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    • 22. 发明授权
    • Device and method for monitoring body fluid and electrolyte disorders
    • 用于监测体液和电解质紊乱的装置和方法
    • US07236811B2
    • 2007-06-26
    • US10441943
    • 2003-05-20
    • Joseph M. Schmitt
    • Joseph M. Schmitt
    • A61B5/1455
    • G01N21/359A61B5/0053A61B5/0059A61B5/02438A61B5/14546A61B5/4878
    • A device and a method for measuring body fluid-related metrics using spectrophotometry to facilitate therapeutic interventions aimed at restoring body fluid balance. The specific body fluid-related metrics include the absolute volume fraction of water in the extravascular and intravascular tissue compartments, as well as the shifts of water between these two compartments. The absolute volume fraction of water is determined using algorithms where received radiation measured at two or more wavelengths are combined to form either a single ratio, a sum of ratios or ratio of ratios of the form log[R(λ1)/R(λ2)] in which the received radiation in the numerator depends primarily on the absorbance of water and the received radiation in the denominator depends primarily on the absorbance of water and the sum of the absorbances of non-heme proteins, lipids and water in tissue. The difference between the fraction of water in the intravascular fluid volume (“IFV”) and extravascular fluid volume (“EFV”) compartments are also determined using a differential method that takes advantage of the observation that pulsations caused by expansion of blood vessels in the skin as the heart beats produce changes in the received radiation at a particular wavelength that are proportional to the difference between the effective absorption of light in the blood and the surrounding tissue. This difference, integrated over time, provides a measure of the quantity of the fluid that shifts into and out of the capillaries. A mechanism for mechanically inducing a pulse is built into the device to improve the reliability of measurements of IFV−EFV under weak-pulse conditions.
    • 一种用于使用分光光度法测量体液相关度量以便于旨在恢复体液平衡的治疗干预的装置和方法。 特定体液相关指标包括血管外和血管内组织隔室中的水的绝对体积分数,以及这两个隔室之间的水位偏移。 使用算法确定水的绝对体积分数,其中在两个或更多个波长处测量的接收辐射被组合以形成单个比率,比率之和或形式log [R(λ< 分子中的接收辐射主要取决于水的吸光度和分母中的接收辐射主要取决于水的吸光度和总和的总和 组织中非血红素蛋白,脂质和水的吸光度。 血管内液体体积(“IFV”)中的水分与血管外液体体积(“EFV”)隔室之间的差异也使用差异法来确定,该差异法利用观察到血管内血管容积膨胀引起的脉动 作为心跳的皮肤在与所述血液和周围组织中的光的有效吸收之间的差成比例的特定波长处产生接收的辐射的变化。 随着时间的推移,这种差异可以提供一种测量流入和流出毛细血管的流体量。 在器件中内置了机械诱导脉冲的机制,以提高弱脉冲条件下IFV-EFV测量的可靠性。
    • 28. 发明授权
    • Method of determining pressure in a vessel as measured by an optical pressure transducer in an optical coherence tomography system
    • 在光学相干断层摄影系统中通过光学压力传感器测量的确定容器中的压力的​​方法
    • US08676299B2
    • 2014-03-18
    • US13484936
    • 2012-05-31
    • Joseph M. SchmittChristopher Petroff
    • Joseph M. SchmittChristopher Petroff
    • A61B5/00
    • A61B5/02154A61B5/0066A61B5/0075A61B5/0084A61B5/02007A61B5/0215A61B5/6852A61B5/742
    • An OCT system and method with integrated pressure measurement. In one embodiment, the system includes an interferometer; a wavelength swept laser; a source arm in communication with the wavelength swept laser; a reference arm in communication with a reference reflector; a first photoreceiver having a signal output; a detector arm in communication with the first photoreceiver, a probe interface; a sample arm in communication with a first optical connector of the probe interface; an acquisition and display system comprising: an A/D converter having a signal input in communication with the first photoreceiver signal output and a signal output; a processor system in communication with the A/D converter signal output; and a display in communication with the processor system; and a probe comprising a pressure sensor and configured for connection to the first optical connector of the probe interface, wherein the pressure transducer comprises an optical pressure transducer.
    • 具有集成压力测量的OCT系统和方法。 在一个实施例中,系统包括干涉仪; 波长扫描激光; 与波长扫描激光器通信的源臂; 与参考反射器连通的参考臂; 具有信号输出的第一光接收器; 与第一光接收器通信的检测器臂,探针接口; 与所述探针接口的第一光学连接器连通的样品臂; 一种采集和显示系统,包括:具有与第一光接收器信号输出通信的信号输入和信号输出的A / D转换器; 与A / D转换器信号输出通信的处理器系统; 以及与处理器系统通信的显示器; 以及探针,其包括压力传感器并且被配置为连接到所述探针接口的所述第一光学连接器,其中所述压力传感器包括光学压力传感器。
    • 29. 发明授权
    • Device and method for monitoring body fluid and electrolyte disorders
    • 用于监测体液和电解质紊乱的装置和方法
    • US08457722B2
    • 2013-06-04
    • US11239815
    • 2005-09-30
    • Joseph M. SchmittMartin Debreczeny
    • Joseph M. SchmittMartin Debreczeny
    • A61B6/00
    • G01N21/3554A61B5/0053A61B5/0059A61B5/02438A61B5/14546G01N21/359G01N2021/3181
    • Devices and methods for measuring body fluid-related metric using spectrophotometry that may be used to facilitate diagnosis and therapeutic interventions aimed at restoring body fluid balance. In one embodiment, the present invention provides a device for measuring a body-tissue water content metric as a fraction of the fat-free tissue content of a patient using optical spectrophotometry. The device includes a probe housing configured to be placed near a tissue location which is being monitored; light emission optics connected to the housing and configured to direct radiation at the tissue location; light detection optics connected to the housing and configured to receive radiation from the tissue location; and a processing device configured to process radiation from the light emission optics and the light detection optics to compute the metric where the metric includes a ratio of the water content of a portion of patient's tissue in relation to the lean or fat-free content of a portion of patient's tissue.
    • 用于使用分光光度法测量体液相关度量的装置和方法,其可用于促进用于恢复体液平衡的诊断​​和治疗干预。 在一个实施方案中,本发明提供了一种用于使用光学分光光度法测量身体组织含水量度量作为患者的无脂肪组织含量的一部分的装置。 该装置包括被配置成放置在被监视的组织位置附近的探针壳体; 光发射光学器件连接到壳体并且被配置成在组织位置处引导辐射; 光检测光学器件连接到壳体并被配置为从组织位置接收辐射; 以及处理装置,其被配置为处理来自所述发光光学器件和所述光检测光学器件的辐射,以计算所述度量,其中所述度量包括患者组织的一部分的水含量相对于所述贫血或无脂肪含量的比例 部分患者组织。