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21. 发明申请

US20120203532A1 Method for Dynamically Switching Analyses and For Dynamically Switching Models in Circuit Simulators 有权
标题翻译：用于动态切换分析和电路模拟器动态切换模型的方法
公开(公告)号：US20120203532A1
公开(公告)日：2012-08-09
申请号：US13023559
申请日：2011-02-09
申请人： Michael Claus Olsen , Jie Deng , Terence B. Hook , Madan Mohan Naga Nutakki
发明人： Michael Claus Olsen , Jie Deng , Terence B. Hook , Madan Mohan Naga Nutakki
IPC分类号： G06F17/50
CPC分类号： G06F17/5022 , G06F17/5036
摘要： Performing a transient analysis with a compact FET model that is predominantly intended for DC analysis, such as an IDDQ leakage model, to enable toggling logic states in sequential logic circuits that cannot otherwise be examined in a DC analysis. An embodiment enables examining the DC or AC conditions of any logic state of any logic circuit in a DC or AC analysis, and additionally, it eliminates a potentially long execution time of a transient analysis with a DC model. Further solved is the present need to run two simulations and to maintain two netlists in order to overcome being unable to toggle certain logic states in the DC analysis. The invention achieves the aforementioned in a single simulation with a single netlist that calculates the DC operating circuit conditions with a model A on the fly at predetermined times or in certain logic states, during a transient analysis with a model B.
摘要翻译：使用主要用于直流分析（例如IDDQ泄漏模型）的紧凑型FET模型进行瞬态分析，以便能够在不能在DC分析中检查的顺序逻辑电路中切换逻辑状态。一个实施例能够检查DC或AC分析中任何逻辑电路的任何逻辑状态的DC或AC条件，此外，它消除了具有DC模型的瞬态分析的潜在长的执行时间。进一步的解决是目前需要运行两个模拟，并维护两个网表，以克服在DC分析中不能切换某些逻辑状态。本发明在具有单个网表的单个模拟中实现上述，在单个网表中，在模型B的瞬态分析期间，在预定时间或在某些逻辑状态下，用模型A计算直流运行电路条件。

22. 发明申请

US20080138319A1 Bone-marrow derived neurogenic cells and uses thereof 审中-公开
标题翻译：骨髓衍生的神经原细胞及其用途
公开(公告)号：US20080138319A1
公开(公告)日：2008-06-12
申请号：US11975683
申请日：2007-10-19
申请人： Jie Deng , Eric D. Laywell , Bryon Petersen , Dennis A. Steindler
发明人： Jie Deng , Eric D. Laywell , Bryon Petersen , Dennis A. Steindler
IPC分类号： A61K48/00 , C12N5/06 , C12N5/10 , A61K35/30
CPC分类号： C12N5/0619 , A61K2035/124 , C12N5/0622 , C12N2501/01 , C12N2501/11 , C12N2501/115 , C12N2501/13 , C12N2501/235 , C12N2506/1353
摘要： Disclosed are cellular compositions, grafts and pharmaceutical products made from bone marrow (BM) cells useful for a wide array of cell-based therapies for diseases and disorders of the nervous system. Transgenic cells in accord with the invention express therapeutic or reporter genes encoded in viral vectors. The cells are capable of extensive expansion in vitro and can generate neurons and glial cells both in culture and in vivo. Upon administration to a nervous system tissue or site in a host subject, the cells can migrate to appropriate target sites and can assimilate therein, differentiating into both neurons and astrocytes without evidence of fusion with endogenous cells of the host nervous tissue. The cells can express an array of therapeutic gene products suitable for treatment of nervous system disorders. Particularly preferred for neurodegenerative disease applications are transgenic BM-derived neurogenic cells expressing neurotrophic factors.
摘要翻译：公开了由骨髓（BM）细胞制成的细胞组合物，移植物和药物制品，其可用于广泛用于神经系统疾病和病症的基于细胞的疗法。符合本发明的转基因细胞表达在病毒载体中编码的治疗或报告基因。细胞能够在体外大量扩增，并且可以在培养和体内产生神经元和神经胶质细胞。当给予宿主受试者的神经系统组织或部位时，细胞可以迁移到适当的靶位点并且可以在其中同化，分化成神经元和星形胶质细胞，而没有与宿主神经组织的内源性细胞融合的证据。细胞可以表达适合于治疗神经系统疾病的一系列治疗性基因产物。特别优选的神经变性疾病应用是表达神经营养因子的转基因BM衍生的神经源性细胞。

23. 发明授权

US08859624B2 Stable rasagiline composition 有权
标题翻译：稳定的雷沙吉兰组合物
公开(公告)号：US08859624B2
公开(公告)日：2014-10-14
申请号：US13504178
申请日：2010-10-28
申请人： Jialiang Lin , Jie Deng , Hao Chen , Tao Zhang
发明人： Jialiang Lin , Jie Deng , Hao Chen , Tao Zhang
IPC分类号： A01N33/02 , A61K31/135 , A61F13/00 , A61K9/70 , A61K31/355 , A61K47/22 , A61K9/00 , A61K47/10 , A61K9/06 , A61K31/375
CPC分类号： A61K31/135 , A61K9/0014 , A61K9/06 , A61K9/7061 , A61K9/7069 , A61K31/355 , A61K31/375 , A61K47/10 , A61K47/22 , A61K2300/00
摘要： The present invention provides a stable composition of rasagiline comprising an effective dosage of rasagiline or its pharmaceutically acceptable salts and an antioxidant used as a stabilizer. The dosage forms of the composition are pharmaceutically common transdermal-drug delivery dosage form and mucoadhesive delivery dosage form, such as patch, gel, ointment, cream, cataplasm, film, spray and solution, etc. The composition can be used to prevent or treat mental disorders.
摘要翻译：本发明提供雷沙吉兰的稳定组合物，其包含有效剂量的雷沙吉兰或其药学上可接受的盐和用作稳定剂的抗氧化剂。组合物的剂型是药学上常见的透皮 - 药物递送剂型和粘膜粘附递送剂型，例如贴剂，凝胶，软膏，霜剂，粘膜，膜，喷雾剂和溶液等。该组合物可用于预防或治疗精神错乱。

24. 发明申请

US20120190160A1 ASYMMETRIC CHANNEL MOSFET 失效
公开(公告)号：US20120190160A1
公开(公告)日：2012-07-26
申请号：US13428061
申请日：2012-03-23
申请人： Xiangdong Chen , Jie Deng , Weipeng Li , Deleep R. Nair , Jae-Eun Park , Daniel Tekleab , Xiaobin Yuan , Nam Sung Kim
发明人： Xiangdong Chen , Jie Deng , Weipeng Li , Deleep R. Nair , Jae-Eun Park , Daniel Tekleab , Xiaobin Yuan , Nam Sung Kim
IPC分类号： H01L21/335
CPC分类号： H01L21/823412 , H01L21/28202 , H01L21/823807 , H01L29/1054 , H01L29/165 , H01L29/518 , H01L29/665 , H01L29/6659 , H01L29/66628 , H01L29/66636 , H01L29/66659 , H01L29/7833 , H01L29/7834 , H01L29/7835
摘要： A field effect transistor includes a partial SiGe channel, i.e., a channel including a SiGe channel portion, located underneath a gate electrode and a Si channel portion located underneath an edge of the gate electrode near the drain region. The SiGe channel portion can be located directly underneath a gate dielectric, or can be located underneath a Si channel layer located directly underneath a gate dielectric. The Si channel portion is located at the same depth as the SiGe channel portion, and contacts the drain region of the transistor. By providing a Si channel portion near the drain region, the GIDL current of the transistor is maintained at a level on par with the GIDL current of a transistor having a silicon channel only during an off state.

25. 发明申请

US20120007145A1 ASYMMETRIC CHANNEL MOSFET 失效
标题翻译：不对称通道MOSFET
公开(公告)号：US20120007145A1
公开(公告)日：2012-01-12
申请号：US12831310
申请日：2010-07-07
申请人： Xiangdong Chen , Jie Deng , Weipeng Li , Deleep R. Nair , Jae-Eun Park , Daniel Tekleab , Xiaobin Yuan , Nam Sung Kim
发明人： Xiangdong Chen , Jie Deng , Weipeng Li , Deleep R. Nair , Jae-Eun Park , Daniel Tekleab , Xiaobin Yuan , Nam Sung Kim
IPC分类号： H01L29/165 , H01L21/336 , H01L21/8234 , H01L27/088
CPC分类号： H01L21/823412 , H01L21/28202 , H01L21/823807 , H01L29/1054 , H01L29/165 , H01L29/518 , H01L29/665 , H01L29/6659 , H01L29/66628 , H01L29/66636 , H01L29/66659 , H01L29/7833 , H01L29/7834 , H01L29/7835
摘要： A field effect transistor includes a partial SiGe channel, i.e., a channel including a SiGe channel portion, located underneath a gate electrode and a Si channel portion located underneath an edge of the gate electrode near the drain region. The SiGe channel portion can be located directly underneath a gate dielectric, or can be located underneath a Si channel layer located directly underneath a gate dielectric. The Si channel portion is located at the same depth as the SiGe channel portion, and contacts the drain region of the transistor. By providing a Si channel portion near the drain region, the GIDL current of the transistor is maintained at a level on par with the GIDL current of a transistor having a silicon channel only during an off state.
摘要翻译：场效应晶体管包括部分SiGe沟道，即包括位于栅极下方的SiGe沟道部分的沟道部分，以及位于漏极区域附近的位于栅电极的边缘下方的Si沟道部分。 SiGe沟道部分可以位于栅极电介质的正下方，或者可以位于位于栅极电介质正下方的Si沟道层下方。 Si沟道部分位于与SiGe沟道部分相同的深度处，并与晶体管的漏极区域接触。通过在漏极区附近提供Si沟道部分，晶体管的GIDL电流仅在断开状态下保持在与具有硅沟道的晶体管的GIDL电流相同的水平上。

26. 发明授权

US08053470B2 Process for the preparation of polynuclear ferric hydroxide-saccaride complexes 有权
标题翻译：制备多核氢氧化铁 - 糖配合物的方法
公开(公告)号：US08053470B2
公开(公告)日：2011-11-08
申请号：US11911449
申请日：2006-04-12
申请人： Jinmai Xiao , Jie Deng , Jinhua Feng , Bo Xiao
发明人： Jinmai Xiao , Jie Deng , Jinhua Feng , Bo Xiao
IPC分类号： A61K31/295
CPC分类号： C07H23/00
摘要： The invention discloses a process for preparing a polynuclear ferric hydroxide-saccharide complex, including: adding an aqueous solution of an alkaline substance drop-wise into an aqueous solution of iron salt at a temperature of 5-20° C. until pH 6-8, collecting the polynuclear ferric hydroxide from the reaction mixture by a conventional method; reacting the polynuclear ferric hydroxide with a saccharide in a solution of an alkaline substance for 10-40 hours at 106-125° C. under pH 10-12, resulting in a crude product having an isoelectric point of 4.4-5.3 and a weight average molecular weight of 20,000-100,000 Daltons, and then harvesting the polynuclear ferric hydroxide-saccharide complex from the crude product. The process can precisely control the molecular weight of the polynuclear ferric hydroxide-saccharide complex without an effect on the other characteristics of the product, for example its saccharide content or isoelectric point etc. Furthermore, it is very simple and readily applicable in industry.
摘要翻译：本发明公开了一种制备多核铁氢氧化物 - 糖复合物的方法，其包括：将碱性物质的水溶液滴加到铁盐水溶液中，温度为5-20℃直至pH6-8 ，通过常规方法从反应混合物中收集多核铁氢氧化物; 使多核铁氢氧化物与糖类在碱性物质的溶液中在106-125℃下在pH 10-12下反应10-40小时，得到等电点为4.4-5.3的粗产物，重均分子量分子量为20,000-100,000道尔顿，然后从粗产物中收获多核铁氢氧化物 - 糖复合物。该方法可以精确地控制多核铁氢氧化物 - 糖复合物的分子量，而不影响产品的其他特性，例如其糖含量或等电点等。此外，它非常简单且易于应用于工业中。

27. 发明申请

US20110112297A1 MORPHINAN DERIVATIVES AND PREPARATION METHODS THEREOF 失效
标题翻译：莫宁衍生物及其制备方法
公开(公告)号：US20110112297A1
公开(公告)日：2011-05-12
申请号：US13000200
申请日：2009-06-19
申请人： Huafu Sun , Jie Luo , Wenrun Ye , Jie Deng , Bo Lin , Chunyan Dan , Bin Fan
发明人： Huafu Sun , Jie Luo , Wenrun Ye , Jie Deng , Bo Lin , Chunyan Dan , Bin Fan
IPC分类号： C07D489/08 , C07F7/18
CPC分类号： C07D489/08 , C07D489/09
摘要： The present invention relates to morphinan derivatives and preparation methods thereof, especially to ketal hydroxyl protected compounds of morphinan derivatives and preparation method thereof, and to a method for preparing corresponding alkylated morphinan derivatives by using the ketal hydroxyl protected compounds as intermediates, and more especially to a ketal hydroxyl protected compound of methylnaltrexone as intermediate for preparing methylnaltrexone and a method for preparing methylnaltrexone through said intermediate.
摘要翻译：本发明涉及吗啡喃衍生物及其制备方法，尤其涉及缩酮羟基保护的吗啡喃衍生物化合物及其制备方法，以及通过使用缩酮羟基保护的化合物作为中间体制备相应的烷基化吗啡喃衍生物的方法，更具体地涉及作为制备甲基纳曲酮的中间体的甲基纳曲酮的缩酮羟基保护的化合物和通过所述中间体制备甲基纳曲酮的方法。

28. 发明申请

US20100305319A1 METHOD OF PURIFYING A SALT, SODIUM SALT AND DISODIUM SALT OF PEMETREXED 有权
标题翻译：盐酸盐，盐酸盐和盐酸盐的净化方法
公开(公告)号：US20100305319A1
公开(公告)日：2010-12-02
申请号：US12739576
申请日：2008-10-21
申请人： Jie Luo , Meng Lin , Bo Lin , Wenrun Ye , Yongmei Qin , Jie Deng
发明人： Jie Luo , Meng Lin , Bo Lin , Wenrun Ye , Yongmei Qin , Jie Deng
IPC分类号： C07D487/04
CPC分类号： C07D487/04
摘要： A method of purifying a salt of pemetrexed have a structure of formula (III) by salting-out, wherein if M3+ is H+, then each of M1+ and M2+ is independently H+, Li+, Na+ or K+, provided that both of them are not H+; if M3+ is Li+, Na+ or K+, then each of M1+ and M2+ is independently Li+, Na+ or K+.
摘要翻译：纯化培美曲塞的盐的方法通过盐析得到式（III）的结构，其中如果M3 +是H +，则M1 +和M2 +各自独立地为H +，Li +，Na +或K +，条件是它们都不是 H +; 如果M3 +为Li +，Na +或K +，则M1 +和M2 +各自独立为Li +，Na +或K +。

29. 发明申请

US20090136549A1 TRANSDERMAL PATCH CONTAINING RASAGILINE FOR TREATMENT OR PROPHYLAXIS OF NERVOUS SYSTEM DISEASE AND ITS PREPARATION PROCESS 审中-公开
标题翻译：含有RASAGILINE用于治疗或预防神经系统疾病及其制备过程的透皮贴
公开(公告)号：US20090136549A1
公开(公告)日：2009-05-28
申请号：US12281875
申请日：2007-03-06
申请人： Jialiang Lin , Jinmai Xiao , Jie Deng
发明人： Jialiang Lin , Jinmai Xiao , Jie Deng
IPC分类号： A61K9/00 , A61K31/136 , A61P25/28
CPC分类号： A61K31/135 , A61K9/7053 , A61K9/7061 , A61K9/7069 , A61K9/7092
摘要： The present invention relates to a rasagiline transdermal patch for treatment or prophylaxis of nervous system diseases, in which the patch comprises an inert backing layer chemically inert to substrate ingredients, a substrate layer comprising rasagiline or a pharmaceutically acceptable salt thereof, and a protective layer to be peeled off before use. The substrate layer is an adhesive system comprising an organic polymer material as basis and an inorganic or organic material as filler, and a plurality of micro-reservoirs containing rasagiline. The substrate further comprises one or more substances for enhancing the transdermal absorption of rasagiline, in which the above organic polymer material in the substrate is used for the reservoir of rasagiline and as adhesive.
摘要翻译：本发明涉及一种用于治疗或预防神经系统疾病的雷沙吉兰透皮贴剂，其中贴片包括对底物成分具有化学惰性的惰性背衬层，包含雷沙吉兰或其药学上可接受的盐的底物层和保护层使用前剥离。基材层是以有机聚合物材料为基础和作为填料的无机或有机材料和含有雷沙吉兰的多个微储层的粘合剂体系。底物还包含一种或多种用于增强雷沙吉兰透皮吸收的物质，其中基质中的上述有机聚合物材料用于雷沙吉兰的储库和粘合剂。

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