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    • 26. 发明授权
    • Hydroxyphenyltriazines
    • 羟基苯基三嗪
    • US06284821B1
    • 2001-09-04
    • US09715799
    • 2000-11-17
    • Dietmar HüglinVien Van ToanHelmut LutherChristophe BulliardGerhard Rytz
    • Dietmar HüglinVien Van ToanHelmut LutherChristophe BulliardGerhard Rytz
    • C08K534
    • A61Q17/04A61K8/4966C07D251/24C09K15/30G03C1/8155
    • A description is given of compounds of the formula I in which R1 is C1-C18alkyl; C5-C12cycloalkyl; C3-C6alkenyl; phenyl; C1-C18alkyl which is substituted by phenyl, OH, C1-C18alkoxy, C5-C12cycloalkoxy, C3-C18alkenyloxy, halogen, —COOH, —COOR4, —O—CO—R5, —O—CO—O—R6, —CO—NH2, —CO—NHR7, —CO—N(R7)(R8), CN, NH2, NHR7, —N(R7)(R8), —NH—CO—R5, phenoxy, C1-C18alkyl-substituted phenoxy, phenyl-C1-C4alkoxy, C6-C15bicycloalkoxy, C6-C15bicycloalkylalkoxy, C6-C15bicycloalkenylalkoxy, or C6-C15tricycloalkoxy; C5-C12cycloalkyl which is substituted by OH, C1-C4alkyl, C2-C6alkenyl or —O—CO—R5; glycidyl; —CO—R9 or —SO2—R10; or R1 is C3-C50alkyl which is interrupted by one or more oxygen atoms and/or substituted by OH, phenoxy or C7-C18alkylphenoxy; or R1 denotes the specific polymerizable radicals indicated in claim 1; R2 is C6-C18alky1; C2-C6alkenyl; phenyl; C7-C11phenylalkyl; COOR4; CN; NH—CO—R5; halogen; trifluoromethyl; —O—R3; R3 embraces the definitions given for R1; the radicals R11 independently of one another are H; C1-C18alkyl; C3-C6alkenyl; phenyl; C7-C11phenylalkyl; halogen or C1-C18alkoxy, and the remaining radicals embrace the definitions given in claim 1, at least one of the radicals R1, R2 and R11 containing 4 or more carbon atoms. The novel compounds are effective as stabilizers for organic material against the damaging effect of light, oxygen and heat; they are also suitable for use in skin or hair protection preparations.
    • 给出式Iin化合物的描述,其中R 1是C 1 -C 18烷基; C5-C12环烷基; C 3 -C 6烯基; 苯基; 被苯基,OH,C1-C18烷氧基,C5-C12环烷氧基,C3-C18链烯氧基,卤素,-COOH,-COOR4,-O-CO-R5,-O-CO-O-R6,-CO- NH,-CO-NHR7,-CO-N(R7)(R8),CN,NH2,NHR7,-N(R7)(R8),-NH-CO-R5,苯氧基,C1-C18烷基取代的苯氧基,苯基 C 1 -C 4烷氧基,C 6 -C 15双环烷氧基,C 6 -C 15双环烷基烷氧基或C 6 -C 15三环烷氧基; 被OH,C 1 -C 4烷基,C 2 -C 6烯基或-O-CO-R 5取代的C 5 -C 12环烷基; 缩水甘油基 -CO-R 9或-SO 2 -R 10; 或R1是被一个或多个氧原子中断和/或被OH,苯氧基或C 7 -C 18烷基苯氧基取代的C 3 -C 50烷基;或R 1表示权利要求1所示的特异性可聚合基团; R 2是C 6 -C 18烷基; C 2 -C 6烯基; 苯基; C7-C11苯基烷基; COOR4; CN; NH-CO-R5; 卤素; 三氟甲基 -O-R3; R3包含给定的R 1的定义;基团R 11彼此独立地是H; C1-C18烷基; C 3 -C 6烯基; 苯基; C7-C11苯基烷基; 卤素或C 1 -C 18烷氧基,其余基团包括权利要求1中给出的定义,含有4个或更多个碳原子的基团R 1,R 2和R 11中的至少一个。 新型化合物有效地作为有机材料的稳定剂,防止光,氧和热的破坏作用; 它们也适用于皮肤或护发制剂。
    • 27. 发明授权
    • Cosmetic use of Bis(resorcinyl)triazine derivatives
    • 双(间苯二酚)三嗪衍生物的化妆品用途
    • US06221342B1
    • 2001-04-24
    • US09485948
    • 2000-02-17
    • Dietmar HüglinHelmut LutherDieter Reinehr
    • Dietmar HüglinHelmut LutherDieter Reinehr
    • A61K742
    • A61Q17/04A61K8/4966
    • A description is given of the use of bis(resorcinyl)triazines of formula (1) wherein R1 and R2 are each independently of the other hydrogen; C1-C18alkyl; C2-C18alkenyl; a radical of formula —CH2—CH(—OH)—CH2—O—T1; a radical of formula (1a); or a radical of radical of formula (1b); R3 and R4 are each independently of the other hydrogen or C1-C5alkyl; R5 is hydroxy; C1-C5alkoxy which is unsubstituted or substituted by one or several OH groups; amino; mono- or di-C1-C5alkylamino; M; a radical of formula (1c); (1d); (1e); (1f); (1g); or (1h); R6 is a direct bond; a straight-chain or branched C1-C4alkylene radical or a radical of formula (a) or (b); R7, R8 and R9 are each independently of one another C1-C18alkyl; C1-C18alkoxy or a radical of formula (1i), R10, R11 and R12 are each independently of one another C1-C14alkyl which is unsubstituted or substitued by one or several OH groups; R13 is hydrogen; M; C1-C5alkyl; or a radical of formula (c) R14 is C1-C5alkyl; M is a metal cation; T1 is hydrogen; or C1-C8alkyl; m1 is 1 to 3; m2 is 2 to 14; and p1 is 0; or a number from 1 to 5, for protecting human and animal skin and hair from the damaging effect of UV radiation. The compounds used according to this invention are very powerful UVA absorbers with fractions in the UVB range and are particularly suitable as sunscreens in cosmetic, pharmaceutical and veterinary compositions.
    • 给出了使用式(1)的双(间苯二酚)三嗪的用途,其中R 1和R 2各自独立地为氢; C1-C18烷基; C 2 -C 18烯基; 式-CH 2 -CH(-OH)-CH 2 -O-T 1的基团; 式(1a)的基团; 或式(1b)的基团的基团; R 3和R 4各自独立地为另一个氢或C 1 -C 5烷基; R5是羟基; 未被取代或被一个或多个OH基团取代的C 1 -C 5烷氧基; 氨基; 单或二-C 1 -C 5烷基氨基; M; 式(1c)的基团; (1d); (1e); (1f); (1g); 或(1h); R6是直接的债券; 直链或支链C 1 -C 4亚烷基或式(a)或(b)的基团; R 7,R 8和R 9各自独立地为C 1 -C 18烷基; C 1 -C 18烷氧基或式(1i)的基团,R 10,R 11和R 12各自独立地为彼此未被取代或被一个或几个OH基取代的C 1 -C 14烷基; R13是氢; M; C1-C5烷基; 或式(c)的基团R 14是C 1 -C 5烷基; M是金属阳离子; T1是氢; 或C 1 -C 8烷基; m1为1〜3; m2为2〜14; p1为0; 或1至5个数字,用于保护人体和动物皮肤和头发免受紫外线辐射的破坏作用。 根据本发明使用的化合物是在UVB范围内具有级分的非常强大的UVA吸收剂,并且特别适合作为化妆品,药​​物和兽医组合物中的防晒剂。
    • 29. 发明授权
    • Hydroxyphenyl triazines
    • 羟基苯基三嗪
    • US06184375B2
    • 2001-02-06
    • US08974263
    • 1997-11-19
    • Dietmar HüglinVien Van ToanHelmut LutherChristophe BulliardGerhard Rytz
    • Dietmar HüglinVien Van ToanHelmut LutherChristophe BulliardGerhard Rytz
    • C07D41300
    • A61Q17/04A61K8/4966C07D251/24C09K15/30G03C1/8155
    • A description is given of compounds of the formula I in which R1 is C1-C18alkyl; C5-C12cycloalkyl; C3-C6alkenyl; phenyl; C1-C18alkyl which is substituted by phenyl, OH, C1-C18alkoxy, C5-C12cycloalkoxy, C3-C18alkenyloxy, halogen, —COOH, —COOR4, —O—CO—R5, —O—CO—O—R6, —CO—NH2, —CO—NHR7, —CO—N(R7)(R8), CN, NH2, NHR7, —N(R7)(R8), —NH—CO—R5, phenoxy, C1-C18alkyl-substituted phenoxy, phenyl-C1-C4alkoxy, C6-C15bicycloalkoxy, C6-C15bicycloalkylalkoxy, C6-C15bicycloalkenylalkoxy, or C6-C15tricycloalkoxy; C5-C12cycloalkyl which is substituted by OH, C1-C4alkyl, C2-C6alkenyl or —O—CO—R5; glycidyl; —CO—R9 or —SO2—R10; or R1 is C3-C50alkyl which is interrupted by one or more oxygen atoms and/or substituted by OH, phenoxy or C7-C18alkylphenoxy; or R1 denotes the specific polymerizable radicals indicated in claim 1; R2 is C6-C18alkyl; C2-C6alkenyl; phenyl; C7-C11phenylalkyl; COOR4; CN; NH—CO—R5; halogen; trifluoromethyl; —O—R3; R3 embraces the definitions given for R1; the radicals R11 independently of one another are H; C1-C18alkyl; C3-C6alkenyl; phenyl; C7-C11phenylalkyl; halogen or C1-C18alkoxy, and the remaining radicals embrace the definitions given in claim 1, at least one of the radicals R1, R2 and R11 containing 4 or more carbon atoms. The novel compounds are effective as stabilizers for organic material against the damaging effect of light, oxygen and heat; they are also suitable for use in skin or hair protection preparations.
    • 给出式Iin化合物的描述,其中R 1是C 1 -C 18烷基; C5-C12环烷基; C 3 -C 6烯基; 苯基; 被苯基,OH,C1-C18烷氧基,C5-C12环烷氧基,C3-C18链烯氧基,卤素,-COOH,-COOR4,-O-CO-R5,-O-CO-O-R6,-CO- NH,-CO-NHR7,-CO-N(R7)(R8),CN,NH2,NHR7,-N(R7)(R8),-NH-CO-R5,苯氧基,C1-C18烷基取代的苯氧基,苯基 C 1 -C 4烷氧基,C 6 -C 15双环烷氧基,C 6 -C 15双环烷基烷氧基或C 6 -C 15三环烷氧基; 被OH,C 1 -C 4烷基,C 2 -C 6烯基或-O-CO-R 5取代的C 5 -C 12环烷基; 缩水甘油基 -CO-R 9或-SO 2 -R 10; 或R1是被一个或多个氧原子中断和/或被OH,苯氧基或C 7 -C 18烷基苯氧基取代的C 3 -C 50烷基;或R 1表示权利要求1中所示的特定可聚合基团; R 2是C 6 -C 18烷基; C 2 -C 6烯基; 苯基; C7-C11苯基烷基; COOR4; CN; NH-CO-R5; 卤素; 三氟甲基 -O-R3; R3包含给定的R 1的定义;基团R 11彼此独立地是H; C1-C18烷基; C 3 -C 6烯基; 苯基; C7-C11苯基烷基; 卤素或C 1 -C 18烷氧基,其余基团包括权利要求1中给出的定义,含有4个或更多个碳原子的基团R 1,R 2和R 11中的至少一个。 新型化合物有效地作为有机材料的稳定剂,防止光,氧和热的破坏作用; 它们也适用于皮肤或护发制剂。