide wire.
摘要翻译：一种单独的可输送栓塞保护装置过滤器，其连接到常规引导件的远端处的螺旋线圈，用于血管中，当进行介入手术以捕获可能产生并释放到血流中的任何栓塞物质时步骤。该装置包括具有近端和远端的过滤器组件和连接到过滤器组件的远端的导丝连接器。导丝连接器能够与导丝的螺旋线圈耦合。以同轴布置放置在过滤器组件上方的限制护套将过滤器组件保持在折叠位置并将过滤器组件分别输送到导丝的螺旋线圈，然后导丝连接器连接到螺旋线圈。或者，引导线可以包括可旋转的线圈部分，其形成导丝上的远端尖端线圈的一部分，其适于联接到过滤器组件。这种布置允许过滤器组件可旋转地安装在导丝上。

30. 发明申请

US20090131971A1 GUIDE WIRE WITH EMBOLIC FILTERING ATTACHMENT 有权
标题翻译：导线与导线连接
公开(公告)号：US20090131971A1
公开(公告)日：2009-05-21
申请号：US12025404
申请日：2008-02-04
申请人： Douglas H. Gesswein , Wayne E. Cornish , Scott J. Huter , Benjamin C. Huter , John E. Papp
发明人： Douglas H. Gesswein , Wayne E. Cornish , Scott J. Huter , Benjamin C. Huter , John E. Papp
IPC分类号： A61M29/00
CPC分类号： A61F2/013 , A61F2002/018 , A61F2230/0006 , A61F2230/0067 , A61F2230/008
摘要： A separate deliverable embolic protection device filter that attaches to a helical coil at a distal end of a conventional guide, for use in a blood vessel when an interventional procedure is being performed to capture any embolic material which may be created and released into the bloodstream during the procedure. The device includes a filter assembly with a proximal end and a distal end, and a guide wire connector attached to the distal end of the filter assembly. The guide wire connector is able to couple with the helical coil of the guide wire. A restraining sheath placed over the filter assembly in a coaxial arrangement maintains the filter assembly in a collapsed position and delivers the filter assembly separately to the helical coil of the guide wire, and then the guide wire connector is joined to the helical coil. Alternatively, the guide wire can include a rotatable coil section forming a portion of the distal tip coil on the guide wire which is adapted to be coupled to the filter assembly. This arrangement allows the filter assembly to be rotatably mounted onto the guide wire.
摘要翻译：一种单独的可输送栓塞保护装置过滤器，其连接到常规引导件的远端处的螺旋线圈，用于血管中，当进行介入手术以捕获可能产生并释放到血流中的任何栓塞物质时步骤。该装置包括具有近端和远端的过滤器组件和连接到过滤器组件的远端的导丝连接器。导丝连接器能够与导丝的螺旋线圈耦合。以同轴布置放置在过滤器组件上方的限制护套将过滤器组件保持在折叠位置并将过滤器组件分别输送到导丝的螺旋线圈，然后导丝连接器连接到螺旋线圈。或者，引导线可以包括可旋转的线圈部分，其形成导丝上的远端尖端线圈的一部分，其适于联接到过滤器组件。这种布置允许过滤器组件可旋转地安装在导丝上。

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