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    • 21. 发明授权
      US5670312A Method of obtaining diagnostic reagents, assays and therapeutics based on clinical manifestations of a disease 失效
    • Method of obtaining diagnostic reagents, assays and therapeutics based on clinical manifestations of a disease
    • 基于疾病临床表现获得诊断试剂，测定法和治疗方法
    • US5670312A
    • 1997-09-23
    • US558235
    • 1995-11-17
    • Daniel V. Santi
    • Daniel V. Santi
    • G01N33/531 , C07K1/04 , C07K16/00 , C07K16/06 , C07K16/10 , C07K16/34 , C12Q1/70 , C40B30/04 , G01N33/543 , G01N33/569 , G01N33/68 , C12Q1/68
    • C40B30/04 , C07K1/047 , C07K16/00 , C07K16/06 , C07K16/065 , C07K16/109 , C07K16/34 , G01N33/6845 , G01N33/6854 , A61K2039/505 , Y10S436/811 , Y10S436/82
    • Antibodies are recovered and isolated from the sera of a number "n" of patients each of which have or have had the same given disease so that each of the "n" patients has, within a large number of different antibodies, some antibodies uniquely associated with the same disease of interest. The antibodies of a first patient are bound to a support surface. To carry out initial screening libraries of molecules are brought into contact with the bound antibodies of the first patient under conditions where binding will occur. Secondary screening is then carried out by extracting and labeling the antibodies of a second patient and using the labeled antibodies to probe the molecules (peptides) isolated in the initial screening. Many of the non-disease specific antibodies (of the second patient) will not bind to the molecules (peptides) of the isolated bacteriophage which bound to the antibodies of the first patient. Hence, the molecules (peptides) which are common to both patients with the same disease will be identified. The process may be repeated with labeled antibodies from a third, fourth, etc. patient to obtain those molecules (peptides) which are common to all patients with the disease, and have the highest affinity to the antibodies specific to the disease. Copies of the characterized molecules (peptides) can be synthesized and bound to a support for use as an assay to detect the presence of antibodies specific to a disease.
    • 从多个“n”个患者的血清中回收和分离抗体，每个患者具有或已经具有相同的给定疾病，使得每个“n”患者在大量不同抗体中具有唯一相关的一些抗体 与同样的感兴趣的疾病。 第一个患者的抗体结合到支撑表面。 为了进行初始筛选，将在发生结合的条件下使分子的文库与第一个患者的结合抗体接触。 然后通过提取和标记第二个患者的抗体并使用标记的抗体来探测在初始筛选中分离的分子（肽）来进行二次筛选。 许多非疾病特异性抗体（第二患者）不会结合到与第一患者的抗体结合的分离的噬菌体的分子（肽）。 因此，对于具有相同疾病的患者常见的分子（肽）将被鉴定。 可以用来自第三，第四等患者的标记抗体重复该过程，以获得所有患有该疾病的患者常见的那些分子（肽），并且对该疾病特异性抗体具有最高的亲和力。 可以合成特征分子（肽）的拷贝并结合到支持物上，用作检测疾病特异性抗体的存在。
    • 基本信息 添加关注 加入工作空间 PDF全文 PDF下载 全文下载 相似专利 双屏查看 权利要求书 说明书全文 Global Dossier Espacenet 法律信息 同族专利 专利引用
    • 29. 发明授权
      US5492807A Method of obtaining diagnostic reagents, assays and therapeutics based on clinical manifestations of a disease 失效
    • Method of obtaining diagnostic reagents, assays and therapeutics based on clinical manifestations of a disease
    • 基于疾病临床表现获得诊断试剂，测定法和治疗方法
    • US5492807A
    • 1996-02-20
    • US155943
    • 1993-11-19
    • Daniel V. Santi
    • Daniel V. Santi
    • G01N33/531 , C07K1/04 , C07K16/00 , C07K16/06 , C07K16/10 , C07K16/34 , C12Q1/70 , C40B30/04 , G01N33/543 , G01N33/569 , G01N33/68
    • C40B30/04 , C07K1/047 , C07K16/00 , C07K16/06 , C07K16/065 , C07K16/109 , C07K16/34 , G01N33/6845 , G01N33/6854 , A61K2039/505 , Y10S436/811 , Y10S436/82
    • Antibodies are recovered and isolated from the sera of a number "n" of patients each of which have or have had the same given disease so that each of the "n" patients has, within a large number of different antibodies, some antibodies uniquely associated with the same disease of interest. The antibodies of a first patient are bound to a support surface. To carry out initial screening libraries of molecules are brought into contact with the bound antibodies of the first patient under conditions where binding will occur. Secondary screening is then carried out by extracting and labeling the antibodies of a second patient and using the labeled antibodies to probe the molecules (peptides) isolated in the initial screening. Many of the non-disease specific antibodies (of the second patient) will not bind to the molecules (peptides) of the isolated bacteriophage which bound to the antibodies of the first patient. Hence, the molecules (peptides) which are common to both patients with the same disease will be identified. The process may be repeated with labeled antibodies from a third, fourth, etc. patient to obtain those molecules (peptides) which are common to all patients with the disease, and have the highest affinity to the antibodies specific to the disease. Copies of the characterized molecules (peptides) can be synthesized and bound to a support for use as an assay to detect the presence of antibodies specific to a disease.
    • 从多个“n”个患者的血清中回收和分离抗体，每个患者具有或已经具有相同的给定疾病，使得每个“n”患者在大量不同抗体中具有唯一相关的一些抗体 与同样的感兴趣的疾病。 第一个患者的抗体结合到支撑表面。 为了进行初始筛选，将在发生结合的条件下使分子的文库与第一个患者的结合抗体接触。 然后通过提取和标记第二个患者的抗体并使用标记的抗体来探测在初始筛选中分离的分子（肽）来进行二次筛选。 许多非疾病特异性抗体（第二患者）不会结合到与第一患者的抗体结合的分离的噬菌体的分子（肽）。 因此，对于具有相同疾病的患者常见的分子（肽）将被鉴定。 可以用来自第三，第四等患者的标记抗体重复该过程，以获得所有患有该疾病的患者常见的那些分子（肽），并且对该疾病特异性抗体具有最高的亲和力。 可以合成特征分子（肽）的拷贝并结合到支持物上，用作检测疾病特异性抗体的存在。
    • 基本信息 添加关注 加入工作空间 PDF全文 PDF下载 全文下载 相似专利 双屏查看 权利要求书 说明书全文 Global Dossier Espacenet 法律信息 同族专利 专利引用
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