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21. 发明授权

US07670559B2 Microfluidic systems with enhanced detection systems 有权
标题翻译：具有增强检测系统的微流控系统
公开(公告)号：US07670559B2
公开(公告)日：2010-03-02
申请号：US10225454
申请日：2002-08-19
申请人： Ring-Ling Chien , Jeffrey A. Wolk , Michael Spaid , Richard J. McReynolds
发明人： Ring-Ling Chien , Jeffrey A. Wolk , Michael Spaid , Richard J. McReynolds
IPC分类号： G01N33/48
CPC分类号： G01N21/05 , B01L3/502715 , B01L2300/0654 , B01L2300/0816 , B01L2300/0861 , B01L2300/0874 , B01L2300/0887 , B01L2400/0415 , B01L2400/0487 , B01L2400/084 , G01N2021/0346 , Y10T436/2575
摘要： Microfluidic devices and systems having enhanced detection sensitivity, particularly for use in non-fluorogenic detection methods, e.g., absorbance. The systems typically employ planar microfluidic devices that include one or more channel networks that are parallel to the major plane of the device, e.g., the predominant plane of the planar structure, and a detection channel segment that is substantially orthogonal to that plane. The detection system is directed along the length of the detection channel segment using a detection orientation that is consistent with conventional microfluidic systems.
摘要翻译：具有增强的检测灵敏度的微流体装置和系统，特别是用于非荧光检测方法，例如吸光度。系统通常采用平面微流体装置，其包括平行于装置的主平面的一个或多个通道网络，例如平面结构的主要平面以及基本上与该平面正交的检测通道段。使用与常规微流体系统一致的检测方向，沿着检测通道段的长度引导检测系统。

22. 发明授权

US07161356B1 Voltage/current testing equipment for microfluidic devices 有权
标题翻译：用于微流体装置的电压/电流检测设备
公开(公告)号：US07161356B1
公开(公告)日：2007-01-09
申请号：US10435947
申请日：2003-05-12
申请人： Ring-Ling Chien
发明人： Ring-Ling Chien
IPC分类号： G01R31/08 , G01N27/00
CPC分类号： B01L3/5027 , B01L2200/143 , B01L2200/148 , B01L2300/0816 , B01L2400/0418 , B01L2400/0421 , B01L2400/0487
摘要： The present invention provides novel methods and devices for testing/verifying the configuration of one or more microfluidic elements in a microfluidic device. In particular the methods and devices of the invention are useful in testing for blockages or the presence of air bubbles in microfluidic elements. For example, a method for verifying the proper function of a microfluidic device is disclosed, which device comprises at least first, second and third fluidic openings, which fluidic openings are fluidly coupled to at least first, second and third microscale channel elements, respectively, the method comprising flowing an electrically conductive buffer through the first, second and third microscale channel elements; setting a known applied voltage potential (or current) between the first and second fluidic openings; setting a current in the third microscale channel element to be approximately zero; detecting a resulting voltage at the third fluidic opening; and, comparing the detected voltage at the third fluidic opening with a calculated target voltage expected at the third fluidic opening to determine whether there is a fault or problem (e.g., air bubble) in at least one of the first and second microscale channel elements. The above method can be repeated one or more times for the other fluidic openings in the microfluidic device to determine whether there is a fault in any one or more microscale elements of the device.
摘要翻译：本发明提供用于测试/验证微流体装置中的一个或多个微流体元件的构造的新颖方法和装置。特别地，本发明的方法和装置可用于测试微流体元件中的阻塞或气泡的存在。例如，公开了一种用于验证微流体装置的正常功能的方法，该装置包括至少第一，第二和第三流体开口，该流体开口分别流体耦合到至少第一，第二和第三微通道元件，所述方法包括使导电缓冲液流过所述第一，第二和第三微量通道元件; 设置在第一和第二流体开口之间的已知施加电压电位（或电流）; 将第三微型通道元件中的电流设置为大约为零; 检测在第三流体开口处产生的电压; 并且将第三流体开口处的检测到的电压与预期在第三流体开口处的计算的目标电压进行比较，以确定在第一和第二微量通道元件中的至少一个中是否存在故障或问题（例如，气泡）。对于微流体装置中的其它流体开口可以重复上述方法一次或多次，以确定装置的任何一个或多个微量元件中是否存在故障。

23. 发明授权

US07040144B2 Microfluidic viscometer 失效
标题翻译：微流体粘度计
公开(公告)号：US07040144B2
公开(公告)日：2006-05-09
申请号：US10207735
申请日：2002-07-26
申请人： Michael Spaid , Andrea W. Chow , Benjamin N. Wang , Ring-Ling Chien , J. Wallace Parce , Anne R. Kopf-Sill , Josh Molho , Anubhav Tripathi , Matthew B. Kerby
发明人： Michael Spaid , Andrea W. Chow , Benjamin N. Wang , Ring-Ling Chien , J. Wallace Parce , Anne R. Kopf-Sill , Josh Molho , Anubhav Tripathi , Matthew B. Kerby
IPC分类号： G01N11/04 , G01F1/708
CPC分类号： G01N27/44791 , B01L3/5027 , B01L3/502715 , B01L3/50273 , B01L3/502746 , B01L9/527 , B01L2200/027 , B01L2300/0663 , B01L2300/0816 , B01L2300/0861 , B01L2300/0864 , B01L2300/0867 , B01L2400/0406 , B01L2400/0415 , B01L2400/0487 , B01L2400/084 , G01N11/08 , G01N2035/1044 , G05D7/0694
摘要： Microfluidic devices, systems, and methods measure viscosity, flow times, and/or pressures, other flow characteristics within the channels, and the measured flow characteristics can be used to generate a desired flow. Multi-reservoir pressure modulator and pressure controller systems, electrokinetic systems and/or other fluid transport mechanisms can generate the flow, controllably mix fluids, and the like.
摘要翻译：微流体装置，系统和方法测量通道内的粘度，流动时间和/或压力，其它流动特性，并且所测量的流动特性可用于产生所需的流量。多储层压力调节器和压力控制器系统，电动系统和/或其它流体输送机构可以产生流动，可控地混合流体等。

24. 发明授权

US06447661B1 External material accession systems and methods 有权
标题翻译：外部材料加入系统和方法
公开(公告)号：US06447661B1
公开(公告)日：2002-09-10
申请号：US09416288
申请日：1999-10-12
申请人： Andrea W. Chow , Robert S. Dubrow , J. Wallace Parce , Steven A. Sundberg , Jeffrey A. Wolk , Ring-Ling Chien , Steven James Gallagher , Michael R. Knapp , Anne R. Kopf-Sill , Tammy Burd Mehta
发明人： Andrea W. Chow , Robert S. Dubrow , J. Wallace Parce , Steven A. Sundberg , Jeffrey A. Wolk , Ring-Ling Chien , Steven James Gallagher , Michael R. Knapp , Anne R. Kopf-Sill , Tammy Burd Mehta
IPC分类号： G01N2726
CPC分类号： B01L3/502715 , B01L3/50273 , B01L3/502746 , B01L2200/027 , B01L2300/0816 , B01L2300/0838 , B01L2300/0867 , B01L2400/0406 , B01L2400/0415 , B01L2400/0487 , B01L2400/084 , G01N2035/00237 , G01N2035/1062 , Y10S366/02 , Y10T436/2575
摘要： Methods, apparatus and systems are provided for introducing large numbers of different materials into a microfluidic analytical device rapidly, efficiently and reproducibly. In particular, improved integrated pipettor chip configurations, e.g. sippers or electropipettors, are described which are capable of sampling extremely small amounts of material for which analysis is desired, transporting material into a microfluidic analytical channel network, and performing the desired analysis on the material.
摘要翻译：提供了方法，装置和系统，用于将大量不同的材料快速，有效和可再现地引入微流体分析装置。特别地，改进的集成移液器芯片配置，例如描述了能够对需要分析的极少量材料进行取样，将材料输送到微流体分析通道网络中并对材料进行所需分析的能力。

25. 发明授权

US5235409A Optical detection system for capillary separation columns 失效
标题翻译：用于毛细分离柱的光学检测系统
公开(公告)号：US5235409A
公开(公告)日：1993-08-10
申请号：US744563
申请日：1991-08-13
申请人： Dean S. Burgi , John C. Helmer , Ring-Ling Chien
发明人： Dean S. Burgi , John C. Helmer , Ring-Ling Chien
IPC分类号： G01N30/74
CPC分类号： G01N30/74
摘要： On-column optical detection apparatus and method for use with capillary separation columns are shown. The apparatus and method minimize the adverse effects of light scattered from the walls of the column, thereby improving detection sensitivity and providing greater dynamic range. Light from a conventional source is focussed onto a column. Spatial filter means are positioned in front of the column to prevent at least some light from striking the column wall. Another spatial filter is positioned in front of a light collecting means which gathers light emanating from the column. In a specific embodiment, a unique monolens design is shown comprising collecting and focussing lens formed as an integral unit with a bore for a capillary column.

26. 发明授权

US5116471A System and method for improving sample concentration in capillary electrophoresis 失效
标题翻译：提高毛细管电泳样品浓度的系统和方法
公开(公告)号：US5116471A
公开(公告)日：1992-05-26
申请号：US771575
申请日：1991-10-04
申请人： Ring-Ling Chien , Dean S. Burgi
发明人： Ring-Ling Chien , Dean S. Burgi
IPC分类号： G01N27/447
CPC分类号： G01N27/44773
摘要： The method for improving sample concentration in capillary electrophoresis by extracting the sample buffer from the capillary column using the electro-osmotic flow while the sample components are stacked into the support buffer utilizes a system for this technique. The system has a separation column 11, sample introduction means 16 for injecting the sample solution, an injection detector means 20 for detecting the volume of injected sample solution, a separation detector means 21 for detecting the sample components, power supply means 17 for applying a high voltage along the separation column 11 for reversing the direction of the electro-osmotic flow thereby causing extraction of the sample buffer from the separation column and afterward providing the separation sample into its components.
摘要翻译：通过使用电渗流从毛细管柱中提取样品缓冲液，同时将样品组分堆叠到支持缓冲液中，从而提高毛细管电泳中的样品浓度的方法利用该技术的系统。该系统具有分离塔11，用于注射样品溶液的样品引入装置16，用于检测注入的样品溶液的体积的注射检测器装置20，用于检测样品组分的分离检测器装置21，沿着分离塔11的高电压，用于反转电渗流的方向，从而导致样品缓冲液从分离塔中提取，然后将分离样品提供到其组分中。

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