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21. 发明授权

US06482993B1 Method for producing long chain polyether polyols without reprocessing 有权
标题翻译：不再加工生产长链聚醚多元醇的方法
公开(公告)号：US06482993B1
公开(公告)日：2002-11-19
申请号：US09673583
申请日：2000-10-18
申请人： Jörg Hofmann , Pramod Gupta
发明人： Jörg Hofmann , Pramod Gupta
IPC分类号： C07C4311
CPC分类号： B01J31/0227 , B01J2231/48 , C08G65/2642 , C08G65/266
摘要： This invention relates to a process for the production of long-chain polyether polyols without working up, in which oligomeric, alkoxylated starter compounds having molecular weights of 200 to 1000 are first obtained by catalysis with perfluoroalkylsulfonates of the metals of group III A of the periodic system of elements (in accordance with the IUPAC convention of 1970) from low molecular weight starters by reaction with alkylene oxides at reaction temperatures of 80 to 200° C. and catalyst concentrations of 5 to 200 ppm, which oligomeric, alkoxylated starter compounds are then converted without working up and removal of the catalyst by means of highly active DMC catalysts at a catalyst concentration of 30 ppm or below, relative to the quantity of polyether polyol to be produced, by reaction with alkylene oxides into higher molecular weight, long-chain polyether polyols.
摘要翻译：本发明涉及一种不加工的长链聚醚多元醇的制备方法，其中分子量为200〜1000的低聚烷氧基化起始化合物首先通过周期性的IIIA族金属的全氟烷基磺酸盐的催化而得到在低分子量起始化合物的反应温度为80〜200℃，催化剂浓度为5〜200ppm的条件下，通过与环氧烷烃反应，从低分子量起始剂中分离出元素系统（按照IUPAC惯例）通过高活性DMC催化剂处理和除去催化剂，催化剂浓度为30ppm或更低，相对于待生产的聚醚多元醇的量，通过与烯化氧反应成较高分子量的长链聚醚多元醇。

22. 发明授权

US06617419B1 Long-chain polyether polyols with a high proportion of primary oh groups 有权
标题翻译：长链聚醚多元醇具有较高比例的原子喔基团
公开(公告)号：US06617419B1
公开(公告)日：2003-09-09
申请号：US10009889
申请日：2002-01-28
申请人： Jörg Hofmann , Pramod Gupta , Manfred Dietrich
发明人： Jörg Hofmann , Pramod Gupta , Manfred Dietrich
IPC分类号： C08G6534
CPC分类号： C08G65/2663 , C08G18/4841 , C08G18/4866
摘要： The invention relates to long-chain polyether polyols having a content of primary OH groups of 40 to 95 mol-% and a total content of oxyethylene units of >25 wt. % as well as a process for their production by DMC-catalysed polyaddition of an ethylene oxide (EO)/propylene oxide (PO) mixture in the weight ratio of 40:60 to 95:5 as an end block to starter compounds having active hydrogen atoms.
摘要翻译：本发明涉及具有40至95摩尔％的伯OH基团的含量和> 25重量％的氧化乙烯单元的总含量的长链聚醚多元醇。％以及通过DMC-催化加成的环氧乙烷（EO）/环氧丙烷（PO）混合物以40:60至95:5的重量比作为末端嵌段生产的方法，其具有活性氢的起始化合物原子

23. 发明授权

US06486361B1 Method for preparing polyether polyols 失效
标题翻译：制备聚醚多元醇的方法
公开(公告)号：US06486361B1
公开(公告)日：2002-11-26
申请号：US10048684
申请日：2002-03-20
申请人： Stephan Ehlers , Jörg Hofmann , Manfred Dietrich , Pramod Gupta , Christian Steinlein , Horst Zwick
发明人： Stephan Ehlers , Jörg Hofmann , Manfred Dietrich , Pramod Gupta , Christian Steinlein , Horst Zwick
IPC分类号： C07C4103
CPC分类号： C08G65/2696 , B01J27/26 , C08G65/2663
摘要： The invention relates to a process for the preparation of polyether polyols by means of double metal cyanide (DMC) catalysts, in which the induction phase is shortened markedly. By continuous dispensing of an alkylene oxide into the starter-catalyst mixture it is possible to achieve a substantial shortening of the induction phase by comparison with the batch-wise activation.
摘要翻译：本发明涉及一种通过双金属氰化物（DMC）催化剂制备聚醚多元醇的方法，其中诱导期明显缩短。通过将烯化氧连续分配到起动催化剂混合物中，可以通过与分批活化相比来实现诱导阶段的显着缩短。

24. 发明申请

US20070142478A1 COMBINATION ANTIMICROBIAL COMPOSITION AND METHOD OF USE 审中-公开
标题翻译：组合抗微生物组合物及其使用方法
公开(公告)号：US20070142478A1
公开(公告)日：2007-06-21
申请号：US11610901
申请日：2006-12-14
申请人： Erning Xia , Hongna Wang , Srini Venkatesh , Pramod Gupta , Norman LaFrance
发明人： Erning Xia , Hongna Wang , Srini Venkatesh , Pramod Gupta , Norman LaFrance
IPC分类号： A61K31/155
CPC分类号： A61K31/155
摘要： Provided herein is a pharmaceutically acceptable composition comprising a biguanide containing antimicrobial agent and an additional antimicrobial agent. The invention further comprises topically administering the pharmaceutically acceptable composition to a patient in need of treatment.
摘要翻译：本文提供了包含含双胍的抗微生物剂和另外的抗微生物剂的药学上可接受的组合物。本发明还包括向需要治疗的患者局部施用药学上可接受的组合物。

25. 发明申请

US20050188436A1 Continuous culture of conifer embryogenic tissue 有权
标题翻译：针叶胚发生组织连续培养
公开(公告)号：US20050188436A1
公开(公告)日：2005-08-25
申请号：US11063416
申请日：2005-02-22
申请人： Pramod Gupta , Diane Holmstrom , Bonnie Larson
发明人： Pramod Gupta , Diane Holmstrom , Bonnie Larson
IPC分类号： A01H20060101 , A01H1/00 , A01H4/00 , A01H7/00 , C12N5/02 , C12N5/04 , C12N15/82
CPC分类号： A01H4/005 , A01H7/00 , C12N5/04
摘要： The present invention provides methods for multiplying conifer embryogenic tissue. The methods of the present invention each include the step of continuously culturing conifer embryogenic tissue in liquid multiplication medium for a period of time sufficient for the embryogenic tissue to multiply.
摘要翻译：本发明提供了用于倍增针叶胚发生组织的方法。本发明的方法各自包括在液体繁殖培养基中连续培养针叶树胚发生组织足以使胚发生组织繁殖的时间的步骤。

26. 发明申请

US20050113337A1 Enhancement of oral bioavailability of non-emulsified formulations of prodrug esters with lecithin 审中-公开
标题翻译：提高前药酯与卵磷脂的非乳化制剂的口服生物利用度
公开(公告)号：US20050113337A1
公开(公告)日：2005-05-26
申请号：US11014798
申请日：2004-12-13
申请人： Rajneesh Taneja , Dale Brinker , Jacqueline Briskin , Dilip Vishwasrao , Roberto Aponte , Pramod Gupta
发明人： Rajneesh Taneja , Dale Brinker , Jacqueline Briskin , Dilip Vishwasrao , Roberto Aponte , Pramod Gupta
IPC分类号： A61K9/00 , A61K9/16 , A61K9/20 , A61K31/343 , A61K31/4375 , A61K31/545 , A61K31/65 , A61K31/7048 , A61K31/685 , A61K31/57
CPC分类号： A61K31/4375 , A61K9/0095 , A61K9/1617 , A61K9/2013 , A61K9/2095 , A61K31/343 , A61K31/545 , A61K31/65 , A61K31/7048
摘要： A method for enhancing the oral bioavailability of a prodrug ester by formulating the ester as a non-emulsified formulation with lecithin; as well as a pharmaceutical composition of at least one antibiotic and lecithin in a non-emulsified formulation; a method of treating infections with the non-emulsified formulation, and a method for preparing tablets by direct compression of blends of drugs with lecithin are disclosed. Non-emulsified formulations include solids, tablets, capsules, lozenges, suspensions, elixirs and solutions, and exclude emulsions, liposomes, lipid matrix systems and micro-emulsions. A suitable prodrug ester is a cephalosporin β-lactam antibiotic such as cefditoren pivoxil, and a suitable non-emulsified formulation is a solid formulation.
摘要翻译：一种通过配制具有卵磷脂的非乳化制剂的酯来提高前药酯的口服生物利用度的方法; 以及非乳化制剂中至少一种抗生素和卵磷脂的药物组合物; 公开了用非乳化制剂治疗感染的方法，以及通过直接压制药物与卵磷脂的混合物制备片剂的方法。非乳化制剂包括固体，片剂，胶囊，锭剂，悬浮液，酏剂和溶液，并且不包括乳剂，脂质体，脂质基质体系和微乳液。合适的前药酯是头孢菌素β-内酰胺抗生素，例如匹戊头孢托仑，合适的非乳化制剂是固体制剂。

27. 发明授权

US5672768A Low-odor, higher molecular weight polyether polyols, a process for producing them, and their use for the production of polymers, cosmetics and pharmaceutical products synthesized from polyether polyols 失效
标题翻译：低气味，高分子量的聚醚多元醇，其制备方法及其用于生产由聚醚多元醇合成的聚合物，化妆品和药物的用途
公开(公告)号：US5672768A
公开(公告)日：1997-09-30
申请号：US780760
申请日：1997-01-08
申请人： Pramod Gupta , Gundolf Jacobs , Joel Leuridan
发明人： Pramod Gupta , Gundolf Jacobs , Joel Leuridan
IPC分类号： A61K8/86 , A61K47/10 , A61Q19/00 , C08G18/48 , C08G65/02 , C08G65/06 , C08G65/26 , C08G65/30 , C08L71/02 , C07C43/11 , C07C43/18 , C07C43/20
CPC分类号： C08G65/30 , A61K47/10 , A61K8/86 , A61Q19/00
摘要： Low-odor, higher molecular weight polyether polyols are produced by purifying the polyether polyols at temperatures of 110.degree. to 150.degree. C. and pressures of 10 to 70 hPa with the addition of 5 to 30% by weight of water, wherein the water is passed in finely divided form, with a droplet diameter of about 5 to 100.mu., through the polyether polyols to be purified for a time of metered addition of 1 to 5 hours.
摘要翻译：通过在110℃至150℃的温度和10至70hPa的压力下纯化聚醚多元醇并加入5至30重量％的水来生产低气味的较高分子量的聚醚多元醇，其中水为通过聚醚多元醇以微细直径约5至100微米的形式通过待纯化的计时加入1至5小时的时间。

28. 发明授权

US5360863A Radiation curable compositions and their use 失效
标题翻译：可辐射固化组合物及其用途
公开(公告)号：US5360863A
公开(公告)日：1994-11-01
申请号：US101518
申请日：1993-08-02
申请人： Jurgen Meixner , Wolfgang Fischer , Pramod Gupta
发明人： Jurgen Meixner , Wolfgang Fischer , Pramod Gupta
IPC分类号： C08F299/04 , C08F283/01 , C08G63/52 , C08G63/676 , C08L67/06 , C09D4/00 , C09D167/06 , C09K3/10
CPC分类号： C08G63/676 , C08L67/06 , C09D167/06
摘要： The present invention relates to compositions which may be cured by radical polymerization at room temperature and containA) 20 to 100 parts by weight of .alpha.,.beta.-ethylenically unsaturated polyesters which are the reaction products ofa) a dicarboxylic acid component containing i) 40 to 100 carboxyl equivalent % of .alpha.,.beta. ethylenically unsaturated dicarboxylic acids and/or their anhydrides and ii) 0 to 60 carboxyl equivalent % of dicarboxylic acids and/or their anhydrides other than those set forth in i) withb) an alcohol component containing i) 25 to 100 hydroxyl equivalent % of alkoxylated 2-butene-1,4-diols having an average molecular weight 130 to 400 and ii) 0 to 75 hydroxyl equivalent % of mono- or poly- hydric alcohols having a molecular weight of 32 to 400 other than those set forth in i) wherein the amounts of a) and b) are chosen such that equivalent ratio of carboxyl groups to hydroxyl groups is no more than 1:1,B) 0 to 80 parts by weight of compounds containing (meth)acryloyl groups and/or vinyl ether groups,wherein the sum of the parts by weight of A) and B) is 100, based on the weight of components A) and B), provided that when components A) and B) are used in a weight ratio exceeding 9:1, component a) contains at least 90 carboxyl equivalent % of component ai) and component b) contains at least 40 hydroxyl equivalent % component bi). The present invention also relates to the use of these compositions as binders for coating, patching or sealing compositions and for the production of molded bodies.
摘要翻译：本发明涉及可在室温下通过自由基聚合固化并含有A）20至100重量份的α，β-烯属不饱和聚酯的组合物，其为a）包含i）的二羧酸组分的反应产物至100个羧基当量％的α，β-烯键式不饱和二羧酸和/或它们的酸酐，和ii）除i）中所列出的那些以外的二羧酸和/或其酸酐的0至60羧基当量％，b）含有 i）平均分子量为130〜400的25〜100个羟基当量％的烷氧基化2-丁烯-1,4-二醇，和ii）分子量为32的单 - 或多元醇的0〜75羟基当量％至a 400），其中选择a）和b）的量使得羧基与羟基的当量比不超过1:1，B）0至80重量份的化合物含有 g（甲基）丙烯酰基和/或乙烯基醚基，其中A）和B）的重量份之和为100，基于组分A）和B）的重量，条件是当组分A）和B ）以重量比超过9:1使用，组分a）含有至少90个羧基当量％的组分ai），组分b）含有至少40个羟基当量％组分bi）。本发明还涉及这些组合物作为粘合剂用于涂覆，修补或密封组合物以及用于生产模塑体的用途。

29. 发明授权

US5028636A Liquid polyisocyanate mixtures, a process for their preparation, and their use in the preparation of polyurethane foams 失效
标题翻译：液体多异氰酸酯混合物，其制备方法及其在制备聚氨酯泡沫体中的应用
公开(公告)号：US5028636A
公开(公告)日：1991-07-02
申请号：US568389
申请日：1990-08-16
申请人： Herbert Gebauer , Pramod Gupta , Gerhard Heilig , Rolf Wiedermann
发明人： Herbert Gebauer , Pramod Gupta , Gerhard Heilig , Rolf Wiedermann
IPC分类号： C08G18/10 , C08G18/12 , C08G18/28 , C08G18/76 , C08G18/77 , C08G18/80 , C08G101/00 , C08J9/04
CPC分类号： C08G18/8064 , C08G18/10 , C08G18/12 , C08G18/283 , C08G18/7664 , C08G18/8009 , C08G2101/0025
摘要： This invention relates to novel urethane-modified polyisocyanate mixtures of the diphenylmethane series prepared by a process comprising reacting polyisocyanates or polyisocyanate mixtures of the diphenylmethane series with certain monohydric and/or polyhydric alcohols and, optionally, subsequently mixing the initially modified products with polyisocyanates or polyisocyanate mixtures of the diphenylmethane series that have not been modified with urethane groups. This invention further relates to the use of the polyisocyanate mixtures in the preparation of polyurethane foams.
摘要翻译：本发明涉及通过包括使二苯基甲烷系列的多异氰酸酯或多异氰酸酯混合物与某些一元醇和/或多元醇反应的方法制备的二苯基甲烷系列的新型氨基甲酸酯改性多异氰酸酯混合物，以及任选地将最初改性的产物与多异氰酸酯或多异氰酸酯未经氨基甲酸酯基团改性的二苯基甲烷系列的混合物。本发明还涉及多异氰酸酯混合物在制备聚氨酯泡沫体中的用途。

30. 发明授权

US4115373A Process for the production of polyisocyanates containing isocyanurate groups 失效
标题翻译：制备含有异氰脲酸酯基团的多异氰酸酯的方法
公开(公告)号：US4115373A
公开(公告)日：1978-09-19
申请号：US737747
申请日：1976-11-01
申请人： Gerhard Henes , Hans Jurgen Muller , Pramod Gupta , Joachim Zirner
发明人： Gerhard Henes , Hans Jurgen Muller , Pramod Gupta , Joachim Zirner
IPC分类号： C08G18/00 , C07D251/34 , C08G18/79 , C07D251/12 , C08G18/18 , C08G18/77 , C08G18/82
CPC分类号： C07D251/34 , C08G18/791
摘要： This invention relates to a new process for the production, in inert organic solvents, of physiologically compatible polyisocyanates containing isocyanurate groups which have a monomeric diisocyanate content, based on solids, of at most 0.7%, by weight. The process uses Mannich bases as the trimerizing catalyst at temperatures below 60.degree. C and the reaction is terminated at the desired degree of trimerization by thermally decomposing the catalyst or by deactivating with a catalyst poison.
摘要翻译：本发明涉及在惰性有机溶剂中生产含有异氰酸酯基团的生理上相容的多异氰酸酯的新方法，所述异氰脲酸酯基团具有至多0.7重量％的基于固体的单体二异氰酸酯含量。该方法在低于60℃的温度下使用曼尼希碱作为三聚催化剂，并通过热分解催化剂或通过催化剂毒物失活将反应终止于期望的三聚度。

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