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21. 发明申请

US20180076949A1 SYSTEM AND METHODS FOR NETWORK SYNCHRONIZATION 审中-公开
公开(公告)号：US20180076949A1
公开(公告)日：2018-03-15
申请号：US15607031
申请日：2017-05-26
申请人： Michael Mayer , Hamid Mehrvar
发明人： Michael Mayer , Hamid Mehrvar
IPC分类号： H04L7/00 , H04B10/40 , H04B10/2507
CPC分类号： H04L7/0075 , H04B10/2507 , H04B10/40 , H04J3/0667
摘要： One aspect of the disclosure is directed to a system and method for determining the propagation delay for a signal to traverse an optical fiber between two transceivers. The method is performed by a first network element and includes transmitting a message to a second transceiver over a first optical fiber. The method further includes configuring both network elements such that the first NE receives a reply message from the second NE on the first optical fiber. This reply message includes an indication of the internal time for the second NE to transmit the reply message. Accordingly the one way propagation delay on the first optical fiber can be determined. Another aspect is directed to a system and method for using the determined one way propagation delay to synchronize clocks of the two NEs using a symmetric network synchronizing protocol such as precision timing protocol, and correcting for differences in the one way propagation delays which make up the round trip propagation delay. Some embodiments can do this without stopping the operation of the network while pausing (buffering) data flows while the one way propagation delays are determined.

22. 发明授权

US08870890B2 Pronged holder for treating spinal stenosis 有权
标题翻译：用于治疗脊柱狭窄的固定支架
公开(公告)号：US08870890B2
公开(公告)日：2014-10-28
申请号：US11997880
申请日：2006-08-03
申请人： Felix Aschmann , Peter Senn , Michael Mayer , Paul Pavlov
发明人： Felix Aschmann , Peter Senn , Michael Mayer , Paul Pavlov
IPC分类号： A61B17/88 , A61B17/70 , A61B17/84 , A61B19/00
CPC分类号： A61B17/7065 , A61B17/848 , A61B17/8897 , A61B90/39
摘要： A device for holding a surgical instrument having a body, an instrument engagement device and a knob. The body has a proximal end, a distal end and a passageway positioned through the body. The instrument engagement device is positioned in the passageway and has at least two prongs moveable relative to each other to hold the surgical instrument therebetween. The knob is preferably positioned on the proximal end of the body and operatively associated with the at least two prongs so that movement of the knob causes movement of the prongs. The prongs may further include at least one ridge for engaging at least one slot on the surgical instrument. The knob may further comprise a cap at its proximal end positioned and designed for impact, for example, by a hammer, to facilitate movement of the surgical instrument into the patient. The knob may also include a locking mechanism to fix the position of the prongs.
摘要翻译：一种用于保持具有身体的外科器械的装置，仪器接合装置和旋钮。身体具有近端，远端和穿过身体定位的通道。仪器接合装置定位在通道中并且具有至少两个相对于彼此可移动的插脚以将手术器械夹持在其间。旋钮优选地定位在身体的近端并且可操作地与至少两个插脚相关联，使得旋钮的运动引起插脚的移动。尖头还可以包括用于接合外科器械上的至少一个狭槽的至少一个脊。旋钮还可以包括在其近端处的定位和设计用于例如用锤子冲击的帽，以便于将外科器械移动到患者体内。旋钮还可以包括用于固定插脚的位置的锁定机构。

23. 发明申请

US20130048499A1 CONTROLLING TRANSLOCATION THROUGH NANOPORES WITH FLUID WALL 有权
标题翻译：通过流体管道通过纳米管控制转移
公开(公告)号：US20130048499A1
公开(公告)日：2013-02-28
申请号：US13400472
申请日：2012-02-20
申请人： Michael Mayer , Erik Yusko , Jerry Yang
发明人： Michael Mayer , Erik Yusko , Jerry Yang
IPC分类号： G01N27/26 , B82Y30/00
CPC分类号： G01N33/48721 , B82Y30/00 , C12Q1/6869 , G01N15/1209 , G01N2015/0038 , C12Q2563/131 , C12Q2565/631
摘要： Improved resolution and detection of nanoparticles are achieved when a nanopore connecting liquid compartments in a device running on the Coulter principle is provided with fluid lipid walls. The fluid lipid walls are made of a lipid bilayer, and preferably include lipid anchored mobile ligands as part of the lipid bilayer. By varying the nature and concentration of the mobile ligand in the lipid bilayer, multifunctional coatings of lipids are provided.
摘要翻译：当在Coulter原理上运行的装置中的纳米孔连接液体隔室设置有流体脂质壁时，实现了纳米颗粒的改进的分辨率和检测。流体脂质壁由脂质双层制成，优选包括脂质锚定的移动配体作为脂质双层的一部分。通过改变脂质双层中的移动配体的性质和浓度，提供脂质的多功能涂层。

24. 发明申请

US20110046020A1 NOVEL ION CHANNEL-FORMING PEPTIDES 有权
标题翻译：新型离子通道肽
公开(公告)号：US20110046020A1
公开(公告)日：2011-02-24
申请号：US12668178
申请日：2008-07-09
申请人： Jerry Yang , Steven Blake , Michael Mayer
发明人： Jerry Yang , Steven Blake , Michael Mayer
IPC分类号： C40B60/00 , C07K2/00 , C07K7/66 , C12Q1/42 , C12M1/34
CPC分类号： G01N33/5438
摘要： The invention pertains generally to novel compositions and methods for constructing chemically sensitive ion channels. The compositions and methods include, for example, novel gramicidin A derivatives and their use in constructing novel ion channels for use as biosensors.
摘要翻译：本发明一般涉及用于构建化学敏感离子通道的新型组合物和方法。组合物和方法包括例如新型短杆菌肽A衍生物及其在构建用作生物传感器的新型离子通道中的用途。

25. 发明授权

US07369578B2 Digital processing of SONET pointers 有权
标题翻译： SONET指针的数字处理
公开(公告)号：US07369578B2
公开(公告)日：2008-05-06
申请号：US10609562
申请日：2003-07-01
申请人： Kim B Roberts , James Harley , Philippe Neusy , Michael Mayer
发明人： Kim B Roberts , James Harley , Philippe Neusy , Michael Mayer
IPC分类号： H04J3/06 , H04L7/00
CPC分类号： H04J3/076
摘要： In a method of estimating a bit rate (f1) of a digital signal conveyed through a SONET network between an originating node and a terminating node, the digital signal received by the originating node is processed to determine a result of a first function of the signal bit rate (f1) and a respective Tx local reference frequency (f2) of the originating node. A result of a second function of the Tx local reference frequency (f2) and a respective Rx local reference frequency (f3) of the terminating node is calculated. Finally, a result of a third function of the respective first and second function results is calculated, to derive an estimate of the signal bit rate (f4) relative to the Rx local reference frequency (f3).
摘要翻译：在估计在始发节点和终止节点之间通过SONET网络传送的数字信号的比特率（f 1）的方法中，由始发节点接收的数字信号被处理以确定第一功能的结果信号比特率（f 1）和相应的Tx本地参考频率（f 2）。计算终端节点的Tx本地参考频率（f 2）和相应的Rx本地参考频率（f 3）的第二功能的结果。最后，计算相应的第一和第二功能结果的第三功能的结果，以导出相对于Rx本地参考频率（f 3）的信号比特率（f 4）的估计。

26. 发明申请

US20060278240A1 System, device, and method for detecting perturbations 有权
标题翻译：用于检测扰动的系统，设备和方法
公开(公告)号：US20060278240A1
公开(公告)日：2006-12-14
申请号：US10534624
申请日：2003-11-17
申请人： William Spillman , Kenith Meissner , Jianmin Gong , Michael Mayer , Jennifer Bennett
发明人： William Spillman , Kenith Meissner , Jianmin Gong , Michael Mayer , Jennifer Bennett
IPC分类号： A61B19/00 , G08B26/00
CPC分类号： G01D5/35306 , G01D5/35341
摘要： Certain exemplary embodiments comprise a spatially distributed multimode optical fiber; a photodetector configured to detect optical signals provided from said fiber; a wireless digital module coupled to said photodetector and adapted to wirelessly transmit a wireless signal encoding a plurality of detected variables of the optical signals; a wireless receiver adapted to receive the wireless signal; and a signal processing module coupled to said wireless receiver and adapted to decode and interpret the plurality of detected variables of the optical signals.
摘要翻译：某些示例性实施例包括空间分布的多模光纤; 光检测器，被配置为检测从所述光纤提供的光信号; 耦合到所述光电检测器并适于无线地传输编码所述光信号的多个检测变量的无线信号的无线数字模块; 适于接收无线信号的无线接收机; 以及信号处理模块，其耦合到所述无线接收器并且适于对所述光信号的所述多个检测变量进行解码和解译。

27. 发明申请

US20050167473A1 METHOD FOR PRODUCING WEDGE-WEDGE WIRE CONNECTION 审中-公开
标题翻译：生产楔形线连接的方法
公开(公告)号：US20050167473A1
公开(公告)日：2005-08-04
申请号：US10905438
申请日：2005-01-04
申请人： Michael Mayer , Heinrich Berchtold
发明人： Michael Mayer , Heinrich Berchtold
IPC分类号： H01L21/60 , B23K20/00 , B23K31/02
CPC分类号： H01L24/85 , B23K20/007 , B23K2101/40 , H01L24/48 , H01L24/49 , H01L24/78 , H01L2224/05554 , H01L2224/48095 , H01L2224/48472 , H01L2224/48479 , H01L2224/49171 , H01L2224/78301 , H01L2224/85045 , H01L2224/85051 , H01L2224/85181 , H01L2224/85203 , H01L2224/85205 , H01L2224/85399 , H01L2924/00014 , H01L2924/01005 , H01L2924/01006 , H01L2924/01023 , H01L2924/01033 , H01L2924/01074 , H01L2924/01082 , H01L2924/014 , H01L2224/45099 , H01L2924/00 , H01L2224/45015 , H01L2924/207 , H01L2224/4554 , H01L2224/05599
摘要： A Ball-Wire Bonder can be used for the production of a wedge-wedge wire connection between first and second connection points when the tearing off of the wire takes place after production of the second wedge connection so that the piece of wire protruding out of the capillary points in the direction of the next wire connection to be made. The following steps are carried out in order to complete the wedge-wedge wire connection by tearing off the wire and to prepare the piece of wire protruding out of the capillary for producing the next wedge-wedge wire connection to be made: calculating a two-dimensional vector v lying in a horizontal plane that points from the desired impact point of the capillary on the first connection point of the next wedge-wedge wire connection to be made towards the desired impact point of the capillary on the second connection point of the next wedge-wedge wire connection to be made, and after attaching the wire to the second connection point, moving the capillary along a travel path that lies in a plane formed by the vector v and the vertical whereby the wire tears off on reaching the end of the travel path.
摘要翻译：当在制造第二楔形连接件之后，当线材的撕裂发生时，可以使用滚珠焊接机来生产在第一和第二连接点之间的楔形楔形线连接，使得该线材突出到毛细管点指向下一个接线方向。执行以下步骤以通过撕下线来完成楔形楔形线连接，并准备从毛细管突出的导线，以产生下一个楔形楔形线连接：位于水平面中的三维矢量v，其从毛细管的期望冲击点指向下一个楔形楔形线连接的第一连接点，以朝着下一个第二连接点处的毛细管的期望冲击点将楔形丝连接制成，并且在将线连接到第二连接点之后，沿着位于由矢量v和垂直线形成的平面中的行进路径移动毛细管，由此线在到达末端旅行路径。

28. 发明授权

US5840995A Precursor for alkoxylation catalysts 失效
标题翻译：烷氧基化催化剂前体
公开(公告)号：US5840995A
公开(公告)日：1998-11-24
申请号：US763715
申请日：1996-12-13
申请人： Michael Mayer , Joachim Hess , Alfred Babiel
发明人： Michael Mayer , Joachim Hess , Alfred Babiel
IPC分类号： C07D301/02 , B01J31/02 , B01J31/04 , B01J31/18 , C07B61/00 , C07C41/03 , C07C43/11 , C07D303/04
CPC分类号： B01J31/0202 , B01J31/223 , C07C41/03 , B01J2531/20 , B01J2531/23 , B01J2531/985 , B01J31/0204 , B01J31/0225 , B01J31/0229 , B01J31/0261 , B01J31/0271 , B01J31/04
摘要： A precursor for alkoxylation catalysts is prepared by reacting a chelating anionic or nonionic phase transfer catalyst with an alkaline earth metal compound in the presence of a compound which can be alkoxylated. Suitable phase transfer catalysts are, in particular, ethoxylated fatty alcohols, ether carboxylic acids, ether sulfonic acids or ether phosphonic acids. Addition of sulfuric acid to such a precursor produces an alkaline earth metal sulfato complex which is the actual catalyst for the alkoxylation.
摘要翻译：烷氧基化催化剂的前体是通过螯合阴离子或非离子相转移催化剂与碱土金属化合物在可以被烷氧基化的化合物存在下反应来制备的。合适的相转移催化剂特别是乙氧基化脂肪醇，醚羧酸，醚磺酸或醚膦酸。向这种前体中加入硫酸产生碱土金属硫酸盐络合物，其是烷氧基化的实际催化剂。

29. 发明授权

US5243982A Device for determining the concentration of at least one substance in organic tissue 失效
标题翻译：用于确定有机组织中至少一种物质浓度的装置
公开(公告)号：US5243982A
公开(公告)日：1993-09-14
申请号：US732401
申请日：1991-07-18
申请人： Anton Mostl , Michael Mayer
发明人： Anton Mostl , Michael Mayer
IPC分类号： A61B5/00 , A61M5/172
CPC分类号： A61B5/14532 , A61M5/1723 , A61M2005/1726 , Y10S128/12
摘要： A device for determining the concentration of at least one substance in organic tissue includes a subcutaneous needle for insertion into the tissue and a pumping and suction unit which is controlled by a microprocessor and is used for delivering a perfusion fluid and draining it after its partial equilibration with the tissue. The device further includes a sensing unit connected to the microprocessor for determining the concentration of the substance to be analyzed and one or more marker variables. The perfusion fluid, a calibrating solution and at least one drug are provided in replaceable metering ampoules sealed with membranes, whose metering plungers can be actuated by a drive unit controlled by the microprocessor. The metering ampoules communicate with a master capillary leading from the pumping and suction unit to the subcutaneous needle; communication is established via capillary tubes piercing the membranes.
摘要翻译：用于确定有机组织中至少一种物质的浓度的装置包括用于插入组织的皮下针和由微处理器控制并用于输送灌注流体并在其部分平衡后排出的抽吸和抽吸单元与组织。该装置还包括连接到微处理器的感测单元，用于确定待分析物质的浓度和一个或多个标记变量。在用膜密封的可更换的计量安瓿中提供灌注流体，校准溶液和至少一种药物，其计量柱塞可由由微处理器控制的驱动单元致动。计量安瓿与从抽吸单元引导到皮下针的主毛细管连通; 通过穿透膜的毛细管建立通信。

30. 发明授权

US11777844B2 Distributing information in communication networks 有权
公开(公告)号：US11777844B2
公开(公告)日：2023-10-03
申请号：US16920569
申请日：2020-07-03
申请人： Mehdi Arashmid Akhavain Mohammadi , Michael Mayer , Peter Ashwood-Smith
发明人： Mehdi Arashmid Akhavain Mohammadi , Michael Mayer , Peter Ashwood-Smith
IPC分类号： H04L45/00 , H04L47/122 , H04L47/25 , H04L45/02
CPC分类号： H04L45/32 , H04L45/02 , H04L45/26 , H04L47/122 , H04L47/25
摘要： Methods and apparatus for distributing link state information are provided. Network nodes propagate link state information via a control plane flooding operation. A first network node can initiate this propagation in response to a local link state change. In addition, some network nodes can via data plane messaging to transmit link state information to a remote node of the network. The remote node responds to the message by initiating a control plane flooding operation at that location. The remote node can be selected based on a variety of criteria, such as network traffic conditions, location, or network topology. Multiple remote nodes can be prompted in this manner to initiate flooding operations.

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