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21. 发明授权

US08691818B2 Cyclic triazo and diazo sodium channel blockers 有权
标题翻译：环状三唑和重氮钠通道阻滞剂
公开(公告)号：US08691818B2
公开(公告)日：2014-04-08
申请号：US12811884
申请日：2009-01-16
申请人： Michael Leach , Laurence Harbige , Dieter Riddall , Karl Franzmann
发明人： Michael Leach , Laurence Harbige , Dieter Riddall , Karl Franzmann
IPC分类号： A61K31/53 , C07D253/06 , C07D253/08
CPC分类号： C07D253/075 , C07D253/06 , C07D253/07 , C07D253/10 , C07D401/04 , C07D405/04 , C07D405/12 , C07D405/14 , C07D409/04 , C07D409/12
摘要： Compounds of general structure in which X and Y are each N or C with at least one of X and Y being N; Z is a single bond or an optionally substituted linking group R1 is hydrogen or a substituent group; R2 is amino or a substituent group; N* is amino when RI is hydrogen or ═NH when R1 is a substituent group; or N* is a group NRaRb where Ra and Rb are independently H or an alkyl group; or N* is an optionally substituted piperazinyl ring; and A is an optionally substituted heterocyclic or carbocyclic ring system which may be linked to the triazo/diazo ring through R2 to form a fused multicyclic ring; are indicated as suitable for treatment of disorders in mammals that are susceptible to sodium channel blockers and antifolates, and particularly disorders such epilepsy, multiple sclerosis, glaucoma and uevitis, cerebral traumas and cerebral ischaemias, stroke, head injury, spinal cord injury, surgical trauma, neurodegenerative disorders, motorneurone disease, Alzheimer's disease, Parkinson's disease, chronic inflammatory pain, neuropathic pain, migraine, bipolar disorder, mood, anxiety and cognitive disorders, schizophrenia and trigeminal autonomic cephalalgias; for treatment of mammalian cancers; and for treatment of malaria.
摘要翻译： X和Y各自为N或C，X和Y中的至少一个为N的一般结构化合物; Z是单键或任选取代的连接基团R 1是氢或取代基; R2是氨基或取代基; 当R 1为氢时，N *为氨基，或当R 1为取代基时为= NH; 或N *为NRaRb基团，其中Ra和Rb独立地为H或烷基; 或N *是任选取代的哌嗪基环; 并且A是任选取代的杂环或碳环系，其可以通过R 2与三偶氮/重氮环连接以形成稠合多环; 适用于治疗对钠通道阻滞剂和抗叶酸剂敏感的哺乳动物的疾病，特别是诸如癫痫，多发性硬化，青光眼和uev病，脑创伤和脑缺血性脑卒中，脑损伤，脊髓损伤，手术创伤神经退行性疾病，运动神经元疾病，阿尔茨海默病，帕金森病，慢性炎性疼痛，神经性疼痛，偏头痛，双相情感障碍，情绪，焦虑和认知障碍，精神分裂症和三叉神经性自主性头痛。用于治疗哺乳动物癌症; 并用于治疗疟疾。

22. 发明授权

US08268823B2 Medical use of triazine derivatives 有权
标题翻译：医药用途三嗪衍生物
公开(公告)号：US08268823B2
公开(公告)日：2012-09-18
申请号：US12373561
申请日：2007-07-13
申请人： Michael Leach , Laurence Harbige , Dieter Riddall , Paul Barraclough
发明人： Michael Leach , Laurence Harbige , Dieter Riddall , Paul Barraclough
IPC分类号： A61K31/53
CPC分类号： A61K31/53 , Y02A50/411
摘要： Compounds of formula (I) especially where R1 is an optionally substituted alkyl, aralkyl or heterocyclyl-alkyl group, are shown to have activity as sodium channel blockers or as antifolates. Some novel compounds where R1 is an aralkyl or heterocyclyl-alkyl are disclosed.
摘要翻译：式（I）化合物，特别是其中R 1为任选取代的烷基，芳烷基或杂环基 - 烷基的化合物显示具有钠通道阻断剂或抗叶酸剂的活性。公开了一些其中R 1是芳烷基或杂环基 - 烷基的新化合物。

23. 发明申请

US20080217264A1 Apparatus And Method For Separating And Concentrating Fluids Containing Multiple Components 有权
标题翻译：用于分离和浓缩含有多种成分的液体的装置和方法
公开(公告)号：US20080217264A1
公开(公告)日：2008-09-11
申请号：US12123132
申请日：2008-05-19
申请人： Michael Leach , Jennifer E. Woodell-May , Joel C. Higgins , Brandon Miller
发明人： Michael Leach , Jennifer E. Woodell-May , Joel C. Higgins , Brandon Miller
IPC分类号： B01D21/26 , A61M37/00 , A61B19/00
CPC分类号： B01L3/502 , B01D17/0217 , B01L3/5021 , B01L3/50215 , B01L9/54 , B01L2200/026 , B01L2400/0409 , B01L2400/0478 , G01N33/491 , Y10T436/25375
摘要： An apparatus is disclosed that allows for separating and collecting a fraction of a sample. The apparatus, when used with a centrifuge, allows for the creation of at least three fractions in the apparatus. It also provides for a new method of extracting the buffy coat phase from a whole blood sample. A buoy system that may include a first buoy portion and a second buoy member operably interconnected may be used to form at least three fractions from a sample during a substantially single centrifugation process. Therefore, the separation of various fractions may be substantially quick and efficient.
摘要翻译：公开了允许分离和收集样品的一部分的装置。当与离心机一起使用时，该装置允许在装置中产生至少三个级分。它还提供了从全血样品中提取血沉棕黄层的新方法。可以使用可包括第一浮标部分和可操作地连接的第二浮标部件的浮标系统，以在基本上单个的离心过程期间从样品形成至少三个级分。因此，各种馏分的分离可以基本上快速有效。

24. 发明申请

US20070111019A1 Methods of manufacturing engineered wood products 审中-公开
标题翻译：制造工程木制品的方法
公开(公告)号：US20070111019A1
公开(公告)日：2007-05-17
申请号：US11394471
申请日：2006-03-31
申请人： Kenneth Lau , Michael Leach , Donald Trudeau
发明人： Kenneth Lau , Michael Leach , Donald Trudeau
IPC分类号： B32B21/14
CPC分类号： B27N1/00 , B27N3/002 , Y10T428/31982
摘要： Methods for manufacturing an engineered wood product are disclosed. The method includes contacting at least part of a first set of wood pieces with a first resin; contacting at least part of a second set of wood pieces with a second resin, wherein the second resin is more washout resistant than the first resin; orienting the first and second set of wood pieces to provide a blanket of oriented pieces, the blanket of oriented pieces including a core layer formed of the second set of wood pieces sandwiched between a pair of face layers formed of the first set of wood pieces; steam preheating at least a portion of the blanket of oriented pieces; and curing the first and second resins by exposing at least a part of the blanket of oriented pieces to at least one of an elevated temperature, an elevated pressure, and radiant energy.
摘要翻译：公开了制造工程木制品的方法。该方法包括使第一组木片与第一树脂接触的至少一部分; 使第二组木片的至少一部分与第二树脂接触，其中第二树脂比第一树脂更耐冲击; 定向第一和第二组木片以提供定向片的毯子，所述定向片的毯包括由第二组木片形成的芯层，所述芯层夹在由第一组木片形成的一对面层之间; 蒸汽预热至少一部分定向片的毯子; 以及通过将取向片的至少一部分毯暴露于升高的温度，升高的压力和辐射能中的至少一个来固化所述第一和第二树脂。

25. 发明申请

US20060273049A1 Method and apparatus for separating and concentrating a component from a multi-component material including macroparticles 有权
标题翻译：用于从包括大颗粒的多组分材料分离和浓缩组分的方法和装置
公开(公告)号：US20060273049A1
公开(公告)日：2006-12-07
申请号：US11441275
申请日：2006-05-25
申请人： Michael Leach , Joel Higgins , Matthew Swift , Nathan Gordon
发明人： Michael Leach , Joel Higgins , Matthew Swift , Nathan Gordon
IPC分类号： C02F1/38
CPC分类号： A61K35/12 , A61M1/3693 , B01L3/502 , B01L3/5021 , B01L3/50215 , B01L9/54 , B01L2200/026 , B01L2300/0681 , B01L2400/0409 , B01L2400/0478 , B01L2400/0605 , G01N33/491
摘要： An apparatus that allows for separating and collecting a fraction of a sample. The apparatus, when used with a centrifuge, allows for the creation of at least three fractions in the apparatus. It also provides for a new method of extracting the buffy coat phase from a whole blood sample and mesenchymal stem cells from bone reaming material. A buoy system that may include a first buoy portion and a second buoy member operably interconnected may be used to form at least three fractions from a sample during a substantially single centrifugation process. Therefore, the separation of various fractions may be substantially quick and efficient.
摘要翻译：允许分离和收集一部分样品的装置。当与离心机一起使用时，该装置允许在装置中产生至少三个级分。它还提供了一种从全骨样细胞和骨髓间充质干细胞中提取血沉棕黄层的新方法。可以使用可包括第一浮标部分和可操作地连接的第二浮标部件的浮标系统，以在基本上单个的离心过程期间从样品形成至少三个级分。因此，各种馏分的分离可以基本上快速有效。

26. 发明申请

US20050109716A1 Apparatus and method for separating and concentrating fluids containing multiple components 有权
标题翻译：用于分离和浓缩含有多种组分的流体的装置和方法
公开(公告)号：US20050109716A1
公开(公告)日：2005-05-26
申请号：US10932882
申请日：2004-09-02
申请人： Michael Leach , Jennifer Woodell-May , Joel Higgins , Brandon Miller
发明人： Michael Leach , Jennifer Woodell-May , Joel Higgins , Brandon Miller
IPC分类号： B01D21/26 , B01L3/00 , B01L3/14 , B01L99/00 , C02F1/38
CPC分类号： B01L3/502 , B01L3/5021 , B01L3/50215 , B01L9/54 , B01L2200/026 , B01L2400/0409 , B01L2400/0478
摘要： An apparatus that allows for separating and collecting a fraction of a sample. The apparatus, when used with a centrifuge, allows for the creation of at least three fractions in the apparatus. It also provides for a new method of extracting the buffy coat phase from a whole blood sample. A buoy system that may include a first buoy portion and a second buoy member operably interconnected may be used to form at least three fractions from a sample during a substantially single centrifugation process. Therefore, the separation of various fractions may be substantially quick and efficient.
摘要翻译：允许分离和收集一部分样品的装置。当与离心机一起使用时，该装置允许在装置中产生至少三个级分。它还提供了从全血样品中提取血沉棕黄层的新方法。可以使用可包括第一浮标部分和可操作地连接的第二浮标部件的浮标系统，以在基本上单个的离心过程期间从样品形成至少三个级分。因此，各种馏分的分离可以基本上快速有效。

27. 发明授权

US06267655B1 Retaining ring for wafer polishing 失效
标题翻译：晶圆抛光保持环
公开(公告)号：US06267655B1
公开(公告)日：2001-07-31
申请号：US09116311
申请日：1998-07-15
申请人： David E. Weldon , Shu-Hsin Kao , Michael Leach , Charles J. Regan , Linh X. Can
发明人： David E. Weldon , Shu-Hsin Kao , Michael Leach , Charles J. Regan , Linh X. Can
IPC分类号： B24B722
CPC分类号： B24B37/32
摘要： An improved wafer polishing machine is disclosed. In one embodiment, the wafer polishing machine has a movable polishing surface and a holder that holds an object, such as a semiconductor wafer, against the movable polishing surface. The holder includes a support structure that supports the object in contact with the polishing surface and an annular retaining ring that retains the object in alignment with the support structure. The retaining ring has a plurality of projections projecting inwardly from its inner circumference. The projections are evenly spaced around the inner circumference of the retaining ring. In one embodiment, the projections on the retaining ring define a circle with a diameter no less than the diameter of the object being polished. In an alternative embodiment, the retaining ring has a smooth, circular inner circumference formed from a flexible material which distends to from a continuous arc of contact with the wafer during polishing. Each retaining ring disclosed herein forms multiple points of contact or a continuous arc of contact between the retaining ring and the wafer, thereby reducing wafer buckling during polishing and improving surface uniformity.
摘要翻译：公开了一种改进的晶片抛光机。在一个实施例中，晶片抛光机具有可动抛光表面和将诸如半导体晶片的物体保持在可动抛光表面上的保持器。保持器包括支撑结构，其支撑与抛光表面接触的物体，以及保持对象与支撑结构对准的环形保持环。保持环具有从其内周向内突出的多个突起。突起围绕保持环的内圆周均匀间隔开。在一个实施例中，保持环上的突起限定直径不小于被抛光物体的直径的圆。在替代实施例中，保持环具有由柔性材料形成的平滑的圆形内圆周，该柔性材料在抛光期间从与晶片的连续弧接触扩展。本文公开的每个固定环在保持环和晶片之间形成多个接触点或连续的接触弧，从而在抛光期间减少晶片屈曲并改善表面均匀性。

28. 发明申请

US20110168193A1 Apparatus and Method for Separating and Concentrating Fluids Containing Multiple Components 有权
标题翻译：用于分离和浓缩含有多个成分的流体的装置和方法
公开(公告)号：US20110168193A1
公开(公告)日：2011-07-14
申请号：US13071565
申请日：2011-03-25
申请人： Michael Leach , Jennifer E. Woodell-May , Joel C. Higgins , Brandon Miller
发明人： Michael Leach , Jennifer E. Woodell-May , Joel C. Higgins , Brandon Miller
IPC分类号： A61B17/00 , B01D21/26
CPC分类号： B01L3/502 , B01D17/0217 , B01L3/5021 , B01L3/50215 , B01L9/54 , B01L2200/026 , B01L2400/0409 , B01L2400/0478 , G01N33/491 , Y10T436/25375
摘要： An apparatus is disclosed that allows for separating and collecting a fraction of a sample. The apparatus, when used with a centrifuge, allows for the creation of at least three fractions in the apparatus. It also provides for a new method of extracting the buffy coat phase from a whole blood sample. A buoy system that may include a first buoy portion and a second buoy member operably interconnected may be used to form at least three fractions from a sample during a substantially single centrifugation process. Therefore, the separation of various fractions may be substantially quick and efficient.
摘要翻译：公开了允许分离和收集样品的一部分的装置。当与离心机一起使用时，该装置允许在装置中产生至少三个级分。它还提供了从全血样品中提取血沉棕黄层的新方法。可以使用可包括第一浮标部分和可操作地连接的第二浮标部件的浮标系统，以在基本上单个的离心过程期间从样品形成至少三个级分。因此，各种馏分的分离可以基本上快速有效。

29. 发明申请

US20110009413A1 CYCLIC TRIAZO AND DIAZO SODIUM CHANNEL BLOCKERS 有权
标题翻译：环状三唑和二氧化硅通道阻塞剂
公开(公告)号：US20110009413A1
公开(公告)日：2011-01-13
申请号：US12811884
申请日：2009-01-16
申请人： Michael Leach , Laurence Harbige , Dieter Riddall , Karl Franzmann
发明人： Michael Leach , Laurence Harbige , Dieter Riddall , Karl Franzmann
IPC分类号： A61K31/53 , C07D253/075 , C07D405/04 , C07D403/12 , C07D409/04 , C07D253/07 , C07D405/14 , C07D401/04 , A61P25/08 , A61P25/00 , A61P27/06 , A61P25/28 , A61P25/16 , A61P25/06 , A61P25/18 , A61P25/22 , A61P29/00
CPC分类号： C07D253/075 , C07D253/06 , C07D253/07 , C07D253/10 , C07D401/04 , C07D405/04 , C07D405/12 , C07D405/14 , C07D409/04 , C07D409/12
摘要： Compounds of general structure in which X and Y are each N or C with at least one of X and Y being N; Z is a single bond or an optionally substituted linking group R1 is hydrogen or a substituent group; R2 is amino or a substituent group; N* is amino when RI is hydrogen or ═NH when R1 is a substituent group; or N* is a group NRaRb where Ra and Rb are independently H or an alkyl group; or N* is an optionally substituted piperazinyl ring; and A is an optionally substituted heterocyclic or carbocyclic ring system which may be linked to the triazo/diazo ring through R2 to form a fused multicyclic ring; are indicated as suitable for treatment of disorders in mammals that are susceptible to sodium channel blockers and antifolates, and particularly disorders such epilepsy, multiple sclerosis, glaucoma and uevitis, cerebral traumas and cerebral ischaemias, stroke, head injury, spinal cord injury, surgical trauma, neurodegenerative disorders, motorneurone disease, Alzheimer's disease, Parkinson's disease, chronic inflammatory pain, neuropathic pain, migraine, bipolar disorder, mood, anxiety and cognitive disorders, schizophrenia and trigeminal autonomic cephalalgias; for treatment of mammalian cancers; and for treatment of malaria.
摘要翻译： X和Y各自为N或C，X和Y中的至少一个为N的一般结构化合物; Z是单键或任选取代的连接基团R 1是氢或取代基; R2是氨基或取代基; 当R 1为氢时，N *为氨基，或当R 1为取代基时为= NH; 或N *为NRaRb基团，其中Ra和Rb独立地为H或烷基; 或N *是任选取代的哌嗪基环; 并且A是任选取代的杂环或碳环系，其可以通过R 2与三偶氮/重氮环连接以形成稠合多环; 适用于治疗对钠通道阻滞剂和抗叶酸剂敏感的哺乳动物的疾病，特别是诸如癫痫，多发性硬化，青光眼和uev病，脑创伤和脑缺血性脑卒中，脑损伤，脊髓损伤，手术创伤神经退行性疾病，运动神经元疾病，阿尔茨海默病，帕金森病，慢性炎性疼痛，神经性疼痛，偏头痛，双相情感障碍，情绪，焦虑和认知障碍，精神分裂症和三叉神经性自主性头痛。用于治疗哺乳动物癌症; 并用于治疗疟疾。

30. 发明申请

US20090291954A1 Medical Use of Triazine Derivatives 有权
标题翻译：三嗪衍生物的医疗用途
公开(公告)号：US20090291954A1
公开(公告)日：2009-11-26
申请号：US12373561
申请日：2007-07-13
申请人： Michael Leach , Laurence Harbige , Dieter Riddall , Paul Barraclough
发明人： Michael Leach , Laurence Harbige , Dieter Riddall , Paul Barraclough
IPC分类号： A61K31/53 , C07D253/06 , A61P25/00
CPC分类号： A61K31/53 , Y02A50/411
摘要： Compounds of formula (I) especially where R1 is an optionally substituted alkyl, aralkyl or heterocyclyl-alkyl group, are shown to have activity as sodium channel blockers or as antifolates. Some novel compounds where R1 is an aralkyl or hetero-cyclyl-alkyl are disclosed.
摘要翻译：式（I）化合物，特别是其中R 1为任选取代的烷基，芳烷基或杂环基 - 烷基的化合物显示具有钠通道阻断剂或抗叶酸剂的活性。公开了一些其中R 1是芳烷基或杂环烷基 - 烷基的新化合物。

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