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21. 发明申请

US20120116179A1 TECHNIQUES FOR DATA RETENTION UPON DETECTION OF AN EVENT IN AN IMPLANTABLE MEDICAL DEVICE 有权
标题翻译：在可移植医疗设备中检测事件的数据保留技术
公开(公告)号：US20120116179A1
公开(公告)日：2012-05-10
申请号：US13349404
申请日：2012-01-12
申请人： Touby A. Drew , Jonathon E. Giftakis , David L. Carlson , Eric J. Panken , Jonathan C. Werder , Nina M. Graves
发明人： Touby A. Drew , Jonathon E. Giftakis , David L. Carlson , Eric J. Panken , Jonathan C. Werder , Nina M. Graves
IPC分类号： A61B5/00 , G06F12/02
CPC分类号： A61B5/4094 , A61B5/0006 , A61B5/0031 , A61B5/02055 , A61B5/021 , A61B5/024 , A61B5/031 , A61B5/04001 , A61B5/04012 , A61B5/0402 , A61B5/0476 , A61B5/0816 , A61B5/1118 , A61B5/165 , A61B5/4082 , A61B5/686 , A61B5/7232 , A61B5/7282 , A61N1/36132 , A61N1/36135 , A61N1/36521 , A61N1/36585 , A61N1/3702 , A61N1/37252 , A61N1/37282 , G06F17/30336 , G06F19/00 , G06F19/3418 , G16H10/60 , G16H40/63
摘要： Methods and apparatus for storing data records associated with a medical monitoring event in a data structure. These include initiating loop recording in an implantable medical device upon determination of a neurological event, wherein loop recording comprises storing a data record of a plurality of data records in a data structure, the plurality of data records representing information about determined neurological events. Methods and apparatus can further include determining a priority index for the plurality of data records based on severity levels of the determined neurological events and replacing older data records of the plurality of data records on the data structure with new data records according to the priority index, wherein the new data records selectively replace those data records in the data structure having the lowest associated priority index.
摘要翻译：用于存储与数据结构中的医疗监视事件相关联的数据记录的方法和装置。这些包括在确定神经学事件时在可植入医疗装置中启动循环记录，其中循环记录包括将多个数据记录的数据记录存储在数据结构中，所述多个数据记录表示关于确定的神经系统事件的信息。方法和装置还可以包括基于所确定的神经病学事件的严重性水平确定多个数据记录的优先级索引，并根据优先级索引用新的数据记录替换数据结构上的多个数据记录的较旧的数据记录，其中新数据记录选择性地替换具有最低相关优先级索引的数据结构中的那些数据记录。

22. 发明申请

US20110166471A1 Patient Event Marking in Combination with Physiological Signals 审中-公开
标题翻译：患者事件标记与生理信号结合
公开(公告)号：US20110166471A1
公开(公告)日：2011-07-07
申请号：US13050659
申请日：2011-03-17
申请人： Touby A. Drew , Jonathon E. Giftakis , Nina M. Graves
发明人： Touby A. Drew , Jonathon E. Giftakis , Nina M. Graves
IPC分类号： A61B5/0476
CPC分类号： A61B5/04 , A61B5/0006 , A61B5/0031 , A61B5/04001 , A61B5/04012 , A61B5/4094 , A61B5/7232 , A61N1/36132 , A61N1/36521 , A61N1/36585 , A61N1/3702 , A61N1/37252 , A61N1/37282 , A61N1/3925 , G06F19/3418 , G16H10/60 , G16H40/63 , G16H50/70
摘要： Methods for receiving a patient mark in an implanted device. A patient may experience symptoms that indicative of a neurological event or are common precursors to more severe clinical symptoms. The patient may activate a patient activator. Activation of the patient activator can cause the patient activator to transmit the patient mark to an implanted device. The implanted device may adjust physiological data being stored in response to the patient mark, including data before and after the patient mark. The patient mark may be used to time tune the detection algorithms and otherwise tune the detection capability of the implanted device and may also be used as an aid in statistical analysis of the stored physiological data.
摘要翻译：用于在植入装置中接收患者标记的方法。患者可能会出现指示神经系统事件的症状，或者是更严重临床症状的常见前兆。患者可能激活患者激活剂。患者激活剂的激活可导致患者活化剂将患者标记传递到植入装置。植入装置可以响应于患者标记调整存储的生理数据，包括患者标记之前和之后的数据。可以使用患者标记来对检测算法进行时间调整，否则调整植入装置的检测能力，并且还可以用作对存储的生理数据的统计分析的辅助。

23. 发明申请

US20100292753A1 Method and Apparatus for Detection of Nervous System Disorders 审中-公开
标题翻译：用于检测神经系统疾病的方法和装置
公开(公告)号：US20100292753A1
公开(公告)日：2010-11-18
申请号：US12816055
申请日：2010-06-15
申请人： David L. Carlson , Eric J. Panken , Touby A. Drew , Jonathan C. Werder
发明人： David L. Carlson , Eric J. Panken , Touby A. Drew , Jonathan C. Werder
IPC分类号： A61N1/36
CPC分类号： A61B5/0478 , A61B5/4094 , A61B5/7221 , A61B5/7275 , A61N1/36082 , G16H20/30 , G16H40/63 , G16H40/67 , G16H50/20
摘要： Systems and methods for detecting and/or treating nervous system disorders, such as seizures. Certain embodiments of the invention relate generally to implantable medical devices (IMDs) adapted to detect and treat nervous system disorders in patients with an IMD. Certain embodiments of the invention include detection of seizures based upon comparisons of long-term and short-term representations of physiological signals. Other embodiments include prediction of seizure activity based upon analysis of physiological signal levels. An embodiment of the invention monitors the quality of physiological signals, and may be able to compensate for signals of low signal quality. A further embodiment of the invention includes detection of seizure activity following the delivery of therapy.
摘要翻译：用于检测和/或治疗神经系统疾病例如癫痫发作的系统和方法。本发明的某些实施方案一般涉及适于检测和治疗患有IMD的患者的神经系统疾病的可植入医疗装置（IMD）。本发明的某些实施方案包括基于生理信号的长期和短期表示的比较来检测癫痫发作。其他实施方案包括基于生理信号水平的分析预测癫痫发作活动。本发明的实施例监测生理信号的质量，并且可能能够补偿低信号质量的信号。本发明的另一个实施方案包括在递送治疗后检测发作活动。

24. 发明申请

US20100185182A1 USER INTERFACE INDICATING FLUID LOCATION FOR AN IMPLANTABLE FLUID DELIVERY DEVICE 有权
标题翻译：用户界面显示可移植流体输送装置的流体位置
公开(公告)号：US20100185182A1
公开(公告)日：2010-07-22
申请号：US12691574
申请日：2010-01-21
申请人： Sarah B. Alme , Touby A. Drew , Jiaying Shen
发明人： Sarah B. Alme , Touby A. Drew , Jiaying Shen
IPC分类号： A61M5/14 , G06F3/048
CPC分类号： A61M5/14276 , A61M2005/14288 , A61M2205/3507 , A61M2205/502 , G06F19/00 , G06F19/3468 , G09B23/285 , G16H50/50
摘要： A programmer device includes an interface that communicates with an implantable fluid delivery device and a user interface that displays a representation of a portion of the implantable fluid delivery device and displays an indication of a location of fluid within the implantable fluid delivery device during a delivery phase, e.g., a priming or bridging phase. The user interface may display a representation of progress of the delivery phase. The user interface may display the indication of the location of the fluid within internal tubing of the implantable fluid delivery device or within a catheter of the implantable fluid delivery device. The programmer device may display the representation of the progress of the delivery phase as a simulation of the delivery phase or during the actual delivery phase of the implantable fluid delivery device. A user may therefore observe a location of fluid corresponding to progress of the delivery phase.
摘要翻译：编程器装置包括与可植入流体输送装置进行通信的界面和显示可植入流体输送装置的一部分的表示的用户界面，并且在输送阶段显示流体在可植入流体输送装置内的位置的指示例如，起动或桥接阶段。用户界面可以显示递送阶段的进展的表示。用户界面可以显示流体在可植入流体输送装置的内部管道内或者在可植入流体输送装置的导管内的位置的指示。编程器装置可以将输送阶段的进展的表示显示为递送阶段的模拟或在可植入流体输送装置的实际输送阶段期间。因此，用户可以观察对应于递送阶段的进展的流体的位置。

25. 发明申请

US20090259216A1 AUTOMATED INTEGRITY TESTS 有权
标题翻译：自动化的完整性测试
公开(公告)号：US20090259216A1
公开(公告)日：2009-10-15
申请号：US12100750
申请日：2008-04-10
申请人： Touby A. Drew , Steven M. Goetz
发明人： Touby A. Drew , Steven M. Goetz
IPC分类号： A61M5/14 , A61N1/00
CPC分类号： A61N1/3706 , A61B5/1117 , A61B2560/0276 , A61N1/36142 , A61N1/36535 , A61N1/36542 , A61N2001/083
摘要： Techniques for testing integrity of various elements of implantable medical device systems are described. Some embodiments automatically test the integrity of one or more system elements in response to detecting an event. Examples of events in response to which an integrity test may be performed include the patient being within a target activity state, a symptomatic event experienced by a patient, an external impact on the patient that exceeds a damage threshold, or an indication that the patient is receiving inappropriate therapy. Some embodiments automatically test integrity in response to failure to autonomously detect an event, which may be indicated by input from a patient. An implantable lead carrying electrodes or a therapeutic substance delivery element, such as a catheter, are examples of system elements for which integrity may be tested in some embodiments.
摘要翻译：描述了用于测试可植入医疗装置系统的各种元件的完整性的技术。响应于检测事件，一些实施例自动测试一个或多个系统元件的完整性。可以进行完整性测试的响应的事件的示例包括患者处于目标活动状态，患者经历的症状事件，超过损伤阈值对患者的外部影响，或患者是接受不适当的治疗。一些实施例响应于自动检测事件而自动测试完整性，该事件可以由患者的输入来指示。可植入导线承载电极或治疗物质递送元件（例如导管）是在一些实施例中可以测试其完整性的系统元件的示例。

26. 发明申请

US20090198304A1 DIVISION APPROXIMATION FOR IMPLANTABLE MEDICAL DEVICES 失效
标题翻译：可植入医疗器械的分类近似
公开(公告)号：US20090198304A1
公开(公告)日：2009-08-06
申请号：US12401896
申请日：2009-03-11
申请人： Touby A. Drew
发明人： Touby A. Drew
IPC分类号： A61N1/08
CPC分类号： G06F7/535 , G06F7/4833
摘要： Methods and devices for performing division approximation in implantable and wearable self-powered medical devices. The present invention provides rapid methods for performing an approximation of division on fixed point numbers, where the methods are easily implemented in small, low power consumption devices as may be found in implantable medical devices. One example of use is in rapidly determining the approximate ratio between foreground and background activity in seizure detection algorithms. Some methods approximate the ratio of Numerator (N) to Denominator (D) by raising 2 to the power of the difference in the number of zeros to the left of the Most Significant Set Bit (MSSB) of D vs. N. Some methods may also pad bits to the right of the approximate ratio MSSB using bits from the right of the N MSSB, and/or pre-process the smaller of D or N by rounding the value upward. Methods may be implemented in firmware and/or in discrete logic.
摘要翻译：用于在可植入和穿戴式自供电医疗设备中进行分割近似的方法和装置。本发明提供了用于执行对固定点编号进行分割的近似的快速方法，其中可以在可植入的医疗装置中可以看到的方法在小的，低功耗的装置中容易地实现。使用的一个例子是快速确定缉获检测算法中前景和背景活动之间的近似比例。一些方法通过将D与N的最高有效位（MSSB）左侧的零的数量的差异的2倍增加到2来近似分子（N）与分母（D）的比率。某些方法可以还使用来自N MSSB右侧的位从大小比MSSB右侧的位填充位，和/或通过向上舍入该值来预处理D或N中的较小者。方法可以在固件和/或离散逻辑中实现。

27. 发明授权

US07526340B2 Division approximation for implantable medical devices 失效
标题翻译：可植入医疗器械的分割近似
公开(公告)号：US07526340B2
公开(公告)日：2009-04-28
申请号：US10976474
申请日：2004-10-29
申请人： Touby A. Drew
发明人： Touby A. Drew
IPC分类号： A61N1/36
CPC分类号： G06F7/535 , G06F7/4833
摘要： Methods and devices for performing division approximation in implantable and wearable self-powered medical devices. The present invention provides rapid methods for performing an approximation of division on fixed point numbers, where the methods are easily implemented in small, low power consumption devices as may be found in implantable medical devices. One example of use is in rapidly determining the approximate ratio between foreground and background activity in seizure detection algorithms. Some methods approximate the ratio of Numerator (N) to Denominator (D) by raising 2 to the power of the difference in the number of zeros to the left of the Most Significant Set Bit (MSSB) of D vs. N. Some methods may also pad bits to the right of the approximate ratio MSSB using bits from the right of the N MSSB, and/or pre-process the smaller of D or N by rounding the value upward. Methods may be implemented in firmware and/or in discrete logic.
摘要翻译：用于在可植入和穿戴式自供电医疗设备中进行分割近似的方法和装置。本发明提供了用于执行对固定点编号进行分割的近似的快速方法，其中可以在可植入的医疗装置中可以看到的方法在小的，低功耗的装置中容易地实现。使用的一个例子是快速确定缉获检测算法中前景和背景活动之间的近似比例。一些方法通过将D与N的最高有效位（MSSB）左侧的零的数量的差异的2倍增加到2来近似分子（N）与分母（D）的比率。某些方法可以还使用来自N MSSB右侧的位从大小比MSSB右侧的位填充位，和/或通过向上舍入该值来预处理D或N中的较小者。方法可以在固件和/或离散逻辑中实现。

28. 发明申请

US20080140162A1 MEDICAL DEVICE PROGRAMMING SAFETY 有权
标题翻译：医疗设备编程安全
公开(公告)号：US20080140162A1
公开(公告)日：2008-06-12
申请号：US11940604
申请日：2007-11-15
申请人： Steven M. Goetz , Donald R. Johnson , Touby A. Drew , Andrew H. Houchins , Jeffrey T. Keacher , Theodore J. Stone , Earle T. Roberts
发明人： Steven M. Goetz , Donald R. Johnson , Touby A. Drew , Andrew H. Houchins , Jeffrey T. Keacher , Theodore J. Stone , Earle T. Roberts
IPC分类号： A61N1/08
CPC分类号： G06F19/3481 , G06F19/00 , G06F19/3418
摘要： Techniques for increasing the safety of medical device programming using general purpose hardware, such as a general purpose personal computer, are described. In some embodiments, a system includes an intermediate computing device comprising an applications module. Information from the applications module, such as instructions for an implantable medical device (IMD), may be presented to a user via a user input terminal that is separate from the intermediate computing device. A user may interact with the user input terminal to select an instruction from the applications module, and the intermediate computing device may transmit the selected instruction to the IMD. In some embodiments, the intermediate computing device comprises a web server and the user input terminal comprises a web browser configured to access the web server. In other embodiments, the intermediate computing device comprises a client server and the user input terminal comprises a client.
摘要翻译：描述用于增加使用通用硬件（例如通用个人计算机）的医疗设备编程安全性的技术。在一些实施例中，系统包括包括应用模块的中间计算设备。可以经由与中间计算设备分离的用户输入终端向用户呈现来自应用模块的信息，诸如可植入医疗设备（IMD）的指令。用户可以与用户输入终端交互以从应用模块选择指令，并且中间计算设备可以将所选择的指令发送到IMD。在一些实施例中，中间计算设备包括web服务器，并且用户输入终端包括被配置为访问web服务器的web浏览器。在其他实施例中，中间计算设备包括客户端服务器，并且用户输入终端包括客户端。

29. 发明申请

US20070249955A1 METHOD AND APPARATUS FOR DETECTION OF NERVOUS SYSTEM DISORDERS 有权
公开(公告)号：US20070249955A1
公开(公告)日：2007-10-25
申请号：US11609432
申请日：2006-12-12
申请人： David L. Carlson , Eric J. Panken , Touby A. Drew , Jonathan C. Werder
发明人： David L. Carlson , Eric J. Panken , Touby A. Drew , Jonathan C. Werder
IPC分类号： A61B5/04 , A61N1/00
CPC分类号： A61B5/0478 , A61B5/4094 , A61B5/7221 , A61B5/7275 , A61N1/36082 , G06F19/00
摘要： Systems and methods for detecting and/or treating nervous system disorders, such as seizures, are disclosed. Certain embodiments of the invention relate generally to implantable medical devices (IMDs) adapted to detect and treat nervous system disorders in patients with an IMD. Certain embodiments of the invention include detection of seizures based upon comparisons of long-term and short-term representations of physiological signals. Other embodiments include prediction of seizure activity based upon analysis of physiological signal levels. An embodiment of the invention monitors the quality of physiological signals, and may be able to compensate for signals of low signal quality. A further embodiment of the invention includes detection of seizure activity following the delivery of therapy.

30. 发明授权

US09996669B2 Intelligent discovery of medical devices by a programming system 有权
公开(公告)号：US09996669B2
公开(公告)日：2018-06-12
申请号：US11800423
申请日：2007-05-04
申请人： Steven M. Goetz , Touby A. Drew , Earle T. Roberts
发明人： Steven M. Goetz , Touby A. Drew , Earle T. Roberts
IPC分类号： A61N1/00 , G06F19/00 , A61N1/372
CPC分类号： G16H40/67 , A61N1/37288 , G06F19/00 , G06F19/3418 , G16H40/20 , G16H40/40
摘要： Techniques for automatically identifying medical devices, e.g., implantable medical device, using wireless communications in order to communicate with the medical devices are described. For instance, a programming system securely discovers a set of medical devices which have the capacity to communicate using wireless communication links. The programming system may then apply one or more search heuristics to identify a set of discovered medical devices that are likely to be a medical device with which a user desires to interact. When the user selects the desired one of the identified medical devices, the programming system launches a device interaction application associated with the desired medical device. The user may use the device interaction application to interact with the desired medical device.

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