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1. 发明授权

US06284821B1 Hydroxyphenyltriazines 有权
标题翻译：羟基苯基三嗪
公开(公告)号：US06284821B1
公开(公告)日：2001-09-04
申请号：US09715799
申请日：2000-11-17
申请人： Dietmar Hüglin , Vien Van Toan , Helmut Luther , Christophe Bulliard , Gerhard Rytz
发明人： Dietmar Hüglin , Vien Van Toan , Helmut Luther , Christophe Bulliard , Gerhard Rytz
IPC分类号： C08K534
CPC分类号： A61Q17/04 , A61K8/4966 , C07D251/24 , C09K15/30 , G03C1/8155
摘要： A description is given of compounds of the formula I in which R1 is C1-C18alkyl; C5-C12cycloalkyl; C3-C6alkenyl; phenyl; C1-C18alkyl which is substituted by phenyl, OH, C1-C18alkoxy, C5-C12cycloalkoxy, C3-C18alkenyloxy, halogen, —COOH, —COOR4, —O—CO—R5, —O—CO—O—R6, —CO—NH2, —CO—NHR7, —CO—N(R7)(R8), CN, NH2, NHR7, —N(R7)(R8), —NH—CO—R5, phenoxy, C1-C18alkyl-substituted phenoxy, phenyl-C1-C4alkoxy, C6-C15bicycloalkoxy, C6-C15bicycloalkylalkoxy, C6-C15bicycloalkenylalkoxy, or C6-C15tricycloalkoxy; C5-C12cycloalkyl which is substituted by OH, C1-C4alkyl, C2-C6alkenyl or —O—CO—R5; glycidyl; —CO—R9 or —SO2—R10; or R1 is C3-C50alkyl which is interrupted by one or more oxygen atoms and/or substituted by OH, phenoxy or C7-C18alkylphenoxy; or R1 denotes the specific polymerizable radicals indicated in claim 1; R2 is C6-C18alky1; C2-C6alkenyl; phenyl; C7-C11phenylalkyl; COOR4; CN; NH—CO—R5; halogen; trifluoromethyl; —O—R3; R3 embraces the definitions given for R1; the radicals R11 independently of one another are H; C1-C18alkyl; C3-C6alkenyl; phenyl; C7-C11phenylalkyl; halogen or C1-C18alkoxy, and the remaining radicals embrace the definitions given in claim 1, at least one of the radicals R1, R2 and R11 containing 4 or more carbon atoms. The novel compounds are effective as stabilizers for organic material against the damaging effect of light, oxygen and heat; they are also suitable for use in skin or hair protection preparations.
摘要翻译：给出式Iin化合物的描述，其中R 1是C 1 -C 18烷基; C5-C12环烷基; C 3 -C 6烯基; 苯基; 被苯基，OH，C1-C18烷氧基，C5-C12环烷氧基，C3-C18链烯氧基，卤素，-COOH，-COOR4，-O-CO-R5，-O-CO-O-R6，-CO- NH，-CO-NHR7，-CO-N（R7）（R8），CN，NH2，NHR7，-N（R7）（R8），-NH-CO-R5，苯氧基，C1-C18烷基取代的苯氧基，苯基 C 1 -C 4烷氧基，C 6 -C 15双环烷氧基，C 6 -C 15双环烷基烷氧基或C 6 -C 15三环烷氧基; 被OH，C 1 -C 4烷基，C 2 -C 6烯基或-O-CO-R 5取代的C 5 -C 12环烷基; 缩水甘油基 -CO-R 9或-SO 2 -R 10; 或R1是被一个或多个氧原子中断和/或被OH，苯氧基或C 7 -C 18烷基苯氧基取代的C 3 -C 50烷基;或R 1表示权利要求1所示的特异性可聚合基团; R 2是C 6 -C 18烷基; C 2 -C 6烯基; 苯基; C7-C11苯基烷基; COOR4; CN; NH-CO-R5; 卤素; 三氟甲基 -O-R3; R3包含给定的R 1的定义;基团R 11彼此独立地是H; C1-C18烷基; C 3 -C 6烯基; 苯基; C7-C11苯基烷基; 卤素或C 1 -C 18烷氧基，其余基团包括权利要求1中给出的定义，含有4个或更多个碳原子的基团R 1，R 2和R 11中的至少一个。新型化合物有效地作为有机材料的稳定剂，防止光，氧和热的破坏作用; 它们也适用于皮肤或护发制剂。

2. 发明授权

US06184375B2 Hydroxyphenyl triazines 失效
标题翻译：羟基苯基三嗪
公开(公告)号：US06184375B2
公开(公告)日：2001-02-06
申请号：US08974263
申请日：1997-11-19
申请人： Dietmar Hüglin , Vien Van Toan , Helmut Luther , Christophe Bulliard , Gerhard Rytz
发明人： Dietmar Hüglin , Vien Van Toan , Helmut Luther , Christophe Bulliard , Gerhard Rytz
IPC分类号： C07D41300
CPC分类号： A61Q17/04 , A61K8/4966 , C07D251/24 , C09K15/30 , G03C1/8155
摘要： A description is given of compounds of the formula I in which R1 is C1-C18alkyl; C5-C12cycloalkyl; C3-C6alkenyl; phenyl; C1-C18alkyl which is substituted by phenyl, OH, C1-C18alkoxy, C5-C12cycloalkoxy, C3-C18alkenyloxy, halogen, —COOH, —COOR4, —O—CO—R5, —O—CO—O—R6, —CO—NH2, —CO—NHR7, —CO—N(R7)(R8), CN, NH2, NHR7, —N(R7)(R8), —NH—CO—R5, phenoxy, C1-C18alkyl-substituted phenoxy, phenyl-C1-C4alkoxy, C6-C15bicycloalkoxy, C6-C15bicycloalkylalkoxy, C6-C15bicycloalkenylalkoxy, or C6-C15tricycloalkoxy; C5-C12cycloalkyl which is substituted by OH, C1-C4alkyl, C2-C6alkenyl or —O—CO—R5; glycidyl; —CO—R9 or —SO2—R10; or R1 is C3-C50alkyl which is interrupted by one or more oxygen atoms and/or substituted by OH, phenoxy or C7-C18alkylphenoxy; or R1 denotes the specific polymerizable radicals indicated in claim 1; R2 is C6-C18alkyl; C2-C6alkenyl; phenyl; C7-C11phenylalkyl; COOR4; CN; NH—CO—R5; halogen; trifluoromethyl; —O—R3; R3 embraces the definitions given for R1; the radicals R11 independently of one another are H; C1-C18alkyl; C3-C6alkenyl; phenyl; C7-C11phenylalkyl; halogen or C1-C18alkoxy, and the remaining radicals embrace the definitions given in claim 1, at least one of the radicals R1, R2 and R11 containing 4 or more carbon atoms. The novel compounds are effective as stabilizers for organic material against the damaging effect of light, oxygen and heat; they are also suitable for use in skin or hair protection preparations.
摘要翻译：给出式Iin化合物的描述，其中R 1是C 1 -C 18烷基; C5-C12环烷基; C 3 -C 6烯基; 苯基; 被苯基，OH，C1-C18烷氧基，C5-C12环烷氧基，C3-C18链烯氧基，卤素，-COOH，-COOR4，-O-CO-R5，-O-CO-O-R6，-CO- NH，-CO-NHR7，-CO-N（R7）（R8），CN，NH2，NHR7，-N（R7）（R8），-NH-CO-R5，苯氧基，C1-C18烷基取代的苯氧基，苯基 C 1 -C 4烷氧基，C 6 -C 15双环烷氧基，C 6 -C 15双环烷基烷氧基或C 6 -C 15三环烷氧基; 被OH，C 1 -C 4烷基，C 2 -C 6烯基或-O-CO-R 5取代的C 5 -C 12环烷基; 缩水甘油基 -CO-R 9或-SO 2 -R 10; 或R1是被一个或多个氧原子中断和/或被OH，苯氧基或C 7 -C 18烷基苯氧基取代的C 3 -C 50烷基;或R 1表示权利要求1中所示的特定可聚合基团; R 2是C 6 -C 18烷基; C 2 -C 6烯基; 苯基; C7-C11苯基烷基; COOR4; CN; NH-CO-R5; 卤素; 三氟甲基 -O-R3; R3包含给定的R 1的定义;基团R 11彼此独立地是H; C1-C18烷基; C 3 -C 6烯基; 苯基; C7-C11苯基烷基; 卤素或C 1 -C 18烷氧基，其余基团包括权利要求1中给出的定义，含有4个或更多个碳原子的基团R 1，R 2和R 11中的至少一个。新型化合物有效地作为有机材料的稳定剂，防止光，氧和热的破坏作用; 它们也适用于皮肤或护发制剂。

3. 发明授权

US06221342B1 Cosmetic use of Bis(resorcinyl)triazine derivatives 失效
标题翻译：双（间苯二酚）三嗪衍生物的化妆品用途
公开(公告)号：US06221342B1
公开(公告)日：2001-04-24
申请号：US09485948
申请日：2000-02-17
申请人： Dietmar Hüglin , Helmut Luther , Dieter Reinehr
发明人： Dietmar Hüglin , Helmut Luther , Dieter Reinehr
IPC分类号： A61K742
CPC分类号： A61Q17/04 , A61K8/4966
摘要： A description is given of the use of bis(resorcinyl)triazines of formula (1) wherein R1 and R2 are each independently of the other hydrogen; C1-C18alkyl; C2-C18alkenyl; a radical of formula —CH2—CH(—OH)—CH2—O—T1; a radical of formula (1a); or a radical of radical of formula (1b); R3 and R4 are each independently of the other hydrogen or C1-C5alkyl; R5 is hydroxy; C1-C5alkoxy which is unsubstituted or substituted by one or several OH groups; amino; mono- or di-C1-C5alkylamino; M; a radical of formula (1c); (1d); (1e); (1f); (1g); or (1h); R6 is a direct bond; a straight-chain or branched C1-C4alkylene radical or a radical of formula (a) or (b); R7, R8 and R9 are each independently of one another C1-C18alkyl; C1-C18alkoxy or a radical of formula (1i), R10, R11 and R12 are each independently of one another C1-C14alkyl which is unsubstituted or substitued by one or several OH groups; R13 is hydrogen; M; C1-C5alkyl; or a radical of formula (c) R14 is C1-C5alkyl; M is a metal cation; T1 is hydrogen; or C1-C8alkyl; m1 is 1 to 3; m2 is 2 to 14; and p1 is 0; or a number from 1 to 5, for protecting human and animal skin and hair from the damaging effect of UV radiation. The compounds used according to this invention are very powerful UVA absorbers with fractions in the UVB range and are particularly suitable as sunscreens in cosmetic, pharmaceutical and veterinary compositions.
摘要翻译：给出了使用式（1）的双（间苯二酚）三嗪的用途，其中R 1和R 2各自独立地为氢; C1-C18烷基; C 2 -C 18烯基; 式-CH 2 -CH（-OH）-CH 2 -O-T 1的基团; 式（1a）的基团; 或式（1b）的基团的基团; R 3和R 4各自独立地为另一个氢或C 1 -C 5烷基; R5是羟基; 未被取代或被一个或多个OH基团取代的C 1 -C 5烷氧基; 氨基; 单或二-C 1 -C 5烷基氨基; M; 式（1c）的基团; （1d）; （1e）; （1f）; （1g）; 或（1h）; R6是直接的债券; 直链或支链C 1 -C 4亚烷基或式（a）或（b）的基团; R 7，R 8和R 9各自独立地为C 1 -C 18烷基; C 1 -C 18烷氧基或式（1i）的基团，R 10，R 11和R 12各自独立地为彼此未被取代或被一个或几个OH基取代的C 1 -C 14烷基; R13是氢; M; C1-C5烷基; 或式（c）的基团R 14是C 1 -C 5烷基; M是金属阳离子; T1是氢; 或C 1 -C 8烷基; m1为1〜3; m2为2〜14; p1为0; 或1至5个数字，用于保护人体和动物皮肤和头发免受紫外线辐射的破坏作用。根据本发明使用的化合物是在UVB范围内具有级分的非常强大的UVA吸收剂，并且特别适合作为化妆品，药物和兽医组合物中的防晒剂。

4. 发明授权

US06217856B1 Symmetrical triazine derivatives 失效
标题翻译：对称三嗪衍生物
公开(公告)号：US06217856B1
公开(公告)日：2001-04-17
申请号：US09308094
申请日：1999-05-17
申请人： Thomas Ehlis , Dietmar Hüglin , Helmut Luther
发明人： Thomas Ehlis , Dietmar Hüglin , Helmut Luther
IPC分类号： A61K706
CPC分类号： C07D251/24 , A61K8/4966 , A61Q17/04
摘要： A description is given of symmetrical triazine derivatives of formula (1), wherein R1 and R2 are each independently of the other hydrogen; C1-C12alkyl, C1-C12alkoxy; and R3 is C1-C12alkyl; or C1-C12alkoxy. The easily accessible triazine derivatives are suitable for protecting ultraviolet-sensitive materials, in particular skin and hair of humans and animals, from the harmful effects of UV radiation.
摘要翻译：给出式（1）的对称三嗪衍生物的描述，其中R 1和R 2各自独立于另一个氢; C 1 -C 12烷基，C 1 -C 12烷氧基; 且R 3为C 1 -C 12烷基; 或C 1 -C 12烷氧基。容易获得的三嗪衍生物适用于防止紫外线辐射的有害影响的紫外线敏感材料，特别是人和动物的皮肤和毛发。

5. 发明授权

US06369268B1 Diester amine adducts 失效
标题翻译：二胺加合物
公开(公告)号：US06369268B1
公开(公告)日：2002-04-09
申请号：US09530537
申请日：2000-05-01
申请人： Thomas Ehlis , Peter Frankhauser , Dietmar Hüglin
发明人： Thomas Ehlis , Peter Frankhauser , Dietmar Hüglin
IPC分类号： C07C22900
CPC分类号： D21C9/1042 , A23L29/035 , A61K8/44 , A61K2800/51 , A61Q5/02 , A61Q15/00 , A61Q17/00 , A61Q19/00 , C07C229/24 , C11D1/46 , C11D3/26 , D06M13/332 , D06M2200/50 , D06P1/645
摘要： Described are diester amine adducts of formula (1) wherein R1, R2, R3, R4 are each independently of one another C4-C22alkyl; C2-C22alkenyl; or C5-C7cycloalkyl; X1 and X2 are each independently of the other hydrogen, C1-C4alkyl; C2-C4hydroxyalkyl or C2-C4hydroxyhaloalkyl; Y is a radical of formula (1b); A1 is C2-C3alkylene or 2-hydroxy-n-propylene; X3 is hydrogen; C1-C4alkyl, C2-C4hydroxyalkyl; or C2-C4hydroxyhaloalkyl; (A) is an asymmetrical carbon atom in the R- or S-configuration, wherein, if C1=R, C2=R; C1=S, C2=S; and C1=R; C2=S; m1 is 1 or 2; and n is an integer from 1 to 4; p is 0 or 1; which adducts may be in the form of free bases or ammonium salts. Said compounds are precursors of compounds having good complex-forming properties and are thus able to effectively bind heavy metal ions such as iron, zinc, magnesium or copper ions and to prevent metal-initiated oxidations after enzymatic or chemical cleavage. They have a plurality of uses, for example in foods, beverages, derusting and decalcification baths, as additives in liquids for cooling-water circuits, in personal-care products, as bleaching stabilizers, in cleaning agents and detergents, in the textile industry and also as soft handle agents for organic fibre materials.
摘要翻译：描述了式（1）的二酯加合物，其中R 1，R 2，R 3，R 4各自独立地为C 1 -C 22烷基; C 2 -C 22烯基; 或C 5 -C 7环烷基; X 1和X 2各自独立地为另一个氢，C 1 -C 4烷基; C 2 -C 4羟烷基或C 2 -C 4羟基卤代烷基; Y是式（1b）的基团; A1是C2-C3亚烷基或2-羟基 - 正丙烯; X3是氢; C 1 -C 4烷基，C 2 -C 4羟烷基; 或C 2 -C 4羟基卤代烷基; （A）是R-或S-构型中的不对称碳原子，其中如果C1 = R，则C2 = R; C1 = S，C2 = S; 和C1 = R; C2 = S; m1为1或2; n为1〜4的整数。 p为0或1; 哪些加成物可以是游离碱或铵盐的形式。所述化合物是具有良好的络合物形成性质的化合物的前体，因此能够有效地结合重金属离子如铁，锌，镁或铜离子，并且在酶或化学裂解后防止金属引发的氧化。它们具有多种用途，例如在食品，饮料，除锈和脱钙浴中，作为用于冷却水回路的液体，个人护理产品中的添加剂，漂白稳定剂，清洁剂和洗涤剂在纺织工业中的用途，以及也作为有机纤维材料的软处理剂。

6. 发明授权

US07871642B2 Use of nanodispersions in pharmaceutical end formulations 有权
标题翻译：在药物末端制剂中使用纳米分散体
公开(公告)号：US07871642B2
公开(公告)日：2011-01-18
申请号：US11446844
申请日：2006-06-05
申请人： Andreas Werner Supersaxo , Hans Georg Weder , Dietmar Hüglin , Joachim Friedrich Röding
发明人： Andreas Werner Supersaxo , Hans Georg Weder , Dietmar Hüglin , Joachim Friedrich Röding
IPC分类号： A61K9/127 , A61K9/107
CPC分类号： A61K9/1075 , A61K9/4858 , A61K9/4866 , Y10S514/846 , Y10S514/937 , Y10S514/938 , Y10S514/941 , Y10S514/947
摘要： A nanodispersion comprises (a) a membrane-forming molecule, (b) a coemulsifier and (c) a lipophilic component, in pharmaceutical end formulations, the nanodispersion being obtainable by (α) mixing the components (a), (b) and (c) until a homogeneous clear liquid is obtained, and (β) adding the liquid obtained in step (α) to the water phase of the pharmaceutical end formulations, where steps (α) and (β) may be carried out without high energy mixing or homogenization. The nanodispersions prepared according to this invention are suitable as transport vehicles for pharmaceutical active agents.
摘要翻译：纳米分散体包含（a）在药物末端制剂中的成膜分子（b）共乳化剂和（c）亲脂性组分，所述纳米分散体可通过（α）混合组分（a），（b）和（ c）直到获得均匀的透明液体，并且将（步骤（α）中获得的液体）添加到药物末端制剂的水相中，其中步骤（α）和（＆bgr）可以在不高的情况下进行能量混合或均质化。根据本发明制备的纳米分散体适合用作药物活性剂的运输工具。

7. 发明授权

US07344706B2 UV absorber compositions comprising a hydroxyphenyltriazine compound 有权
标题翻译：包含羟基苯基三嗪化合物的紫外线吸收剂组合物
公开(公告)号：US07344706B2
公开(公告)日：2008-03-18
申请号：US10507295
申请日：2003-03-04
申请人： Jürg Haase , Thomas Ehlis , Elek Borsos , Dietmar Hüglin , Bernd Herzog
发明人： Jürg Haase , Thomas Ehlis , Elek Borsos , Dietmar Hüglin , Bernd Herzog
IPC分类号： A61Q17/00 , A61Q17/04 , A61Q19/00 , A61K8/02 , A61K31/53
CPC分类号： A61K8/4966 , A61Q17/04
摘要： UV absorber compositions are described, comprising (a) from 1 to 99% by weight of a hydroxyphenyltriazine compound of formula (I) wherein R1, R2 and R3 are each independently of the others C1-C18alkyl; C2-C10,alkenyl; or phenyl-C1-C4 alkyl; R4 is hydrogen; or C1-C5alkyl; and (b) from 99 to 1% by weight of a further UV absorber selected from the group of (b) hydroxyphenyltriazines that are different from component (a), (b2) benzotriazoles, (b3) dibenzoylmethane derivatives and (b4) camphor derivatives. The compositions are suitable as UV filters in cosmetic compositions
摘要翻译：描述了UV吸收剂组合物，其包含（a）1至99重量％的式（I）的羟基苯基三嗪化合物，其中R 1，R 2和R 2 > 3 各自独立地为C 1 -C 12烷基; C 2 -C 10，烯基; 或苯基-C 1 -C 4烷基; R 4是氢; 或C 1 -C 5烷基; （b）99〜1重量％的另外的紫外线吸收剂，其选自（b）不同于组分（a），（b-2）苯并三唑的（b）羟基苯基三嗪，（b < （3/4）二苯甲酰甲烷衍生物和（b 4 S）樟脑衍生物。该组合物适用于化妆品组合物中的UV过滤器

8. 发明授权

US07008638B2 Use of nanodispersions in cosmetic end formulations 有权
公开(公告)号：US07008638B2
公开(公告)日：2006-03-07
申请号：US10016903
申请日：2001-12-14
申请人： Dietmar Hüglin , Joachim Friedrich Röding , Andreas Werner Supersaxo , Hans Georg Weder
发明人： Dietmar Hüglin , Joachim Friedrich Röding , Andreas Werner Supersaxo , Hans Georg Weder
IPC分类号： A61K9/127 , A61K7/00
CPC分类号： A61K8/04 , A61K8/553 , A61K8/68 , A61K2800/21 , A61Q1/02 , A61Q17/00 , A61Q17/04 , A61Q19/00 , A61Q19/10 , B82Y5/00
摘要： A description is given of the use of a nanodispersion, which comprises (a) a membrane-forming molecule, (b) a coemulsifier and (c) a lipophilic component, in cosmetic end formulation, which nanodispersion is obtainable by (α) mixing the components (a), (b) and (c) until a homogeneous clear liquid is obtained, and (β) adding the liquid obtained in step (α) to the water phase of the cosmetic end formulations, steps (α) and (β) being carried out without any additional supply of energy. The nanodispersions used according to this invention can be easily prepared and are suitable as carrier systems for a very wide range of cosmetic active agents and oil-soluble dyes.

9. 发明授权

US08449868B2 Preparation of cationic nanoparticles and personal care compositions comprising said nanoparticles 失效
公开(公告)号：US08449868B2
公开(公告)日：2013-05-28
申请号：US12378567
申请日：2009-02-17
申请人： John Jennings , Dietmar Hüglin , Jianwen Mao , Andreas Mühlebach
发明人： John Jennings , Dietmar Hüglin , Jianwen Mao , Andreas Mühlebach
IPC分类号： A61K8/02 , A61Q19/00 , A61Q5/00 , A61Q11/00 , A61Q15/00 , A61Q9/02 , A61Q5/02 , A61Q5/04 , A61Q5/10 , A61Q5/08 , A61Q3/02 , A61Q1/06 , A61Q1/10 , A61Q17/04 , A01N25/00 , A01P1/00
CPC分类号： A61K8/8117 , A61K8/11 , A61K8/8129 , A61K2800/413 , A61Q5/02 , A61Q5/12 , A61Q17/005 , A61Q17/04 , A61Q19/04
摘要： The present invention is directed to cationic nanoparticles, methods to make them, and the use of compositions containing said nanoparticles in personal care compositions or formulations. The nanoparticles are useful in personal care applications and impart antimicrobial properties to home and personal care products containing them. These cationic nanoparticles also contribute useful conditioning properties to hair-care and skin-care products.

10. 发明授权

US08404257B1 Stabilisation of body-care and household products 失效
标题翻译：稳定身体护理和家庭用品
公开(公告)号：US08404257B1
公开(公告)日：2013-03-26
申请号：US09830787
申请日：1999-10-21
申请人： Dietmar Hüglin , Thomas Ehlis , Erich Kramer , Joseph Anthony Lupia
发明人： Dietmar Hüglin , Thomas Ehlis , Erich Kramer , Joseph Anthony Lupia
IPC分类号： A61K8/00
CPC分类号： A61K8/347 , A61K8/37 , A61K8/42 , A61K8/46 , A61K8/466 , A61K8/4926 , A61K8/4966 , A61K8/4973 , A61K8/498 , A61K2800/522 , A61Q1/02 , A61Q1/06 , A61Q1/08 , A61Q1/10 , A61Q1/12 , A61Q5/02 , A61Q5/06 , A61Q9/02 , A61Q11/00 , A61Q13/00 , A61Q15/00 , A61Q17/04 , A61Q19/007 , A61Q19/10 , C11D3/0084 , C11D3/2034 , C11D3/28 , C11D3/30 , C11D3/32 , C11D3/349
摘要： A description is given of the use of phenolic antioxidants of formulae (1) and/or (2) and/or (3) for stabilizing body-care and household products.
摘要翻译：给出了使用式（1）和/或（2）和/或（3）的酚类抗氧化剂来稳定身体护理和家用产品的描述。

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