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21. 发明申请

US20090175948A1 AEROSOL METHOD FOR NANO SILVER-SILICA COMPOSITE ANTI-MICROBIAL AGENT 有权
标题翻译：用于纳米银二氧化硅复合抗微生物剂的气溶胶法
公开(公告)号：US20090175948A1
公开(公告)日：2009-07-09
申请号：US12324318
申请日：2008-11-26
申请人： Xingmao JIANG , C. Jeffrey Brinker , Yong Lin , Yung-Sung Cheng
发明人： Xingmao JIANG , C. Jeffrey Brinker , Yong Lin , Yung-Sung Cheng
IPC分类号： A61K9/16 , A01N59/16 , A01P1/00 , A61K33/38 , A61P31/00
CPC分类号： A61K33/38 , A01N59/16 , A61K9/5115 , A61K9/5192 , A01N25/06 , A01N25/34 , A01N2300/00
摘要： A method of forming and resulting nano-structured composite includes atomizing a mixture of an amount of each of aminopropyltriethoxysilane, AgNO3, DI water, and ethanol in a carrier gas; heating the atomized droplets at a selected temperature for a time sufficient to reduce the Ag to its elemental form in a silica matrix; and outputting the nano structured composite particles. A predetermined heating time is from about 0.01 to about 40 seconds and a selected heating temperature is from about 200 to about 800° C. The nano structured composite includes a plurality of nano particles at a contact surface of the composite, dispersed throughout and at a contact surface of the composite, or dispersed throughout the composite.
摘要翻译：形成和得到的纳米结构复合材料的方法包括在载气中雾化一定量的氨基丙基三乙氧基硅烷，AgNO 3，去离子水和乙醇的混合物; 在所选择的温度下加热雾化的液滴足以将Ag还原成二氧化硅基质中其元素的时间; 并输出纳米结构复合颗粒。预定的加热时间为约0.01至约40秒，选定的加热温度为约200至约800℃。纳米结构复合材料包括在复合材料的接触表面处的多个纳米颗粒，分散在整个和复合材料的接触表面，或分散在整个复合材料中。

22. 发明授权

US07485343B1 Preparation of hydrophobic coatings 有权
标题翻译：疏水涂层的制备
公开(公告)号：US07485343B1
公开(公告)日：2009-02-03
申请号：US11104917
申请日：2005-04-13
申请人： Eric D. Branson , Pratik B. Shah , Seema Singh , C. Jeffrey Brinker
发明人： Eric D. Branson , Pratik B. Shah , Seema Singh , C. Jeffrey Brinker
IPC分类号： B05D3/04 , B05D3/06
CPC分类号： B05D5/083 , B05D3/046 , B05D3/067 , B05D7/222
摘要： A method for preparing a hydrophobic coating by preparing a precursor sol comprising a metal alkoxide, a solvent, a basic catalyst, a fluoroalkyl compound and water, depositing the precursor sol as a film onto a surface, such as a substrate or a pipe, heating, the film and exposing the film to a hydrophobic silane compound to form a hydrophobic coating with a contact angle greater than approximately 150°. The contact angle of the film can be controlled by exposure to ultraviolet radiation to reduce the contact angle and subsequent exposure to a hydrophobic silane compound to increase the contact angle.
摘要翻译：通过制备包含金属醇盐，溶剂，碱性催化剂，氟代烷基化合物和水的前体溶胶来制备疏水性涂层的方法，将前体溶胶作为膜沉积到诸如基材或管的表面上，加热，并将膜暴露于疏水性硅烷化合物以形成接触角大于约150°的疏水涂层。可以通过暴露于紫外线辐射来控制膜的接触角，以降低接触角并随后暴露于疏水硅烷化合物以增加接触角。

23. 发明授权

US6057377A Molecular receptors in metal oxide sol-gel materials prepared via molecular imprinting 有权
标题翻译：通过分子印迹制备的金属氧化物溶胶 - 凝胶材料中的分子受体
公开(公告)号：US6057377A
公开(公告)日：2000-05-02
申请号：US183848
申请日：1998-10-30
申请人： Darryl Y. Sasaki , C. Jeffrey Brinker , Carol S. Ashley , Charles E. Daitch , Kenneth J. Shea , Daniel J. Rush
发明人： Darryl Y. Sasaki , C. Jeffrey Brinker , Carol S. Ashley , Charles E. Daitch , Kenneth J. Shea , Daniel J. Rush
IPC分类号： C03C1/00 , C03C3/06 , C03C3/00 , B01D21/01 , C03C14/00 , G01N31/00
CPC分类号： C03C1/006 , C03C3/06 , C03C2203/28 , C03C2203/52 , Y10T436/10
摘要： A method is provided for molecularly imprinting the surface of a sol-gel material, by forming a solution comprised of a sol-gel material, a solvent, an imprinting molecule, and a functionalizing siloxane monomer of the form Si(OR).sub.3-n X.sub.n, wherein n is an integer between zero and three and X is a functional group capable of reacting with the imprinting molecule, evaporating the solvent, and removing the imprinting molecule to form the molecularly imprinted metal oxide sol-gel material. The use of metal oxide sol-gels allows the material porosity, pore size, density, surface area, hardness, electrostatic charge, polarity, optical density, and surface hydrophobicity to be tailored and be employed as sensors and in catalytic and separations operations.
摘要翻译：提供了通过形成由溶胶 - 凝胶材料，溶剂，印迹分子和Si（OR）3-nXn形式的官能化硅氧烷单体组成的溶液来分子印刷溶胶 - 凝胶材料的表面的方法其中n是0和3之间的整数，X是能够与压印分子反应的官能团，蒸发溶剂，以及去除压印分子以形成分子印迹的金属氧化物溶胶 - 凝胶材料。使用金属氧化物溶胶凝胶允许定制材料孔隙率，孔径，密度，表面积，硬度，静电电荷，极性，光密度和表面疏水性，并用作传感器和催化分离操作。

24. 发明申请

US20210030675A1 MESOPOROUS SILICA NANOPARTICLES AND SUPPORTED LIPID BI-LAYER NANOPARTICLES FOR BIOMEDICAL APPLICATIONS 有权
公开(公告)号：US20210030675A1
公开(公告)日：2021-02-04
申请号：US16828137
申请日：2020-03-24
申请人： C. Jeffrey Brinker , Paul N. Durfee , Jason Townson , Yu-Shen Lin , Stanley Shihyao Chou , Jacob Erstling
发明人： C. Jeffrey Brinker , Paul N. Durfee , Jason Townson , Yu-Shen Lin , Stanley Shihyao Chou , Jacob Erstling
IPC分类号： A61K9/127 , A61K47/62 , A61K47/69 , A61P31/14 , A61P35/02
摘要： The present disclosure is directed to methods of producing monosized protocells from monosized mesoporous silica nanoparticles (mMSNPs) and their use for targeted drug delivery formulations and systems and for biomedical applications. The present disclosure is also directed in part to a multilamellar or unilamellar protocell vaccine to deliver full length viral protein and/or plasmid encoded viral protein to antigen presenting cells (APCs) in order to induce an immunogenic response to a virus.

25. 发明申请

US20190262469A1 PROTOCELLS TO TREAT MICROBIAL INFECTION AND FOR SYNERGISTIC DELIVERY 审中-公开
公开(公告)号：US20190262469A1
公开(公告)日：2019-08-29
申请号：US15757254
申请日：2016-09-02
申请人： C. Jeffrey Brinker , Eric C. Carnes , Carlee Erin Ashley , Oscar Negrete , Dan C Wilkinson , Brian S Wilkinson , David Patrick Padilla
发明人： C. Jeffrey Brinker , Eric C. Carnes , Carlee Erin Ashley , Oscar Negrete , Dan C Wilkinson , Brian S Wilkinson , David Patrick Padilla
IPC分类号： A61K47/69 , A61K31/337 , A61P31/04
摘要： The present disclosure relates to protocells that are useful in the treatment and prevention of viral infections, including but not limited to infections caused by a Hendra virus and Nipah virus (NiV). The present disclosure relates to protocells that are useful in the treatment of bacterial infections, including antibiotic-resistant bacterial infections. The protocells are coated with a lipid bi- or multilayer comprising at least one moiety that targets a viral cellular receptor and at least one moiety that ruptures a virally-infected cell membrane. The present disclosure further relates to novel mesoporous metal oxide nanoparticles and related protocells that are useful in the treatment and/or prevention of a wide variety of disorders, including a cancer or a bacterial or viral infection. Such nanoparticles and protocells can be functionalized to allow for synergistic loading of a wide variety of active ingredients.

26. 发明授权

US09927397B1 Innovative nanopore sequencing technology including a self-assembled porous membrane 有权
公开(公告)号：US09927397B1
公开(公告)日：2018-03-27
申请号：US14555453
申请日：2014-11-26
申请人： Steven R. J. Brueck , Jeremy Scott Edwards , Alexander Neumann , Yuliya Kuznetsova , Edgar A. Mendoza , C. Jeffrey Brinker
发明人： Steven R. J. Brueck , Jeremy Scott Edwards , Alexander Neumann , Yuliya Kuznetsova , Edgar A. Mendoza , C. Jeffrey Brinker
IPC分类号： G01N27/447 , C12Q1/68 , B01L3/00
CPC分类号： G01N27/44791 , B01L3/502707 , B01L3/50273 , B01L3/502746 , B01L2200/0663 , B01L2300/0645 , B01L2300/0896 , B01L2400/0421 , B81C1/00 , C12Q1/6869 , G01N33/48721 , C12Q2563/157 , C12Q2563/159 , C12Q2565/631
摘要： Methods and apparatus for long read, label-free, optical nanopore long chain molecule sequencing. In general, the present disclosure describes a novel sequencing technology based on the integration of nanochannels to deliver single long-chain molecules with widely spaced (>wavelength), ˜1-nm aperture “tortuous” nanopores that slow translocation sufficiently to provide massively parallel, single base resolution using optical techniques. A novel, directed self-assembly nanofabrication scheme using simple colloidal nanoparticles is used to form the nanopore arrays atop nanochannels that unfold the long chain molecules. At the surface of the nanoparticle array, strongly localized electromagnetic fields in engineered plasmonic/polaritonic structures allow for single base resolution using optical techniques.

27. 发明授权

US09486742B1 Biomimetic membranes and methods of making biomimetic membranes 有权
标题翻译：仿生膜和制造仿生膜的方法
公开(公告)号：US09486742B1
公开(公告)日：2016-11-08
申请号：US13253964
申请日：2011-10-06
申请人： Susan Rempe , C. Jeffrey Brinker , David Michael Rogers , Ying-Bing Jiang , Shaorong Yang
发明人： Susan Rempe , C. Jeffrey Brinker , David Michael Rogers , Ying-Bing Jiang , Shaorong Yang
IPC分类号： B01D63/06 , B01D69/04 , B01D69/10 , B01D71/02
CPC分类号： B01D63/066 , B01D63/063 , B01D69/04 , B01D69/10 , B01D69/105 , B01D69/142 , B01D71/02 , B01D71/024 , B01D71/027 , B01D2323/283 , B01D2325/02
摘要： The present disclosure is directed to biomimetic membranes and methods of manufacturing such membranes that include structural features that mimic the structures of cellular membrane channels and produce membrane designs capable of high selectivity and high permeability or adsorptivity. The membrane structure, material and chemistry can be selected to perform liquid separations, gas separation and capture, ion transport and adsorption for a variety of applications.
摘要翻译：本公开涉及仿生膜和制造这种膜的方法，其包括模拟细胞膜通道的结构并产生能够具有高选择性和高渗透性或吸附性的膜设计的结构特征。可以选择膜结构，材料和化学物质进行液体分离，气体分离和捕获，离子传输和吸附用于各种应用。

28. 发明授权

US08246933B2 Aerosol method for nano silver-silica composite anti-microbial agent 有权
标题翻译：纳米银二氧化硅复合抗菌剂气溶胶法
公开(公告)号：US08246933B2
公开(公告)日：2012-08-21
申请号：US12324318
申请日：2008-11-26
申请人： Xingmao Jiang , C. Jeffrey Brinker , Yong Lin , Yung-Sung Cheng
发明人： Xingmao Jiang , C. Jeffrey Brinker , Yong Lin , Yung-Sung Cheng
IPC分类号： A61K9/14 , A01N59/16
CPC分类号： A61K33/38 , A01N59/16 , A61K9/5115 , A61K9/5192 , A01N25/06 , A01N25/34 , A01N2300/00
摘要： A method of forming and resulting nano-structured composite includes atomizing a mixture of an amount of each of aminopropyltriethoxysilane, AgNO3, DI water, and ethanol in a carrier gas; heating the atomized droplets at a selected temperature for a time sufficient to reduce the Ag to its elemental form in a silica matrix; and outputting the nano structured composite particles. A predetermined heating time is from about 0.01 to about 40 seconds and a selected heating temperature is from about 200 to about 800° C. The nano structured composite includes a plurality of nano particles at a contact surface of the composite, dispersed throughout and at a contact surface of the composite, or dispersed throughout the composite.
摘要翻译：形成和得到的纳米结构复合材料的方法包括在载气中雾化一定量的氨基丙基三乙氧基硅烷，AgNO 3，去离子水和乙醇的混合物; 在所选择的温度下加热雾化的液滴足以将Ag还原成二氧化硅基质中其元素的时间; 并输出纳米结构复合颗粒。预定的加热时间为约0.01至约40秒，选定的加热温度为约200至约800℃。纳米结构复合材料包括在复合材料的接触表面处的多个纳米颗粒，分散在整个和复合材料的接触表面，或分散在整个复合材料中。

29. 发明申请

US20100178468A1 ULTRA-THIN MICROPOROUS/HYBRID MATERIALS 有权
标题翻译：超细微孔/混合材料
公开(公告)号：US20100178468A1
公开(公告)日：2010-07-15
申请号：US12271719
申请日：2008-11-14
申请人： Ying-Bing JIANG , Joseph L. Cecchi , C. Jeffrey Brinker
发明人： Ying-Bing JIANG , Joseph L. Cecchi , C. Jeffrey Brinker
IPC分类号： C23C16/02 , B32B3/02 , B32B3/26 , B05D3/06
CPC分类号： B01D69/122 , B01D67/0002 , B01D67/0079 , B01D67/0083 , B01D67/009 , B01D69/148 , C23C16/401 , C23C16/45536 , C23C16/45555 , Y10T428/24521 , Y10T428/24545 , Y10T428/249953
摘要： Ultra-thin hybrid and/or microporous materials and methods for their fabrication are provided. In one embodiment, the exemplary hybrid membranes can be formed including successive surface activation and reaction steps on a porous support that is patterned or non-patterned. The surface activation can be performed using remote plasma exposure to locally activate the exterior surfaces of porous support. Organic/inorganic hybrid precursors such as organometallic silane precursors can be condensed on the locally activated exterior surfaces, whereby ALD reactions can then take place between the condensed hybrid precursors and a reactant. Various embodiments can also include an intermittent replacement of ALD precursors during the membrane formation so as to enhance the hybrid molecular network of the membranes.
摘要翻译：提供了超薄混合和/或微孔材料及其制造方法。在一个实施方案中，可以形成示例性混合膜，包括在图案化或非图案化的多孔载体上的连续表面活化和反应步骤。表面活化可以使用远程等离子体暴露来局部激活多孔载体的外表面。有机/无机混合前体例如有机金属硅烷前体可以在局部活化的外表面上缩合，由此ALD反应可以在冷凝的杂化前体和反应物之间进行。各种实施方案还可以包括在膜形成期间ALD前体的间歇替代，以增强膜的杂合分子网络。

30. 发明授权

US06387453B1 Method for making surfactant-templated thin films 有权
标题翻译：制备表面活性剂模板薄膜的方法
公开(公告)号：US06387453B1
公开(公告)日：2002-05-14
申请号：US09517873
申请日：2000-03-02
申请人： C. Jeffrey Brinker , Yunfeng Lu , Hongyou Fan
发明人： C. Jeffrey Brinker , Yunfeng Lu , Hongyou Fan
IPC分类号： B05D302
CPC分类号： B82Y30/00
摘要： An evaporation-induced self-assembly method to prepare a porous, surfactant-templated, thin film by mixing a silica sol, a solvent, a surfactant, and an interstitial compound, evaporating a portion of the solvent to form a liquid, crystalline thin film mesophase material, and then removal of the surfactant template. Coating onto a substrate produces a thin film with the interstitial compound either covalently bonded to the internal surfaces of the ordered or disordered mesostructure framework or physically entrapped within the ordered or disordered mesostructured framework. Particles can be formed by aerosol processing or spray drying rather than coating onto a substrate. The selection of the interstitial compound provides a means for developing thin films for applications including membranes, sensors, low dielectric constant films, photonic materials and optical hosts.
摘要翻译：通过混合硅溶胶，溶剂，表面活性剂和间隙化合物制备多孔表面活性剂模板化薄膜的蒸发诱导自组装方法，蒸发溶剂的一部分以形成液体，晶体薄膜中间相材料，然后除去表面活性剂模板。涂覆在基材上产生薄膜，其中间隙化合物共价键合到有序或无序的介观结构框架的内表面或物理地截留在有序或无序的介观结构框架内。颗粒可以通过气溶胶处理或喷雾干燥形成，而不是涂覆在基材上。间隙化合物的选择提供了一种用于开发用于包括膜，传感器，低介电常数膜，光子材料和光学主体的薄膜的薄膜的方法。

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