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    • 24. 发明申请
    • Method of designing circuit board
    • 电路板设计方法
    • US20060040532A1
    • 2006-02-23
    • US11019156
    • 2004-12-23
    • Kaname OzawaMitsutaka SatoTetsuya FujisawaYoshiyuki YonedaRyuji NomotoYoshitaka Aiba
    • Kaname OzawaMitsutaka SatoTetsuya FujisawaYoshiyuki YonedaRyuji NomotoYoshitaka Aiba
    • H01R13/648
    • G06F17/5068H05K3/0005
    • A method of design of a circuit board enabling high density conductor lines to be drawn efficiently. A rats nest is formed by connecting pads to which terminals of an electronic device are connected and external connection terminals by lines. A region with the highest density of lines of the rats nest is then selected and design rules relating to routes and dimensions of conductor lines are set in the region with the highest density of lines of the rats nest. Conductor lines are then laid at the region with the highest density of lines of the rats nest, and whether or not the conductor lines can be laid at the region with the highest density of lines of the rats nest is confirmed. Setting of the design rules and laying of conductor lines are if the conductor lines cannot be laid, and the conductor lines of the remaining regions are laid by the set design rules if the conductor lines can be laid.
    • 一种能够高效率地绘制高密度导线的电路板的设计方法。 大鼠巢通过连接电子装置的端子的连接垫和通过线路的外部连接端子形成。 然后选择大鼠巢线密度最高的区域,并且在具有最大密度的大鼠巢的区域中设置与导线的路线和尺寸相关的设计规则。 然后将导体线放置在具有最高密度的大鼠巢的区域,并且确定导线是否可以放置在具有最大密度的大鼠巢的密度的区域。 如果导体线不能铺设,则设计规则和布线的设置,如果可以铺设导线,则通过设定的规则布置其余区域的导体线。
    • 25. 发明申请
    • Method to ameliorate osteolysis and metastasis
    • 改善骨质溶解和转移的方法
    • US20050244414A1
    • 2005-11-03
    • US11109470
    • 2005-04-18
    • Gregory MundyYoshiyuki YonedaTheresa Guise
    • Gregory MundyYoshiyuki YonedaTheresa Guise
    • C12N15/09A61K9/08A61K31/66A61K31/675A61K38/00A61K39/395A61K45/06A61P35/00A61P43/00C07K16/22C07K16/24C07K16/26C12P21/08A61K31/663
    • C07K16/244A61K38/00A61K45/06C07K16/22C07K16/241C07K16/26
    • A therapeutically effective amount of an antibody for a compound selected from the group consisting of PTHrp, TGFα, IL-1α, IL-1β, IL-6, Lymphotoxin, TNF, PGE; 1,25 dihydroxy vitamin D3 and an antigenic fragment thereof used in the treatment of cancer metastasis to bone and cancer cell growth in bone as well as osteolysis and symptomatic sequelae thereof. An antibody immunoreactive with parathyroid hormone-related protein (PTHrp) is particularly preferred. Antibodies with human characteristics are included in the invention for application of the invention method to human subjects. Also, the antibody can be administered in an injectable is formulation in combination with a therapeutically effective amount of a bisphosphonate or pyrophosphate having the general structure formula wherein X is a linking moiety allowing for the interconnection of the phosphonate groups, and pharmaceutically acceptable salts, hydrates and partial hydrates thereof. The antibody and bisphosphonate act synergistically in the treatment of cancer metastases to bone and symptomatic sequelae thereof and particularly as regards bone resorption.
    • 治疗有效量的选自PTHrp,TGFα,IL-1α,IL-1β,IL-6,淋巴毒素,TNF,PGE的化合物的抗体; 1,25二羟基维生素D 3及其抗原性片段用于治疗癌症转移至骨骼和骨细胞中的癌细胞,以及骨溶解及其症状后遗症。 与甲状旁腺激素相关蛋白(PTHrp)免疫反应的抗体是特别优选的。 具有人类特征的抗体包括在本发明中,用于将本发明方法应用于人类受试者。 此外,抗体可以以可注射的制剂与治疗有效量的具有以下通式结构式的二膦酸盐或焦磷酸盐组合施用:其中X是允许膦酸酯基团互连的连接部分,以及药学上可接受的盐,水合物 和其部分水合物。 抗体和双膦酸盐协同作用于治疗癌症转移至骨骼及其有症状的后遗症,特别是关于骨吸收。