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21. 发明授权

US08032200B2 Methods and systems for tissue analysis 有权
标题翻译：组织分析方法和系统
公开(公告)号：US08032200B2
公开(公告)日：2011-10-04
申请号：US11534095
申请日：2006-09-21
申请人： Guillermo J. Tearney , Brett Eugene Bouma
发明人： Guillermo J. Tearney , Brett Eugene Bouma
IPC分类号： A61B5/00
CPC分类号： A61B5/6885 , A61B1/00082 , A61B1/0615 , A61B1/07 , A61B5/0066 , A61B5/0068 , A61B5/0075 , A61B5/0084 , A61B5/02007 , A61B5/7207 , A61B5/7257 , G01N21/49
摘要： The invention relates to methods and systems to optically analyze samples such as tissue based on speckle patterns of microscopic motion, such as Brownian motion.
摘要翻译：本发明涉及基于诸如布朗运动的微观运动的斑纹图案光学分析诸如组织的样品的方法和系统。

22. 发明授权

US07903257B2 Apparatus and method for ranging and noise reduction of low coherence interferometry (LCI) and optical coherence tomography (OCT) signals by parallel detection of spectral bands 有权
标题翻译：用于通过光谱带的并行检测的低相干干涉测量（LCI）和光学相干断层扫描（OCT）信号的测距和降噪的装置和方法
公开(公告)号：US07903257B2
公开(公告)日：2011-03-08
申请号：US11954794
申请日：2007-12-12
申请人： Johannes F. de Boer , Guillermo J. Tearney , Brett Eugene Bouma
发明人： Johannes F. de Boer , Guillermo J. Tearney , Brett Eugene Bouma
IPC分类号： G01B11/02 , G01B9/02 , G01J3/45
CPC分类号： G01B9/02007 , A61B5/0059 , A61B5/0066 , A61B5/7257 , G01B9/02008 , G01B9/0201 , G01B9/02032 , G01B9/02044 , G01B9/02045 , G01B9/02079 , G01B9/0209 , G01B9/02091 , G01B2290/45 , G01N21/4795
摘要： Apparatus and method for increasing the sensitivity in the detection of optical coherence tomography and low coherence interferometry (“LCI”) signals by detecting a parallel set of spectral bands, each band being a unique combination of optical frequencies. The LCI broad bandwidth source is split into N spectral bands. The N spectral bands are individually detected and processed to provide an increase in the signal-to-noise ratio by a factor of N. Each spectral band is detected by a separate photo detector and amplified. For each spectral band the signal is band pass filtered around the signal band by analog electronics and digitized, or, alternatively, the signal may be digitized and band pass filtered in software. As a consequence, the shot noise contribution to the signal is reduced by a factor equal to the number of spectral bands. The signal remains the same. The reduction of the shot noise increases the dynamic range and sensitivity of the system.
摘要翻译：通过检测并行的一组光谱带来增加光学相干断层扫描和低相干干涉测量（“LCI”）信号的灵敏度的装置和方法，每个频带是光频率的唯一组合。 LCI宽带宽源分为N个频谱带。 N个光谱带被单独检测和处理，以使信噪比增加N倍。每个光谱带由单独的光检测器检测并被放大。对于每个光谱带，信号通过模拟电子装置在信号带周围进行带通滤波，并且被数字化，或者，信号可以被数字化并且在软件中进行带通滤波。结果，对信号的散粒噪声贡献减小了等于光谱带数的因子。信号保持不变。喷射噪声的降低增加了系统的动态范围和灵敏度。

23. 发明申请

US20090036770A1 METHOD AND APPARATUS FOR DETERMINATION OF ATHEROSCLEROTIC PLAQUE TYPE BY MEASUREMENT OF TISSUE OPTICAL PROPERTIES 有权
标题翻译：用于通过测量组织光学性质来确定角质层型的方法和装置
公开(公告)号：US20090036770A1
公开(公告)日：2009-02-05
申请号：US12188623
申请日：2008-08-08
申请人： Guillermo J. Tearney , Brett Eugene Bouma
发明人： Guillermo J. Tearney , Brett Eugene Bouma
IPC分类号： A61B5/05
CPC分类号： G01B9/02014 , A61B1/00165 , A61B5/0066 , A61B5/0084 , G01B9/02007 , G01B9/02072 , G01B9/02083 , G01B9/02088 , G01B9/02091 , G01B2290/70
摘要： Methods for diagnosing vulnerable atherosclerotic plaque using optical coherence tomography to measure tissue optical properties, including backreflectance of heterogeneous layers, such as plaque cap, lipid pool composition and macrophage presence. Methods also include measurement of spatially and temporally dependent reflectance, measurement of multiple wavelength reflectance, low coherence interferometry, polarization and quantification of macrophage content.
摘要翻译：使用光学相干断层扫描来诊断易受伤害的动脉粥样硬化斑块的方法来测量组织光学性质，包括异质层的后向反射，例如斑块盖，脂质池组成和巨噬细胞存在。方法还包括空间和时间依赖反射率的测量，多波长反射率的测量，低相干干涉测量，极化和巨噬细胞含量的定量。

24. 发明授权

US07366376B2 System and method for optical coherence imaging 有权
标题翻译：光学相干成像系统和方法
公开(公告)号：US07366376B2
公开(公告)日：2008-04-29
申请号：US11241907
申请日：2005-09-29
申请人： Milen Shishkov , Brett Eugene Bouma , Guillermo J. Tearney
发明人： Milen Shishkov , Brett Eugene Bouma , Guillermo J. Tearney
IPC分类号： G02B6/32 , G02B6/12 , G02B6/26 , G02B6/42 , G02B6/44 , G02B6/02 , G02B6/028 , G02B6/032 , G02B6/036
CPC分类号： H04J14/0267 , A61B5/0066 , A61B5/0084 , A61B5/6852 , G02B6/2552 , G02B6/262 , G02B6/2856
摘要： Apparatus and method are provided for transmitting at least one electro-magnetic radiation is provided. In particular, at least one optical fiber having at least one end extending along a first axis may be provided. Further, a light transmissive optical arrangement may be provided in optical cooperation with the optical fiber. The optical arrangement may have a first surface having a portion that is perpendicular to a second axis, and a second surface which includes a curved portion. The first axis can be provided at a particular angle that is more than 0° and less than 90° with respect to the second axis.
摘要翻译：提供了用于传送至少一个电磁辐射的装置和方法。特别地，可以提供至少一个具有沿着第一轴线延伸的至少一个端部的光纤。此外，可以与光纤光学协作地提供透光的光学装置。光学装置可以具有第一表面，其具有垂直于第二轴线的部分，以及包括弯曲部分的第二表面。第一轴可以相对于第二轴线以大于0°且小于90°的特定角度设置。

25. 发明授权

US07365859B2 System and method for optical coherence imaging 有权
标题翻译：光学相干成像系统和方法
公开(公告)号：US07365859B2
公开(公告)日：2008-04-29
申请号：US11225840
申请日：2005-09-12
申请人： Seok-Hyun Yun , Brett Eugene Bouma , Guillermo J. Tearney , Johannes F. deBoer
发明人： Seok-Hyun Yun , Brett Eugene Bouma , Guillermo J. Tearney , Johannes F. deBoer
IPC分类号： G01B11/02
CPC分类号： G01B9/02014 , G01B9/02004 , G01B9/02044 , G01B9/02069 , G01B9/02077 , G01B9/02091 , G01B2290/45 , G01B2290/70 , G01N21/4795
摘要： A system and method for imaging of a sample, e.g., biological sample, are provided. In particular, at least one source electro-magnetic radiation forwarded to the sample and a reference may be generated. A plurality of detectors may be used, at least one of the detectors capable of detecting a signal associated with a combination of at least one first electro-magnetic radiation received from the sample and at least one second electro-magnetic radiation received from the reference. At least one particular detector may have a particular electrical integration time, and can receive at least a portion of the signal for a time duration which has a first portion with a first power level greater than a predetermined threshold and a second portion immediately preceding or following the first portion. The second portion may have a second power level that is less than the predetermined threshold, and extends for a time period which may be, e.g., approximately more than 10% of the particular electrical integration time.
摘要翻译：提供了用于成像样品例如生物样品的系统和方法。特别地，可以产生转发到样品的至少一个源电磁辐射和参考。可以使用多个检测器，所述检测器中的至少一个检测器能够检测与从样本接收的至少一个第一电磁辐射的组合相关联的信号和从参考接收的至少一个第二电磁辐射。至少一个特定检测器可以具有特定的电积分时间，并且可以接收信号的至少一部分持续一段持续时间，该持续时间具有第一部分具有大于预定阈值的第一功率电平，以及紧接在之前或之后的第二部分第一部分。第二部分可以具有小于预定阈值的第二功率电平，并且延伸可以是例如大约超过特定电积分时间的10％的时间段。

26. 发明授权

US10534129B2 System and method providing intracoronary laser speckle imaging for the detection of vulnerable plaque 有权
公开(公告)号：US10534129B2
公开(公告)日：2020-01-14
申请号：US12058279
申请日：2008-03-28
申请人： Guillermo J. Tearney , Seemantini K. Nadkarni , Brett Eugene Bouma
发明人： Guillermo J. Tearney , Seemantini K. Nadkarni , Brett Eugene Bouma
IPC分类号： G02B6/04 , G02B6/06 , A61B1/00 , A61B5/00 , G02B6/32
摘要： Apparatus and method according to an exemplary embodiment of the present invention can be provided for analyzing tissue. For example, the apparatus can include at least one first arrangement configured to illuminate at least one anatomical structure with at least one of at least one electro-magnetic radiation. The apparatus can also include at least one second arrangement that may include at least two wave-guiding arrangements associated with one another that are configured to receive a further electro-magnetic radiation reflected from the tissue and transmit at least one speckle pattern associated with the further electro-magnetic radiation. The wave-guiding arrangements may be structured so as to reduce crosstalk therebetween.

27. 发明授权

US09897538B2 Method and apparatus for improving image clarity and sensitivity in optical coherence tomography using dynamic feedback to control focal properties and coherence gating 有权
公开(公告)号：US09897538B2
公开(公告)日：2018-02-20
申请号：US10136813
申请日：2002-04-30
申请人： Guillermo J. Tearney , Brett Eugene Bouma
发明人： Guillermo J. Tearney , Brett Eugene Bouma
IPC分类号： A61B5/00 , G01N21/47 , G01B9/02
CPC分类号： G01N21/4795 , A61B5/0066 , A61B5/0068 , A61B5/0084 , A61B5/6852 , A61B5/6853 , G01B9/0205 , G01B9/02063 , G01B9/02068 , G01B9/02083 , G01B9/02085 , G01B9/02091 , G01B2290/35
摘要： Methods for optical imaging, particularly with optical coherence tomography, using a low coherence light beam reflected from a sample surface and compared to a reference light beam, wherein real time dynamic optical feedback is used to detect the surface position of a tissue sample with respect to a reference point and the necessary delay scan range. The delay is provided by a tilting/rotating mirror actuated by a voltage adjustable galvanometer. An imaging probe apparatus for implementing the method is provided. The probe initially scans along one line until it finds the tissue surface, identifiable as a sharp transition from no signal to a stronger signal. The next time the probe scans the next line it adjusts the waveform depending on the previous scan. An algorithm is disclosed for determining the optimal scan range.

28. 发明授权

US09295391B1 Spectrally encoded miniature endoscopic imaging probe 有权
标题翻译：光谱编码微型内窥镜成像探头
公开(公告)号：US09295391B1
公开(公告)日：2016-03-29
申请号：US09709162
申请日：2000-11-10
申请人： Guillermo J. Tearney , Brett Eugene Bouma , Milen Stefanov Shishkov , Jonathan Jay Rosen
发明人： Guillermo J. Tearney , Brett Eugene Bouma , Milen Stefanov Shishkov , Jonathan Jay Rosen
IPC分类号： A61B6/00 , A61B5/00
CPC分类号： A61B5/0059 , A61B1/00096 , A61B1/0017 , A61B1/043 , A61B1/07 , A61B5/0062 , A61B5/0071 , A61B5/0084 , G02B21/0036 , G02B21/0048 , G02B21/0064
摘要： A spectrally encoded endoscopic probe having high resolution and small diameter comprising at least one flexible optical fiber; an energy source; a grating through which said energy is transmitted such that the energy spectrum is dispersed; a lens for focusing the dispersed energy spectrum onto a sample such that the impingement spot for each wavelength is a separate position on the sample, the wavelength spectrum defining a wavelength encoded axis; means for mechanically scanning the sample with focused energy in a direction perpendicular to the wavelength encoded axis; a means for receiving energy reflected from the sample; and, a means for detecting the received reflected energy. The probe grating and lens delivers a beam of multi-spectral light having spectral components extending in one dimension across a target region and which is moved to scan in another direction. The reflected spectrum is measured to provide two dimensional imaging of the region.
摘要翻译：一种具有高分辨率和小直径的光谱编码内窥镜探针，包括至少一个柔性光纤; 能源; 所述能量通过所述光栅传播，使得能谱被分散; 用于将分散的能谱聚焦到样品上的透镜，使得每个波长的冲击点是样品上的分离位置，所述波长谱定义波长编码轴; 用于在垂直于波长编码轴的方向上以聚焦能量机械扫描样品的装置; 用于接收样品反射的能量的方法; 以及用于检测所接收的反射能量的装置。探测光栅和透镜提供具有在一个维度上延伸穿过目标区域并且被移动以沿另一个方向扫描的光谱分量的多光谱光束。测量反射光谱以提供该区域的二维成像。

29. 发明授权

US08416818B2 Process and apparatus for a wavelength tuning source 有权
公开(公告)号：US08416818B2
公开(公告)日：2013-04-09
申请号：US13160335
申请日：2011-06-14
申请人： Brett Eugene Bouma , Seok-Hyun (Andy) Yun , Wang-Yuhl (William) Oh , Johannes F. De Boer , Guillermo J. Tearney
发明人： Brett Eugene Bouma , Seok-Hyun (Andy) Yun , Wang-Yuhl (William) Oh , Johannes F. De Boer , Guillermo J. Tearney
IPC分类号： H01S3/10
CPC分类号： G01J3/10 , A61B5/0059 , A61B5/0066 , G01B9/02004 , G01B9/02091 , G01J3/12 , G01J9/0215 , G01N21/4795 , G02B27/48 , H01S3/08009 , H01S3/08063 , H01S3/105 , H01S5/141 , H01S5/146 , H01S5/4087
摘要： An apparatus and source arrangement for filtering an electromagnetic radiation can be provided which may include at least one spectral separating arrangement configured to physically separate one or more components of the electromagnetic radiation based on a frequency of the electromagnetic radiation. The apparatus and source arrangement may also have at least one continuously rotating optical arrangement which is configured to receive at least one signal that is associated with the one or more components. Further, the apparatus and source arrangement can include at least one beam selecting arrangement configured to receive the signal.

30. 发明申请

US20120281237A1 SPECKLE REDUCTION IN OPTICAL COHERENCE TOMOGRAPHY BY PATH LENGTH ENCODED ANGULAR COMPOUNDING 有权
标题翻译：通过路径长度编码角度化合物进行光学相干光谱中的光谱减少
公开(公告)号：US20120281237A1
公开(公告)日：2012-11-08
申请号：US13465517
申请日：2012-05-07
申请人： Guillermo J. Tearney , Nicusor Iftimia , Brett Eugene Bouma
发明人： Guillermo J. Tearney , Nicusor Iftimia , Brett Eugene Bouma
IPC分类号： G01B9/02 , G02B27/12
CPC分类号： A61B5/0066 , A61B5/0059 , A61B5/6852 , G01B9/02028 , G01B9/02082 , G01B9/02087 , G01B9/02091 , G01J9/0215 , G01N21/4795 , G02B26/105 , G02B27/48
摘要： Accordingly, exemplary embodiments of an apparatus probe catheter and method can be provided for irradiating a structure. In particular, an interferometer may forward forwarding an electromagnetic radiation. In addition, a sample arm may receive the electromagnetic radiation, and can include an arrangement which facilitates a production of at least two radiations from the electromagnetic radiation so as to irradiate the structure. Such exemplary arrangement can be configured to delay a first radiation of the at least two radiations with respect to a second radiation of the at least two radiations.
摘要翻译：因此，可以提供用于照射结构的装置探针导管和方法的示例性实施例。具体地，干涉仪可以转发电磁辐射。此外，样品臂可以接收电磁辐射，并且可以包括便于从电磁辐射产生至少两个辐射以便照射结构的装置。这种示例性布置可以被配置为相对于至少两个辐射的第二辐射来延迟所述至少两个辐射的第一辐射。

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