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21. 发明授权

US06548477B1 Therapeutic agents and methods of use thereof for the modulation of angiogenesis 有权
公开(公告)号：US06548477B1
公开(公告)日：2003-04-15
申请号：US09704251
申请日：2000-11-01
申请人： Gary L. Olson , Christopher Self , Lily Lee , Charles Michael Cook , Jens J. Birktoft
发明人： Gary L. Olson , Christopher Self , Lily Lee , Charles Michael Cook , Jens J. Birktoft
IPC分类号： A61K31336
CPC分类号： C07K5/0202 , A61K38/00 , C07K5/0606 , C07K5/0806 , C07K5/081 , C07K5/0817 , C07K5/1008 , C07K14/8146 , Y02A50/409 , Y02A50/411
摘要： The present invention provides angiogenesis inhibitor compounds comprising a MetAP-2 inhibitory core coupled to a peptide, as well as pharmaceutical compositions comprising the angiogenesis inhibitor compounds and a pharmaceutically acceptable carrier. The present invention also provides methods of treating an angiogenic disease, e.g., cancer, in a subject by administering to the subject a therapeutically effective amount of one or more of the angiogenesis inhibitor compounds of the invention.

22. 发明授权

US6013347A Method of continuous tone imaging to provide an imaged high loft mat product 失效
标题翻译：连续色调成像方法提供成像的高蓬松垫产品
公开(公告)号：US6013347A
公开(公告)日：2000-01-11
申请号：US895416
申请日：1997-07-16
申请人： Philip G. Martin , Gary L. Olson , Gerald A. Ridlehoover , Randall R. Schickler
发明人： Philip G. Martin , Gary L. Olson , Gerald A. Ridlehoover , Randall R. Schickler
IPC分类号： B41J2/01 , D06B11/00 , D06P5/00 , D06P5/30 , B32B3/02
CPC分类号： D06P5/001 , B41J2/01 , D06B11/0059 , D06P5/30 , Y10T428/23929 , Y10T428/23936 , Y10T428/23957 , Y10T428/23993
摘要： A method for continuous tone imaging on a mat product having a web material with a three dimensional open structure provides a mat product with a sufficiently clear image. Moreover, it is a specific aspect of the present method to provide a clear image on such a three dimensional structure without negatively affecting the characteristics of the web material having the three dimensional structure. More specifically, the present invention is directed to a method for imaging a flexible high loft matting material which can be used in providing a floor covering mat product. The present invention is also directed to the imaged mat product produced in accordance with this method.
摘要翻译：在具有三维开放结构的纤维网材料的垫产品上连续色调成像的方法提供具有足够清晰图像的垫产品。此外，本方法的一个具体方面是在这样的三维结构上提供清晰的图像，而不会不利地影响具有三维结构的纤维网材料的特性。更具体地，本发明涉及一种可用于提供地板覆盖垫产品的柔性高抛光材料的成像方法。本发明还涉及根据该方法生产的成像垫产品。

23. 发明授权

US5722552A Collapsible stackable container system for flowable materials 失效
标题翻译：用于可流动材料的可折叠可堆叠容器系统
公开(公告)号：US5722552A
公开(公告)日：1998-03-03
申请号：US549420
申请日：1995-10-27
申请人： Gary L. Olson
发明人： Gary L. Olson
IPC分类号： B65D77/06 , B65D90/20 , B65D21/02 , B65D90/04 , B65D90/12
CPC分类号： B65D77/061 , B65D90/205
摘要： A collapsible container system for flowable materials includes a collapsible bag for holding the materials and a collapsible frame for supporting and retaining the bag. The collapsible frame includes top and bottom portions and a plurality of spaced apart upright members extending therebetween. The upright members each include a removable support portion that normally extends in a generally vertical direction and in supporting relation between the top and bottom portions. When all of the support portions are removed from supporting relation between the top and bottom portions the frame is collapsible and its height is reduced.
摘要翻译：用于可流动材料的可折叠容器系统包括用于保持材料的可折叠袋和用于支撑和保持袋的可折叠框架。可折叠框架包括顶部和底部以及在它们之间延伸的多个间隔开的直立构件。直立构件各自包括通常沿大致垂直方向延伸并且支撑顶部和底部之间的关系的可移除支撑部分。当所有支撑部分从顶部和底部之间的支撑关系中移除时，框架是可折叠的并且其高度减小。

24. 发明授权

US4388467A Cycloalka[4,5]pyrrolo[2,3-g]isoquinolines 失效
标题翻译：环唑[4,5]吡咯并[2,3-g]异喹啉
公开(公告)号：US4388467A
公开(公告)日：1983-06-14
申请号：US361667
申请日：1982-03-25
申请人： Leo Berger , Gary L. Olson
发明人： Leo Berger , Gary L. Olson
IPC分类号： C07D209/88 , C07D217/04 , C07D471/04
CPC分类号： C07D471/04 , C07D209/88 , C07D217/04
摘要： Neuroleptically active cycloalka[4,5]pyrrolo[2,3-g]isoquinolines of the formula ##STR1## wherein n, R.sub.1, R.sub.2 and X are as hereinafter set forth, and intermediates therefore are described.
摘要翻译：其中n，R1，R2和X如下文所述，其中描述了具有下式的神经屏障活性环烷并[4,5]吡咯并[2,3-g]异喹啉。

25. 发明授权

US4349678A Octahydro-2-methyl-isoquinoline-6,8-dione 失效
标题翻译：八氢-2-甲基 - 异喹啉-6,8-二酮
公开(公告)号：US4349678A
公开(公告)日：1982-09-14
申请号：US215941
申请日：1980-12-12
申请人： Leo Berger , Gary L. Olson
发明人： Leo Berger , Gary L. Olson
IPC分类号： C07D209/08 , C07D217/04 , C07D471/04 , C07D217/24
CPC分类号： C07D471/04 , C07D209/08 , C07D217/04
摘要： Neuroleptically active octahydro-1H-pyrrolo[2,3-g]isoquinolines of the formula ##STR1## wherein R.sub.1, R.sub.2, R.sub.3, R.sub.4 and X are as hereinafter set forth, are described.
摘要翻译：描述了其中R 1，R 2，R 3，R 4和X如下文所述的式ⅩⅧ的神经荧光活性八氢-1H-吡咯并[2,3-g]异喹啉。

26. 发明授权

US4334070A Cycloalka[4,5]pyrrolo[2,3-g]isoquinolines 失效
标题翻译：环唑[4,5]吡咯并[2,3-g]异喹啉
公开(公告)号：US4334070A
公开(公告)日：1982-06-08
申请号：US230765
申请日：1981-02-02
申请人： Leo Berger , Gary L. Olson
发明人： Leo Berger , Gary L. Olson
IPC分类号： C07D209/88 , C07D217/04 , C07D471/04 , A61K31/475
CPC分类号： C07D471/04 , C07D209/88 , C07D217/04
摘要： Neuroleptically active cycloalka[4,5]pyrrolo[2,3-g]isoquinolines of the formula ##STR1## wherein n, R.sub.1, R.sub.2 and X are as hereinafter set forth, are described.
摘要翻译：描述了其中n，R 1，R 2和X如下文所述的具有下式的神经荧光活性环烷并[4,5]吡咯并[2,3-g]异喹啉。

27. 发明授权

US4222943A Process for the preparation of esters of 5-formyl-3-methyl-2,4-pentadien-1-ol 失效
标题翻译： 5-甲酰基-3-甲基-2,4-戊二烯-1-醇的酯的制备方法
公开(公告)号：US4222943A
公开(公告)日：1980-09-16
申请号：US9218
申请日：1979-02-05
申请人： Gary L. Olson
发明人： Gary L. Olson
IPC分类号： C07D309/30 , C07D309/32
CPC分类号： C07D309/30 , C07C67/297 , C07D309/32
摘要： A novel process for the preparation of esters of 5-formyl-3-methyl-2,4-pentadien-1-ol which employs as starting materials 2-substituted-3-methyl-6-alkoxy-3,6-dihydro-2H-pyrans. Novel intermediates are also disclosed.
摘要翻译：一种制备5-甲酰基-3-甲基-2,4-戊二烯-1-醇的新方法，其采用2-取代-3-甲基-6-烷氧基-3,6-二氢-2H- -pyrans。还公开了新的中间体。

28. 发明授权

US07497359B2 Dosing device 有权
标题翻译：给药装置
公开(公告)号：US07497359B2
公开(公告)日：2009-03-03
申请号：US10842060
申请日：2004-05-10
申请人： Cathleen A. Bergin , John J. Dyer , Steven J. Maxa , Gary L. Olson
发明人： Cathleen A. Bergin , John J. Dyer , Steven J. Maxa , Gary L. Olson
IPC分类号： G01F11/28
CPC分类号： G01F11/38 , G01F11/32
摘要： A dosing device is described, in which a predetermined amount of a material such as a concentrated fluid can be dispensed from the device by finger pressure. In one embodiment, the device includes a shuttle that can move between first and second positions. In the second position, fluid can escape from a dosing chamber.
摘要翻译：描述了一种计量装置，其中可以通过手指压力从装置中分配预定量的诸如浓缩流体的材料。在一个实施例中，该装置包括可在第一和第二位置之间移动的梭子。在第二位置，流体可以从计量室逸出。

29. 发明授权

US06854912B2 Mop assembly and cart 有权
标题翻译：拖把装配和推车
公开(公告)号：US06854912B2
公开(公告)日：2005-02-15
申请号：US10454051
申请日：2003-06-04
申请人： John J. Dyer , Gary L. Olson , David A. Maurer , Raymond N Maurer , Joseph J. Fodrocy
发明人： John J. Dyer , Gary L. Olson , David A. Maurer , Raymond N Maurer , Joseph J. Fodrocy
IPC分类号： A47L13/22 , A47L13/30 , A47L13/51 , B62B1/26 , A47L13/26
CPC分类号： B62B1/26 , A47L13/22 , A47L13/30 , A47L13/51 , B62B2202/50
摘要： A mop assembly including a mop head and handle, and a supply of liquid connected to a valve assembly on the handle adjacent the mop head. The valve assembly includes a length of resiliently flexible tubing that has a portion extending transversely through the handle and first and second members on opposite sides of the length of tubing that are relatively movable between a closed position at which the first and second members pinch together opposite sides of the length of tubing to stop the flow of liquid through it, and an open position at which the first and second members are spaced apart to afford flow of liquid through it. Should the tubing become plugged, it can easily be replaced by disconnecting one end from a liquid supply length of tubing, withdrawing the tubing from between the first and second members, and then installing a new length of tubing. A storage cart for use with the mop assembly includes an elongate upwardly projecting main portion having walls providing a side surface, and an elongate tray portion that provides a receptacle adapted to receive the mop head. The tray portion is mounted on a bottom end of the main portion for relative movement between a closed position at which the side surface covers an open side of the receptacle to thereby afford retention of the mop head in the receptacle; and an open position with the tray portion disposed at about a right angle with respect to the main portion so that the mop head can be inserted into or removed from the receptacle and so that the bottom wall can be supported along a horizontal surface such as a floor surface with side walls of the receptacle projecting upwardly.
摘要翻译：包括拖把头和把手的拖把组件以及连接到与拖把头相邻的手柄上的阀组件的液体供应。阀组件包括一定长度的弹性柔性管道，该管道具有横向延伸通过手柄延伸的部分，并且在长度的管道的相对侧上的第一和第二构件可在第一和第二构件夹在一起的关闭位置之间相对移动管的长度的两侧以阻止液体流过其中，并且第一和第二构件间隔开的打开位置以提供液体通过其的流动。如果管道堵塞，可以通过断开一端与液体供应长度的管道，从第一和第二构件之间取出管道，然后安装新的管道长度来轻松更换。与拖把组合件一起使用的存放车包括一个细长的向上突出的主要部分，其具有提供侧面的壁，以及细长的托盘部分，其提供适于接收拖把头的插座。托盘部分安装在主要部分的底端上，用于在侧面覆盖容器的开口侧的关闭位置之间进行相对运动，从而使拖把头保持在容器中; 以及打开位置，其中托盘部分相对于主要部分以大约直角设置，使得拖把头可以插入或从插座移除，从而底壁可以沿着水平表面（例如，容器的侧壁向上突出的地板表面。

30. 发明授权

US5972463A Undrawn, tough, durably melt-bondable, macrodenier, thermoplastic, multicomponent filaments 失效
公开(公告)号：US5972463A
公开(公告)日：1999-10-26
申请号：US769723
申请日：1996-12-18
申请人： Philip G. Martin , Gary L. Olson , Dennis G. Welygan
发明人： Philip G. Martin , Gary L. Olson , Dennis G. Welygan
IPC分类号： B24D11/00 , B24D18/00 , B32B5/02 , C08L23/08 , C08L23/10 , C08L33/06 , C09K3/10 , D01D5/34 , D01F8/04 , D01F8/06 , D01F8/10 , D01F8/12 , D04H1/42 , D04H1/54 , D04H3/14 , B32B3/02 , D03D27/00
CPC分类号： D01D5/0885 , B24D11/005 , B24D18/0063 , C09K3/10 , D01D5/22 , D01F8/04 , D01F8/06 , D01F8/12 , D04H1/42 , D04H1/54 , D04H3/03 , D04H3/14 , D04H3/16 , C08L33/068 , C09K2200/06 , C09K2200/0635 , Y10T428/23979 , Y10T428/23986 , Y10T428/2929 , Y10T428/2931 , Y10T442/181 , Y10T442/627 , Y10T442/637 , Y10T442/638 , Y10T442/641
摘要： Undrawn, tough, durably melt-bondable, macrodenier, thermoplastic, multicomponent filaments, such as sheath-core and side-by-side filaments, comprising a first plastic component and a second lower-melting component defining all or at least part of the material-air boundary of the filaments. The filaments can be made by melt-extruding thermoplastics to form hot filaments, cooling and solidifying the hot filaments, and recovering the solidified filaments without any substantial tension being placed thereon. Aggregations of the filaments can be made in the form of floor matting and abrasive articles.

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