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21. 发明授权

US08362563B2 Thin film transistor, method for manufacturing the same, and semiconductor device 有权
公开(公告)号：US08362563B2
公开(公告)日：2013-01-29
申请号：US13558638
申请日：2012-07-26
申请人： Toshikazu Kondo , Hideyuki Kishida
发明人： Toshikazu Kondo , Hideyuki Kishida
IPC分类号： H01L27/12 , H01L29/66
CPC分类号： H01L27/1225 , H01L21/02554 , H01L21/02565 , H01L21/02614 , H01L21/0262 , H01L21/02631 , H01L21/477 , H01L27/1222 , H01L27/124 , H01L27/1248 , H01L27/1255 , H01L27/1259 , H01L27/3248 , H01L27/3262 , H01L29/24 , H01L29/45 , H01L29/458 , H01L29/4908 , H01L29/66765 , H01L29/66969 , H01L29/78603 , H01L29/78606 , H01L29/78618 , H01L29/78663 , H01L29/78678 , H01L29/7869 , H01L29/78693
摘要： In a thin film transistor, an increase in off current or negative shift of the threshold voltage is prevented. In the thin film transistor, a buffer layer is provided between an oxide semiconductor layer and each of a source electrode layer and a drain electrode layer. The buffer layer includes a metal oxide layer which is an insulator or a semiconductor over a middle portion of the oxide semiconductor layer. The metal oxide layer functions as a protective layer for suppressing incorporation of impurities into the oxide semiconductor layer. Therefore, in the thin film transistor, an increase in off current or negative shift of the threshold voltage can be prevented.

22. 发明申请

US20090246186A1 AGENT FOR IMPROVING NERVOUS SYSTEM CELL FUNCTIONS 审中-公开
标题翻译：改善神经系统细胞功能的代理
公开(公告)号：US20090246186A1
公开(公告)日：2009-10-01
申请号：US12295258
申请日：2007-03-29
申请人： Yoshiyuki Shinagawa , Hideyuki Kishida , Taizo Kawabe , Hirokazu Sakamoto , Hiroshi Kubo , Kazunori Hosoe
发明人： Yoshiyuki Shinagawa , Hideyuki Kishida , Taizo Kawabe , Hirokazu Sakamoto , Hiroshi Kubo , Kazunori Hosoe
IPC分类号： A61K31/122 , A61P25/00
CPC分类号： A61K31/09 , A61K31/122
摘要： The present invention aims to activate neural cells in brain, and further provide a useful composition having an action to protect intracerebral neural cells from external and internal stresses.An agent for improving a neural cell function containing reduced coenzyme Q as an active ingredient, more specifically, an agent for activating neural cells and an agent for protecting neural cells, is useful, and can be used for the improvement or prophylaxis of central neurological diseases or neuropathy symptoms derived from or associated with a neurodegenerative disease, promotion of cognitive function or improvement of learning and memory disorders.
摘要翻译：本发明旨在激活脑中的神经细胞，并进一步提供一种有用的组合物，其具有保护脑内神经细胞免受外部和内部应激的作用。用于改善包含还原型辅酶Q作为活性成分的神经细胞功能的药剂，更具体地，用于激活神经细胞的药剂和用于保护神经细胞的药剂是有用的，并且可用于改善或预防中枢神经系统疾病或由神经退行性疾病引起或与之相关的神经病症状，促进认知功能或改善学习和记忆障碍。

23. 发明申请

US20050074860A1 Reduced coenzyme Q10 crystal with excellent stability and composition containing said reduced coenzyme Q10 crystal 有权
标题翻译：具有优异稳定性的还原型辅酶Q10晶体，含有所述还原型辅酶Q10晶体的组合物
公开(公告)号：US20050074860A1
公开(公告)日：2005-04-07
申请号：US10938431
申请日：2004-09-09
申请人： Takahiro Ueda , Shiro Kitamura , Taizo Kawabe , Hideyuki Kishida , Yasuyoshi Ueda
发明人： Takahiro Ueda , Shiro Kitamura , Taizo Kawabe , Hideyuki Kishida , Yasuyoshi Ueda
IPC分类号： A23L1/30 , C07C43/23 , C07C43/20 , C12N9/00 , C12Q1/48
CPC分类号： C07C43/23 , A23L33/10
摘要： The present invention provides a reduced coenzyme Q10 crystal with excellent stability and a composition containing said reduced coenzyme Q10 crystals. According to the present invention, after dissolving reduced coenzyme Q10 in a fat and oil, it is cooled, making it possible to obtain reduced coenzyme Q10 crystals with excellent stability and which exhibit an x-ray diffraction pattern (using a CuKα emission line) that differs from ordinary reduced coenzyme Q10 crystals. Moreover, said crystals are also excellent in bioabsorbability.
摘要翻译：本发明提供具有优异稳定性的还原型辅酶Q10晶体和含有所述还原型辅酶Q10晶体的组合物。根据本发明，在将脂肪和油中的还原型辅酶Q10溶解后，将其冷却，可以获得稳定性优异的还原型辅酶Q10晶体，并显示出X射线衍射图（使用CuKα发射线）与普通还原型辅酶Q10晶体不同。此外，所述晶体的生物吸收性也优异。

24. 发明授权

US5270339A Phenoxybenzene derivative 失效
标题翻译：苯氧基苯衍生物
公开(公告)号：US5270339A
公开(公告)日：1993-12-14
申请号：US938164
申请日：1992-12-03
申请人： Kozo Yamamoto , Yoshihide Fuse , Hideyuki Kishida , Naoko Yasuhara , Toshiaki Miwa , Ikuo Katsumi , Takayoshi Hidaka
发明人： Kozo Yamamoto , Yoshihide Fuse , Hideyuki Kishida , Naoko Yasuhara , Toshiaki Miwa , Ikuo Katsumi , Takayoshi Hidaka
IPC分类号： C07D207/08 , C07D207/20 , C07D207/24 , C07D207/26 , C07D207/36 , C07D405/12 , C07D207/06
CPC分类号： C07D207/26 , C07D207/08 , C07D207/20 , C07D207/24 , C07D207/36 , C07D405/12
摘要： There are described a phenoxybenzene derivative having the formula (I): ##STR1## wherein R.sup.1 is hydrogen atom; an alkyl group having 1 to 3 carbon atoms; --OR.sup.6 or a halogen atom,R.sup.2 is hydrogen atom, nitro group or amino group,R.sup.3 is hydrogen atom, an alkyl group having 1 to 8 carbon atoms, a cycloalkyl group having 3 to 5 carbon atoms, allyl group, vinyl group or --(CH.sub.2)n.sup.1 R.sup.7R.sup.4 is hydrogen atom, an alkyl group having 1 to 3 carbon atoms or --(CH.sub.2)n.sup.3 R.sup.25R.sup.5 hydrogen atom; an alkyl group having 1 to 3 carbon atoms; or phenyl group,X is ##STR2## wherein Y is oxygen atom or sulfur atom; or --CHR.sup.27 -- and line means a single bond or a double bond provided that n is 2 in case that the line means a single bond and n is 1 in case that the line means a double bond, ora pharmacologically acceptable salt thereof,a cognition enhancer comprising the same as an effective ingredient andan antidepressant comprising the same as an effective ingredient.
摘要翻译： PCT No.PCT / JP92 / 00410 Sec。 371日期1992年12月3日 102（e）日期1992年12月3日PCT提交1992年4月2日PCT公布。 WO92 / 17447 PCT出版物描述了具有式（I）的苯氧基苯衍生物：其中R 1是氢原子;（I）其中R 1是氢原子; 具有1至3个碳原子的烷基; -OR 6或卤原子，R 2为氢原子，硝基或氨基，R 3为氢原子，碳原子数1〜8的烷基，碳原子数3〜5的环烷基，烯丙基，乙烯基或 - （CH2）n1R7 R4为氢原子，碳原子数1〜3的烷基或 - （CH2）n3R25 R5氢原子; 具有1至3个碳原子的烷基; 或苯基，X是其中Y是氧原子或硫原子; 或-CHR27-，并且线表示单键或双键，条件是在线表示单键的情况下n为2，并且在该线表示双键的情况下n为1，或其药理学上可接受的盐，包含与有效成分相同的认知增强剂和包含其作为有效成分的抗抑郁药。

25. 发明授权

US09295656B2 Composition containing reduced coenzyme Q10 and production method thereof 有权
标题翻译：含有还原型辅酶Q10的组合物及其制备方法
公开(公告)号：US09295656B2
公开(公告)日：2016-03-29
申请号：US11812887
申请日：2007-06-22
申请人： Takashi Ueda , Shinsuke Akao , Shiro Kitamura , Hideyuki Kishida , Takahiro Ueda
发明人： Takashi Ueda , Shinsuke Akao , Shiro Kitamura , Hideyuki Kishida , Takahiro Ueda
IPC分类号： A61K31/122 , A61K9/00 , A61K9/16 , A61K9/20 , A61K9/48 , A61K9/107
CPC分类号： C07C50/28 , A61K9/0056 , A61K9/107 , A61K9/1652 , A61K9/1664 , A61K9/2018 , A61K9/4858 , A61K9/4875 , A61K31/122
摘要： The present invention provides a particulate composition wherein an oil component containing reduced coenzyme Q10 is polydispersed forming a domain in a matrix containing a water-soluble excipient, which simultaneously shows high oxidative stability and high oral absorbability, a production method thereof, and a stabilizing method thereof. It also provides a food, food with nutrient function claims, food for specified health uses, dietary supplement, nutritional product, animal drug, drink, feed, pet food, cosmetic, pharmaceutical product, therapeutic drug, prophylactic drug and the like, which contain the composition.
摘要翻译：本发明提供了一种颗粒组合物，其中含有还原型辅酶Q10的油成分是多分散的，在含有水溶性赋形剂的基质中形成一个结构域，其同时表现出高氧化稳定性和高口服吸收性，其制备方法和稳定化方法其中。它还提供食物，具有营养功能的食物，特定健康用途的食物，膳食补充剂，营养产品，动物药物，饮料，饲料，宠物食品，化妆品，药物，治疗药物，预防药物等，其含有组成。

26. 发明授权

US08388950B2 Coenzyme Q10-containing water-soluble composition and process for production thereof 失效
标题翻译：含辅酶Q10的水溶性组合物及其生产方法
公开(公告)号：US08388950B2
公开(公告)日：2013-03-05
申请号：US11917454
申请日：2006-06-14
申请人： Toshinori Ikehara , Hideyuki Kishida
发明人： Toshinori Ikehara , Hideyuki Kishida
IPC分类号： A61K38/43
CPC分类号： A23K20/174 , A23L29/10 , A23L33/10 , A61K8/355 , A61K8/39 , A61K9/107 , A61K31/122 , A61K47/14 , A61K47/26 , A61Q19/00
摘要： A coenzyme Q10-containing water soluble composition comprises coenzyme Q10, a hydrophilic polyglycerol fatty acid ester, a lipophilic sucrose fatty acid ester and an aqueous phase component and a process for producing the same are disclosed. A coenzyme Q10-containing water-soluble dry powder can be obtained by drying the above-mentioned coenzyme Q10-containing water soluble composition. A food, functional food, beverage, pharmaceutical product, quasi drug, cosmetic, or animal food can be obtained by using the above-mentioned coenzyme Q10-containing water soluble composition or the above-mentioned coenzyme Q10-containing water-soluble dry powder. The coenzyme Q10-containing water soluble composition has a high bioavailability, and maintains a stable emulsion form for a long period of time from refrigeration temperature to room temperature and allows efficient supply.
摘要翻译：含有辅酶Q10的水溶性组合物包括辅酶Q10，亲水性聚甘油脂肪酸酯，亲脂性蔗糖脂肪酸酯和水相成分及其制造方法。可以通过干燥上述含有辅酶Q10的水溶性组合物来获得含辅酶Q10的水溶性干粉。可以通过使用上述含有辅酶Q10的水溶性组合物或上述含有辅酶Q10的水溶性干粉来获得食品，功能性食品，饮料，药物，准药物，化妆品或动物性食品。含有辅酶Q10的水溶性组合物具有高的生物利用度，并且从制冷温度到室温长时间保持稳定的乳液形式并且可以有效地供应。

27. 发明申请

US20070098761A1 Processed fat composition for preventing/ameliorating lifestyle-related diseases 审中-公开
标题翻译：用于预防/改善生活方式相关疾病的加工脂肪组合物
公开(公告)号：US20070098761A1
公开(公告)日：2007-05-03
申请号：US10560900
申请日：2004-07-14
申请人： Naoki Arai , Hideyuki Kishida , Toshinori Ikehara , Tatsumasa Mae
发明人： Naoki Arai , Hideyuki Kishida , Toshinori Ikehara , Tatsumasa Mae
IPC分类号： A61K9/48 , A61K47/00
CPC分类号： A61K36/484 , A23L33/105 , A23L33/115 , A23V2002/00 , A61K9/4858 , A61K31/352 , A61K31/353 , A23V2200/332
摘要： The object of the invention is to provide a composition for prevention and/or amelioration of life-style related disease, and/or a composition for inhibition and/or amelioration of increase in body weight, comprising at least one compound selected from the group consisting of glabrene, glabridin, glabrol, 3′-hydroxy-4′-O-methylglabridin, 4′-O-methylglabridin and hyspaglabridin B as compounds having a PPAR ligand activity effective in amelioration of insulin resistance and in prevention and/or amelioration of life-style related diseases such as visceral fat obesity, type 2 diabetes, hyperlipemia and hypertension, which can be utilized in food and drink such as health food and health functional food (food for specified uses and food with nutrient function), pharmaceutical preparations, non-pharmaceutical preparations, cosmetics etc. At least one compound selected from the group consisting of glabrene, glabridin, glabrol, 3′-hydroxy-4′-O-methylglabridin, 4′-O-methylglabridin and hyspaglabridin B is dissolved in medium-chain fatty acid triglycerides and/or partial glycerides, whereby the stability of the compound(s) is improved and the processability thereof into food and drink, pharmaceutical preparations, non-pharmaceutical preparations, cosmetics etc. is also improved.
摘要翻译：本发明的目的是提供一种用于预防和/或改善生命方式相关疾病的组合物和/或用于抑制和/或改善体重增加的组合物，其包含至少一种选自以下的化合物： glabrene，glabridin，glabrol，3'-羟基-4'-O-甲基吡咯啶，4'-O-甲基吡咯啶和嗜麦芽窄食idin宾B作为具有有效改善胰岛素抵抗和预防和/或改善生命的PPAR配体活性的化合物类风湿性关节疾病，如内脏脂肪肥胖，2型糖尿病，高脂血症和高血压，可用于食品和饮料，如保健食品和保健功能食品（特定用途的食品和营养功能食品），药物制剂，药物制剂，化妆品等。至少一种选自由Glabrene，glabridin，glabrol，3'-羟基-4'-O-甲基吡咯啶，4'-O-甲基吡咯烷和hyspaglab ridin B溶解在中链脂肪酸甘油三酯和/或部分甘油酯中，从而提高了化合物的稳定性，并且其加工成食品和饮料，药物制剂，非药物制剂，化妆品等也是改进。

28. 发明申请

US20100284983A1 COENZYME Q10-CONTAINING WATER-SOLUBLE COMPOSITION AND PROCESS FOR PRODUCTION THEREOF 失效
标题翻译： COYZYME Q10-含水溶性组合物及其生产方法
公开(公告)号：US20100284983A1
公开(公告)日：2010-11-11
申请号：US11917454
申请日：2006-06-14
申请人： Toshinori Ikehara , Hideyuki Kishida
发明人： Toshinori Ikehara , Hideyuki Kishida
IPC分类号： A61K31/122 , A61K38/43 , A61K9/14 , A61K8/92 , A61Q1/02 , A61Q11/00 , A61Q19/00 , A61P43/00 , A23L1/30 , A23K1/00 , A23L2/52
CPC分类号： A23K20/174 , A23L29/10 , A23L33/10 , A61K8/355 , A61K8/39 , A61K9/107 , A61K31/122 , A61K47/14 , A61K47/26 , A61Q19/00
摘要： A coenzyme Q10-containing water soluble composition comprises coenzyme Q10, a hydrophilic polyglycerol fatty acid ester, a lipophilic sucrose fatty acid ester and an aqueous phase component and a process for producing the same are disclosed. A coenzyme Q10-containing water-soluble dry powder can be obtained by drying the above-mentioned coenzyme Q10-containing water soluble composition. A food, functional food, beverage, pharmaceutical product, quasi drug, cosmetic, or animal food can be obtained by using the above-mentioned coenzyme Q10-containing water soluble composition or the above-mentioned coenzyme Q10-containing water-soluble dry powder. The coenzyme Q10-containing water soluble composition has a high bioavailability, and maintains a stable emulsion form for a long period of time from refrigeration temperature to room temperature and allows efficient supply.
摘要翻译：含有辅酶Q10的水溶性组合物包括辅酶Q10，亲水性聚甘油脂肪酸酯，亲脂性蔗糖脂肪酸酯和水相成分及其制造方法。可以通过干燥上述含有辅酶Q10的水溶性组合物来获得含辅酶Q10的水溶性干粉。可以通过使用上述含有辅酶Q10的水溶性组合物或上述含有辅酶Q10的水溶性干粉来获得食品，功能性食品，饮料，药物，准药物，化妆品或动物性食品。含有辅酶Q10的水溶性组合物具有高的生物利用度，并且从制冷温度到室温长时间保持稳定的乳液形式并且可以有效地供应。

29. 发明授权

US07358402B2 Reduced coenzyme Q10 crystal with excellent stability and composition containing said reduced coenzyme Q10 crystal 有权
标题翻译：具有优异稳定性的还原型辅酶Q10晶体，含有所述还原型辅酶Q10晶体的组合物
公开(公告)号：US07358402B2
公开(公告)日：2008-04-15
申请号：US10938431
申请日：2004-09-09
申请人： Takahiro Ueda , Shiro Kitamura , Taizo Kawabe , Hideyuki Kishida , Yasuyoshi Ueda
发明人： Takahiro Ueda , Shiro Kitamura , Taizo Kawabe , Hideyuki Kishida , Yasuyoshi Ueda
IPC分类号： C07C43/20 , C07C43/215
CPC分类号： C07C43/23 , A23L33/10
摘要： The present invention provides a reduced coenzyme Q10 crystal with excellent stability and a composition containing said reduced coenzyme Q10 crystals.According to the present invention, after dissolving reduced coenzyme Q10 in a fat and oil, it is cooled, making it possible to obtain reduced coenzyme Q10 crystals with excellent stability and which exhibit an x-ray diffraction pattern (using a CuKα emission line) that differs from ordinary reduced coenzyme Q10 crystals. Moreover, said crystals are also excellent in bioabsorbability.
摘要翻译：本发明提供了具有优异稳定性的还原型辅酶Q 10 O 2结晶和含有所述还原型辅酶Q 10 O 2结晶的组合物。根据本发明，在将脂肪和油中的还原型辅酶Q 10 O溶解后，将其冷却，可以获得具有优异稳定性的还原型辅酶Q 10 N 2结晶，其表现出与普通还原型辅酶Q 10 N结晶不同的x射线衍射图（使用CuKα发射谱线）。此外，所述晶体的生物吸收性也优异。

30. 发明申请

US20070293572A1 Anti-Fatigue Composition 审中-公开
标题翻译：抗疲劳成分
公开(公告)号：US20070293572A1
公开(公告)日：2007-12-20
申请号：US11596059
申请日：2005-05-09
申请人： Hideyuki Kishida , Taizo Kawabe , Kazunori Hosoe , Kenji Fujii
发明人： Hideyuki Kishida , Taizo Kawabe , Kazunori Hosoe , Kenji Fujii
IPC分类号： A61K31/05 , A61K31/205 , A61P25/26
CPC分类号： A61K31/205 , A23L33/10 , A23V2002/00 , A61K31/09 , A61K31/122 , A61K45/06 , A61K2300/00 , A23V2200/31 , A23V2250/314 , A23V2250/0612
摘要： Fatigue is significantly involved in the lifestyle of people today. Although many anti-fatigue products are on market, those with definite and reliable effects are still few. Under such circumstances, the inventors of the present invention have conducted studies aiming at providing a composition which exhibits a distinctive anti-fatigue effect, and consequently accomplished the present invention. The present invention provides an anti-fatigue composition containing reduced coenzyme Q and a carnitine derivative. By administering the anti-fatigue composition of the present invention to a mammal, anti-fatigue effects can be synergistically seen even at doses which are not effective when the components are individually used. According to the present invention, an anti-fatigue composition having a reliable effect can be provided.
摘要翻译：疲劳显着地涉及到今天人们的生活方式。虽然许多抗疲劳产品在市场上，但具有确定和可靠影响的产品仍然很少。在这种情况下，本发明的发明人进行了旨在提供具有显着抗疲劳效果的组合物的研究，从而完成了本发明。本发明提供含有还原型辅酶Q和肉碱衍生物的抗疲劳组合物。通过将本发明的抗疲劳组合物施用于哺乳动物，即使在单独使用组分时没有效果的剂量，也可以协同地看到抗疲劳作用。根据本发明，可以提供具有可靠效果的抗疲劳组合物。

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