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21. 发明授权

US5387720A Process for the production of acrolein 失效
标题翻译：丙烯醛生产工艺
公开(公告)号：US5387720A
公开(公告)日：1995-02-07
申请号：US151390
申请日：1993-11-12
申请人： Armin Neher , Thomas Haas , Dietrich Arntz , Herbert Klenk , Walter Girke
发明人： Armin Neher , Thomas Haas , Dietrich Arntz , Herbert Klenk , Walter Girke
IPC分类号： C07B61/00 , C07C45/52 , C07C47/22
CPC分类号： C07C45/52
摘要： A process for the production of acrolein by dehydration of glycerol in the liquid phase or in the gaseous phase, in each case on acidic solid catalysts, is described. Compared with previously known processes, the space-time yield and catalyst service life may be surprisingly increased with higher selectivity by treating a glycerol-water mixture with a glycerol content of 10 to 40 wt. % at 180.degree. to 340.degree. C. (liquid phase) or at 250.degree. to 340.degree. C. (gaseous phase) on a solid catalyst with an H.sub.o value (Hammett acidity function) of less than +2, preferably less than -3.
摘要翻译：描述了通过在液相或气相中，在各种情况下在酸性固体催化剂上脱水甘油来生产丙烯醛的方法。与先前已知的方法相比，通过用甘油含量为10-40重量％的甘油 - 水混合物处理，通过更高的选择性可以惊人地增加时空产率和催化剂使用寿命。在180℃至340℃（液相）下或在250℃至340℃（气相）下，在Ho值（哈米特酸度函数）小于+2，优选小于-3的固体催化剂上。

22. 发明授权

US4492793A Process for the production of 2-amino-5-mercapto-1,3,4-thiadiazole 失效
标题翻译： 2-氨基-5-巯基-1,3,4-噻二唑的制备方法
公开(公告)号：US4492793A
公开(公告)日：1985-01-08
申请号：US408131
申请日：1982-08-13
申请人： Herbert Klenk
发明人： Herbert Klenk
IPC分类号： C07D277/16 , C07D285/12 , C07D285/135
CPC分类号： C07D285/135
摘要： 2-Amino-5-mercapto-1,3,4-thiadiazoles can be produced in very high yields from thiosemicarbazides and carbon disulfide in aqueous phase by working in the presence of the corresponding ammonium salt of bis-2,5-mercapto-1,3,4-thiadiazole at a temperature above 40.degree. C. Preferably the process is carried out in the presence of the mother liquor from a previous reaction.
摘要翻译： 2-氨基-5-巯基-1,3,4-噻二唑可以通过在相应的双-2,5-巯基-1的铵盐存在下，从硫代氨基脲和二硫化碳在水相中以非常高的产率制备，3,4-二噻二唑在40℃以上的温度下进行。优选地，该方法在来自先前反应的母液的存在下进行。

23. 发明授权

US4490307A Process for the production of .beta.-mercaptopropionic acid derivatives 失效
标题翻译：生产β-巯基丙酸衍生物的方法
公开(公告)号：US4490307A
公开(公告)日：1984-12-25
申请号：US504422
申请日：1983-06-15
申请人： Herbert Klenk
发明人： Herbert Klenk
IPC分类号： C07C319/04 , C07C67/00 , C07C313/00 , C07C323/52 , C07C121/16 , C07C149/20 , C07C149/237
CPC分类号： C07C323/60 , C07C323/00
摘要： There is provided a process for the production of .beta.-mercaptopropionic acid and its esters and nitriles by reacting the corresponding acrylic acid derivatives with trithiocarbonates in aqueous solution.
摘要翻译：提供了通过使相应的丙烯酸衍生物与水溶液中的三硫代碳酸酯反应来生产β-巯基丙酸及其酯和腈的方法。

24. 发明授权

US4341709A Preparation of .epsilon.-caprolactone 失效
标题翻译： ε-己内酯的制备
公开(公告)号：US4341709A
公开(公告)日：1982-07-27
申请号：US150260
申请日：1980-05-15
申请人： Willi Hofen , Herbert Klenk , Gerd Schreyer , Otto Weiberg , Helmut Waldmann , Hermann Seifert , Karl-Hermann Reissinger , Wolfgang Swodenk
发明人： Willi Hofen , Herbert Klenk , Gerd Schreyer , Otto Weiberg , Helmut Waldmann , Hermann Seifert , Karl-Hermann Reissinger , Wolfgang Swodenk
IPC分类号： C07D313/04 , C07D315/00 , C07D313/02
CPC分类号： C07D315/00
摘要： A process for the preparation of .epsilon.-caprolactone comprising:(a) reacting cyclohexanone with a solution of perpropionic acid in an organic solvent at a molar ratio of cyclohexanone;perpropionic acid of about 1.1-5:1 at a temperature of about 10.degree. to 80.degree. C. to form a reaction mixture consisting essentially of .epsilon.-caprolactone, propionic acid and organic solvent,(b) distilling the reaction mixture from (a) in a first distillation unit to obtain a distillate comprising the organic solvent and a distillation residue,(c) introducing the distillation residue from (b) at a point into a second distillation unit to obtain a distillate comprising propionic acid and unreacted cyclohexanone, removing from the second distillation unit, separately from one another and at a point below the point of introduction into the second distillation unit, .epsilon.-caprolactone and any high-boiling constituents, and,(d) distilling in a third distillation unit the distillate from (c) to obtain a distillate consisting essentially of propionic acid and a distillation residue comprising a mixture of propionic acid and cyclohexanone.
摘要翻译：一种制备ε-己内酯的方法，包括：（a）使环己酮与过丙酸在有机溶剂中的溶液以环己酮的摩尔比约1.1-5:1的约0.1〜5:1的摩尔比在约10℃〜形成基本上由ε-己内酯，丙酸和有机溶剂组成的反应混合物，（b）在第一蒸馏单元中将反应混合物从（a）中蒸馏，得到包含有机溶剂和蒸馏残余物的馏出物（c）在一点将来自（b）的蒸馏残余物引入第二蒸馏单元以获得包含丙酸和未反应的环己酮的馏出物，从第二蒸馏单元彼此分离并在低于引入第二蒸馏装置，ε-己内酯和任何高沸点组分，和（d）在第三蒸馏装置中蒸馏出馏出物（c）得到基本上由丙酸组成的馏出物和包含丙酸和环己酮的混合物的蒸馏残渣。

25. 发明授权

US4209461A Process for the production of benzoyl cyanide (I) 失效
标题翻译：苯甲酰氰（I）的制备方法
公开(公告)号：US4209461A
公开(公告)日：1980-06-24
申请号：US965691
申请日：1978-12-01
申请人： Herbert Klenk , Theodor Lussling , Alfred Maierhofer , Heribert Offermanns , Hans Wagner
发明人： Herbert Klenk , Theodor Lussling , Alfred Maierhofer , Heribert Offermanns , Hans Wagner
IPC分类号： C07B61/00 , B01J31/00 , B01J31/02 , C07C20060101 , C07C63/06 , C07C67/00 , C07C253/00 , C07C253/14 , C07C255/40 , C07C255/56
CPC分类号： C07C253/14
摘要： The process described in Klenk U.S. Pat. No. 4,113,773 is improved by employing alkali metal cyanide in which at least half of the alkali metal cyanide has a particle size below 0.4 mm and the remainder has a particle size below 1.0 mm.
摘要翻译： Klenk美国专利中描述的方法碱金属氰化物其中至少一半的碱金属氰化物的粒度小于0.4mm，其余的粒径小于1.0mm，改善了No.4,113,773。

26. 发明授权

US4360682A Stabilizing caprolactones with dihydroxybenzenes 失效
标题翻译：用二羟基苯稳定己内酯
公开(公告)号：US4360682A
公开(公告)日：1982-11-23
申请号：US148869
申请日：1980-05-12
申请人： Herbert Klenk , Rolf Wirthwein , Helmut Waldmann , Hermann Seifert
发明人： Herbert Klenk , Rolf Wirthwein , Helmut Waldmann , Hermann Seifert
IPC分类号： C07D313/04 , C07D315/00
CPC分类号： C07D315/00
摘要： Caprolactones such as .epsilon.-caprolactone are stabilized against discoloration with dihydroxybenzenes such as hydroquinone or compounds of the formula ##STR1## in which R.sub.1 is alkyl of 1 to 8 carbon atoms, andR.sub.2 is hydrogen or alkyl of 1 to 8 carbon atoms.Even the presence of air is not detrimental.
摘要翻译：己内酯如ε-己内酯通过二羟基苯如氢醌或其中R 1为1至8个碳原子的烷基，且R 2为氢或1至8个碳原子的烷基的式“IMAGE”的化合物稳定化。即使空气的存在也不是有害的。

27. 发明授权

US4175188A Process for the production of 1,2,4-triazin-5-one derivatives 失效
标题翻译：制备1,2,4-三嗪-5-酮衍生物的方法
公开(公告)号：US4175188A
公开(公告)日：1979-11-20
申请号：US924062
申请日：1978-07-12
申请人： Herbert Klenk , Werner Schwarze , Wolfgang Leuchtenberger
发明人： Herbert Klenk , Werner Schwarze , Wolfgang Leuchtenberger
IPC分类号： C07D253/06 , A01N43/707 , C07D253/075
CPC分类号： C07D253/075 , A01N43/707
摘要： 1,2,4-triazin-5-one compounds of the general formula (I) ##STR1## where R is ##STR2## are prepared by reacting a compound of general formula (II) ##STR3## in which R is defined above with either (a) a tertiary alcohol of general formula (III)HO--R' (III) in which R' is a t-alkyl group having 4 to 18 carbon atoms, especially t-amyl or t-octyl or preferably t-butyl or(b) an alkene of general formula (IV) ##STR4## in which R.sub.1 and R.sub.2 are the same or different and are hydrogen or an alkyl group and R.sub.3 and R.sub.4 are the same or different and wherein the alkyl groups in each case can be 1 to 15 carbon atoms and wherein preferably R.sub.1 and R.sub.2 are hydrogen and R.sub.3 and R.sub.4 each are methyl to form an .alpha.-ketocarboxylic acid amide of general formula (V) ##STR5## and this, in a given case after previous saponification to the free acid, condensed with thiocarbohydrazide ##STR6## to form a 1,2,4-triazin-5-one compound of general formula (VI) ##STR7## and then the mercapto group is methylated.
摘要翻译：通式（I）的化合物通过使通式（II）的化合物（II）的化合物在其中R定义如上：（a）通式（III）的叔醇HO-R'（III），其中R'是具有4至18个碳原子的叔烷基，特别是叔戊基或t- 辛基或优选叔丁基或（b）通式（IV）的烯烃其中R 1和R 2相同或不同，为氢或烷基，且R 3和R 4相同或不同并且其中每种情况下的烷基可以是1至15个碳原子，并且其中优选地，R 1和R 2是氢，并且R 3和R 4各自是甲基，形成通式（V）的α-酮羧酸酰胺。并且在给定情况下，在先前皂化成游离酸后，与硫代碳酰肼“IMAGE”缩合形成通式（VI）的化合物VI（VI），然后巯基是甲基 ted。

28. 发明授权

US4144269A Process for the production of benzoyl cyanide (IV) 失效
标题翻译：生产苯甲酰氰（IV）的方法
公开(公告)号：US4144269A
公开(公告)日：1979-03-13
申请号：US802943
申请日：1977-06-02
申请人： Herbert Klenk , Theodor Lussling , Alfred Maierhofer , Heribert Offermanns , Hans Wagner
发明人： Herbert Klenk , Theodor Lussling , Alfred Maierhofer , Heribert Offermanns , Hans Wagner
IPC分类号： C07B61/00 , B01J31/00 , B01J31/02 , C07C20060101 , C07C51/54 , C07C67/00 , C07C253/00 , C07C253/14 , C07C255/33 , C07C255/40 , C07C255/50 , C07C255/56 , C07C120/00
CPC分类号： C07C253/14
摘要： Benzoyl cyanide is made from benzoyl chloride and an alkali metal cyanide in a two phase system comprising water and an inert organic solvent which has only slight miscibility with water in the presence of a tertiary amine and hydrogen cyanide.
摘要翻译：苯甲酰氰由含有水和惰性有机溶剂的两相体系中的苯甲酰氯和碱金属氰化物制成，其在叔胺和氰化氢的存在下与水仅具有轻微的混溶性。

29. 发明授权

US4122116A Substituted cyclopropyl glyoxylnitriles 失效
标题翻译：取代的环丙基乙醛腈
公开(公告)号：US4122116A
公开(公告)日：1978-10-24
申请号：US880483
申请日：1978-02-23
申请人： Herbert Klenk , Heribert Offermanns , Werner Schwarze
发明人： Herbert Klenk , Heribert Offermanns , Werner Schwarze
IPC分类号： C07C255/45 , C07C255/56 , C07D307/54 , C07C61/00 , C07C51/00 , C07C121/46
CPC分类号： C07C253/14 , C07D307/54
摘要： There are prepared acyl cyanides of the formula ##STR1## where R is a straight or branched chain alkyl group having 1 to 18 carbon atoms, preferably 1 to 10 carbon atoms, and which also can be substituted by one or more phenyl groups or halogen atoms, preferably chlorine, or R is preferably a cycloalkyl group having 3 to 8 carbon atoms, preferably cyclopropyl, which can have one or more 1 to 3 carbon atoms alkyl or halogen, preferably chlorine, substituents wherein in all of the above set forth substitutions the halogen atoms and the phenyl groups are not on the carbon atom adjacent to the carbonyl group or R is a substituted phenyl group, a naphthyl group, a substituted naphthyl group or a five membered heterocyclic group, e.g., furyl, thienyl or alkyl substituted thienyl wherein the substituents on the phenyl or naphthyl are halogen atoms, nitro groups or alkyl or alkoxy groups having 1 to 5 carbon atoms. The process comprises reacting and acyl halide of the formulaR--CO--Hal (II)in which R is as defined above and Hal is a chlorine or bromine atoms, with CuCN at a temperature of about 50.degree. to 180.degree. C in the presence of a carboxylic acid nitrile inert under the reaction conditions, there being employed about 1 to 10 parts by weight of the carboxylic acid nitrile and about 0.5 to 20 parts by weight of at least one organic solvent which is inert under the reaction conditions. Certain of the compounds are novel per se.
摘要翻译：制备式（I）的酰基氰化物，其中R是具有1至18个碳原子，优选1至10个碳原子的直链或支链烷基，并且也可被一个或多个苯基取代或卤素原子，优选氯，或R优选为具有3至8个碳原子的环烷基，优选环丙基，其可以具有一个或多个1至3个碳原子的烷基或卤素，优选氯，取代基，其中在所有上述定义卤素原子和苯基不在与羰基相邻的碳原子上，或者R是取代的苯基，萘基，取代的萘基或五元杂环基，例如呋喃基，噻吩基或烷基取代的噻吩基，其中苯基或萘基上的取代基是卤素原子，硝基或具有1至5个碳原子的烷基或烷氧基。该方法包括在存在下将式R-CO-Hal（II）的酰卤与其中R定义如上和Hal为氯或溴原子的酰卤与CuCN在约50-180℃的温度下反应，的在反应条件下为惰性的羧酸腈，使用约1-10重量份的羧酸腈和约0.5-20重量份的至少一种在反应条件下为惰性的有机溶剂。某些化合物本身是新颖的。

30. 发明授权

US4108877A Process for the production of acyl cyanides (A) 失效
标题翻译：酰基氰的制备方法（A）
公开(公告)号：US4108877A
公开(公告)日：1978-08-22
申请号：US802944
申请日：1977-06-02
申请人： Herbert Klenk , Heribert Offermanns , Werner Schwarze
发明人： Herbert Klenk , Heribert Offermanns , Werner Schwarze
IPC分类号： C07C67/00 , C07C253/00 , C07C253/14 , C07C255/16 , C07C255/17 , C07C255/18 , C07C255/31 , C07C255/40 , C07C255/45 , C07C255/53 , C07C255/56 , C07D307/06 , C07D307/38 , C07D307/46 , C07D307/54 , C07D307/56 , C07D333/16 , F28F3/00 , C07D307/36 , C07C57/00 , C07C63/06
CPC分类号： C07C255/00 , C07C253/14 , C07D307/54
摘要： There are prepared acyl cyanides of the formula ##STR1## where R is a straight or branched chain alkyl group having 1 to 18 carbon atoms, preferably 1 to 10 carbon atoms, and which also can be substituted by one or more phenyl groups or halogen atoms, preferably chlorine, or R is preferably a cycloalkyl group having 3 to 8 carbon atoms, preferably cyclopropyl, which can have one or more 1 to 3 carbon atom alkyl or halogen, preferably chlorine, substituents wherein in all of the above set forth substitutions the halogen atoms and the phenyl groups are not on the carbon atom adjacent to the carbonyl group or R is a substituted phenyl group, a naphthyl group, a substituted naphthyl group or a five membered heterocyclic group, e.g., furyl, thienyl or alkyl substituted thienyl, wherein the substituents on the phenyl or naphthyl are halogen atoms, nitro groups or alkyl or alkoxy groups having 1 to 5 carbon atoms. The process comprises reacting an acyl halide of the formulaR -- Co -- Hal (II)in which R is as defined above and Hal is a chlorine or bromine atom, with CuCN at a temperature of about 50.degree. to 180.degree. C in the presence of a carboxylic acid nitrile inert under the reaction conditions, there being employed about 1 to 10 parts by weight of the carboxylic acid nitrile and about 0.5 to 20 parts by weight of at least one organic solvent which is inert under the reaction conditions. Certain of the compounds are novel per se.
摘要翻译：制备式（I）的酰基氰化物，其中R是具有1至18个碳原子，优选1至10个碳原子的直链或支链烷基，并且也可被一个或多个苯基取代或卤素原子，优选氯，或R优选为具有3至8个碳原子的环烷基，优选环丙基，其可以具有一个或多个1至3个碳原子的烷基或卤素，优选氯，取代基，其中在上述所有卤素原子和苯基不在与羰基相邻的碳原子上，或者R是取代的苯基，萘基，取代的萘基或五元杂环基，例如呋喃基，噻吩基或烷基取代的噻吩基，其中苯基或萘基上的取代基是卤素原子，硝基或具有1-5个碳原子的烷基或烷氧基。该方法包括使式R-Co-Hal（II）的酰卤，其中R如上所定义，Hal是氯或溴原子，与CuCN在约50-180℃的温度下反应，的在反应条件下为惰性的羧酸腈，使用约1-10重量份的羧酸腈和约0.5-20重量份的至少一种在反应条件下为惰性的有机溶剂。某些化合物本身是新颖的。

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