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21. 发明申请

US20060211077A1 Methods and compositions to diagnose disease using concatenated oligopeptide standard 审中-公开
标题翻译：使用连接寡肽标准诊断疾病的方法和组合物
公开(公告)号：US20060211077A1
公开(公告)日：2006-09-21
申请号：US11082348
申请日：2005-03-17
申请人： Kenneth Abel , Andreas Braun , Johanna Whitacre , Kai Tang
发明人： Kenneth Abel , Andreas Braun , Johanna Whitacre , Kai Tang
IPC分类号： C12Q1/37 , G01N33/00
CPC分类号： C12Q1/37
摘要： The present invention is a method to quantitate proteins associated with a disease or disease state comprising the steps of isolating at least two target proteins from a test sample, combining the target proteins with a known concentration of a concatenated oligopeptide standard and a proteinase to form peptide fragments and standard peptide fragments. The concatenated oligopeptide standard comprising at least one peptide having an amino acid sequence substantially similar to a unique amino acid sequence of a peptide fragment of the two target proteins. The peptides for each of the target proteins are joined by proteinase cleavage sites to form the concatenated oligopeptide. Quantitation of the target proteins is determined by comparison of the peptide fragments to the standard peptide fragments using mass spectroscopy.
摘要翻译：本发明是一种定量与疾病或疾病状态相关的蛋白质的方法，包括以下步骤：从测试样品中分离出至少两种靶蛋白，将目标蛋白质与已知浓度的连接寡肽标准品和蛋白酶组合以形成肽片段和标准肽片段。连接的寡肽标准品包含至少一种具有与两种靶蛋白的肽片段的独特氨基酸序列基本相似的氨基酸序列的肽。用于每种靶蛋白的肽通过蛋白酶切割位点连接以形成连接的寡肽。通过使用质谱法将肽片段与标准肽片段进行比较来确定靶蛋白质的定量。

22. 发明申请

US20050277118A1 Methods for identifying subjects at risk of melanoma and treatments thereof 审中-公开
标题翻译：鉴别患有黑素瘤风险的受试者及其治疗方法
公开(公告)号：US20050277118A1
公开(公告)日：2005-12-15
申请号：US10661966
申请日：2003-09-11
申请人： Richard Roth , Matthew Nelson , Andreas Braun
发明人： Richard Roth , Matthew Nelson , Andreas Braun
IPC分类号： A61B20060101 , A61K31/7105 , A61K38/45 , A61K48/00 , A61P35/00 , C07H21/00 , C07H21/04 , C12N9/12 , C12N15/54 , C12Q1/48 , C12Q1/68
CPC分类号： C12Q1/6886 , C12Q2600/106 , C12Q2600/112 , C12Q2600/136 , C12Q2600/156 , C12Q2600/172
摘要： Provided herein are methods for identifying risk of melanoma in a subject, reagents and kits for carrying out the methods, methods for identifying candidate therapeutics for treating melanoma, and therapeutic methods for treating melanoma in a subject. These embodiments are based upon an analysis of polymorphic variations in a BRAF nucleic acid, which has a nucleotide sequence exemplified by SEQ ID NO:1.
摘要翻译：本文提供用于鉴定受试者中黑素瘤风险的方法，用于实施该方法的试剂和试剂盒，用于鉴定治疗黑素瘤的候选治疗剂的方法，以及用于治疗受试者中黑素瘤的治疗方法。这些实施方案基于具有SEQ ID NO：1示例的核苷酸序列的BRAF核酸中的多态性变异的分析。

23. 发明授权

US06669216B1 Hydropneumatic suspension system 失效
标题翻译：液压气动悬挂系统
公开(公告)号：US06669216B1
公开(公告)日：2003-12-30
申请号：US09806388
申请日：2001-07-02
申请人： Dieter Elser , Andreas Braun , Manfred Heintschel , Wolfgang Zeitz
发明人： Dieter Elser , Andreas Braun , Manfred Heintschel , Wolfgang Zeitz
IPC分类号： B60G1126
CPC分类号： B60G17/0432 , B60G17/056 , B60G21/067 , B60G21/073 , B60G2202/154
摘要： A hydropneumatic suspension system for motor vehicles, having at least one hydropneumatic support aggregate and one automatic level control system cooperating with the aggregate, the automatic level control system, as a function of the lift position of the wheels, sending hydraulic fluid from the hydropneumatic pressure reservoir into the hydropneumatic suspension cylinders, or drawing hydraulic fluid from the hydropneumatic suspension cylinders into the pressure reservoirs, and the functions of suspension, roll stabilization, and automatic level control being able to be performed using the hydropneumatic suspension cylinders.
摘要翻译：一种用于机动车辆的液压气动悬挂系统，具有至少一个液压气动支撑骨架和与骨料配合的一个自动液位控制系统，自动液位控制系统作为车轮的提升位置的函数，从液压气动压力液压气动悬架液压缸，或将液压油缸从液压气动悬架滚筒拉入压力储存器，并且能够使用液压气动悬架气缸进行悬架，滚动稳定和自动液位控制的功能。

24. 发明授权

US06602662B1 DNA diagnostics based on mass spectrometry 失效
标题翻译：基于质谱的DNA诊断
公开(公告)号：US06602662B1
公开(公告)日：2003-08-05
申请号：US09724877
申请日：2000-11-28
申请人： Hubert Köster , Daniel P. Little , Andreas Braun
发明人： Hubert Köster , Daniel P. Little , Andreas Braun
IPC分类号： C12Q168
CPC分类号： C12Q1/6872 , C12Q1/6816 , C12Q1/6827 , C12Q1/6837 , C12Q1/6858 , C12Q1/686 , C12Q1/6862 , C12Q1/6883 , C12Q1/706 , G01N35/1067 , H01J49/00 , Y10T436/143333 , Y10T436/24 , C12Q2565/627 , C12Q2537/113 , C12Q2535/113 , C12Q2521/325 , C12Q2535/131 , C12Q2525/107 , C12Q2523/107 , C12Q2523/319 , C12Q2565/625 , C12Q2535/125
摘要： Fast and highly accurate mass spectrometry-based processes for detecting particular nucleic acid molecules and sequences in the molecules are provided. Depending upon the sequence to be detected, the processes, for example, can be used to diagnose a genetic disease or a chromosomal abnormality, a predisposition to a disease or condition, or infection by a pathogen, or for determining identity or heredity. One aspect provides a process for determining whether a target nucleotide is present in a nucleic acid molecule including hybridizing a nucleic acid molecule with a primer oligonucleotide; contacting the hybridized primer with deoxyribonucleoside triphosphates, chain terminating nucleotides and a DNA polymerase, whereby the hybridized primer is extended until a chain terminating nucleotide is incorporated, producing an extended primer, and determining the molecular mass of the extended primer, thereby determining whether the target nucleotide is present in a nucleic acid molecule.
摘要翻译：提供了用于检测分子中特定核酸分子和序列的基于质谱的快速和高精度的方法。根据待检测的序列，例如，该过程可用于诊断遗传疾病或染色体异常，疾病或病症的易感性或病原体的感染，或用于确定身份或遗传。一方面提供了确定靶核苷酸是否存在于核酸分子中的方法，包括将核酸分子与引物寡核苷酸杂交; 使杂交引物与脱氧核糖核苷三磷酸，链终止核苷酸和DNA聚合酶接触，由此将杂交引物延伸直到引入链终止核苷酸，产生延伸引物，并测定延伸引物的分子量，由此确定靶核苷酸存在于核酸分子中。

25. 发明授权

US06428955B1 DNA diagnostics based on mass spectrometry 失效
标题翻译：基于质谱的DNA诊断
公开(公告)号：US06428955B1
公开(公告)日：2002-08-06
申请号：US08744481
申请日：1996-11-06
申请人： Hubert Köster , Kai Tang , Dong-Jing Fu , Carsten W. Siegert , Daniel P. Little , Andreas Braun , Brigitte Darnhofer-Demar , Christian Jurinke , Dirk Van den Boom
发明人： Hubert Köster , Kai Tang , Dong-Jing Fu , Carsten W. Siegert , Daniel P. Little , Andreas Braun , Brigitte Darnhofer-Demar , Christian Jurinke , Dirk Van den Boom
IPC分类号： C12Q168
CPC分类号： C12Q1/6827 , G01N35/1067 , C12Q2537/113 , C12Q2535/113 , C12Q2521/325 , C12Q2565/627 , C12Q2535/131
摘要： The invention provides fast and highly accurate mass spectrometer based processes for detecting a particular nucleic acid sequence in a biological sample. Depending on the sequence to be detected, the processes can be used, for example, to diagnose a genetic disease or chromosomal abnormality; a predisposition to a disease or condition, infection by a pathogenic organism, or for determining identity or heredity.
摘要翻译：本发明提供用于检测生物样品中特定核酸序列的基于快速和高精度的基于质谱仪的方法。根据待检测的序列，可以使用例如诊断遗传病或染色体异常的方法; 疾病或病症的倾向，病原体感染或确定身份或遗传。

26. 发明授权

US06258538B1 DNA diagnostics based on mass spectrometry 有权
公开(公告)号：US06258538B1
公开(公告)日：2001-07-10
申请号：US09287679
申请日：1999-04-06
申请人： Hubert Köster , Daniel P. Little , Andreas Braun
发明人： Hubert Köster , Daniel P. Little , Andreas Braun
IPC分类号： C12Q168
CPC分类号： C12Q1/6872 , C12Q1/6816 , C12Q1/6827 , C12Q1/6837 , C12Q1/6858 , C12Q1/686 , C12Q1/6862 , C12Q1/6883 , C12Q1/706 , G01N35/1067 , H01J49/00 , Y10T436/143333 , Y10T436/24 , C12Q2565/627 , C12Q2537/113 , C12Q2535/113 , C12Q2521/325 , C12Q2535/131 , C12Q2525/107 , C12Q2523/107 , C12Q2523/319 , C12Q2565/625 , C12Q2535/125
摘要： Fast and highly accurate mass spectrometry-based processes for detecting particular nucleic acid molecules and sequences in the molecules are provided. Depending upon the sequence to be detected, the processes, for example, can be used to diagnose a genetic disease or a chromosomal abnormality, a predisposition to a disease or condition, or infection by a pathogen, or for determining identity or heredity.

27. 发明授权

US10708199B2 Heterogeneous packet-based transport 有权
公开(公告)号：US10708199B2
公开(公告)日：2020-07-07
申请号：US16055864
申请日：2018-08-06
申请人： Nils Endric Schubert , David Epping , Andreas Braun , Ulrich Langenbach
发明人： Nils Endric Schubert , David Epping , Andreas Braun , Ulrich Langenbach
IPC分类号： H04J3/22 , H04L12/939 , H04L12/861 , H04L12/947 , H04L12/721 , H04L12/851 , H04L12/54 , H04L12/801 , H04L12/835 , H04L12/70
摘要： Deadlocks in a heterogeneous packet-based transport system are avoided. When receiving a plurality of packets from a root complex where contents of each packet from the plurality of packets organized in accordance with a first protocol, a sequence number is added to each packet and a packet type is identified. Every packet in the first plurality of packets is encapsulated into at least one packet organized in accordance with a second protocol to form a second plurality of packets organized in accordance with the second protocol. All the packets from the second plurality of packets are sent via a plurality of connections so that each connection from the plurality of connections only transports packets from the second plurality of packets that encapsulate packets from the first plurality that have a same packet type.

28. 发明授权

US10414193B2 Highly flexible foil composite material and its use in card bodies 有权
公开(公告)号：US10414193B2
公开(公告)日：2019-09-17
申请号：US13579449
申请日：2011-02-23
申请人： Josef Riedl , Andreas Braun
发明人： Josef Riedl , Andreas Braun
IPC分类号： B32B27/08 , B42D25/305 , B42D25/45 , B32B7/02 , B32B27/36 , B32B27/40 , B29D7/01 , B42D25/00 , B32B7/10 , B32B27/18 , B32B27/28 , B29C48/30 , B29C48/08 , B29C48/21 , B29C48/305 , B29K21/00 , B29K67/00 , B29K69/00 , B29K105/00 , B29L17/00 , B29C48/15 , B29C48/49
摘要： A foil composite material usable as a layer in a card body of a portable data carrier, that includes one outer plastic layer, one inner plastic layer and one second outer plastic layer. All the layers jointly form a coextruded composite, and the plastic of one outer layer is a thermoplastic polymer or a mixture thereof. The plastic of the one inner layer is a mixture of at least one thermoplastic elastomer and at least one thermoplastic polymer. The plastic of the second outer layer is a thermoplastic polymer or a mixture thereof.

29. 发明申请

US20190058675A1 Heterogeneous Packet-Based Transport 审中-公开
公开(公告)号：US20190058675A1
公开(公告)日：2019-02-21
申请号：US16055864
申请日：2018-08-06
申请人： Nils Endric Schubert , David Epping , Andreas Braun , Ulrich Langenbach
发明人： Nils Endric Schubert , David Epping , Andreas Braun , Ulrich Langenbach
IPC分类号： H04L12/939 , H04L12/861 , H04L12/947 , H04L12/721 , H04L12/801 , H04L12/851 , H04L12/54
摘要： Deadlocks in a heterogeneous packet-based transport system are avoided. When receiving a plurality of packets from a root complex where contents of each packet from the plurality of packets organized in accordance with a first protocol, a sequence number is added to each packet and a packet type is identified. Every packet in the first plurality of packets is encapsulated into at least one packet organized in accordance with a second protocol to form a second plurality of packets organized in accordance with the second protocol. All the packets from the second plurality of packets are sent via a plurality of connections so that each connection from the plurality of connections only transports packets from the second plurality of packets that encapsulate packets from the first plurality that have a same packet type.

30. 发明授权

US08921080B2 Pig liver esterases 有权
标题翻译：猪肝酯酶
公开(公告)号：US08921080B2
公开(公告)日：2014-12-30
申请号：US13265178
申请日：2010-04-26
申请人： Martin Kietzmann , Harald Pichler , Helmut Schwab , Amin El-Heliebi , Christine Winkler , Andreas Braun
发明人： Martin Kietzmann , Harald Pichler , Helmut Schwab , Amin El-Heliebi , Christine Winkler , Andreas Braun
IPC分类号： C12N9/18
CPC分类号： C12N9/18
摘要： The invention relates to an isolated polypeptide having esterase activity comprising an amino acid sequence shown in any one of SEQ ID NO's 2, 4, 6, 8, 10, 12 or 14 or a homologue thereof, comprising an amino acid substitution or deletion of one or more amino acids as shown in said SEQ ID NO's and resulting in a mutant polypeptide having an increased concentration of the fraction of the mutant polypeptide being present as an active and soluble protein in cleared lysate of the mutant polypeptide expressed in E. coli relative to the concentration of the fraction of the polypeptide without the mutation being present as an active and soluble protein in cleared lysate of the polypeptide without the one or more deletion or substitution expressed in E. coli under the same conditions. The invention also relates to nucleic acid encoding the polypeptides according to the invention, and the use of the polypeptides.
摘要翻译：本发明涉及具有酯酶活性的分离多肽，其包含SEQ ID NO：2,4,6,8,10,12或14中任一项所示的氨基酸序列或其同源物，其包含氨基酸取代或缺失的一个或更多的氨基酸，如所述SEQ ID NO所示，并且产生突变体多肽的浓度增加，所述突变体多肽作为活性和可溶性蛋白质存在于大肠杆菌中表达的突变多肽的澄清裂解物中，相对于不存在突变的多肽的级分的浓度作为活性和可溶性蛋白质存在于多肽的澄清裂解物中，而在相同条件下在大肠杆菌中表达的一个或多个缺失或取代。本发明还涉及编码根据本发明的多肽的核酸和多肽的用途。

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