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21. 发明授权

US07847243B2 Ion trapping 有权
标题翻译：离子捕获
公开(公告)号：US07847243B2
公开(公告)日：2010-12-07
申请号：US11909850
申请日：2006-03-29
申请人： Alexander Alekseevich Makarov , Eduard V. Denisov , Gerhard Jung , Robert Malek , Oliver Lange
发明人： Alexander Alekseevich Makarov , Eduard V. Denisov , Gerhard Jung , Robert Malek , Oliver Lange
IPC分类号： H01J49/00
CPC分类号： H01J49/423 , H01J49/004 , H01J49/425 , H01J49/4295
摘要： This invention relates to a method of trapping ions and to an ion trapping assembly. In particular, the present invention has application in gas-assisted trapping of ions in an ion trap prior to a mass analysis of the ions in a mass spectrometer. The invention provides a method of trapping ions in a target ion trap of an ion trapping assembly that comprises a series of volumes arranged such that ions can traverse from one volume to the next, the volumes including the target ion trap, whereby ions are allowed to pass repeatedly through the volumes such that they also pass into and out from the target ion trap without being trapped. Potentials may be used to reflect the ions from respective ends of the ion trapping assembly. Optionally, a potential well and/or gas-assisted cooling may be used to cause the ions to settle in the target ion trap.
摘要翻译：本发明涉及一种捕获离子和离子捕获组件的方法。特别地，本发明在质谱仪中对离子的质量分析之前，已经将其应用于离子阱中的气体辅助捕获。本发明提供了一种捕集离子捕获组件的靶离子阱中的离子的方法，该离子捕获组件包括一系列体积，这些体积被布置成使得离子可以从一个体积向下一个体积穿过，包括靶离子阱，其中离子被允许反复通过体积，使得它们也被进入和离开目标离子阱而不被捕获。电位可用于从离子捕获组件的相应末端反射离子。任选地，潜在的井和/或气体辅助冷却可用于使离子沉淀在目标离子阱中。

22. 发明申请

US20100271631A1 Sample Excitation Apparatus and Method for Spectroscopic Analysis 有权
标题翻译：样品激发装置和光谱分析方法
公开(公告)号：US20100271631A1
公开(公告)日：2010-10-28
申请号：US12810222
申请日：2008-12-23
申请人： Hans-Jürgen Schlüter , Robert Malek
发明人： Hans-Jürgen Schlüter , Robert Malek
IPC分类号： H01J49/04 , H01J49/10 , G01J3/30
CPC分类号： G01N21/714 , G01J3/443 , G01N21/72 , G01N21/73 , H01J49/105 , H01J49/165
摘要： Sample excitation apparatus for a spectrometric analyser, the apparatus comprising a sample introduction stage comprising an electrospray nebuliser for generating a nebulised sample; and a sample excitation stage arranged to operate in an atmospheric pressure environment and to receive and excite the nebulised sample in a sample excitation region for spectrometric analysis thereof. ‘Excitation’ includes ionisation in ICP and MIP, flame excitation in AES, and optical excitation in AAS. For example, analyte solution (38) is fed out of the outlet end of a capillary (30,40,60,96), to a plasma source. A potential difference is applied between the capillary, its outlet end or the analyte solution and an opposing effective (counter) electrode, which may comprise a tube (64), a grid (80), or the plasma (34) itself, to promote formation of smaller droplets (46). The pressure of the plasma source is similar to the pressure in the region of the capillary outlet end.
摘要翻译：用于光谱分析仪的样品激发装置，该装置包括样品引入级，其包括用于产生雾化样品的电喷雾雾化器; 以及样品激发级，被布置成在大气压环境中操作并且接收和激发样品激发区域中的雾化样品用于其光谱分析。 “激发”包括ICP和MIP中的电离，AES中的火焰激发和AAS中的光激发。例如，将分析物溶液（38）从毛细管（30,40,60,96）的出口端送出到等离子体源。毛细管，其出口端或分析物溶液之间的潜在差异以及可包括管（64），网格（80）或等离子体（34）本身的相对的有效（反向）电极，以促进形成较小的液滴（46）。等离子体源的压力类似于毛细管出口端的区域中的压力。

23. 发明授权

US07657387B2 Method of processing and storing mass spectrometry data 有权
标题翻译：处理和储存质谱数据的方法
公开(公告)号：US07657387B2
公开(公告)日：2010-02-02
申请号：US10573395
申请日：2004-09-23
申请人： Robert Malek , Oliver Lange
发明人： Robert Malek , Oliver Lange
IPC分类号： G06F17/00
CPC分类号： H01J49/0036 , H03M7/30
摘要： A data compression technique is disclosed for Fourier Transform Mass Spectrometry (FTMS). A statistical analysis is applied to the data in the frequency domain since most of this data is a result of randomly distributed electronic noise. A fit of the whole frequency dataset to the distribution is made to determine preliminary moments of the distribution. The data in the tail of that distribution (which is mainly the peak data) is then removed and the remaining data points are re-fitted to the distribution, to identify the moments of distribution of that remaining noise data. A noise threshold for the mass spectrum is then applied using the calculated moments. The data above the threshold is kept. The whole spectrum can be reconstituted by storing the moments of distribution along with the peak data and then regenerating the noise from those moments and adding it to the peak data.
摘要翻译：公开了用于傅立叶变换质谱（FTMS）的数据压缩技术。对频域中的数据进行统计分析，因为这些数据大部分是随机分布的电子噪声的结果。将整个频率数据集合到分布上进行确定分布的初步时刻。然后删除该分布尾部的数据（主要是峰值数据），并将剩余的数据点重新拟合到分布中，以识别该剩余噪声数据的分布时刻。然后使用计算的时刻应用质谱的噪声阈值。保持阈值以上的数据。可以通过将分布的时刻与峰值数据一起存储，然后从那些时刻再生噪声并将其加到峰值数据来重构整个频谱。

24. 发明授权

US06987261B2 Controlling ion populations in a mass analyzer 有权
标题翻译：在质量分析仪中控制离子群体
公开(公告)号：US06987261B2
公开(公告)日：2006-01-17
申请号：US10763401
申请日：2004-01-23
申请人： Stevan Horning , Robert Malek , John E. P. Syka , Andreas Wieghaus
发明人： Stevan Horning , Robert Malek , John E. P. Syka , Andreas Wieghaus
IPC分类号： H01J49/00
CPC分类号： H01J49/4265
摘要： Method and apparatus of controlling an ion population to be analyzed in a mass analyzer. Ions are accumulated for an injection time interval determined as a function of an ion accumulation rate and a predetermined desired population of ions. The accumulation rate represents a flow rate of ions from a source of ions into an ion accumulator. Ions derived from the accumulated ions are introduced into the mass analyzer for analysis.
摘要翻译：控制在质量分析仪中分析离子群体的方法和装置。以作为离子累积速率和预定的期望离子群的函数确定的注入时间间隔累积离子。累积速率表示离子从离子源到离子蓄能器的流速。从积聚的离子得到的离子被引入质量分析器进行分析。

25. 发明申请

US20220121814A1 PARSING IMPLICIT TABLES 有权
公开(公告)号：US20220121814A1
公开(公告)日：2022-04-21
申请号：US17478948
申请日：2021-09-19
申请人： Mark Rosno , Patrick Deziel , Christopher Korzenowski , Rebecca Bilbro , Kelsey L. Bruso , Robert Malek
发明人： Mark Rosno , Patrick Deziel , Christopher Korzenowski , Rebecca Bilbro , Kelsey L. Bruso , Robert Malek
IPC分类号： G06F40/205 , G06F16/93 , G06F16/245
摘要： A method of parsing implicit tables within a document includes parsing, by a processor, a document to determine a pattern for a set of text that sets apart the information contained therein from the rest of the text; determining, by the processor, from the pattern of spacing, a first descriptive phrase and a second descriptive phrase; and assigning, by the processor, the first descriptive phrase as an action and the second descriptive phrase as a trigger.

26. 发明申请

US20220121666A1 CREATING A TRAINED DATABASE 有权
公开(公告)号：US20220121666A1
公开(公告)日：2022-04-21
申请号：US17478947
申请日：2021-09-19
申请人： Mark Rosno , Patrick Deziel , Christopher Korzenowski , Rebecca Bilbro , Kelsey L. Bruso , Robert Malek
发明人： Mark Rosno , Patrick Deziel , Christopher Korzenowski , Rebecca Bilbro , Kelsey L. Bruso , Robert Malek
IPC分类号： G06F16/2453 , G06F16/2457 , G06F16/93 , G06N3/08 , G06F40/40
摘要： A method of creating a trained database from a document corpus includes creating a tailored neural network for the document corpus by using sentences to create word-level association and sentence-level association; and applying action-trigger phrase sets, created front the document corpus independent of creating the tailored neural network, to the tailored neural network to create a trained database; wherein processing a query through the trained database, rather than the document corpus, increases the speed of processing the query and increases the accuracy of the result.

27. 发明授权

US08288714B2 Ion trapping 有权
标题翻译：离子捕获
公开(公告)号：US08288714B2
公开(公告)日：2012-10-16
申请号：US12944357
申请日：2010-11-11
申请人： Alexander A. Makarov , Eduard V. Denisov , Gerhard Jung , Robert Malek , Oliver Lange
发明人： Alexander A. Makarov , Eduard V. Denisov , Gerhard Jung , Robert Malek , Oliver Lange
IPC分类号： H01J49/00
CPC分类号： H01J49/423 , H01J49/004 , H01J49/425 , H01J49/4295
摘要： This invention relates to a method of trapping ions and to an ion trapping assembly. In particular, the present invention has application in gas-assisted trapping of ions in an ion trap prior to a mass analysis of the ions in a mass spectrometer. The invention provides a method of trapping ions in a target ion trap of an ion trapping assembly that comprises a series of volumes arranged such that ions can traverse from one volume to the next, the volumes including the target ion trap, whereby ions are allowed to pass repeatedly through the volumes such that they also pass into and out from the target ion trap without being trapped. Potentials may be used to reflect the ions from respective ends of the ion trapping assembly. Optionally, a potential well and/or gas-assisted cooling may be used to cause the ions to settle in the target ion trap.
摘要翻译：本发明涉及一种捕获离子和离子捕获组件的方法。特别地，本发明在质谱仪中对离子的质量分析之前，已经将其应用于离子阱中的气体辅助捕获。本发明提供了一种捕获离子捕获组件的靶离子阱中的离子的方法，该方法包括一系列体积排列使得离子可以从一个体积向下一个体积横越，该体积包括目标离子阱，从而使离子被允许反复通过体积，使得它们也被进入和离开目标离子阱而不被捕获。电位可用于从离子捕获组件的相应末端反射离子。任选地，潜在的井和/或气体辅助冷却可用于使离子沉淀在目标离子阱中。

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