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21. 发明申请

US20100143965A1 METHOD FOR PRODUCTION OF ANTIMUTAGENIC SUBSTANCE USING LACTIC ACID BACTERIUM 有权
标题翻译：使用乳酸菌生产抗生素的方法
公开(公告)号：US20100143965A1
公开(公告)日：2010-06-10
申请号：US12450817
申请日：2008-04-18
申请人： Minoru Fujita , Masaharu Nakayama , Yasuteru Nakamura , Takahiro Inoue
发明人： Minoru Fujita , Masaharu Nakayama , Yasuteru Nakamura , Takahiro Inoue
IPC分类号： C12P1/00
CPC分类号： C12P1/04 , A61K35/747 , C12R1/225 , C12R1/25
摘要： Disclosed is a method for producing an antimutagenic substance by using a lactic acid bacterium, which can produce the antimutagenic substance in a large quantity in an extremely simple manner and is economically advantageous; particularly a method for producing an antimutagenic substance effective for a carcinogenic substance, particularly a heterocyclic amine (HCA) which is a carcinogenic substance derived from a food, by using a lactic acid bacterium. Specifically disclosed is a method for producing an antimutagenic substance by using a lactic acid bacterium, which is characterized by suspending the lactic acid bacterium in a poorly nutrient or nutrient-free medium and leaving the lactic acid bacterium in the medium. Preferably, the poorly nutrient or nutrient-free medium is selected from the group consisting of physiological saline, a phosphate-buffered saline without a calcium or magnesium salt (PBS (−)), a citrate buffer, a distilled water, an ion-exchanged water, a natural water, a well water, a tap water, a mineral-added water, a vitamin-added water, an ion supply beverage for an athlete and the like. More preferably, the lactic acid bacterium is Lactobacillus plantarum strain KK-2503 or Lactobacillus alimentarius strain KN-15.
摘要翻译：本发明公开了一种通过使用乳酸菌制造抗诱变物质的方法，其能够以非常简单的方式大量生产抗诱变物质，在经济上是有利的; 特别是通过使用乳酸菌，制造对致癌物质，特别是作为来自食品的致癌物质的杂环胺（HCA）有效的抗诱变物质的方法。具体公开了通过使用乳酸菌制造抗诱变物质的方法，其特征在于将乳酸菌悬浮于营养不良或营养不良的培养基中，并将乳酸菌留在培养基中。优选地，营养不良或营养不良的培养基选自生理盐水，不含钙或镁盐的磷酸盐缓冲盐水（PBS（ - ）），柠檬酸盐缓冲液，蒸馏水，离子交换水，天然水，井水，自来水，矿物质添加水，维生素添加水，运动员的离子供应饮料等。更优选地，乳酸菌是植物乳杆菌菌株KK-2503或者乳酸乳杆菌菌株KN-15。

22. 发明申请

US20090105253A1 Triazole Derivative and Use Thereof 失效
标题翻译：三唑衍生物及其用途
公开(公告)号：US20090105253A1
公开(公告)日：2009-04-23
申请号：US11887936
申请日：2006-04-06
申请人： Keiji Kubo , Mamoru Tobisu , Eiji Honda , Takahiko Taniguchi , Yoshiyuki Fukase , Masaki Kawamura , Masaharu Nakayama
发明人： Keiji Kubo , Mamoru Tobisu , Eiji Honda , Takahiko Taniguchi , Yoshiyuki Fukase , Masaki Kawamura , Masaharu Nakayama
IPC分类号： A61K31/5377 , C07D249/06 , C07D413/12 , A61K31/4192
CPC分类号： C07D249/06 , C07D401/04 , C07D401/10 , C07D401/12 , C07D403/06 , C07D403/12 , C07D405/12 , C07D409/04 , C07D409/12 , C07D411/12 , C07D413/06 , C07D413/12 , C07D417/06 , C07D417/12 , C07D471/04 , C07D487/04
摘要： The present invention relates to a thrombin receptor antagonist containing a compound represented by the formula (I) wherein R1a, R1b and R2 are each a hydrogen atom, an optionally substituted hydrocarbon group, an optionally substituted heterocyclic group, or an optionally substituted alkoxy, R3 is a group represented by the formula —NHCOR4, —NHSO2R5, —NHCON(R6a)(R6b), —NHCOOR7 or —CONHR8 wherein R4, R5, R6a, R6b, R7 and R8 are each a hydrogen atom, an optionally substituted hydrocarbon group, an optionally substituted heterocyclic group and the like), ring A is monocyclic aromatic ring optionally further having substituent(s), R1a and R1b are optionally bonded to each other to form an optionally substituted nitrogen-containing non-aromatic heterocycle, or a salt thereof or a prodrug thereof. The thrombin receptor antagonist of the present invention has a thrombin receptor (particularly PAR-1) antagonistic action and is useful for the prophylaxis or treatment of PAR-1 mediated pathological condition or disease.
摘要翻译：本发明涉及含有式（I）表示的化合物的凝血酶受体拮抗剂，其中R1a，R1b和R2各自为氢原子，任选取代的烃基，任选取代的杂环基或任选取代的烷氧基，R 3 是由式-NHCOR4，-NHSO2R5，-NHCON（R6a）（R6b），-NHCOOR7或-CONHR8表示的基团，其中R4，R5，R6a，R6b，R7和R8各自为氢原子，任选取代的烃基，任选取代的杂环基等），环A是任选进一步具有取代基的单环芳环，R 1a和R 1b任选地彼此键合以形成任选取代的含氮非芳族杂环，或盐或其前药。本发明的凝血酶受体拮抗剂具有凝血酶受体（特别是PAR-1）拮抗作用，可用于预防或治疗PAR-1介导的病理状态或疾病。

23. 发明授权

US4604425A Method for modifying the surface of polymer materials 失效
标题翻译：改性聚合物材料表面的方法
公开(公告)号：US4604425A
公开(公告)日：1986-08-05
申请号：US601577
申请日：1984-04-18
申请人： Hiroshi Ohmura , Yoshihiro Oshibe , Masaharu Nakayama , Takashi Yamamoto
发明人： Hiroshi Ohmura , Yoshihiro Oshibe , Masaharu Nakayama , Takashi Yamamoto
IPC分类号： C08F4/00 , C08F4/04 , C08F4/28 , C08F4/36 , C08F293/00 , C08J7/04 , C08L1/00 , C08L7/00 , C08L21/00 , C08L23/00 , C08L23/02 , C08L27/00 , C08L33/00 , C08L33/02 , C08L51/00 , C08L51/02 , C08L53/00 , C08L67/00 , C08L77/00 , C08L101/00 , D01F1/10 , D01F6/54 , C08L9/00 , C08L31/00
CPC分类号： C08L53/00 , C08F293/00 , C08L101/00 , C08L23/02 , C08L2555/40 , Y10S260/17 , Y10S260/18 , Y10T428/31536
摘要： The surface of a polymer material is modified by adding to the material a block copolymer. The block copolymer has a hydrophilic polymer portion and a polymer portion which is compatible with the polymer material to be modified. The block copolymer can be easily syntheized in the presence of a polymeric peroxide and can easily and permanently modify the surface of the polymer material.
摘要翻译：通过向该材料中加入嵌段共聚物来改性聚合物材料的表面。嵌段共聚物具有亲水性聚合物部分和与要改性的聚合物材料相容的聚合物部分。嵌段共聚物可以在聚合过氧化物的存在下容易地合成，并且可以容易且永久地改性聚合物材料的表面。

24. 发明授权

US4318834A Method for producing an aqueous liquid dispersion of polymers 失效
标题翻译：聚合物水性分散体的制造方法
公开(公告)号：US4318834A
公开(公告)日：1982-03-09
申请号：US192161
申请日：1980-09-29
申请人： Hiroshi Ohmura , Masaharu Nakayama
发明人： Hiroshi Ohmura , Masaharu Nakayama
IPC分类号： C08F2/10 , C08F4/36 , C08F4/38 , C08F283/00 , C08L73/00
CPC分类号： C08F4/36 , C08F283/00
摘要： An aqueous liquid dispersion of polymers can be obtained by two steps of reaction comprising the first step of copolymerizing polymeric peroxide with vinyl type monomers, whereby copolymers having peroxy bonds therein are obtained and the second step of subjecting said copolymers having peroxy bonds therein to block copolymerization with vinyl type monomers which are different in kind from the one employed in the first step of reaction, whereby said copolymers having peroxy bonds therein are cleaved at the peroxy bonds thereof, thereby obtaining block copolymers with high efficiency.
摘要翻译：聚合物的水性液体分散体可以通过两步反应获得，包括使聚合过氧化物与乙烯基类单体共聚的第一步骤，由此得到其中具有过氧键的共聚物，第二步是使其中具有过氧键的共聚物嵌段共聚与在第一反应步骤中使用的类型不同的乙烯基型单体，其中所述具有过氧键的共聚物在其过氧键断裂，从而获得高效率的嵌段共聚物。

25. 发明授权

US5144044A Non-linear optical material and non-linear optical device 失效
标题翻译：非线性光学材料和非线性光学器件
公开(公告)号：US5144044A
公开(公告)日：1992-09-01
申请号：US586756
申请日：1990-09-24
申请人： Yoshitaka Goto , Masaharu Nakayama
发明人： Yoshitaka Goto , Masaharu Nakayama
IPC分类号： G02F1/35 , C07D333/22 , C09K9/02 , G02F1/355 , G02F1/361
CPC分类号： G02F1/3614 , C07D333/22
摘要： A non-linear optical material consists essentially of 3-(2-thienyl)-1-(4-methylphenyl)propene-3-one represented by the formula (I) ##STR1## A non-linear optical device contains an organic compound disposed in a light beam. The organic compound is represented by the formula (I) and has a crystal in which a space group determined by the X-ray analytical method is P2.sub.1.

26. 发明授权

US5100584A Non-linear optical device 失效
标题翻译：非线性光学器件
公开(公告)号：US5100584A
公开(公告)日：1992-03-31
申请号：US629147
申请日：1990-12-18
申请人： Yoshitaka Goto , Zhang G. Jian , Masaharu Nakayama
发明人： Yoshitaka Goto , Zhang G. Jian , Masaharu Nakayama
IPC分类号： G02F1/35 , C07D307/46 , G02F1/355 , G02F1/361
CPC分类号： C07D307/46 , G02F1/3611 , G02F1/3613
摘要： A non-linear optical device is provided in which an organic compound is disposed in a light beam. The organic compound is a benzalacetofuran derivative represented by the following formula (I) ##STR1## wherein R is CH.sub.3, CH.sub.3 S, Br, CN or NO.sub.2.

27. 发明授权

US4892681A Non-linear optical article 失效
标题翻译：非线性光学制品
公开(公告)号：US4892681A
公开(公告)日：1990-01-09
申请号：US102193
申请日：1987-09-29
申请人： Seizo Miyata , Toshiyuki Watanabe , Yoshitaka Goto , Masaharu Nakayama
发明人： Seizo Miyata , Toshiyuki Watanabe , Yoshitaka Goto , Masaharu Nakayama
IPC分类号： C07C49/76 , C07C45/00 , C07C45/74 , C07C49/796 , C07C49/813 , C07C49/84 , C07C67/00 , C07C213/00 , C07C225/22 , G02F1/35 , G02F1/355 , G02F1/361
CPC分类号： G02F1/3611 , C07C45/74 , C07C49/796 , C07C49/813 , C07C49/84
摘要： A non-linear optical article is constituted of a derivative of benzalacetophenone represented by the following general formula: ##STR1## wherein A and B each represent the same or different atom or group and stand for a hydrogen atom, an alkoxy group having 1 to 4 carbon atoms, a chlorine atom, a bromine atom, an amino group or a dialkylamino group having 1 to 2 carbon atoms.

28. 发明授权

US4698388A Method for modifying the surface of polymer materials 失效
标题翻译：改性聚合物材料表面的方法
公开(公告)号：US4698388A
公开(公告)日：1987-10-06
申请号：US829934
申请日：1986-02-18
申请人： Hiroshi Ohmura , Yoshihiro Oshibe , Masaharu Nakayama , Takashi Yamamoto
发明人： Hiroshi Ohmura , Yoshihiro Oshibe , Masaharu Nakayama , Takashi Yamamoto
IPC分类号： C08F4/00 , C08F4/04 , C08F4/28 , C08F4/36 , C08F293/00 , C08J7/04 , C08L1/00 , C08L7/00 , C08L21/00 , C08L23/00 , C08L23/02 , C08L27/00 , C08L33/00 , C08L33/02 , C08L51/00 , C08L51/02 , C08L53/00 , C08L67/00 , C08L77/00 , C08L101/00 , D01F1/10 , D01F6/54 , C08L9/00 , C08L31/00
CPC分类号： C08L53/00 , C08F293/00 , C08L101/00 , C08L23/02 , C08L2555/40 , Y10S260/17 , Y10S260/18 , Y10T428/31536
摘要： The surface of a polymer material is modified by adding to the material a block copolymer. The block copolymer has a hydrophilic polymer portion and a polymer portion which is compatible with the polymer material to be modified. The block copolymer can be easily synthesized in the presence of a polymeric peroxide and can easily and permanently modify the surface of the polymer material.

29. 发明授权

US4607087A Method for producing a plastic lens 失效
标题翻译：塑料透镜的制造方法
公开(公告)号：US4607087A
公开(公告)日：1986-08-19
申请号：US478023
申请日：1983-03-23
申请人： Yasuo Moriya , Kyosuke Fukushi , Masaharu Nakayama
发明人： Yasuo Moriya , Kyosuke Fukushi , Masaharu Nakayama
IPC分类号： B29C39/02 , B29C39/00 , B29C39/22 , B29C39/26 , B29C41/46 , B29C61/00 , B29D11/00 , B29K69/00 , B29K105/24 , C08F18/00 , C08F18/24 , C08F218/00 , G02B1/04 , C08F4/28
CPC分类号： C08F18/24 , G02B1/041
摘要： A plastic lens which has high hardness and excellent scratch resistance and can form a transparent and uniform reflection preventing film through vacuum deposition, is produced by mixing(a) diethylene glycol bis(allyl carbonate) with(b) at least one of organic peroxides having a decomposition temperature at selected half-life value for ten hours of not higher than 80.degree. C. and(c) at least one of organic peroxides having a decomposition temperature at selected half-life value for ten hours of 90.degree.-110.degree. C., which have no copolymerizability to the diethylene glycol bis(allyl carbonate) (a), as a polymerization initiator, and polymerizing and casting the resulting mixture in a desired lens-forming mold.
摘要翻译：通过将（a）二甘醇双（碳酸烯丙酯）与（b）至少一种有机过氧化物混合（a）具有高硬度和优异的耐擦伤性并且可以通过真空沉积形成透明均匀防反射膜的塑料透镜，选择的半衰期值为不高于80℃的10小时的分解温度和（c）在90℃-110℃下10分钟的分解温度在选定的半衰期值的有机过氧化物中的至少一种对于二甘醇双（碳酸烯丙酯）（a），作为聚合引发剂不具有共聚性，并将所得混合物聚合并浇注到所需的透镜成形模具中。

30. 发明授权

US4303762A Low shrinking unsaturated polyester resin composition 失效
标题翻译：低收缩不饱和聚酯树脂组合物
公开(公告)号：US4303762A
公开(公告)日：1981-12-01
申请号：US210101
申请日：1980-11-24
申请人： Masaharu Nakayama , Masaru Matsushima , Shigeki Banno , Nobuo Kanazawa
发明人： Masaharu Nakayama , Masaru Matsushima , Shigeki Banno , Nobuo Kanazawa
IPC分类号： C08F4/00 , C08F4/28 , C08F4/36 , C08F283/01 , C08F293/00 , C08F295/00 , C08L23/00 , C08L51/00 , C08L51/02 , C08L53/00 , C08L67/00 , C08L67/06 , C08L77/00 , C08L101/00
CPC分类号： C08L67/06
摘要： A composition of matter which is prepared by blended with an unsaturated resin with a block copolymer which is obtained by employing a polymeric peroxide has dispersion stability during long storage found in no conventional one.A hardened moulding product obtained from the aforementioned composition matters is small in its volume shrinkage and exhibit smoothness and gloss to the surface thereof even it is employed after long period storage.
摘要翻译：通过与不饱和树脂共混制备的通过使用聚合过氧化物获得的嵌段共聚物制备的物质组合物在长期储存期间具有不存在常规的分散稳定性。由上述组合物获得的硬化成型品的体积收缩率小，即使长时间保存后使用也表现出平滑性和光泽。

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