专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

21. 发明申请

US20060266958A1 BIOCHEMICAL ANALYSIS DATA PRODUCING METHOD AND SCANNER USED THEREFOR 失效
标题翻译：生物化学分析数据生成方法及其使用的扫描仪
公开(公告)号：US20060266958A1
公开(公告)日：2006-11-30
申请号：US10141555
申请日：2002-05-09
申请人： Hitoshi Shimizu , Keiko Neriishi , Nobuhiko Ogura
发明人： Hitoshi Shimizu , Keiko Neriishi , Nobuhiko Ogura
IPC分类号： G03B42/08
CPC分类号： G01N21/6452 , G01N21/253 , G01N33/54373
摘要： A biochemical analysis data producing method includes the steps of selectively storing one of radiation energy and light energy in a plurality of stimulable phosphor layer regions two-dimensionally formed in a support of a stimulable phosphor sheet and spaced apart from each other, moving the stimulable phosphor sheet and a stimulating ray relative to each other in a main scanning direction and a sub-scanning direction, sequentially irradiating the plurality of stimulable phosphor layer regions so that energy of the stimulating ray projected onto the plurality of stimulable phosphor layer regions per unit area is higher than that projected on regions other than the plurality of stimulable phosphor layer regions, thereby exciting stimulable phosphor contained in the plurality of stimulable phosphor layer regions, and photoelectrically detecting stimulated emission released from the stimulable phosphor layer to produce biochemical analysis data. According to this method, it is possible to effectively prevent the stimulating ray from entering a neighboring stimulable phosphor layer region to be next stimulated as the stimulating ray is scanned and thus prevent stimulable phosphor contained in the neighboring stimulable phosphor layer region from being excited to release radiation energy or light energy stored therein, and, therefore, biochemical analysis data having an excellent quantitative characteristic can be produced in a desired manner.
摘要翻译：生物化学分析数据生成方法包括以下步骤：将辐射能量和光能中的一种选择性地存储在可激发的荧光体片的支撑体中二维地形成并且彼此间隔开的多个可刺激的荧光体层区域中，将可刺激的荧光体并且在主扫描方向和副扫描方向上相对于彼此产生刺激光线，顺序地照射多个可刺激的荧光体层区域，使得投影到每单位面积的多个可激发荧光体层区域上的刺激光线的能量为高于在多个可刺激的荧光体层区域以外的区域上投影的激光荧光体层，从而激发包含在多个可刺激的荧光体层区域中的可激发的荧光体，以及光电检测从可刺激的荧光体层释放的受激发射以产生生化分析数据。根据该方法，可以有效地防止刺激光线随着刺激射线被扫描而进入下一个被刺激的刺激性射线区域，从而防止相邻可刺激荧光体层区域中包含的可刺激的荧光体被激发释放辐射能量或光能存储在其中，因此可以以期望的方式产生具有优异定量特性的生化分析数据。

22. 发明授权

US07453573B2 Apparatus and method for measuring interaction between measurement-target sample substance and bioactive substance 失效
标题翻译：用于测量目标样本物质与生物活性物质之间相互作用的仪器和方法
公开(公告)号：US07453573B2
公开(公告)日：2008-11-18
申请号：US11905029
申请日：2007-09-27
申请人： Nobuhiko Ogura
发明人： Nobuhiko Ogura
IPC分类号： G01J1/00 , G01N21/01 , B01L3/00
CPC分类号： G01N21/553 , G01N2201/1217
摘要： A measuring apparatus and a measuring method are configured to measure a concentration of an organic solvent in a sample solution, measure a concentration of the organic solvent in a concentration control solution, calculate a mixture amount by which the concentration control solution is mixed into the sample solution of a preset amount so that the concentration of the organic solvent in the sample solution is equal to a preset concentration based on the two concentrations, mix the concentration control solution of the calculated mixture amount with the sample solution of the preset amount, supply a mixture solution obtained by the mixing unit to a measurement region in which a bioactive substance is immobilized in advance, and measure an interaction between the bioactive substance and the sample substance in the mixture solution based on a result of measuring a refraction index of a light incident on the measurement region.
摘要翻译：配置测定装置和测定方法，测定样品溶液中的有机溶剂的浓度，测定浓度对照溶液中的有机溶剂的浓度，算出将浓度对照溶液混合到样品中的混合量溶液，使得样品溶液中的有机溶剂的浓度基于两种浓度等于预设浓度，将计算出的混合物量的浓度对照溶液与预先设定量的样品溶液混合，供给通过混合单元获得的混合溶液预先固定有生物活性物质的测量区域，并且基于测量光入射的折射率的结果测量混合溶液中生物活性物质与样品物质之间的相互作用在测量区域。

23. 发明授权

US07279323B2 Method for conducting receptor-ligand association reaction and reactor used therefor 失效
标题翻译：用于进行受体 - 配体缔合反应的方法和用于其的反应器
公开(公告)号：US07279323B2
公开(公告)日：2007-10-09
申请号：US10351358
申请日：2003-01-27
申请人： Nobuhiko Ogura
发明人： Nobuhiko Ogura
IPC分类号： C12M1/34 , C12M3/00
CPC分类号： G01N33/5438 , B01J2219/00286 , B01J2219/00378 , B01J2219/00423 , B01J2219/00527 , B01J2219/00574 , B01J2219/00576 , B01J2219/00578 , B01J2219/00585 , B01J2219/00596 , B01J2219/00644 , B01J2219/00653 , B01J2219/00659 , B01J2219/00677 , B01J2219/00689 , B01J2219/00707 , B01J2219/00722 , B01J2219/00725 , B01L3/5085 , C12Q1/6837 , G01N33/54366 , C12Q2565/607
摘要： A method for conducting a receptor-ligand association reaction includes the steps of dipping a biochemical analysis unit including a substrate formed with a plurality of absorptive regions which contain receptors or ligands and are formed to be spaced apart from each other in a reaction solution containing a ligand or receptor labeled with a labeling substance, simultaneously inserting a plurality of electrodes into all of the plurality of absorptive regions containing the receptors or ligands and sequentially applying a positive voltage to one of the electrodes at a time while other electrodes are grounded, thereby conducting a receptor-ligand association reaction. According to the this method, it is possible to efficiently react a ligand or receptor with receptors or ligands fixed in the plurality of absorptive regions of the biochemical analysis unit and produce biochemical analysis data having an excellent quantitative characteristic with good repeatability.
摘要翻译：用于进行受体 - 配体缔合反应的方法包括以下步骤：浸渍生物化学分析单元，其包括形成有多个吸收区的底物，所述吸收区包含受体或配体，并形成为在包含受体或配体的反应溶液中彼此间隔开配体或受体用标记物标记的受体，同时将多个电极插入到包含受体或配体的多个吸收区域的所有多个吸收区域中，并且在其它电极接地时一次在一个电极上顺序施加正电压，由此导通受体 - 配体缔合反应。根据该方法，可以使配体或受体与生物化学分析单元的多个吸收区域中固定的受体或配体有效反应，生成具有良好的重复性优异的定量特性的生化分析数据。

24. 发明申请

US20060003395A1 Measurement method using biosensor 有权
标题翻译：使用生物传感器的测量方法
公开(公告)号：US20060003395A1
公开(公告)日：2006-01-05
申请号：US11137390
申请日：2005-05-26
申请人： Masayoshi Yamamoto , Toshihide Ezoe , Nobuhiko Ogura , Katsumi Hayashi
发明人： Masayoshi Yamamoto , Toshihide Ezoe , Nobuhiko Ogura , Katsumi Hayashi
IPC分类号： C12Q1/68 , G01N33/53 , G01N33/537 , G01N33/543 , C12M1/34
CPC分类号： G01N33/54373 , Y10S435/808 , Y10S436/805 , Y10S436/806
摘要： It is an object of the present invention to provide a method for simultaneously carrying out the detection or measurement of a substance interacting with a physiologically active substance immobilized on a biosensor and the analysis of the effects of the above substance on the biological activity of the physiologically active substance. The present invention provides a measurement method using a biosensor formed by immobilizing a physiologically active substance on a substrate, wherein the detection and measurement of a substance interacting with said physiologically active substance and the measurement of the biological activity of said physiologically active substance are carried out on said single biosensor.
摘要翻译：本发明的目的是提供一种同时进行与固定在生物传感器上的生理活性物质相互作用的物质的检测或测量的方法，以及上述物质对生理活性的生物学活性的影响的分析活性物质。本发明提供一种使用通过将生理活性物质固定在基材上形成的生物传感器的测量方法，其中进行与所述生理活性物质相互作用的物质的检测和测量以及所述生理活性物质的生物活性的测量。在所述单个生物传感器上。

25. 发明申请

US20050014291A1 Assay method using biochemical analysis units and cleaning apparatus for the same 审中-公开
标题翻译：测定方法采用生化分析装置和清洗装置相同
公开(公告)号：US20050014291A1
公开(公告)日：2005-01-20
申请号：US10890156
申请日：2004-07-14
申请人： Nobuhiko Ogura
发明人： Nobuhiko Ogura
IPC分类号： B01L3/00 , C12M1/34 , C12Q1/68 , C40B60/14 , G01N33/543 , G01N35/02
CPC分类号： B01L3/5027 , B01J2219/00286 , B01J2219/00644 , B01J2219/00653 , B01J2219/0072 , B01L2300/0636 , B01L2300/0819 , B01L2300/0877 , B01L2400/0415 , C40B60/14 , G01N33/5438
摘要： At a stage between a step for subjecting a receptor or a ligand to specific binding with ligands or receptors, each of which has been bound to one of porous adsorptive regions of a biochemical analysis unit, and a step for detecting the receptor or the ligand, which has been specifically bound to at least one of the ligands or at least one of the receptors, by the utilization of the labeling substance, at least one electrode is located such that the electrode is capable of causing an electric current to flow across each of the porous adsorptive regions of the biochemical analysis unit. A voltage is applied to the electrode in order to cause the electric current to flow across each of the porous adsorptive regions of the biochemical analysis unit.
摘要翻译：在受体或配体与配体或受体的特异性结合的步骤之间的阶段，其各自已经结合生物化学分析单元的多孔吸附区域之一和检测受体或配体的步骤，其通过利用标记物质特异性地结合至至少一种配体或至少一种受体，至少一个电极被定位成使得电极能够使电流流过每个生化分析单元的多孔吸附区。向电极施加电压，以使电流流过生化分析单元的多孔吸附区域。

26. 发明授权

US5047643A Radiation image read-out apparatus 失效
标题翻译：辐射图像读出装置
公开(公告)号：US5047643A
公开(公告)日：1991-09-10
申请号：US667357
申请日：1991-03-08
申请人： Nobuhiko Ogura
发明人： Nobuhiko Ogura
IPC分类号： G03B42/02 , G02B26/12 , G21K4/00 , H04N1/04 , H04N1/06
CPC分类号： H04N1/0664 , H04N1/0607 , G21K4/00
摘要： A radiation image read-out apparatus comprises a sheet holding device for holding a stimulable phosphor sheet on a cylindrical surface, and a spinner having a deflection mirror for reflecting stimulating rays coming from a semi-transparent mirror to the stimulable phosphor sheet, and a condensing lens which converges the reflected stimulating rays on the stimulable phosphor sheet and which has equal focal lengths with respect to stimulating rays and light emitted by the stimulable phosphor sheet. The deflection mirror and the condensing lens rotate together to scan the stimulating rays on the stimulable phosphor sheet in a main scanning direction, which sheet is moved in a sub-scanning direction. A detection lens converges the emitted light, which has passed through the condensing lens and comes from the semi-transparent mirror. An aperture plate allows only the emitted light after being thus converged to pass therethrough, and a photodetector is positioned at the rear of the aperture plate to detect the emitted light.
摘要翻译：放射线图像读取装置包括用于将可刺激的荧光体片保持在圆柱形表面上的片材保持装置和具有用于将来自半透明反射镜的刺激光线反射到可刺激的荧光片的偏转镜的旋转器，将反射的刺激光线会聚在可刺激的荧光体片上并且相对于刺激由可刺激的荧光体片发射的光线和光线具有相等焦距的透镜。偏转镜和聚光透镜一起旋转，以扫描主扫描方向上的可刺激的荧光体片上的刺激光线，该扫描方向的片材沿副扫描方向移动。检测透镜会聚通过聚光透镜并从半透明反射镜出射的发射光。光圈板仅允许发射的光在会聚后穿过其中，并且光电检测器位于孔板的后部以检测发射的光。

27. 发明授权

US08244478B2 Method of classifying gene expression strength in lung cancer tissues 失效
标题翻译：肺癌组织中基因表达强度分类方法
公开(公告)号：US08244478B2
公开(公告)日：2012-08-14
申请号：US12942770
申请日：2010-11-09
申请人： Takashi Takahashi , Shuta Tomita , Tetsuya Mitsudomi , Yasushi Yatabe , Nobuhiko Ogura , Masato Some
发明人： Takashi Takahashi , Shuta Tomita , Tetsuya Mitsudomi , Yasushi Yatabe , Nobuhiko Ogura , Masato Some
IPC分类号： G06F7/00
CPC分类号： C12Q1/6886 , C12Q2600/118 , C12Q2600/158
摘要： The present invention provides a method of confirming the gene expression, useful in the decision of a five year survival rate of a patient with lung cancer and the use of a DNA probe kit in the method. A method useful in the decision of a survival rate of a patient with non-small cell lung cancer comprising confirming the expression strength of at least one gene in lung cancer tissues isolated from the patient.
摘要翻译：本发明提供一种确认基因表达的方法，该方法可用于决定患者肺癌的5年生存率，并在该方法中使用DNA探针试剂盒。用于决定患有非小细胞肺癌的患者存活率的方法，其包括确认从患者分离的肺癌组织中至少一种基因的表达强度。

28. 发明授权

US07473547B2 Test piece, method of and apparatus for manufacturing the test piece and method of and system for reading the same 失效
标题翻译：试件的制造方法及其制造方法及其读取方法及系统
公开(公告)号：US07473547B2
公开(公告)日：2009-01-06
申请号：US09373585
申请日：1999-08-13
申请人： Nobuhiko Ogura
发明人： Nobuhiko Ogura
IPC分类号： C12M1/34 , C12M1/00 , C12Q1/68 , G01N15/06 , C07H21/02
CPC分类号： G01N21/6452 , B01J19/0046 , B01J2219/0036 , B01J2219/00518 , B01J2219/00576 , B01J2219/00596 , B01J2219/00605 , B01J2219/00657 , B01J2219/00677 , B01J2219/00702 , B01J2219/00722 , B01L3/508 , B01L2300/0636 , B01L2300/0822 , B01L2300/0825 , B82Y30/00 , C12Q2565/625 , C40B40/06 , C40B60/14 , G01N21/6428 , G01N21/8483 , G01N33/558
摘要： A test piece for use in biological analysis of a sample is formed of a strip-like substrate and numbers of known specific binding agents which are different from each other and are arranged in a line at predetermined intervals in the longitudinal direction of the strip-like substrate.
摘要翻译：用于样品的生物分析的试片由带状基材和数目不同的已知特定粘合剂形成，并且沿带状基材的长度方向以预定间隔排列成一行基质。

29. 发明申请

US20070015272A1 Toxicity testing apparatus for cell stack cultures 审中-公开
标题翻译：细胞堆培养的毒性试验装置
公开(公告)号：US20070015272A1
公开(公告)日：2007-01-18
申请号：US11485274
申请日：2006-07-13
申请人： Nobuhiko Ogura , Yasuhiro Shimada , Satoru Toda , Nobufumi Mori
发明人： Nobuhiko Ogura , Yasuhiro Shimada , Satoru Toda , Nobufumi Mori
IPC分类号： C12M3/00
CPC分类号： C12M41/46 , C12M23/12 , C12M33/04 , G01N2035/0427
摘要： A toxicity testing apparatus for testing toxicity of a sample with respect to a cell stack culture comprises an incubator for incubating at least one cell stack culture, a culture medium exchanger for exchanging a culture medium for the cell stack culture, a sample dispenser for adding the sample to the cell stack culture, and a detector for detecting an effect of the sample with respect to the cell stack culture.
摘要翻译：用于测试样品相对于细胞堆叠培养物的毒性的毒性测试装置包括用于孵育至少一个细胞堆叠培养物的培养箱，用于更换用于细胞堆叠培养的培养基的培养基交换器，用于添加样品到细胞堆培养物，以及检测器，用于检测样品相对于细胞堆培养物的影响。

30. 发明申请

US20050170386A1 Method of classifying gene expression strength in lung cancer tissues 有权
标题翻译：肺癌组织中基因表达强度分类方法
公开(公告)号：US20050170386A1
公开(公告)日：2005-08-04
申请号：US11008265
申请日：2004-12-10
申请人： Takashi Takahashi , Shuta Tomita , Tetsuya Mitsudomi , Yasushi Yatabe , Nobuhiko Ogura , Masato Some
发明人： Takashi Takahashi , Shuta Tomita , Tetsuya Mitsudomi , Yasushi Yatabe , Nobuhiko Ogura , Masato Some
IPC分类号： C12N15/09 , C12Q1/68 , G01N33/48 , G01N33/50 , G06F19/00
CPC分类号： C12Q1/6886 , C12Q2600/118 , C12Q2600/158
摘要： The present invention provides a method of confirming the gene expression, useful in the decision of a five year survival rate of a patient with lung cancer and the use of a DNA probe kit in the method. A method useful in the decision of a survival rate of a patient with non-small cell lung cancer comprising confirming the expression strength of at least one gene selected from the group consisting of in lung cancer tissues isolated from the patient.
摘要翻译：本发明提供一种确认基因表达的方法，该方法可用于决定患者肺癌的5年生存率，并在该方法中使用DNA探针试剂盒。一种用于决定非小细胞肺癌患者的存活率的方法，其包括确认从患者分离的肺癌组织中选出的至少一种基因的表达强度。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式