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21. 发明授权

US06900350B2 Method for the production of ω-aminoalkylsulphonic acids 失效
标题翻译：生产ω-氨基烷基磺酸的方法
公开(公告)号：US06900350B2
公开(公告)日：2005-05-31
申请号：US10275753
申请日：2001-04-27
申请人： Volker Schaefer , Wolfgang Knoll , Alexander Schmitt , Christoph Huettner
发明人： Volker Schaefer , Wolfgang Knoll , Alexander Schmitt , Christoph Huettner
IPC分类号： C07C303/02 , C07C303/44 , C07C309/14 , C07D295/088
CPC分类号： C07D295/088 , C07C303/02 , C07C309/14
摘要： The invention relates to a method for the production of ω-aminoalkylsulphonic acids of general formula (I), where R1 and R2=optionally substituted alkyl groups with 1 20 C atoms and n=a whole number from 2 6, whereby an amine of formula (II), where R1 and R2 have the above meanings is reacted with an alkyl dihalide of formula (III), where n has the above meaning and X1 and X2=chlorine or bromine, with addition of alkali hydroxide at a pH of 8 10. The pH is then adjusted to a value of 0 1, by addition of a hydrohalic acid and excess alkyl dihalide is separated off, before the reaction solution is adjusted to a pH of 6 7.5 with alkali liquor, alkali sulphite is added and the product (I) formed at elevated temperate.
摘要翻译：本发明涉及一种制备通式（I）的ω-氨基烷基磺酸的方法，其中R 1和R 2 =具有1-20个碳原子的任选取代的烷基，n =总数为26，由此得到式（II）其中R1和R2具有上述含义与式（III）的烷基二卤化物反应，其中n具有上述含义，X 1和X 2， =氯或溴，加入pH8.8的碱金属氢氧化物。然后通过加入氢卤酸将pH调节至零值，分离出过量的烷基二卤化物，然后将反应溶液调节至用碱液pH为6 7.5，加入碱金属亚硫酸盐，产物（I）在升温下形成。

22. 发明授权

US06758139B2 Cylinder 失效
标题翻译：圆筒
公开(公告)号：US06758139B2
公开(公告)日：2004-07-06
申请号：US10275266
申请日：2003-04-10
申请人： Wolfgang Knoll
发明人： Wolfgang Knoll
IPC分类号： B41F1310
CPC分类号： B41F13/18
摘要： The invention relates to a cylinder in a rotary press, in particular, for interacting with a form cylinder for a gravure press. According to the invention, the cylinder is improved with regard to its variable adaptability by the provision of a linear drive located at the end of the cylinder between the fixed support and rotating outer surface. Said linear drive operates in a vertical radial direction upwards toward the inner ring of a roller bearing,
摘要翻译：本发明涉及一种旋转式压榨机中的圆筒，特别涉及用于凹版印刷机的成型滚筒的相互作用。根据本发明，通过在固定支撑件和旋转的外表面之间设置位于气缸端部的线性驱动，关于其可变适应性改进了气缸。所述线性驱动器在垂直径向方向上朝向滚子轴承的内圈工作，

23. 发明授权

US5763191A Universal binding film 失效
标题翻译：通用装订胶片
公开(公告)号：US5763191A
公开(公告)日：1998-06-09
申请号：US279715
申请日：1994-07-25
申请人： Wolfgang Knoll , Franz-Josef Schmitt , Christian Klein , Hans-Joachim Guder , Martha Liley , Jurgen Spinke
发明人： Wolfgang Knoll , Franz-Josef Schmitt , Christian Klein , Hans-Joachim Guder , Martha Liley , Jurgen Spinke
IPC分类号： G01N33/543 , G01N33/553 , G01N33/53 , B05D3/10 , B32B15/00
CPC分类号： B82Y15/00 , B82Y30/00 , B82Y40/00 , G01N33/54353 , G01N33/553 , Y10T428/12493 , Y10T428/12535 , Y10T428/12556
摘要： The invention concerns a binding matrix containing a carrier material and a solid phase reactant which is adsorbed to this via anchor groups that is capable of binding to at least one free reaction partner wherein the solid phase reactant forms a dilute and essentially laterally homogeneous binding layer on the surface of the carrier material. In addition a method for the determination of an analyte in a sample solution is claimed in which a solid phase reactant is used which is a component of a binding matrix according to the present invention. In this process the specific binding reaction is preferably determined by optical reflection techniques.
摘要翻译：本发明涉及含有载体材料和固相反应物的结合基质，其通过能够结合至少一个游离反应配偶体的锚定基团吸附到其上，其中固相反应物形成稀释且基本上横向均匀的结合层载体材料的表面。此外，还要求一种用于测定样品溶液中的分析物的方法，其中使用作为根据本发明的结合基质的组分的固相反应物。在该方法中，特异性结合反应优选通过光学反射技术来确定。

24. 发明授权

US5028132A Examination of surface structure 失效
标题翻译：表面结构检查
公开(公告)号：US5028132A
公开(公告)日：1991-07-02
申请号：US494403
申请日：1990-03-16
申请人： Werner Hickel , Wolfgang Knoll , Benno Rothenhaeusler
发明人： Werner Hickel , Wolfgang Knoll , Benno Rothenhaeusler
IPC分类号： G01B11/06 , G01B11/30 , G01N21/552 , G01N21/88
CPC分类号： G01N21/553 , G01B11/306
摘要： A technique for examining surface structures which differ in respect of refractive index and/or height modulation of the surface comprises introducing these surface structures into a plasmon surface polariton field and scanning them by means of surface plasmon microscopy.
摘要翻译：用于检查在表面的折射率和/或高度调制方面不同的表面结构的技术包括将这些表面结构引入等离子体表面极化子场中，并通过表面等离子体显微镜扫描它们。

25. 发明授权

US08657620B2 Connector assembly having a cable clamp coupled to a collet including an arbor 有权
标题翻译：连接器组件具有耦合到包括心轴的夹头的电缆夹
公开(公告)号：US08657620B2
公开(公告)日：2014-02-25
申请号：US13334294
申请日：2011-12-22
申请人： Wolfgang Knoll , Reinhold Bruesite , Erich Birglehner , Christian Heinrich , Christian Holl
发明人： Wolfgang Knoll , Reinhold Bruesite , Erich Birglehner , Christian Heinrich , Christian Holl
IPC分类号： H01R13/58
CPC分类号： H01R13/567 , A61B8/4411 , A61B8/4444 , A61B8/466 , A61B8/483 , A61B8/5246 , H01R13/58 , H01R2201/12 , Y10T29/49174
摘要： A connector assembly for coupling an coaxial cable to an ultrasound probe includes a cable clamp having an opening extending therethrough, the opening sized to receive a coaxial cable therethrough, the coaxial cable including a strain member and a plurality of coaxial cables extending therethrough, and a collet configured to couple to the cable clamp, the collet including an arbor that is configured to tension the strain member to a predetermined tension. A method of fabricating a connector assembly and an ultrasound imaging system are also described herein.
摘要翻译：用于将同轴电缆耦合到超声波探头的连接器组件包括具有延伸穿过其中的开口的电缆夹，所述开口的尺寸设计成接收穿过其中的同轴电缆，所述同轴电缆包括应变构件和延伸穿过其中的多个同轴电缆，套筒构造成联接到电缆夹，夹头包括心轴，其构造成将应变构件张紧到预定张力。本文还描述了制造连接器组件和超声成像系统的方法。

26. 发明授权

US08300226B2 Method for detecting surface plasmon resonance 有权
标题翻译：表面等离子体共振检测方法
公开(公告)号：US08300226B2
公开(公告)日：2012-10-30
申请号：US12312715
申请日：2007-11-23
申请人： Yun Zong , Wolfgang Knoll , Xiaodi Su
发明人： Yun Zong , Wolfgang Knoll , Xiaodi Su
IPC分类号： G01N21/55
CPC分类号： G01N21/553 , G01N21/554 , G01N29/12 , G01N29/2418 , G01N29/2437
摘要： There is disclosed a method and system for detecting a surface plasmon resonance associated with a fluid sample. The method includes the step of providing a piezoelectric substrate having at least two electrodes thereon, wherein at least one of said electrodes is coupled to a fluid sample. A light beam is transmitted toward the fluid sample to induce a oscillation frequency in the piezoelectric substrate. The oscillation frequency from said electrodes is then measured during transmittance of the light to detect the surface plasmon resonance associated with the fluid sample.
摘要翻译：公开了一种用于检测与流体样品相关联的表面等离子体共振的方法和系统。该方法包括提供其上具有至少两个电极的压电基片的步骤，其中所述电极中的至少一个耦合到流体样品。光束朝向流体样品传输，以在压电基片中引起振荡频率。然后在光的透射率期间测量来自所述电极的振荡频率，以检测与流体样品相关联的表面等离子体共振。

27. 发明申请

US20120032122A1 METHOD FOR FORMING A CADMIUM CONTAINING NANOCRYSTAL 审中-公开
标题翻译：形成含铌的纳米晶的方法
公开(公告)号：US20120032122A1
公开(公告)日：2012-02-09
申请号：US12672270
申请日：2007-08-06
申请人： Yun Zong , Mingyong Han , Wolfgang Knoll
发明人： Yun Zong , Mingyong Han , Wolfgang Knoll
IPC分类号： H01B1/06 , C01G11/02 , C01B19/04 , B82Y40/00 , B82Y30/00
CPC分类号： C30B29/60 , C30B7/00 , C30B29/48 , C30B29/50
摘要： The present invention provides a method of forming a nanocrystal of the composition CdA, with A being S or Se. The method includes forming in a suitable solvent a solution of cadmium, or a compound thereof, in a form suitable for the generation of a nanocrystal. The solvent includes a compound selected from an ether and an amine. The method further includes bringing the solution to a temperature selected in the range from about 20° C. to about 200° C. The method also includes adding at the temperature selected in the range from about 20° C. to about 200° C. the element A in a form suitable for the generation of a nanocrystal. Thereby the forming of a nanocrystal of the composition CdA is allowed.
摘要翻译：本发明提供一种形成组合物CdA的纳米晶体的方法，其中A为S或Se。该方法包括在合适的溶剂中形成适于产生纳米晶体的形式的镉或其化合物的溶液。溶剂包括选自醚和胺的化合物。该方法还包括使溶液达到在约20℃至约200℃范围内选择的温度。该方法还包括在约20℃至约200℃范围内加入的温度。元素A以适于产生纳米晶体的形式。从而允许形成组合物CdA的纳米晶体。

28. 发明申请

US20080163688A1 Surface Plasmon Resonance and Quartz Crystal Microbalance Sensor 失效
标题翻译：表面等离子体共振和石英晶体微量天平传感器
公开(公告)号：US20080163688A1
公开(公告)日：2008-07-10
申请号：US11662826
申请日：2004-09-15
申请人： Guangyu Wang , Xiaodi Su , Wolfgang Knoll , Ying-Ju Wu
发明人： Guangyu Wang , Xiaodi Su , Wolfgang Knoll , Ying-Ju Wu
IPC分类号： G01G3/16 , G01N21/41 , G01N29/12 , G01N21/55 , H01L41/053
CPC分类号： G01N29/022 , G01N5/02 , G01N21/553 , G01N2291/0255 , G01N2291/0256 , G01N2291/02818 , G01N2291/0421 , G01N2291/0422
摘要： A sensor chip assembly for use in a sensor capable of Surface Plasmon Resonance (SPR) and gravimetric sensing. The assembly comprising a transparent piezoelectric substrate (I) having a first surface and a second surface opposite to the first surface. The assembly also comprising first and second thin film metal electrodes (2,3) respectively provided on the first and second surfaces of the substrate (1). The second thin film metal electrode (3) being position on the second surface of the substrate (1) such that a light beam is capable of being transmitted through the second surface of the substrate and reflected from the first thin film metal electrode. The assembly also comprising an attenuated total reflection (ATR) coupler (11) disposed adjacent to the second thin film metal electrode (3).
摘要翻译：用于能够进行表面等离子体共振（SPR）和重量测量的传感器的传感器芯片组件。该组件包括具有第一表面和与第一表面相对的第二表面的透明压电基片（I）。该组件还包括分别设置在基板（1）的第一和第二表面上的第一和第二薄膜金属电极（2,3）。第二薄膜金属电极（3）位于基板（1）的第二表面上，使得光束能够透过基板的第二表面并从第一薄膜金属电极反射。组件还包括与第二薄膜金属电极（3）相邻设置的衰减全反射（ATR）耦合器（11）。

29. 发明申请

US20060292637A1 Biomimetic systems consisting of lipid membranes bound to an electrically conducting substrate 失效
公开(公告)号：US20060292637A1
公开(公告)日：2006-12-28
申请号：US11448127
申请日：2006-06-07
申请人： Vladimir Atanasov , Ingo Koper , Wolfgang Knoll , Stefan Schiller
发明人： Vladimir Atanasov , Ingo Koper , Wolfgang Knoll , Stefan Schiller
IPC分类号： G01N1/28 , G01N33/53 , C07F7/02 , C12M3/00
CPC分类号： C07F7/12 , C07F7/1804
摘要： The invention concerns lipids functionalized with a terminal C═C double bond which can be transformed into an anchor group for binding to a substrate surface. The invention further concerns lipids comprising such an anchor group for binding to a substrate surface. The invention also concerns self-assembled monolayers of lipids on substrates, in particular on silicon oxide substrates. The lipids and the lipid monolayers or bilayers containing these lipids can be used to produce biomimetic supported membrane systems. These membrane systems can be directly anchored on silicon microelectronic devices. After the optional incorporation of functional molecules such as membrane-associated proteins such systems can used for applications such as model systems for examining biological membranes, screening methods, sensors and bioelectronic devices such as biocomputers.

30. 发明申请

US20050164236A1 Device and method of detecting mutations and polymorphisms in DNA 失效
标题翻译：检测DNA突变和多态性的装置和方法
公开(公告)号：US20050164236A1
公开(公告)日：2005-07-28
申请号：US10948275
申请日：2004-09-22
申请人： Xiaodi Su , Rudolf Robelek , Wolfgang Knoll , Sean O'Shea
发明人： Xiaodi Su , Rudolf Robelek , Wolfgang Knoll , Sean O'Shea
IPC分类号： C12Q1/68 , G01N33/48 , G01N33/50 , G01N33/543 , G06F19/00
CPC分类号： C12Q1/6825 , C12Q2600/156 , G01N33/54373 , C12Q2565/607
摘要： There is provided a resonator sensor useful for detecting polymorphisms and mutations in DNA. The resonator sensor has a capture molecule immobilised on its surface, the capture molecule being either a probe DNA containing a reference sequence, or a mismatch binding molecule, and being capable of forming a probe DNA/target DNA/mismatch binding molecule complex on the surface of the resonator. A method for detecting mutations in a target DNA, including single nucleotide polymorphisms, is also provided.
摘要翻译：提供了一种用于检测DNA多态性和突变的谐振传感器。谐振器传感器具有固定在其表面上的捕获分子，捕获分子是包含参考序列的探针DNA或错配结合分子，并且能够在表面上形成探针DNA /靶DNA /错配结合分子复合物的谐振器。还提供了检测靶DNA突变的方法，包括单核苷酸多态性。

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