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1. 发明授权

US07476699B2 Amino- and hydroxysubstituted triphenyl-s-triazines as stabilizers 失效
标题翻译：氨基和羟基取代的三苯基-s-三嗪作为稳定剂
公开(公告)号：US07476699B2
公开(公告)日：2009-01-13
申请号：US11891554
申请日：2007-08-10
申请人： Dieter Reinehr , Georges Metzger , Peter Michaelis , Helmut Luther
发明人： Dieter Reinehr , Georges Metzger , Peter Michaelis , Helmut Luther
IPC分类号： C08K5/3492
CPC分类号： A61K8/4966 , A61K31/785 , A61K2800/52 , A61Q17/04 , C07D251/24 , C07D265/22 , Y10S514/972
摘要： The present invention provides compounds having the formula: in which R is hydrogen, hydroxy, halogen, C1-C20-alkyl, C4-C12cycloalkyl, C2-C20alkenyl, C2-C20alkynyl, C1-C20-alkoxy, C4-C12cycloalkoxy, C2-C20alkenoxy, C2-C20alkynoxy or C7-C13aralkyl; R1 and R2, independently, are hydrogen, C1-C20alkyl, C4-C12cycloalkyl, C7-C13 aralkyl, —C(═O)—R4 (in which R4 is C1-C20alkyl, C2-C20alkyl interrupted by 1 to 6 oxygen atoms, hetero-substituted C1-C20alkyl, C4-C12cycloalkyl, C2-C20alkenyl, C2-C20alkynyl, C1-C20-alkoxy, C4-C12cycloalkoxy, C2-C20alkenoxy, C2-C20alkynoxy, C6-C12 aryl, C6-C12 aryloxy or C7-C13 aralkyl), or —C(═O)—NH—R1 in which R1 has its previous significance; and R3 is hydrogen, halogen, hydroxy, C1-C20alkyl, C4-C12cycloalkyl, C2-C20alkenyl, C2-C20alkynyl, C1-C20-alkoxy, C4-C12cycloalkoxy, C2-C20alkenoxy, C2-C20alkynoxy, phenyl, C7-C13 aralkyl or —N(R1)(R2) in which R1 and R2 have their previous significance, or R1 and R2 together form a C4-C12 membered ring. The new triphenyltriazine compounds have improved absorption spectrum characteristics and superior resistance to exposure to UV light, relative to known triphenyltriazine compounds.
摘要翻译：本发明提供具有下式的化合物：其中R是氢，羟基，卤素，C 1 -C 20烷基，C 4 -C 12环烷基，C 2 -C 20烯基，C 2 -C 20炔基，C 1 -C 20烷氧基，C 4 -C 12环烷氧基，C 2 -C 20链烯氧基，C 2 -C 20炔氧基或C 7 -C 13芳烷基; R 1和R 2独立地是氢，C 1 -C 20烷基，C 4 -C 12环烷基，C 7 -C 13芳烷基，-C（-O）-R 4（其中R 4是C 1 -C 20烷基，被1至6个氧原子间断的C 2 -C 20烷基， C 1 -C 20烷基，C 2 -C 20炔基，C 1 -C 20烷氧基，C 4 -C 12环烷氧基，C 2 -C 20烯烃氧基，C 2 -C 20炔氧基，C 6 -C 12芳基，C 6 -C 12芳氧基或C 7 -C 13 芳烷基）或-C（-O）-NH-R 1，其中R 1具有其先前的含义; 并且R 3是氢，卤素，羟基，C 1 -C 20烷基，C 4 -C 12环烷基，C 2 -C 20烯基，C 2 -C 20炔基，C 1 -C 20烷氧基，C 4 -C 12环烷氧基，C 2 -C 20链烯氧基，C 2 -C 20炔氧基，苯基，C 7 -C 13芳烷基或 -N（R 1）（R 2），其中R 1和R 2具有其先前的含义，或者R 1和R 2一起形成C 4 -C 12元环。相对于已知的三苯基三嗪化合物，新的三苯基三嗪化合物具有改善的吸收光谱特性和对UV光的暴露性优异的抗性。

2. 发明申请

US20070274933A1 Amino- and hydroxysubstituted triphenyl-S-triazines as stabilizers 失效
公开(公告)号：US20070274933A1
公开(公告)日：2007-11-29
申请号：US11891554
申请日：2007-08-10
申请人： Dieter Reinehr , Georges Metzger , Peter Michaelis , Helmut Luther
发明人： Dieter Reinehr , Georges Metzger , Peter Michaelis , Helmut Luther
IPC分类号： A61K31/785 , A61K47/22 , A61K8/00 , A61Q17/04
CPC分类号： A61K8/4966 , A61K31/785 , A61K2800/52 , A61Q17/04 , C07D251/24 , C07D265/22 , Y10S514/972
摘要： The present invention provides compounds having the formula: in which R is hydrogen, hydroxy, halogen, C1-C20-alkyl, C4-C12cycloalkyl, C2-C20alkenyl, C2-C20alkynyl, C1-C20-alkoxy, C4-C12cycloalkoxy, C2-C20alkenoxy, C2-C20alkynoxy or C7-C13aralkyl; R1 and R2, independently, are hydrogen, C1-C20alkyl, C4-C12cycloalkyl, C7-C13 aralkyl, —C(═O)—R4 (in which R4 is C1-C20alkyl, C2-C20alkyl interrupted by 1 to 6 oxygen atoms, hetero-substituted C1-C20alkyl, C4-C12cycloalkyl, C2-C20alkenyl, C2-C20alkynyl, C1-C20-alkoxy, C4-C12cycloalkoxy, C2-C20alkenoxy, C2-C20alkynoxy, C6-C12 aryl, C6-C12 aryloxy or C7-C13 aralkyl), or —C(═O)—NH—R1 in which R1 has its previous significance; and R3 is hydrogen, halogen, hydroxy, C1-C20alkyl, C4-C12cycloalkyl, C2-C20alkenyl, C2-C20alkynyl, C1-C20-alkoxy, C4-C12cycloalkoxy, C2-C20alkenoxy, C2-C20alkynoxy, phenyl, C7-C13 aralkyl or —N(R1)(R2) in which R1 and R2 have their previous significance, or R1 and R2 together form a C4-C12 membered ring. The new triphenyltriazine compounds have improved absorption spectrum characteristics and superior resistance to exposure to UV light, relative to known triphenyltriazine compounds.

3. 发明授权

US06193960B1 Triazine derivatives 失效
标题翻译：三嗪衍生物
公开(公告)号：US06193960B1
公开(公告)日：2001-02-27
申请号：US09544852
申请日：2000-04-06
申请人： Georges Metzger , Dieter Reinehr , Helmut Luther
发明人： Georges Metzger , Dieter Reinehr , Helmut Luther
IPC分类号： A61K742
CPC分类号： C07D251/52 , A61K8/4966 , A61K8/4993 , A61Q17/04 , C07D251/48 , C07D251/50 , C07D251/70
摘要： The present invention relates to novel s-triazine compounds, processes for their preparation and the use of these novel compounds as UV filters in sunscreen compositions. The novel compounds are those of the formula The triazine compounds of the formula (1) according to the invention are distinguished by a high UV absorption and are particularly suitable as UV filters, i.e. for protecting ultra-violet-sensitive organic materials, in particular the skin and the hair of man and animals, from the harmful action of UV radiation.
摘要翻译：本发明涉及新型的三嗪化合物，它们的制备方法以及这些新化合物作为防晒组合物中的紫外线过滤剂的用途。新化合物是下式的那些：根据本发明的式（1）的三嗪化合物是其特征在于高的紫外线吸收，并且特别适用于紫外线过滤器，即用于保护紫外线有害的紫外线辐射有害作用的紫外线敏感有机材料，特别是人和动物的皮肤和头发。

4. 发明授权

US06818205B2 Use of fluorescent whitening agents 失效
标题翻译：使用荧光增白剂
公开(公告)号：US06818205B2
公开(公告)日：2004-11-16
申请号：US10149396
申请日：2002-06-11
申请人： Dieter Reinehr , Helmut Luther , Georges Metzger
发明人： Dieter Reinehr , Helmut Luther , Georges Metzger
IPC分类号： A61K742
CPC分类号： A61Q19/02 , A61K8/466 , A61K8/49 , A61K8/494 , A61K8/4966 , A61K8/498 , A61K8/731 , A61K8/732 , A61K8/8147 , A61K8/8158 , A61K2800/434 , A61Q17/04
摘要： The use of a polymeric carrier material treated with a fluorescent whitening agent, for lightening human skin and for protecting human skin against UV radiation, is described.
摘要翻译：描述了使用用荧光增白剂处理的聚合物载体材料，用于减轻人体皮肤和保护人体皮肤免受紫外线辐射。

5. 发明授权

US5760111A o-Hydroxyphenyl-s-triazines 失效
标题翻译：邻羟基苯基-s-三嗪
公开(公告)号：US5760111A
公开(公告)日：1998-06-02
申请号：US715056
申请日：1996-09-17
申请人： Jean-Luc Birbaum , Jurgen Kaschig , Dieter Reinehr , Manfred Rembold , Andre Schmitter , Helmut Luther , Bernd Herzog , Dietmar Huglin
发明人： Jean-Luc Birbaum , Jurgen Kaschig , Dieter Reinehr , Manfred Rembold , Andre Schmitter , Helmut Luther , Bernd Herzog , Dietmar Huglin
IPC分类号： C07D251/02 , A61K8/00 , A61K8/42 , A61K8/49 , A61K8/85 , A61Q17/04 , C07D251/12 , C07D251/24 , C08K5/3492 , C08L67/00 , C09K3/00 , D06P1/642 , D06P3/52 , C08K5/3495
CPC分类号： C08K5/3492 , A61K8/4966 , A61Q17/04 , C07D251/24 , D06P1/6426
摘要： o-Hydroxyphenyl-s-triazines are described which contain at least two alkoxyphenyl substituents. They have the formula (1). The compounds according to the invention are suitable as stabilizers for textile fiber materials, in particular polyester fiber materials, and for organic polymers. Furthermore, they are suitable for use as sunscreens in cosmetic preparations.
摘要翻译：描述了含有至少两个烷氧基苯基取代基的邻羟基苯基-s-三嗪。他们有公式（1）。根据本发明的化合物适用于纺织纤维材料，特别是聚酯纤维材料和有机聚合物的稳定剂。此外，它们适合用作化妆品制剂中的防晒剂。

6. 发明授权

US06384284B1 Biphenyl compounds substituted by camphor or hydantoin derivatives as sunscreen compositions 有权
标题翻译：由樟脑或乙内酰脲衍生物取代的联苯化合物作为防晒组合物
公开(公告)号：US06384284B1
公开(公告)日：2002-05-07
申请号：US09806358
申请日：2001-03-29
申请人： Rudolf Zink , Dieter Reinehr , Helmut Luther , Bernd Herzog
发明人： Rudolf Zink , Dieter Reinehr , Helmut Luther , Bernd Herzog
IPC分类号： C07C4900
CPC分类号： C07C309/24 , A61K8/35 , A61K8/466 , A61K8/4946 , A61Q17/04 , C07C45/74 , C07C49/683
摘要： A description is given of diphenyl compounds of formula wherein R is a camphor or hydantoin derivative; and R1 is hydrogen; or C1-C5alkyl. These compounds are suitable as light stabilizers in cosmetic, pharmaceutical and veterinary formulations.
摘要翻译：给出了二烷基化合物的描述，R是樟脑或乙内酰脲衍生物; 并且R 1是氢; 或C1-C5烷基。这些化合物在化妆品，药物和兽药制剂中适合作为光稳定剂。

7. 发明授权

US06221342B1 Cosmetic use of Bis(resorcinyl)triazine derivatives 失效
标题翻译：双（间苯二酚）三嗪衍生物的化妆品用途
公开(公告)号：US06221342B1
公开(公告)日：2001-04-24
申请号：US09485948
申请日：2000-02-17
申请人： Dietmar Hüglin , Helmut Luther , Dieter Reinehr
发明人： Dietmar Hüglin , Helmut Luther , Dieter Reinehr
IPC分类号： A61K742
CPC分类号： A61Q17/04 , A61K8/4966
摘要： A description is given of the use of bis(resorcinyl)triazines of formula (1) wherein R1 and R2 are each independently of the other hydrogen; C1-C18alkyl; C2-C18alkenyl; a radical of formula —CH2—CH(—OH)—CH2—O—T1; a radical of formula (1a); or a radical of radical of formula (1b); R3 and R4 are each independently of the other hydrogen or C1-C5alkyl; R5 is hydroxy; C1-C5alkoxy which is unsubstituted or substituted by one or several OH groups; amino; mono- or di-C1-C5alkylamino; M; a radical of formula (1c); (1d); (1e); (1f); (1g); or (1h); R6 is a direct bond; a straight-chain or branched C1-C4alkylene radical or a radical of formula (a) or (b); R7, R8 and R9 are each independently of one another C1-C18alkyl; C1-C18alkoxy or a radical of formula (1i), R10, R11 and R12 are each independently of one another C1-C14alkyl which is unsubstituted or substitued by one or several OH groups; R13 is hydrogen; M; C1-C5alkyl; or a radical of formula (c) R14 is C1-C5alkyl; M is a metal cation; T1 is hydrogen; or C1-C8alkyl; m1 is 1 to 3; m2 is 2 to 14; and p1 is 0; or a number from 1 to 5, for protecting human and animal skin and hair from the damaging effect of UV radiation. The compounds used according to this invention are very powerful UVA absorbers with fractions in the UVB range and are particularly suitable as sunscreens in cosmetic, pharmaceutical and veterinary compositions.
摘要翻译：给出了使用式（1）的双（间苯二酚）三嗪的用途，其中R 1和R 2各自独立地为氢; C1-C18烷基; C 2 -C 18烯基; 式-CH 2 -CH（-OH）-CH 2 -O-T 1的基团; 式（1a）的基团; 或式（1b）的基团的基团; R 3和R 4各自独立地为另一个氢或C 1 -C 5烷基; R5是羟基; 未被取代或被一个或多个OH基团取代的C 1 -C 5烷氧基; 氨基; 单或二-C 1 -C 5烷基氨基; M; 式（1c）的基团; （1d）; （1e）; （1f）; （1g）; 或（1h）; R6是直接的债券; 直链或支链C 1 -C 4亚烷基或式（a）或（b）的基团; R 7，R 8和R 9各自独立地为C 1 -C 18烷基; C 1 -C 18烷氧基或式（1i）的基团，R 10，R 11和R 12各自独立地为彼此未被取代或被一个或几个OH基取代的C 1 -C 14烷基; R13是氢; M; C1-C5烷基; 或式（c）的基团R 14是C 1 -C 5烷基; M是金属阳离子; T1是氢; 或C 1 -C 8烷基; m1为1〜3; m2为2〜14; p1为0; 或1至5个数字，用于保护人体和动物皮肤和头发免受紫外线辐射的破坏作用。根据本发明使用的化合物是在UVB范围内具有级分的非常强大的UVA吸收剂，并且特别适合作为化妆品，药物和兽医组合物中的防晒剂。

8. 发明授权

US06201000B1 Use of selected benzotriazole derivatives for protecting human and animal skin and hair from the harmful effects of UV radiation 失效
标题翻译：使用选择的苯并三唑衍生物保护人体和动物皮肤和头发免受紫外线辐射的有害影响
公开(公告)号：US06201000B1
公开(公告)日：2001-03-13
申请号：US09308423
申请日：1999-05-18
申请人： Helmut Luther , Dieter Reinehr , Rudolf Zink
发明人： Helmut Luther , Dieter Reinehr , Rudolf Zink
IPC分类号： A61K3141
CPC分类号： C07D249/20 , A61K8/49 , A61K8/496 , A61K8/69 , A61Q5/02 , A61Q5/04 , A61Q5/06 , A61Q5/08 , A61Q5/10 , A61Q17/04
摘要： The invention is related to a composition containing benzotriazole derivatives of formula (I) and the method of treating skin damages due to harmful UV radiation using this claimed composition.
摘要翻译：本发明涉及包含式（I）的苯并三唑衍生物的组合物和使用所要求保护的组合物治疗由于有害的紫外线辐射引起的皮肤损伤的方法。

9. 发明授权

US5591850A o-Hydroxyphenyl-s-triazines 失效
标题翻译：邻羟基苯基-s-三嗪
公开(公告)号：US5591850A
公开(公告)日：1997-01-07
申请号：US340952
申请日：1994-11-17
申请人： Jean-Luc Birbaum , J urgen Kaschig , Dieter Reinehr , Manfred Rembold , Andr e Schmitter , Helmut Luther , Bernd Herzog , Dietmar H uglin
发明人： Jean-Luc Birbaum , J urgen Kaschig , Dieter Reinehr , Manfred Rembold , Andr e Schmitter , Helmut Luther , Bernd Herzog , Dietmar H uglin
IPC分类号： C07D251/02 , A61K8/00 , A61K8/42 , A61K8/49 , A61K8/85 , A61Q17/04 , C07D251/12 , C07D251/24 , C08K5/3492 , C08L67/00 , C09K3/00 , D06P1/642 , D06P3/52 , C07D251/00
CPC分类号： C08K5/3492 , A61K8/4966 , A61Q17/04 , C07D251/24 , D06P1/6426
摘要： o-Hydroxyphenyl-s-triazines are described which contain at least two alkoxyphenyl substituents. They have the formula (1).The compounds according to the invention are suitable as stabilizers for textile fiber materials, in particular polyester fiber materials, and for organic polymers. Furthermore, they are suitable for use as sunscreens in cosmetic preparations.
摘要翻译：描述了含有至少两个烷氧基苯基取代基的邻羟基苯基-s-三嗪。他们有公式（1）。根据本发明的化合物适用于纺织纤维材料，特别是聚酯纤维材料和有机聚合物的稳定剂。此外，它们适合用作化妆品制剂中的防晒剂。

10. 发明申请

US20050048012A1 Use of biotin or a biotin derivative for skin lightening purposes and for the treatment of senile lentigines 审中-公开
标题翻译：使用生物素或生物素衍生物用于皮肤增亮目的和治疗老年斑
公开(公告)号：US20050048012A1
公开(公告)日：2005-03-03
申请号：US10833983
申请日：2004-04-28
申请人： Roland Jermann , Helmut Luther
发明人： Roland Jermann , Helmut Luther
IPC分类号： A61K8/49 , A61K8/67 , A61K31/4188 , A61Q19/02 , A61K7/135
CPC分类号： A61K31/375 , A61K8/67 , A61K8/676 , A61K31/4188 , A61Q19/02
摘要： The present invention relates to the use of biotin and biotin derivatives alone, or with vitamin C or a derivative thereof, for the preparation of a cosmetic composition or of a pharmaceutical composition for skin-lightening purposes, for the elimination of skin color irregularities and for the treatment of senile lentigines.
摘要翻译：本发明涉及生物素和生物素衍生物单独或与维生素C或其衍生物在制备化妆品组合物或用于减轻皮肤的目的的药物组合物中的用途，用于消除皮肤颜色不规则和老年斑的治疗。

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