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1. 发明授权

US09649385B2 Hydrogels with biodegradable crosslinking 有权
公开(公告)号：US09649385B2
公开(公告)日：2017-05-16
申请号：US14343819
申请日：2012-09-07
申请人： Gary W. Ashley , Daniel V. Santi , Jeffrey C. Henise
发明人： Gary W. Ashley , Daniel V. Santi , Jeffrey C. Henise
IPC分类号： A61K47/30 , A61K47/34 , A61K47/48 , A61L15/26 , A61L27/18 , A61L27/52 , C07C271/08
CPC分类号： A61K47/34 , A61K47/60 , A61K47/6903 , A61L15/26 , A61L27/18 , A61L27/52 , C07C271/08 , C08G2650/30
摘要： Hydrogels that degrade under appropriate conditions of pH and temperature by virtue of crosslinking compounds that cleave through an elimination reaction are described. The hydrogels may be used for delivery of various agents, such as pharmaceuticals. This invention provides hydrogels that degrade to smaller, soluble components in a non-enzymatic process upon exposure to physiological conditions and to methods to prepare them. The hydrogels are prepared from crosslinking agents that undergo elimination reactions under physiological conditions, thus cleaving the crosslinking agent from the backbone of the hydrogel. The invention also relates to the crosslinking agents themselves and intermediates in forming the hydro gels of the invention. The biodegradable hydro gels prepared according to the methods of the invention may be of use in diverse fields, including biomedical engineering, absorbent materials, and as carriers for drug delivery.

2. 发明申请

US20140288190A1 HYDROGELS WITH BIODEGRADABLE CROSSLINKING 有权
标题翻译： HYDROGELS可生物降解的交织
公开(公告)号：US20140288190A1
公开(公告)日：2014-09-25
申请号：US14343819
申请日：2012-09-07
申请人： Gary W. Ashley , Daniel V. Santi , Jeffrey C. Henise
发明人： Gary W. Ashley , Daniel V. Santi , Jeffrey C. Henise
IPC分类号： A61K47/34 , A61L27/52 , A61L27/18 , A61L15/26 , C07C271/08
CPC分类号： A61K47/34 , A61K47/60 , A61K47/6903 , A61L15/26 , A61L27/18 , A61L27/52 , C07C271/08 , C08G2650/30
摘要： Hydrogels that degrade under appropriate conditions of pH and temperature by virtue of crosslinking compounds that cleave through an elimination reaction are described. The hydrogels may be used for delivery of various agents, such as pharmaceuticals. This invention provides hydrogels that degrade to smaller, soluble components in a non-enzymatic process upon exposure to physiological conditions and to methods to prepare them. The hydrogels are prepared from crosslinking agents that undergo elimination reactions under physiological conditions, thus cleaving the crosslinking agent from the backbone of the hydrogel. The invention also relates to the crosslinking agents themselves and intermediates in forming the hydro gels of the invention. The biodegradable hydro gels prepared according to the methods of the invention may be of use in diverse fields, including biomedical engineering, absorbent materials, and as carriers for drug delivery.
摘要翻译：描述了在适当的pH和温度条件下通过切割消除反应的交联化合物降解的水凝胶。水凝胶可用于递送各种试剂，例如药物。本发明提供在暴露于生理条件时以非酶过程降解成较小的可溶组分的水凝胶以及制备它们的方法。水凝胶由在生理条件下进行消除反应的交联剂制备，从而从水凝胶的骨架切割交联剂。本发明还涉及交联剂本身和形成本发明的水凝胶的中间体。根据本发明的方法制备的可生物降解的水凝胶可用于各种领域，包括生物医学工程，吸收材料和用于药物递送的载体。

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