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1. 发明授权

US07923445B2 Methods for treatment of diseases related to activated lymphocytes 失效
标题翻译：治疗与活化淋巴细胞有关的疾病的方法
公开(公告)号：US07923445B2
公开(公告)日：2011-04-12
申请号：US11897669
申请日：2007-08-31
申请人： Stephen Roth , Clayton Buck , Christopher Self , Gary Olson
发明人： Stephen Roth , Clayton Buck , Christopher Self , Gary Olson
IPC分类号： A01K31/54 , A01K31/497
CPC分类号： C07D279/26 , C07D279/28 , C07D417/06 , C07D417/12 , C09B21/00
摘要： The present invention relates to inhibiting proliferation and inducing apoptosis in activated lymphocytes, including T cells and B cells. The invention also provides compositions and methods for inhibiting proliferation and inducing apoptosis in activated lymphocytes, as well methods for treating diseases associated with activated lymphocytes by administering 5-HT receptor antagonists.
摘要翻译：本发明涉及抑制增殖并诱导活化的淋巴细胞（包括T细胞和B细胞）的细胞凋亡。本发明还提供了用于抑制增殖和诱导活化淋巴细胞凋亡的组合物和方法，以及通过施用5-HT受体拮抗剂治疗与活化淋巴细胞相关的疾病的方法。

2. 发明申请

US20090275557A1 Novel Composition for Treatment of Diseases Related to Activated Lymphocytes 审中-公开
标题翻译：用于治疗与活化淋巴细胞相关的疾病的新型组合物
公开(公告)号：US20090275557A1
公开(公告)日：2009-11-05
申请号：US12393888
申请日：2009-02-26
申请人： Stephen Roth , Clayton Buck , Christopher Self , Gary Olson , Nallaganchu Rao
发明人： Stephen Roth , Clayton Buck , Christopher Self , Gary Olson , Nallaganchu Rao
IPC分类号： A61K31/397 , C07D417/06 , C12N5/00 , A61K31/5415 , A61P11/06 , A61P19/02 , C07D417/14
CPC分类号： C07D417/06 , C07D417/14
摘要： The present invention relates to inhibiting proliferation and inducing apoptosis in activated lymphocytes, including T cells and B cells. The invention also provides compositions and methods for inhibiting proliferation and inducing apoptosis in activated lymphocytes, as well methods for treating diseases associated with activated lymphocytes by administering 5-HT receptor antagonists.
摘要翻译：本发明涉及抑制增殖并诱导活化的淋巴细胞（包括T细胞和B细胞）的细胞凋亡。本发明还提供了用于抑制增殖和诱导活化淋巴细胞凋亡的组合物和方法，以及通过施用5-HT受体拮抗剂治疗与活化淋巴细胞相关的疾病的方法。

3. 发明申请

US20090155846A1 KINASE ANCHOR PROTEIN MUTEINS, PEPTIDES THEREOF AND RELATED METHODS 审中-公开
标题翻译：激酶锚定蛋白，其蛋白及相关方法
公开(公告)号：US20090155846A1
公开(公告)日：2009-06-18
申请号：US12237199
申请日：2008-09-24
申请人： Andreas Braun , Charles R. Cantor , Stefan M. Kammerer , Susan Taylor , Lora Burns-Hamuro , Charles Cook , Gary Olson , Christopher Self
发明人： Andreas Braun , Charles R. Cantor , Stefan M. Kammerer , Susan Taylor , Lora Burns-Hamuro , Charles Cook , Gary Olson , Christopher Self
IPC分类号： C12P21/00 , C07H21/00 , C12N15/63 , C12N5/00 , C12N1/00
CPC分类号： C07K14/47 , A01K67/0275 , A01K2207/15 , A01K2217/00 , A01K2217/072 , A01K2227/105 , A01K2267/03
摘要： A-kinase anchor protein (AKAPS) muteins, peptides thereof, and nucleic acids encoding the peptides are provided herein. Also provided are transgenic animals, cells comprising transgenes and various methods employing such peptides.
摘要翻译：本文提供α-激酶锚蛋白（AKAPS）突变蛋白，其肽，以及编码肽的核酸。还提供了转基因动物，包含转基因的细胞和使用这种肽的各种方法。

4. 发明授权

US07348307B2 Methionine aminopeptidase-2 inhibitors and methods of use thereof 有权
标题翻译：甲硫氨酸氨肽酶-2抑制剂及其使用方法
公开(公告)号：US07348307B2
公开(公告)日：2008-03-25
申请号：US11416622
申请日：2006-05-03
申请人： Gary L. Olson , Christopher Self , Lily Lee , Charles M. Cook , Jens Birktoft , Barry Morgan , Christopher C. Arico-Muendel
发明人： Gary L. Olson , Christopher Self , Lily Lee , Charles M. Cook , Jens Birktoft , Barry Morgan , Christopher C. Arico-Muendel
IPC分类号： A61K31/336 , A61K38/08
CPC分类号： A61K38/4886 , A61K38/05 , A61K38/07 , A61K38/08 , A61K47/64 , C07D303/16 , C07D405/14 , C07K5/0202 , C07K5/0606 , C07K5/06078 , C07K5/0806 , C07K5/081 , C07K5/0817 , C07K5/1008 , C07K5/1024 , C07K7/06 , C07K14/8146 , Y02A50/409 , Y02A50/411
摘要： The present invention provides methods of treating a lymphoma (e.g., a T-cell lymphoma or a B-cell lymphoma) in a subject by administering to the subject a therapeutically effective amount of one or more of the compounds of the invention, for example, compounds of formulae I and XV:
摘要翻译：本发明提供了通过向受试者施用治疗有效量的一种或多种本发明化合物来治疗受试者的淋巴瘤（例如，T细胞淋巴瘤或B细胞淋巴瘤）的方法，例如，式I和XV的化合物：

5. 发明申请

US20070117758A1 Therapeutic agents and methods of use thereof for the modulation of angiogenesis 审中-公开
标题翻译：治疗剂及其用于调节血管生成的方法
公开(公告)号：US20070117758A1
公开(公告)日：2007-05-24
申请号：US11593998
申请日：2006-11-07
申请人： Gary Olson , Christopher Self , Lily Lee , Charles Cook , Jens Birktoft , Barry Morgan , Christopher Arico-Muendel
发明人： Gary Olson , Christopher Self , Lily Lee , Charles Cook , Jens Birktoft , Barry Morgan , Christopher Arico-Muendel
IPC分类号： A61K38/10 , A61K38/08 , C07K7/08 , C07K7/06
CPC分类号： C07D405/14 , A61K38/4886 , A61K47/64 , C07D303/16 , C07K5/0202 , C07K5/0606 , C07K5/0806 , C07K5/081 , C07K5/0817 , C07K5/1008 , C07K5/1024 , C07K7/06 , C07K14/8146 , Y02A50/409 , Y02A50/411
摘要： The present invention provides angiogenesis inhibitor compounds comprising a MetAP-2 inhibitory core coupled to a peptide, as well as pharmaceutical compositions comprising the angiogenesis inhibitor compounds and a pharmaceutically acceptable carrier. The present invention also provides methods of treating an angiogenic disease, e.g., cancer, in a subject by administering to the subject a therapeutically effective amount of one or more of the angiogenesis inhibitor compounds of the invention.
摘要翻译：本发明提供包含与肽偶联的MetAP-2抑制性核心的血管生成抑制剂化合物，以及包含血管生成抑制剂化合物和药学上可接受的载体的药物组合物。本发明还提供了通过向受试者施用治疗有效量的一种或多种本发明的血管发生抑制剂化合物来治疗受试者中血管生成疾病例如癌症的方法。

6. 发明申请

US20050137128A1 Modulators of ß-amyloid peptide aggregation 失效
标题翻译： β-淀粉样肽聚集的调节剂
公开(公告)号：US20050137128A1
公开(公告)日：2005-06-23
申请号：US10989763
申请日：2004-11-15
申请人： Mark Findeis , Kathryn Phillips , Gary Olsen , Christopher Self
发明人： Mark Findeis , Kathryn Phillips , Gary Olsen , Christopher Self
IPC分类号： G01N33/68 , A61K38/00 , A61K38/17 , A61P25/28 , A61P43/00 , C07K5/083 , C07K7/06 , C07K14/47 , A61K38/12 , C07K5/12
CPC分类号： C07K14/4711 , A61K38/00
摘要： Compounds that modulate natural β amyloid peptide aggregation are provided. The modulators of the invention comprise a peptide, preferably based on a β amyloid peptide, that is comprised entirely of D-amino acids. Preferably, the peptide comprises 3-5 D-amino acid residues and includes at least two D-amino acid residues independently selected from the group consisting of D-leucine, D-phenylalanine and D-valine. In a particularly preferred embodiment, the peptide is a retro-inverso isomer of a β amyloid peptide, preferably a retro-inverso isomer of Aβ17-21. In certain embodiments, the peptide is modified at the amino-terminus, the carboxy-terminus, or both. Preferred amino-terminal modifying groups alkyl groups. Preferred carboxy-terminal modifying groups include an amide group, an acetate group, an alkyl amide group, an aryl amide group or a hydroxy group. Pharmaceutical compositions comprising the compounds of the invention, and diagnostic and treatment methods for amyloidogenic diseases using the compounds of the invention, are also disclosed.
摘要翻译：提供调节天然β淀粉样肽聚集的化合物。本发明的调节剂包含优选基于β-淀粉样肽的肽，其完全由D-氨基酸组成。优选地，肽包含3-5个D-氨基酸残基，并且包括独立地选自D-亮氨酸，D-苯丙氨酸和D-缬氨酸的至少两个D-氨基酸残基。在特别优选的实施方案中，肽是β淀粉样肽的逆反异构体，优选Abeta 17-21的逆反异构体。在某些实施方案中，肽在氨基末端，羧基末端或两者都被修饰。优选的氨基末端修饰基团是烷基。优选的羧基末端修饰基团包括酰胺基，乙酸基，烷基酰胺基，芳基酰胺基或羟基。还公开了包含本发明化合物的药物组合物，以及使用本发明化合物的淀粉样变性疾病的诊断和治疗方法。

7. 发明授权

US07803774B2 Modulators of β-amyloid peptide aggregation 失效
标题翻译： β-淀粉样肽聚集的调节剂
公开(公告)号：US07803774B2
公开(公告)日：2010-09-28
申请号：US10989763
申请日：2004-11-15
申请人： Mark A. Findeis , Kathryn Phillips , Gary L. Olsen , Christopher Self
发明人： Mark A. Findeis , Kathryn Phillips , Gary L. Olsen , Christopher Self
IPC分类号： A61K38/00 , A61K49/00
CPC分类号： C07K14/4711 , A61K38/00
摘要： Compounds that modulate natural β amyloid peptide aggregation are provided. The modulators of the invention comprise a peptide, preferably based on a β amyloid peptide, that is comprised entirely of D-amino acids. Preferably, the peptide comprises 3-5 D-amino acid residues and includes at least two D-amino acid residues independently selected from the group consisting of D-leucine, D-phenylalanine and D-valine. In a particularly preferred embodiment, the peptide is a retro-inverso isomer of a β amyloid peptide, preferably a retro-inverso isomer of Aβ17-21. In certain embodiments, the peptide is modified at the amino-terminus, the carboxy-terminus, or both. Preferred amino-terminal modifying groups alkyl groups. Preferred carboxy-terminal modifying groups include an amide group, an acetate group, an alkyl amide group, an aryl amide group or a hydroxy group. Pharmaceutical compositions comprising the compounds of the invention, and diagnostic and treatment methods for amyloidogenic diseases using the compounds of the invention, are also disclosed.
摘要翻译：调节天然化合物的化合物提供淀粉样肽聚集。本发明的调节剂包含肽，优选基于淀粉样肽，其完全由D-氨基酸组成。优选地，肽包含3-5个D-氨基酸残基，并且包括独立地选自D-亮氨酸，D-苯丙氨酸和D-缬氨酸的至少两个D-氨基酸残基。在一个特别优选的实施方案中，该肽是一种反式异构体，淀粉样蛋白肽，优选A-Bgr; 17-21的逆反异构体。在某些实施方案中，肽在氨基末端，羧基末端或两者都被修饰。优选的氨基末端修饰基团是烷基。优选的羧基末端修饰基团包括酰胺基，乙酸基，烷基酰胺基，芳基酰胺基或羟基。还公开了包含本发明化合物的药物组合物，以及使用本发明化合物的淀粉样变性疾病的诊断和治疗方法。

8. 发明申请

US20090156624A1 Methionine aminopeptidase-2 inhibitors and methods of use thereof 审中-公开
标题翻译：甲硫氨酸氨肽酶-2抑制剂及其使用方法
公开(公告)号：US20090156624A1
公开(公告)日：2009-06-18
申请号：US12011685
申请日：2008-01-29
申请人： Gary L. Olson , Christopher Self , Lily Lee , Charles Michael Cook , Jens Birktoft , Barry Morgan , Christopher C. Arico-Muendel
发明人： Gary L. Olson , Christopher Self , Lily Lee , Charles Michael Cook , Jens Birktoft , Barry Morgan , Christopher C. Arico-Muendel
IPC分类号： A61K31/336 , C07D303/08 , C07D207/08 , A61K31/4427 , A61P37/00 , A61P19/02 , A61P35/00 , A61P33/00 , A61K31/4025 , C07D213/24
CPC分类号： C07K5/0202 , A61K38/00 , C07K5/0606 , C07K5/0806 , C07K5/081 , C07K5/0817 , C07K5/1008 , C07K14/8146 , Y02A50/409 , Y02A50/411
摘要： The present invention provides methods of parasitic infections, thymoma, and lymphoid malignancies in a subject by administering to the subject a therapeutically effective amount of one or more of the compounds of the invention.
摘要翻译：本发明通过向受试者施用治疗有效量的一种或多种本发明化合物来提供受试者的寄生虫感染，胸腺瘤和淋巴恶性肿瘤的方法。

9. 发明授权

US07439231B2 Inhibitors of antigen presentation by MHC class II molecules and methods of use thereof 有权
标题翻译： MHC II类分子的抗原呈递抑制剂及其使用方法
公开(公告)号：US07439231B2
公开(公告)日：2008-10-21
申请号：US10778756
申请日：2004-02-13
申请人： Gary Olson , Charles Cook , Christopher Self
发明人： Gary Olson , Charles Cook , Christopher Self
IPC分类号： A61K38/08
CPC分类号： C07K7/06 , A61K38/00 , C07K7/08
摘要： The present invention relates to compounds, pharmaceutical compositions containing such compounds and methods for their use. In particular, the compounds of the invention are useful for the treatment or prevention of diseases associated with T cell proliferation such as autoimmune diseases and disorders.
摘要翻译：本发明涉及化合物，含有这些化合物的药物组合物及其使用方法。特别地，本发明的化合物可用于治疗或预防与T细胞增殖相关的疾病，例如自身免疫性疾病和病症。

10. 发明申请

US20080132697A1 Novel compositions for treatment of diseases related to activated lymphocytes 失效
标题翻译：用于治疗与活化淋巴细胞相关的疾病的新型组合物
公开(公告)号：US20080132697A1
公开(公告)日：2008-06-05
申请号：US11897598
申请日：2007-08-31
申请人： Stephen Roth , Clayton Buck , Christopher Self , Gary Olson
发明人： Stephen Roth , Clayton Buck , Christopher Self , Gary Olson
IPC分类号： C07D279/18
CPC分类号： C07D279/26 , C07D279/28 , C07D417/06 , C07D417/12 , C09B21/00
摘要： The present invention relates to inhibiting proliferation and inducing apoptosis in activated lymphocytes, including T cells and B cells. The invention also provides compositions and methods for inhibiting proliferation and inducing apoptosis in activated lymphocytes, as well methods for treating diseases associated with activated lymphocytes by administering 5-HT receptor antagonists.
摘要翻译：本发明涉及抑制增殖并诱导活化的淋巴细胞（包括T细胞和B细胞）的细胞凋亡。本发明还提供了用于抑制增殖和诱导活化淋巴细胞凋亡的组合物和方法，以及通过施用5-HT受体拮抗剂治疗与活化淋巴细胞相关的疾病的方法。

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