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21. 发明授权

US07846674B2 Assessing rheumatoid arthritis by measuring anti-CCP and interleukin 6 有权
标题翻译：通过测量抗CCP和白细胞介素6评估类风湿关节炎
公开(公告)号：US07846674B2
公开(公告)日：2010-12-07
申请号：US11472069
申请日：2006-06-21
申请人： Norbert Wild , Viet Peter Grunert , Johann Karl , Werner Zolg
发明人： Norbert Wild , Viet Peter Grunert , Johann Karl , Werner Zolg
IPC分类号： G01N33/53
CPC分类号： G01N33/564 , G01N33/6869
摘要： The present invention relates to a method aiding in the assessment of rheumatoid arthritis. The method especially is used in assessing the absence or presence of rheumatoid arthritis in vitro. The method is for example practiced by analyzing biochemical markers, comprising measuring in a sample the concentration of anti-CCP and interleukin 6 and correlating the concentrations determined to the absence or presence of rheumatoid arthritis. To further improve the assessment of RA in a method of this invention the level of one or more additional marker may be determined together with anti-CCP and interleukin 6 and be correlated to the absence or presence of RA. The invention also relates to the use of a marker panel comprising anti-CCP and interleukin 6 in the diagnosis of rheumatoid arthritis and it teaches a kit for performing the method of the invention.
摘要翻译：本发明涉及一种协助评估类风湿性关节炎的方法。该方法特别用于评估体外不存在或存在类风湿性关节炎。该方法例如通过分析生物化学标记实施，包括在样品中测量抗CCP和白细胞介素6的浓度，并将确定的浓度与不存在或存在类风湿性关节炎相关联。为了进一步改善本发明方法中RA的评估，可以与抗CCP和白细胞介素6一起测定一种或多种另外的标记物的水平，并与RA的不存在或存在相关。本发明还涉及包含抗CCP和白介素6的标记物在诊断类风湿性关节炎中的用途，并且其教导了用于实施本发明方法的试剂盒。

22. 发明授权

US08062907B2 Method to assess the severity of rheumatoid arthritis by measuring anti-CCP and serum amyloid A 有权
标题翻译：通过测量抗CCP和血清淀粉样蛋白A评估类风湿关节炎的严重程度的方法
公开(公告)号：US08062907B2
公开(公告)日：2011-11-22
申请号：US13024543
申请日：2011-02-10
申请人： Norbert Wild , Veit Peter Grunert , Johann Karl , Werner Zolg
发明人： Norbert Wild , Veit Peter Grunert , Johann Karl , Werner Zolg
IPC分类号： G01N33/564 , C07K14/47 , C07K16/18
CPC分类号： G01N33/564 , G01N2800/102 , G01N2800/24 , G01N2800/52
摘要： Disclosed is a method for assessing a severity of rheumatoid arthritis. The method involves measuring in a patient sample a concentration of anti-cyclic citrullinated peptides (anti-CCP) and serum amyloid A, combining the concentrations determined to obtain a combined value, and comparing the combined value to a cut-off value established from a reference population. In another method, a marker selected from the group consisting of C-reactive protein (CRP), interleukin 6 (IL-6), S100 protein, osteopontin, rheumatoid factor (RF), matrix metalloprotease 1 (MMP-1), matrix metalloprotease 3 (MMP-3), hyaluronic acid, and soluble CD14 (sCD14) may also be determined along with the anti-CCP and serum amyloid A.
摘要翻译：公开了一种评估类风湿性关节炎严重程度的方法。该方法包括在患者样品中测量抗环瓜氨酸肽（抗CCP）和血清淀粉样蛋白A的浓度，将确定的浓度组合以获得组合值，并将组合值与从参考人口。在另一种方法中，选自C反应蛋白（CRP），白介素6（IL-6），S100蛋白，骨桥蛋白，类风湿因子（RF），基质金属蛋白酶1（MMP-1），基质金属蛋白酶 3（MMP-3），透明质酸和可溶性CD14（sCD14）也可以与抗CCP和血清淀粉样蛋白A一起测定。

23. 发明申请

US20110129861A1 MEASUREMENT OF ANTI-CCP AND SERUM AMYLOID A METHOD TO ASSESS RHEUMATOID ARTHRITIS 有权
标题翻译：抗CCP和血清淀粉样蛋白的测定方法评估炎症性脑膜炎
公开(公告)号：US20110129861A1
公开(公告)日：2011-06-02
申请号：US13024543
申请日：2011-02-10
申请人： Norbert Wild , Veit Peter Grunert , Johann Karl , Werner Zolg
发明人： Norbert Wild , Veit Peter Grunert , Johann Karl , Werner Zolg
IPC分类号： G01N33/53
CPC分类号： G01N33/564 , G01N2800/102 , G01N2800/24 , G01N2800/52
摘要： The present invention relates to a method aiding in the assessment of rheumatoid arthritis. The method especially is used in assessing the absence or presence of rheumatoid arthritis in vitro. It can be best practiced by analyzing biochemical markers, comprising measuring in a sample the concentration of anti-CCP and serum amyloid A and correlating the concentrations determined to the absence or presence of rheumatoid arthritis. To further improve the assessment of RA in a method of this invention the level of one or more additional marker may be determined together with anti-CCP and serum amyloid A and be correlated to the absence or presence of RA. The invention also relates to the use of a marker panel comprising anti-CCP and serum amyloid A in the diagnosis of rheumatoid arthritis and it teaches a kit for performing the method of the invention.
摘要翻译：本发明涉及一种协助评估类风湿性关节炎的方法。该方法特别用于评估体外不存在或存在类风湿性关节炎。通过分析生物化学标记可以最好地实践，包括在样品中测量抗CCP和血清淀粉样蛋白A的浓度，并将确定的浓度与不存在或存在类风湿性关节炎相关联。为了进一步改善本发明方法中RA的评估，可以与抗CCP和血清淀粉样蛋白A一起测定一种或多种另外的标记物的水平，并与RA的不存在或存在相关。本发明还涉及包含抗CCP和血清淀粉样蛋白A的标记物在诊断类风湿性关节炎中的用途，并且其教导了用于实施本发明方法的试剂盒。

24. 发明申请

US20070264673A1 Assessing rheumatoid arthritis by measuring anti-CCP and interleukin 6 有权
标题翻译：通过测量抗CCP和白细胞介素6评估类风湿关节炎
公开(公告)号：US20070264673A1
公开(公告)日：2007-11-15
申请号：US11472069
申请日：2006-06-21
申请人： Nobert Wild , Viet Grunert , Johann Karl , Werner Zolg
发明人： Nobert Wild , Viet Grunert , Johann Karl , Werner Zolg
IPC分类号： G01N33/53
CPC分类号： G01N33/564 , G01N33/6869
摘要： The present invention relates to a method aiding in the assessment of rheumatoid arthritis. The method especially is used in assessing the absence or presence of rheumatoid arthritis in vitro. The method is for example practiced by analyzing biochemical markers, comprising measuring in a sample the concentration of anti-CCP and interleukin 6 and correlating the concentrations determined to the absence or presence of rheumatoid arthritis. To further improve the assessment of RA in a method of this invention the level of one or more additional marker may be determined together with anti-CCP and interleukin 6 and be correlated to the absence or presence of RA. The invention also relates to the use of a marker panel comprising anti-CCP and interleukin 6 in the diagnosis of rheumatoid arthritis and it teaches a kit for performing the method of the invention.
摘要翻译：本发明涉及一种协助评估类风湿性关节炎的方法。该方法特别用于评估体外不存在或存在类风湿性关节炎。该方法例如通过分析生物化学标记实施，包括在样品中测量抗CCP和白细胞介素6的浓度，并将确定的浓度与不存在或存在类风湿性关节炎相关联。为了进一步改善本发明方法中RA的评估，可以与抗CCP和白细胞介素6一起测定一种或多种另外的标记物的水平，并与RA的不存在或存在相关。本发明还涉及包含抗CCP和白介素6的标记物在诊断类风湿性关节炎中的用途，并且其教导了用于实施本发明方法的试剂盒。

25. 发明申请

US20070072237A1 Method of assessing rheumatoid arthritis by measuring rheumatoid factor and interleukin-6 审中-公开
标题翻译：通过测量类风湿因子和白细胞介素-6评估类风湿关节炎的方法
公开(公告)号：US20070072237A1
公开(公告)日：2007-03-29
申请号：US11509416
申请日：2006-08-24
申请人： Norbert Wild , Veit Grunert , Johann Karl , Werner Zolg
发明人： Norbert Wild , Veit Grunert , Johann Karl , Werner Zolg
IPC分类号： G01N33/53
CPC分类号： G01N33/564 , G01N2800/102 , G01N2800/52
摘要： The present invention relates to a method aiding in the assessment of rheumatoid arthritis. The method especially is used in assessing the absence or presence of rheumatoid arthritis in vitro. It can be best practiced by analyzing biochemical markers, comprising measuring in a sample the concentration of RF and interleukin-6 and correlating the concentrations determined to the absence or presence of rheumatoid arthritis. To further improve the assessment of RA in a method of this invention the level of one or more additional marker may be determined together with RF and interleukin-6 and be correlated to the absence or presence of RA. The invention also relates to the use of a marker panel comprising RF and interleukin-6 in the diagnosis of rheumatoid arthritis and it teaches a kit for performing the method of the invention.
摘要翻译：本发明涉及一种协助评估类风湿性关节炎的方法。该方法特别用于评估体外不存在或存在类风湿性关节炎。通过分析生物化学标记可以最好地实践，包括在样品中测量RF和白细胞介素-6的浓度，并将确定的浓度与不存在或存在类风湿性关节炎相关联。为了进一步改善RA在本发明方法中的评估，可以与RF和白介素-6一起确定一种或多种另外的标记物的水平，并与RA的不存在或存在相关。本发明还涉及包含RF和白细胞介素-6的标记物在诊断类风湿性关节炎中的用途，并且其教导了用于实施本发明方法的试剂盒。

26. 发明申请

US20070298518A1 Measurment of anti-CCP and serum amyloid a method to assess rheumatoid arthritis 有权
标题翻译：抗CCP和血清淀粉样蛋白的测定法评估类风湿关节炎
公开(公告)号：US20070298518A1
公开(公告)日：2007-12-27
申请号：US11509548
申请日：2006-08-24
申请人： Norbert Wild , Veit Grunert , Johann Karl , Werner Zolg
发明人： Norbert Wild , Veit Grunert , Johann Karl , Werner Zolg
IPC分类号： G01N33/564
CPC分类号： G01N33/564 , G01N2800/102 , G01N2800/24 , G01N2800/52
摘要： The present invention relates to a method aiding in the assessment of rheumatoid arthritis. The method especially is used in assessing the absence or presence of rheumatoid arthritis in vitro. It can be best practiced by analyzing biochemical markers, comprising measuring in a sample the concentration of anti-CCP and serum amyloid A and correlating the concentrations determined to the absence or presence of rheumatoid arthritis. To further improve the assessment of RA in a method of this invention the level of one or more additional marker may be determined together with anti-CCP and serum amyloid A and be correlated to the absence or presence of RA. The invention also relates to the use of a marker panel comprising anti-CCP and serum amyloid A in the diagnosis of rheumatoid arthritis and it teaches a kit for performing the method of the invention.
摘要翻译：本发明涉及一种协助评估类风湿性关节炎的方法。该方法特别用于评估体外不存在或存在类风湿性关节炎。通过分析生物化学标记可以最好地实践，包括在样品中测量抗CCP和血清淀粉样蛋白A的浓度，并将确定的浓度与不存在或存在类风湿性关节炎相关联。为了进一步改善本发明方法中RA的评估，可以与抗CCP和血清淀粉样蛋白A一起测定一种或多种另外的标记物的水平，并与RA的不存在或存在相关。本发明还涉及包含抗CCP和血清淀粉样蛋白A的标记物在诊断类风湿性关节炎中的用途，并且其教导了用于实施本发明方法的试剂盒。

27. 发明授权

US07981693B2 Combined measurement of anti-CCP and serum amyloid A to assess rheumatoid arthritis 有权
标题翻译：联合测定抗CCP和血清淀粉样蛋白A以评估类风湿关节炎
公开(公告)号：US07981693B2
公开(公告)日：2011-07-19
申请号：US11509548
申请日：2006-08-24
申请人： Norbert Wild , Veit Peter Grunert , Johann Karl , Werner Zolg
发明人： Norbert Wild , Veit Peter Grunert , Johann Karl , Werner Zolg
IPC分类号： G01N33/564 , C07K14/47 , C07K16/18
CPC分类号： G01N33/564 , G01N2800/102 , G01N2800/24 , G01N2800/52
摘要： The present invention relates to a method aiding in the assessment of rheumatoid arthritis. The method especially is used in assessing the absence or presence of rheumatoid arthritis in vitro. It can be best practiced by analyzing biochemical markers, comprising measuring in a sample the concentration of anti-CCP and serum amyloid A and correlating the concentrations determined to the absence or presence of rheumatoid arthritis. To further improve the assessment of RA in a method of this invention the level of one or more additional marker may be determined together with anti-CCP and serum amyloid A and be correlated to the absence or presence of RA. The invention also relates to the use of a marker panel comprising anti-CCP and serum amyloid A in the diagnosis of rheumatoid arthritis and it teaches a kit for performing the method of the invention.
摘要翻译：本发明涉及一种协助评估类风湿性关节炎的方法。该方法特别用于评估体外不存在或存在类风湿性关节炎。通过分析生物化学标记可以最好地实践，包括在样品中测量抗CCP和血清淀粉样蛋白A的浓度，并将确定的浓度与不存在或存在类风湿性关节炎相关联。为了进一步改善本发明方法中RA的评估，可以与抗CCP和血清淀粉样蛋白A一起测定一种或多种另外的标记物的水平，并与RA的不存在或存在相关。本发明还涉及包含抗CCP和血清淀粉样蛋白A的标记物在诊断类风湿性关节炎中的用途，并且其教导了用于实施本发明方法的试剂盒。

28. 发明授权

US5525463A Method and reagents for detection of mycobacteria using superoxide dismutase gene targeting 失效
标题翻译：使用超氧化物歧化酶基因靶向检测分枝杆菌的方法和试剂
公开(公告)号：US5525463A
公开(公告)日：1996-06-11
申请号：US133711
申请日：1993-10-07
申请人： Werner Zolg
发明人： Werner Zolg
IPC分类号： C12N15/09 , C12Q1/68 , C12R1/32 , C07H21/04 , C12P19/34
CPC分类号： C12Q1/689
摘要： The use of the superoxide dismutase (SOD) gene system as a target for the detection and differentiation of pathogenic and non-pathogenic organisms including bacteria, fungi and protozoans is described. Also described are oligonucleotides which may be used in the form of primers and probes to amplify and detect target sequences derived from SOD genes, especially from SOD genes of pathogenic and non-pathogenic organisms.
摘要翻译：描述了使用超氧化物歧化酶（SOD）基因系统作为包括细菌，真菌和原生动物在内的致病和非致病生物的检测和分化的靶标。还描述了可以以引物和探针形式使用的寡核苷酸，以扩增和检测衍生自SOD基因，特别是病原性和非致病生物体的SOD基因的靶序列。

29. 发明申请

US20080193457A1 Ra Antigenic Peptides 审中-公开
标题翻译： Ra抗原肽
公开(公告)号：US20080193457A1
公开(公告)日：2008-08-14
申请号：US10567386
申请日：2004-07-30
申请人： Nikolaos Berntenis , Gerrit Buurman , Harald Kropshofer , Bernd Christian Mueller , Sebastian Thomas Spindeldreher , Anne Vogt , Werner Zolg
发明人： Nikolaos Berntenis , Gerrit Buurman , Harald Kropshofer , Bernd Christian Mueller , Sebastian Thomas Spindeldreher , Anne Vogt , Werner Zolg
IPC分类号： A61K39/395 , C07K7/00 , C07K14/00 , C07K16/18 , C12N15/11 , A61P43/00 , C12N15/00 , C12N5/06 , A61K38/00 , G01N33/00
CPC分类号： C07K14/4713 , C07K14/70539
摘要： The present invention provides novel naturally-processed MHC class II antigenic peptides; which originate from interferon-γ-inducible lysosomal thiol reductase, integrin beta-2, phosphatitylinositol-4,5-bisphosphate 3-kinase, urokinase-type plas-minogen activator, immunoglobulin heavy chain V-III region (VH26), DJ-1 protein, apolipoprotein B-100, 26S proteasome non-AT-Pase regulatory subunit 8, interleukin-1 receptor, fibromodulin, GM-CSF/IL-3/IL-5 receptor, sorting nexin 3, inter-α-trypsin inhibitor heavy chain H4, complement C4, complement C3 (α-chain), complement C3 (β-chain), SH3 domain-binding glutamic acid-rich-like protein 3, interleukin-4-induced protein 1, hemopexin, Hsc70-interacting protein, invariant chain (Ii), retinoic acid receptor responder protein 2, fibronectin, cathepsin B, tripeptidyl-peptidase II, legumain, platelet activating factor receptor, poly-alpha-2.8-sialyltrans-ferase, and ras-leated protein Rab-11B. Also provided are these antigenic peptides and the proteins they are derived from as markers for erosive and/or non-erosive RA. Moreover, these antigenic peptides linked to MHC class II molecules, antibodies reactive with said antigenic peptides, nucleic acids encoding said antigenic peptides, and nucleic acid constructs, host cells and methods for expressing said antigenic peptides are provided. The antigenic peptides of the invention can be used as markers in diagnosis of RA and in therapy as anti-RA vaccines.
摘要翻译：本发明提供了新型的天然加工的MHC II类抗原肽; 其衍生自干扰素-γ诱导型溶酶体硫醇还原酶，整联蛋白β-2，磷脂酰肌醇-4,5-二磷酸3-激酶，尿激酶型血小板原激活物，免疫球蛋白重链V-III区（V < / - 26），DJ-1蛋白，载脂蛋白B-100,26S蛋白酶体非AT-Pase调节亚单位8，白细胞介素-1受体，纤维调节蛋白，GM-CSF / IL-3 / IL-5受体，分选nexin 3 ，α间胰蛋白酶抑制剂重链H4，补体C4，补体C3（α链），补体C3（β链），SH3结构域结合谷氨酸样蛋白3，白细胞介素-4诱导蛋白1 ，血凝素，Hsc70相互作用蛋白，不变链（Ii），视黄酸受体应答蛋白2，纤连蛋白，组织蛋白酶B，三肽基肽酶II，legumain，血小板激活因子受体，聚α-2.8-唾液酸转移酶和ras - 蛋白质Rab-11B。还提供了这些抗原肽和它们作为侵蚀性和/或非侵蚀性RA的标记物衍生的蛋白质。此外，提供了与MHC II类分子连接的这些抗原肽，与所述抗原肽反应的抗体，编码所述抗原肽的核酸和核酸构建体，宿主细胞和用于表达所述抗原肽的方法。本发明的抗原肽可用作RA诊断和抗RA疫苗治疗中的标志物。

30. 发明申请

US20070148704A1 Anti-CCPand antinuclear antibodies in diagnosis of rheumatoid arthritis 审中-公开
标题翻译：抗CCPA抗核抗体在类风湿关节炎诊断中的应用
公开(公告)号：US20070148704A1
公开(公告)日：2007-06-28
申请号：US11538198
申请日：2006-10-03
申请人： Ursula Klause , Hans-Peter Lehmann , Iris Fuehling , Susanne Schmolke , Werner Zolg
发明人： Ursula Klause , Hans-Peter Lehmann , Iris Fuehling , Susanne Schmolke , Werner Zolg
IPC分类号： G01N33/567 , G01N33/53
CPC分类号： G01N33/564 , G01N33/6887 , G01N2800/102
摘要： The present invention relates to a method aiding in the assessment of rheumatoid arthritis. The method especially is used in the differential diagnosis of rheumatoid arthritis in vitro. The method is for example practiced by analyzing biochemical markers, comprising measuring in a sample both the concentration of anti-CCP and of antinuclear antibodies (ANA) correlating the concentrations determined to the diagnosis of rheumatoid arthritis. To further improve the assessment of RA in a method of this invention the level of one or more additional marker may be determined together with anti-CCP and ANA and be correlated to the absence or presence of RA. The invention also relates to the use of a marker panel comprising anti-CCP and ANA in the diagnosis of rheumatoid arthritis and it teaches a kit for performing the method of the invention.
摘要翻译：本发明涉及一种协助评估类风湿性关节炎的方法。该方法特别用于体外类风湿关节炎的鉴别诊断。该方法例如通过分析生物化学标记来实施，包括在样品中测量抗CCP的浓度和与确定为类风湿性关节炎诊断的浓度相关的抗核抗体（ANA）。为了进一步改善本发明方法中RA的评估，可以与抗CCP和ANA一起测定一种或多种另外的标记物的水平，并与RA的不存在或存在相关。本发明还涉及包含抗CCP和ANA的标记物在诊断类风湿性关节炎中的用途，并且其教导了用于实施本发明方法的试剂盒。

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