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1. 发明申请

US20060292637A1 Biomimetic systems consisting of lipid membranes bound to an electrically conducting substrate 失效
公开(公告)号：US20060292637A1
公开(公告)日：2006-12-28
申请号：US11448127
申请日：2006-06-07
申请人： Vladimir Atanasov , Ingo Koper , Wolfgang Knoll , Stefan Schiller
发明人： Vladimir Atanasov , Ingo Koper , Wolfgang Knoll , Stefan Schiller
IPC分类号： G01N1/28 , G01N33/53 , C07F7/02 , C12M3/00
CPC分类号： C07F7/12 , C07F7/1804
摘要： The invention concerns lipids functionalized with a terminal C═C double bond which can be transformed into an anchor group for binding to a substrate surface. The invention further concerns lipids comprising such an anchor group for binding to a substrate surface. The invention also concerns self-assembled monolayers of lipids on substrates, in particular on silicon oxide substrates. The lipids and the lipid monolayers or bilayers containing these lipids can be used to produce biomimetic supported membrane systems. These membrane systems can be directly anchored on silicon microelectronic devices. After the optional incorporation of functional molecules such as membrane-associated proteins such systems can used for applications such as model systems for examining biological membranes, screening methods, sensors and bioelectronic devices such as biocomputers.

2. 发明授权

US07518010B2 Biomimetic systems consisting of lipid membranes bound to an electrically conducting substrate 失效
标题翻译：由与导电基底结合的脂质膜组成的生物模拟系统
公开(公告)号：US07518010B2
公开(公告)日：2009-04-14
申请号：US11448127
申请日：2006-06-07
申请人： Vladimir Atanasov , Ingo Köper , Wolfgang Knoll , Stefan Schiller
发明人： Vladimir Atanasov , Ingo Köper , Wolfgang Knoll , Stefan Schiller
IPC分类号： C07F7/04 , C07F7/08
CPC分类号： C07F7/12 , C07F7/1804
摘要： The invention concerns lipids functionalized with a terminal C═C double bond which can be transformed into an anchor group for binding to a substrate surface. The invention further concerns lipids comprising such an anchor group for binding to a substrate surface. The invention also concerns self-assembled monolayers of lipids on substrates, in particular on silicon oxide substrates. The lipids and the lipid monolayers or bilayers containing these lipids can be used to produce biomimetic supported membrane systems. These membrane systems can be directly anchored on silicon microelectronic devices. After the optional incorporation of functional molecules such as membrane-associated proteins such systems can used for applications such as model systems for examining biological membranes, screening methods, sensors and bioelectronic devices such as biocomputers.
摘要翻译：本发明涉及用末端C-C双键官能化的脂质，其可转化成用于结合底物表面的锚定基团。本发明还涉及包含用于结合到基底表面的这种锚定基团的脂质。本发明还涉及在基底上，特别是在氧化硅衬底上的脂质的自组装单层。含有这些脂质的脂质和脂质单层或双层可用于产生仿生支持的膜系统。这些膜系统可以直接锚定在硅微电子器件上。在功能性分子例如膜相关蛋白质的任选引入之后，这样的系统可以用于诸如用于检查生物膜的模型系统，筛选方法，传感器和诸如生物计算机的生物电子装置之类的应用。

3. 发明申请

US20110076718A1 IN VIVO INCORPORATION OF AN UNNATURAL AMINO ACID COMPRISING A 1,2-AMINOTHIOL GROUP 审中-公开
标题翻译：含有1,2氨基酸组合的单一氨基酸的体外实验
公开(公告)号：US20110076718A1
公开(公告)日：2011-03-31
申请号：US12735966
申请日：2009-02-27
申请人： Simon Ficht , Michael Jahnz , Jan Grunewald , Stefan Schiller , Peter G. Schultz
发明人： Simon Ficht , Michael Jahnz , Jan Grunewald , Stefan Schiller , Peter G. Schultz
IPC分类号： C12P21/02 , C12N9/00 , C07H21/00
CPC分类号： C12N15/67 , C12P21/02
摘要： The invention relates to orthogonal pairs of tRNAs and aminoacyl-tRNA synthetases that can incorporate unnatural amino acids that comprise a 1,2 aminothiol group into polypeptides. The invention provides translation systems in which polypeptides comprising unnatural amino acids that comprise a 1,2 aminothiol group can be produced. The invention also provides methods for producing polypeptides containing unnatural amino acids that comprise a 1,2 aminothiol group. Also provided by the invention are compositions comprising orthogonal aminoacyl-tRNA synthetases that preferentially aminoacylate a cognate orthogonal tRNA with unnatural amino acids that comprise a 1,2 aminothiol group. The invention provides methods for the synthesis of the unnatural amino acid 2-amino-3-(4-(2-amino-3-mercaptopropan-amido)phenyl)-propanoic acid.
摘要翻译：本发明涉及tRNA和氨酰-tRNA合成酶的正交对，其可将含有1,2氨基硫醇基团的非天然氨基酸掺入多肽中。本发明提供翻译系统，其中可以制备包含含有1,2氨基硫醇基团的非天然氨基酸的多肽。本发明还提供了生产含有包含1,2氨基硫醇基团的非天然氨基酸的多肽的方法。本发明还提供了包含正交氨酰-tRNA合成酶的组合物，其优先地将同源正交tRNA与包含1,2-氨基硫醇基团的非天然氨基酸氨酰化。本发明提供合成非天然氨基酸2-氨基-3-（4-（2-氨基-3-巯基丙酰氨基）苯基） - 丙酸的方法。

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