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1. 发明授权

US07541163B2 Interferon-alpha polypeptides and conjugates 失效
公开(公告)号：US07541163B2
公开(公告)日：2009-06-02
申请号：US11838730
申请日：2007-08-14
申请人： Phillip A. Patten , Sridhar Viswanathan , Torben Lauesgaard Nissen , Anne Vogt , Harald Kropshofer , Ralf Schumacher , Stephan Fischer , Stefan Seeber , Adelbert Grossmann , Friederike Hesse
发明人： Phillip A. Patten , Sridhar Viswanathan , Torben Lauesgaard Nissen , Anne Vogt , Harald Kropshofer , Ralf Schumacher , Stephan Fischer , Stefan Seeber , Adelbert Grossmann , Friederike Hesse
IPC分类号： C12N15/00 , C12N15/63 , C12P21/00 , C07H21/04
CPC分类号： A61K38/212 , A61K47/60 , C07K14/56 , Y02A50/463
摘要： The present invention provides interferon-alpha polypeptides and conjugates, and nucleic acids encoding the polypeptides. The invention also includes compositions comprising these polypeptides, conjugates, and nucleic acids; cells containing or expressing the polypeptides, conjugates, and nucleic acids; methods of making the polypeptides, conjugates, and nucleic acids; and methods of using the polypeptides, conjugates, and nucleic acids.

2. 发明申请

US20080193457A1 Ra Antigenic Peptides 审中-公开
标题翻译： Ra抗原肽
公开(公告)号：US20080193457A1
公开(公告)日：2008-08-14
申请号：US10567386
申请日：2004-07-30
申请人： Nikolaos Berntenis , Gerrit Buurman , Harald Kropshofer , Bernd Christian Mueller , Sebastian Thomas Spindeldreher , Anne Vogt , Werner Zolg
发明人： Nikolaos Berntenis , Gerrit Buurman , Harald Kropshofer , Bernd Christian Mueller , Sebastian Thomas Spindeldreher , Anne Vogt , Werner Zolg
IPC分类号： A61K39/395 , C07K7/00 , C07K14/00 , C07K16/18 , C12N15/11 , A61P43/00 , C12N15/00 , C12N5/06 , A61K38/00 , G01N33/00
CPC分类号： C07K14/4713 , C07K14/70539
摘要： The present invention provides novel naturally-processed MHC class II antigenic peptides; which originate from interferon-γ-inducible lysosomal thiol reductase, integrin beta-2, phosphatitylinositol-4,5-bisphosphate 3-kinase, urokinase-type plas-minogen activator, immunoglobulin heavy chain V-III region (VH26), DJ-1 protein, apolipoprotein B-100, 26S proteasome non-AT-Pase regulatory subunit 8, interleukin-1 receptor, fibromodulin, GM-CSF/IL-3/IL-5 receptor, sorting nexin 3, inter-α-trypsin inhibitor heavy chain H4, complement C4, complement C3 (α-chain), complement C3 (β-chain), SH3 domain-binding glutamic acid-rich-like protein 3, interleukin-4-induced protein 1, hemopexin, Hsc70-interacting protein, invariant chain (Ii), retinoic acid receptor responder protein 2, fibronectin, cathepsin B, tripeptidyl-peptidase II, legumain, platelet activating factor receptor, poly-alpha-2.8-sialyltrans-ferase, and ras-leated protein Rab-11B. Also provided are these antigenic peptides and the proteins they are derived from as markers for erosive and/or non-erosive RA. Moreover, these antigenic peptides linked to MHC class II molecules, antibodies reactive with said antigenic peptides, nucleic acids encoding said antigenic peptides, and nucleic acid constructs, host cells and methods for expressing said antigenic peptides are provided. The antigenic peptides of the invention can be used as markers in diagnosis of RA and in therapy as anti-RA vaccines.
摘要翻译：本发明提供了新型的天然加工的MHC II类抗原肽; 其衍生自干扰素-γ诱导型溶酶体硫醇还原酶，整联蛋白β-2，磷脂酰肌醇-4,5-二磷酸3-激酶，尿激酶型血小板原激活物，免疫球蛋白重链V-III区（V < / - 26），DJ-1蛋白，载脂蛋白B-100,26S蛋白酶体非AT-Pase调节亚单位8，白细胞介素-1受体，纤维调节蛋白，GM-CSF / IL-3 / IL-5受体，分选nexin 3 ，α间胰蛋白酶抑制剂重链H4，补体C4，补体C3（α链），补体C3（β链），SH3结构域结合谷氨酸样蛋白3，白细胞介素-4诱导蛋白1 ，血凝素，Hsc70相互作用蛋白，不变链（Ii），视黄酸受体应答蛋白2，纤连蛋白，组织蛋白酶B，三肽基肽酶II，legumain，血小板激活因子受体，聚α-2.8-唾液酸转移酶和ras - 蛋白质Rab-11B。还提供了这些抗原肽和它们作为侵蚀性和/或非侵蚀性RA的标记物衍生的蛋白质。此外，提供了与MHC II类分子连接的这些抗原肽，与所述抗原肽反应的抗体，编码所述抗原肽的核酸和核酸构建体，宿主细胞和用于表达所述抗原肽的方法。本发明的抗原肽可用作RA诊断和抗RA疫苗治疗中的标志物。

3. 发明申请

US20070025966A1 INTERFERON-ALPHA POLYPEPTIDES AND CONJUGATES 失效
公开(公告)号：US20070025966A1
公开(公告)日：2007-02-01
申请号：US11531557
申请日：2006-09-13
申请人： Phillip Patten , Sridhar Viswanathan , Torben Nissen , Anne Vogt , Harald Kropshofer , Ralf Schumacher , Stephan Fischer , Stefan Seeber , Adelbert Grossmann , Friederike Hesse , Andreas Schaubmar , Roberto Falkenstein , Hans Koll , Markus Dembowski
发明人： Phillip Patten , Sridhar Viswanathan , Torben Nissen , Anne Vogt , Harald Kropshofer , Ralf Schumacher , Stephan Fischer , Stefan Seeber , Adelbert Grossmann , Friederike Hesse , Andreas Schaubmar , Roberto Falkenstein , Hans Koll , Markus Dembowski
IPC分类号： A61K38/21 , C07H21/04 , C12P21/04 , C07K14/56
CPC分类号： A61K38/212 , A61K47/60 , C07K14/56 , Y02A50/463
摘要： The present invention provides interferon-alpha polypeptides and conjugates, and nucleic acids encoding the polypeptides. The invention also includes compositions comprising these polypeptides, conjugates, and nucleic acids; cells containing or expressing the polypeptides, conjugates, and nucleic acids; methods of making the polypeptides, conjugates, and nucleic acids; and methods of using the polypeptides, conjugates, and nucleic acids.

4. 发明授权

US07531324B2 Interferon-alpha polypeptides and conjugates 失效
公开(公告)号：US07531324B2
公开(公告)日：2009-05-12
申请号：US11531557
申请日：2006-09-13
申请人： Phillip A. Patten , Sridhar Viswanathan , Torben Lauesgaard Nissen , Anne Vogt , Harald Kropshofer , Ralf Schumacher , Stephan Fischer , Stefan Seeber , Andreas Schaubmar , Roberto Falkenstein
发明人： Phillip A. Patten , Sridhar Viswanathan , Torben Lauesgaard Nissen , Anne Vogt , Harald Kropshofer , Ralf Schumacher , Stephan Fischer , Stefan Seeber , Andreas Schaubmar , Roberto Falkenstein
IPC分类号： C12N15/00 , C12N15/63 , C12P21/00 , C07H21/04
CPC分类号： A61K38/212 , A61K47/60 , C07K14/56 , Y02A50/463
摘要： The present invention provides interferon-alpha polypeptides and conjugates, and nucleic acids encoding the polypeptides. The invention also includes compositions comprising these polypeptides, conjugates, and nucleic acids; cells containing or expressing the polypeptides, conjugates, and nucleic acids; methods of making the polypeptides, conjugates, and nucleic acids; and methods of using the polypeptides, conjugates, and nucleic acids.

5. 发明申请

US20050266465A1 Interferon-alpha polypeptides and conjugates 失效
标题翻译：干扰素-α多肽和缀合物
公开(公告)号：US20050266465A1
公开(公告)日：2005-12-01
申请号：US11132722
申请日：2005-05-18
申请人： Phillip Patten , Sridhar Viswanathan , Torben Nissen , Anne Vogt , Harald Kropshofer , Ralf Schumacher , Stephan Fischer , Stefan Seeber , Adelbert Grossmann , Friederike Hesse , Andreas Schaubmar , Roberto Falkenstein , Hans Koll , Markus Dembowski , Stephens Adam
发明人： Phillip Patten , Sridhar Viswanathan , Torben Nissen , Anne Vogt , Harald Kropshofer , Ralf Schumacher , Stephan Fischer , Stefan Seeber , Adelbert Grossmann , Friederike Hesse , Andreas Schaubmar , Roberto Falkenstein , Hans Koll , Markus Dembowski , Stephens Adam
IPC分类号： A61K38/21 , A61K47/48 , C07H21/04 , C07K14/555 , C07K14/56 , C12P21/02 , C12Q1/68
CPC分类号： A61K38/212 , A61K47/60 , C07K14/56 , Y02A50/463
摘要： The present invention provides interferon-alpha polypeptides and conjugates, and nucleic acids encoding the polypeptides. The invention also includes compositions comprising these polypeptides, conjugates, and nucleic acids; cells containing or expressing the polypeptides, conjugates, and nucleic acids; methods of making the polypeptides, conjugates, and nucleic acids; and methods of using the polypeptides, conjugates, and nucleic acids.
摘要翻译：本发明提供了干扰素-α多肽和缀合物，以及编码多肽的核酸。本发明还包括包含这些多肽，缀合物和核酸的组合物; 含有或表达多肽，缀合物和核酸的细胞; 制备多肽，缀合物和核酸的方法; 以及使用多肽，缀合物和核酸的方法。

6. 发明授权

US07541436B2 Interferon-alpha polypeptides and conjugates 失效
公开(公告)号：US07541436B2
公开(公告)日：2009-06-02
申请号：US11744424
申请日：2007-05-04
申请人： Phillip A. Patten , Sridhar Viswanathan , Torben Lauesgaard Nissen , Anne Vogt , Harald Kropshofer , Ralf Schumacher , Stephan Fischer , Stefan Seeber , Andreas Schaubmar , Hans Koll
发明人： Phillip A. Patten , Sridhar Viswanathan , Torben Lauesgaard Nissen , Anne Vogt , Harald Kropshofer , Ralf Schumacher , Stephan Fischer , Stefan Seeber , Andreas Schaubmar , Hans Koll
IPC分类号： C07K14/52 , C07K14/00 , A61K38/21
CPC分类号： A61K38/212 , A61K47/60 , C07K14/56 , Y02A50/463
摘要： The present invention provides interferon-alpha polypeptides and conjugates, and nucleic acids encoding the polypeptides. The invention also includes compositions comprising these polypeptides, conjugates, and nucleic acids; cells containing or expressing the polypeptides, conjugates, and nucleic acids; methods of making the polypeptides, conjugates, and nucleic acids; and methods of using the polypeptides, conjugates, and nucleic acids.

7. 发明授权

US07531630B2 Interferon-alpha polypeptides and conjugates 失效
标题翻译：干扰素-α多肽和缀合物
公开(公告)号：US07531630B2
公开(公告)日：2009-05-12
申请号：US11531531
申请日：2006-09-13
申请人： Phillip A. Patten , Sridhar Viswanathan , Torben Lauesgaard Nissen , Anne Vogt , Harald Kropshofer , Ralf Schumacher , Stephan Fischer , Stefan Seeber , Andreas Schaubmar , Hans Koll
发明人： Phillip A. Patten , Sridhar Viswanathan , Torben Lauesgaard Nissen , Anne Vogt , Harald Kropshofer , Ralf Schumacher , Stephan Fischer , Stefan Seeber , Andreas Schaubmar , Hans Koll
IPC分类号： C07K14/52 , C07K14/00 , A61K38/21
CPC分类号： A61K38/212 , A61K47/60 , C07K14/56 , Y02A50/463
摘要： The present invention provides interferon-alpha polypeptides and conjugates, and nucleic acids encoding the polypeptides. The invention also includes compositions comprising these polypeptides, conjugates, and nucleic acids; cells containing or expressing the polypeptides, conjugates, and nucleic acids; methods of making the polypeptides, conjugates, and nucleic acids; and methods of using the polypeptides, conjugates, and nucleic acids.
摘要翻译：本发明提供了干扰素-α多肽和缀合物，以及编码多肽的核酸。本发明还包括包含这些多肽，缀合物和核酸的组合物; 含有或表达多肽，缀合物和核酸的细胞; 制备多肽，缀合物和核酸的方法; 以及使用多肽，缀合物和核酸的方法。

8. 发明申请

US20080031853A1 INTERFERON-ALPHA POLYPEPTIDES AND CONJUGATES 失效
标题翻译：干扰素多肽和结合蛋白
公开(公告)号：US20080031853A1
公开(公告)日：2008-02-07
申请号：US11839493
申请日：2007-08-15
申请人： Phillip Patten , Sridhar Viswanathan , Torben Nissen , Anne Vogt , Harald Kropshofer , Ralf Schumacher , Stephan Fischer , Stefan Seeber , Adelbert Grossmann , Friederike Hesse , Andreas Schaubmar , Roberto Falkenstein , Hans Koll , Markus Dembowski
发明人： Phillip Patten , Sridhar Viswanathan , Torben Nissen , Anne Vogt , Harald Kropshofer , Ralf Schumacher , Stephan Fischer , Stefan Seeber , Adelbert Grossmann , Friederike Hesse , Andreas Schaubmar , Roberto Falkenstein , Hans Koll , Markus Dembowski
IPC分类号： A61K38/21 , A61P31/12 , C12N7/04
CPC分类号： A61K38/212 , A61K47/60 , C07K14/56 , Y02A50/463
摘要： The present invention provides interferon-alpha polypeptides and conjugates, and nucleic acids encoding the polypeptides. The invention also includes compositions comprising these polypeptides, conjugates, and nucleic acids; cells containing or expressing the polypeptides, conjugates, and nucleic acids; methods of making the polypeptides, conjugates, and nucleic acids; and methods of using the polypeptides, conjugates, and nucleic acids.
摘要翻译：本发明提供了干扰素-α多肽和缀合物，以及编码多肽的核酸。本发明还包括包含这些多肽，缀合物和核酸的组合物; 含有或表达多肽，缀合物和核酸的细胞; 制备多肽，缀合物和核酸的方法; 以及使用多肽，缀合物和核酸的方法。

9. 发明申请

US20070020734A1 INTERFERON-ALPHA POLYPEPTIDES AND CONJUGATES 审中-公开
公开(公告)号：US20070020734A1
公开(公告)日：2007-01-25
申请号：US11531570
申请日：2006-09-13
申请人： Phillip Patten , Sridhar Viswanathan , Torben Nissen , Anne Vogt , Harald Kropshofer , Ralf Schumacher , Stephan Fischer , Stefan Seeber , Adelbert Grossmann , Friederike Hesse , Andreas Schaubmar , Roberto Falkenstein , Hans Koll , Markus Dembowski
发明人： Phillip Patten , Sridhar Viswanathan , Torben Nissen , Anne Vogt , Harald Kropshofer , Ralf Schumacher , Stephan Fischer , Stefan Seeber , Adelbert Grossmann , Friederike Hesse , Andreas Schaubmar , Roberto Falkenstein , Hans Koll , Markus Dembowski
IPC分类号： C07K14/56 , C07H21/04 , C12P21/04
CPC分类号： A61K38/212 , A61K47/60 , C07K14/56 , Y02A50/463
摘要： The present invention provides interferon-alpha polypeptides and conjugates, and nucleic acids encoding the polypeptides. The invention also includes compositions comprising these polypeptides, conjugates, and nucleic acids; cells containing or expressing the polypeptides, conjugates, and nucleic acids; methods of making the polypeptides, conjugates, and nucleic acids; and methods of using the polypeptides, conjugates, and nucleic acids.

10. 发明申请

US20070020235A1 INTERFERON-ALPHA POLYPEPTIDES AND CONJUGATES 失效
公开(公告)号：US20070020235A1
公开(公告)日：2007-01-25
申请号：US11531531
申请日：2006-09-13
申请人： Phillip Patten , Sridhar Viswanathan , Torben Nissen , Anne Vogt , Harald Kropshofer , Ralf Schumacher , Stephan Fischer , Stefan Seeber , Adelbert Grossmann , Friederike Hesse , Andreas Schaubmar , Roberto Falkenstein , Hans Koll , Markus Dembowski
发明人： Phillip Patten , Sridhar Viswanathan , Torben Nissen , Anne Vogt , Harald Kropshofer , Ralf Schumacher , Stephan Fischer , Stefan Seeber , Adelbert Grossmann , Friederike Hesse , Andreas Schaubmar , Roberto Falkenstein , Hans Koll , Markus Dembowski
IPC分类号： A61K38/21 , C07H21/04 , A61K48/00 , C07K14/55 , C08L89/00
CPC分类号： A61K38/212 , A61K47/60 , C07K14/56 , Y02A50/463
摘要： The present invention provides interferon-alpha polypeptides and conjugates, and nucleic acids encoding the polypeptides. The invention also includes compositions comprising these polypeptides, conjugates, and nucleic acids; cells containing or expressing the polypeptides, conjugates, and nucleic acids; methods of making the polypeptides, conjugates, and nucleic acids; and methods of using the polypeptides, conjugates, and nucleic acids.

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