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21. 发明授权

US07892537B1 High activity mutants of butyrylcholinesterase for cocaine hydrolysis 有权
标题翻译：用于可卡因水解的丁酰胆碱酯酶的高活性突变体
公开(公告)号：US07892537B1
公开(公告)日：2011-02-22
申请号：US12767128
申请日：2010-04-26
申请人： Chang-Guo Zhan , Fang Zheng , Wenchao Yang
发明人： Chang-Guo Zhan , Fang Zheng , Wenchao Yang
IPC分类号： A61K38/46 , C12N9/16
CPC分类号： A61K38/465 , A61K38/00 , C12N9/18 , C12Y301/01008
摘要： Butyrylcholinesterase (BChE) polypeptide variants of the presently-disclosed subject matter have enhanced catalytic efficiency for (−)-cocaine, as compared to wild-type BChE. Pharmaceutical compositions of the presently-disclosed subject matter include a BChE polypeptide variant having an enhanced catalytic efficiency for (−)-cocaine. A method of the presently-disclosed subject matter for treating a cocaine-induced condition includes administering to an individual an effective amount of a BChE polypeptide variant, as disclosed herein, to lower blood cocaine concentration.
摘要翻译：与野生型BChE相比，目前公开的主题的丁酰胆碱酯酶（BChE）多肽变体具有增强（ - ） - 可卡因的催化效率。目前公开的主题的药物组合物包括对（ - ） - 可卡因具有增强的催化效率的BChE多肽变体。用于治疗可卡因诱导病症的目前公开的主题的方法包括向个体施用有效量的如本文公开的BChE多肽变体以降低可卡因浓度。

22. 发明授权

US06897195B2 Composition of menthol and menthyl lactate, its preparation method and its applications as a cooling agent 失效
标题翻译：薄荷醇和薄荷酸乳酸的组成及其制备方法及其作为冷却剂的应用
公开(公告)号：US06897195B2
公开(公告)日：2005-05-24
申请号：US10202543
申请日：2002-07-24
申请人： Evelyn G. Su , Chang-Guo Wang
发明人： Evelyn G. Su , Chang-Guo Wang
IPC分类号： A61K8/34 , A61K8/37 , A61Q13/00 , A61K7/46
CPC分类号： A61Q13/00 , A61K8/34 , A61K8/37 , A61K2800/244
摘要： Disclosed here is a composition containing menthol and menthyl lactate, and its preparation method and its applications as a cooling agent and a flavoring agent.The present invention provides a composition characterized in that it comprises menthol and menthyl lactate in a ratio by weight in the range of 1:4˜4:1 and the corresponding crystallization point is below room temperature of 25° C. Such composition has the advantages of being liquid at room temperature; easy to use as a cooling agent or a flavoring agent; no need to use heat to melt menthol and menthyl lactate, which not only saves time, money and heating equipment, but also simplifies manufacturing process and can be used in cold processes at room temperature. The composition can be used as a cooling and/or flavoring agent and/or a fragrance ingredient in toothpaste, mouthwash, fragrance, cleansers, shaving cream, after shave products; shampoo, deodorant, antiperspirant, bath products, drinks, confectionary products, tobacco, pharmaceutical, foods, flavoring and fragrance products.
摘要翻译：这里公开了含有薄荷醇和乳酸薄荷酯的组合物及其制备方法及其作为冷却剂和调味剂的应用。本发明提供一种组合物，其特征在于，其包含薄荷醇和乳酸薄荷酯，其重量比为1：4〜4：1，相应的结晶点低于室温25℃。该组合物具有优点在室温下为液体; 易于用作冷却剂或调味剂; 不需要使用热量来熔化薄荷醇和乳酸薄荷酯，这不仅节省了时间，金钱和加热设备，而且简化了制造工艺，可以在室温的冷加工中使用。该组合物可以用作在牙膏，漱口剂，香料，清洁剂，剃须膏，剃须产品之后的冷却和/或调味剂和/或香料成分; 洗发水，除臭剂，止汗剂，沐浴用品，饮料，糖果制品，烟草，制药，食品，调味香料等。

23. 发明申请

US20160160195A1 ANTI-COCAINE COMPOSITIONS AND TREATMENT 审中-公开
公开(公告)号：US20160160195A1
公开(公告)日：2016-06-09
申请号：US14954813
申请日：2015-11-30
申请人： Donald Landry , Chang-Guo Zhan , James H. Woods , Roger Sunahara , Diwahar L. Narasimhan , Joanne MacDonald , Victor Yang , Mei-Chuan Holden Ko , Shi-Xian Deng , John J. Tesmer , Tien-Yi Lee , Young Min Kwon , Daquan Gao
发明人： Donald Landry , Chang-Guo Zhan , James H. Woods , Roger Sunahara , Diwahar L. Narasimhan , Joanne MacDonald , Victor Yang , Mei-Chuan Holden Ko , Shi-Xian Deng , John J. Tesmer , Tien-Yi Lee , Young Min Kwon , Daquan Gao
IPC分类号： C12N9/18 , A61K38/46
CPC分类号： C12N9/18 , A61K38/00 , A61K38/465 , C12Y301/01084
摘要： Embodiments of the invention disclosed herein generally relate to anti-cocaine therapeutics. Specifically, some embodiments of the invention relate to highly efficient, thermostable, and long-lasting cocaine esterase (CocE) mutants that can protect against the toxic and reinforcing effects of cocaine in subjects. Provided herein are mutant CocE polypeptides displaying thermostable esterase activity. Also provided are methods of treating cocaine-induced conditions in a subject in need via administration of mutant CocE as well as methods for high-throughput screening of candidate esterase polypeptides.

24. 发明授权

US08592193B1 High activity mutants of butyrylcholinesterase for cocaine hydrolysis 有权
标题翻译：用于可卡因水解的丁酰胆碱酯酶的高活性突变体
公开(公告)号：US08592193B1
公开(公告)日：2013-11-26
申请号：US13399406
申请日：2012-02-17
申请人： Chang-Guo Zhan , Fang Zheng , Wenchao Yang , Liu Xue , Shurong Hou
发明人： Chang-Guo Zhan , Fang Zheng , Wenchao Yang , Liu Xue , Shurong Hou
IPC分类号： C12N9/16 , C12N9/18 , A61K38/46 , C07H21/04
CPC分类号： C12N9/18 , A61K38/00 , C12Y301/01008
摘要： Butyrylcholinesterase (BChE) polypeptide variants of the presently-disclosed subject matter have enhanced catalytic efficiency for (−)-cocaine, as compared to wild-type BChE. Pharmaceutical compositions of the presently-disclosed subject matter include a BChE polypeptide variant having an enhanced catalytic efficiency for (−)-cocaine. A method of the presently-disclosed subject matter for treating a cocaine-induced condition includes administering to an individual an effective amount of a BChE polypeptide variant, as disclosed herein, to lower blood cocaine concentration.
摘要翻译：与野生型BChE相比，目前公开的主题的丁酰胆碱酯酶（BChE）多肽变体具有增强（ - ） - 可卡因的催化效率。目前公开的主题的药物组合物包括对（ - ） - 可卡因具有增强的催化效率的BChE多肽变体。用于治疗可卡因诱导的病症的目前公开的主题的方法包括向个体施用有效量的本文所公开的BChE多肽变体以降低可卡因浓度。

25. 发明申请

US20110168636A1 CHELATING COMPOUNDS AND IMMOBILIZED TETHERED CHELATORS 有权
标题翻译：化学化合物和固定化的螯合剂
公开(公告)号：US20110168636A1
公开(公告)日：2011-07-14
申请号：US13052477
申请日：2011-03-21
申请人： Robert A. Yokel , Wesley R. Harris , Christopher D. Spilling , Chang-Guo Zhan
发明人： Robert A. Yokel , Wesley R. Harris , Christopher D. Spilling , Chang-Guo Zhan
IPC分类号： B01D15/38
CPC分类号： C07C259/06 , B01D15/3828 , B01J20/3204 , B01J20/321 , B01J20/3212 , B01J20/3219 , B01J20/3251 , B01J20/3253 , C02F2101/20 , C07C217/28 , C07C255/13 , C07C311/17 , C08F8/28 , C08F8/30 , C08F12/30 , C08F212/08 , C08F212/36 , C08F212/14 , C08F8/36
摘要： Methods are described for removing aluminum from a solution using novel di- and tripodal compounds as chelators.
摘要翻译：描述了使用新的二 - 和三峰化合物作为螯合剂从溶液中除去铝的方法。

26. 发明授权

US07740840B1 High activity mutants of butyrylcholinesterase for cocaine hydrolysis 有权
标题翻译：用于可卡因水解的丁酰胆碱酯酶的高活性突变体
公开(公告)号：US07740840B1
公开(公告)日：2010-06-22
申请号：US12685341
申请日：2010-01-11
申请人： Chang-Guo Zhan , Fang Zheng , Wenchao Yang
发明人： Chang-Guo Zhan , Fang Zheng , Wenchao Yang
IPC分类号： A61K38/46 , C12N9/16
CPC分类号： A61K38/465 , A61K38/00 , C12N9/18 , C12Y301/01008
摘要： Butyrylcholinesterase (BChE) polypeptide variants of the presently-disclosed subject matter have enhanced catalytic efficiency for (−)-cocaine, as compared to wild-type BChE. Pharmaceutical compositions of the presently-disclosed subject matter include a BChE polypeptide variant having an enhanced catalytic efficiency for (−)-cocaine. A method of the presently-disclosed subject matter for treating a cocaine-induced condition includes administering to an individual an effective amount of a BChE polypeptide variant, as disclosed herein, to lower blood cocaine concentration.
摘要翻译：与野生型BChE相比，目前公开的主题的丁酰胆碱酯酶（BChE）多肽变体具有增强（ - ） - 可卡因的催化效率。目前公开的主题的药物组合物包括对（ - ） - 可卡因具有增强的催化效率的BChE多肽变体。用于治疗可卡因诱导病症的目前公开的主题的方法包括向个体施用有效量的如本文公开的BChE多肽变体以降低可卡因浓度。

27. 发明申请

US20100034799A1 ANTI-COCAINE COMPOSITIONS AND TREATMENT 有权
标题翻译：抗COCOINE组合物和治疗
公开(公告)号：US20100034799A1
公开(公告)日：2010-02-11
申请号：US12373510
申请日：2007-07-10
申请人： Donald Landry , Chang-Guo Zhan , James H. Woods , Roger Sunahara , Diwahar L. Narasimhan , Joanne MacDonald , Victor Yang , Mei-Chuan Holden Ko , Shi-Xian Deng , John J. Tesmer , Tien-Yi Lee , Young Min Kwon , Daquan Gao
发明人： Donald Landry , Chang-Guo Zhan , James H. Woods , Roger Sunahara , Diwahar L. Narasimhan , Joanne MacDonald , Victor Yang , Mei-Chuan Holden Ko , Shi-Xian Deng , John J. Tesmer , Tien-Yi Lee , Young Min Kwon , Daquan Gao
IPC分类号： A61K38/46 , C12N9/16 , C07H21/04 , A61P25/30
CPC分类号： C12N9/18 , A61K38/00 , A61K38/465 , C12Y301/01084
摘要： Embodiments of the invention disclosed herein generally relate to anti-cocaine therapeutics. Specifically, some embodiments of the invention relate to highly efficient, thermostable, and long-lasting cocaine esterase (CocE) mutants that can protect against the toxic and reinforcing effects of cocaine in subjects. Provided herein are mutant CocE polypeptides displaying thermostable esterase activity. Also provided are methods of treating cocaine-induced conditions in a subject in need via administration of mutant CocE as well as methods for high-throughput screening of candidate esterase polypeptides.
摘要翻译：本文公开的本发明的实施方案通常涉及抗可卡因治疗剂。具体地，本发明的一些实施方案涉及可以防止可卡因在受试者中的有毒和增强作用的高效，耐热和持久的可卡因酯酶（CocE）突变体。本文提供显示耐热酯酶活性的突变型CocE多肽。还提供了通过施用突变体CocE处理需要的受试者中可卡因诱导的病症的方法以及候选酯酶多肽的高通量筛选方法。

28. 发明申请

US20090261043A1 CHELATING COMPOUNDS AND IMMOBILIZED TETHERED CHELATORS 有权
标题翻译：化学化合物和固定化的螯合剂
公开(公告)号：US20090261043A1
公开(公告)日：2009-10-22
申请号：US12104066
申请日：2008-04-16
申请人： Robert A. Yokel , Wesley R. Harris , Christopher D. Spilling , Chang-Guo Zhan
发明人： Robert A. Yokel , Wesley R. Harris , Christopher D. Spilling , Chang-Guo Zhan
IPC分类号： B01D15/38 , C07C259/06 , C08F12/08 , C07C311/19 , C07C229/24 , C07C255/13
CPC分类号： C07C259/06 , B01D15/3828 , B01J20/3204 , B01J20/321 , B01J20/3212 , B01J20/3219 , B01J20/3251 , B01J20/3253 , C02F2101/20 , C07C217/28 , C07C255/13 , C07C311/17 , C08F8/28 , C08F8/30 , C08F12/30 , C08F212/08 , C08F212/36 , C08F212/14 , C08F8/36
摘要： Novel di- and tripodal compounds useful as chelators, intermediates for their production and a method for treating an aqueous solution to remove trivalent metal ions are presented.
摘要翻译：提出了可用作螯合剂的新型二 - 和三萜化合物，其生产中间体和一种处理水溶液以除去三价金属离子的方法。

29. 发明申请

US20070293195A1 Message Sender Controllable Messaging System 有权
标题翻译：消息发送者可控消息系统
公开(公告)号：US20070293195A1
公开(公告)日：2007-12-20
申请号：US11664078
申请日：2005-09-09
申请人： Alastair Angwin , Chang Guo , Jun Shen , Song Song , Pei Sun , Jian Zhang
发明人： Alastair Angwin , Chang Guo , Jun Shen , Song Song , Pei Sun , Jian Zhang
IPC分类号： H04M1/663
CPC分类号： H04M1/72547 , H04W4/12
摘要： The present invention relates to a mobile phone and a method for its operation and control. The mobile phone is capable of receiving the message sent by other mobile phones through a message transmission system. The method comprises: receiving the message from another mobile phone, wherein the received message comprises a presentation part and an associated control part, the control part being used for the control and management of the processing of the received message; extracting the control part from the received message; and executing the operation related to the message based on the extracted control part. According to an embodiment, if the control part received by the mobile phone comprises the notification mode control command, the mobile phone issues a message notification according to the notification mode control command, disregarding the message notification mode pre-configured on the mobile phone. Thus the requirement of the sender personalized message service can be satisfied.
摘要翻译：本发明涉及一种移动电话及其操作和控制方法。移动电话能够通过消息传输系统接收其他移动电话发送的消息。该方法包括：从另一个移动电话接收消息，其中所接收的消息包括呈现部分和相关联的控制部分，所述控制部分用于控制和管理所接收的消息的处理; 从接收到的消息中提取控制部分; 以及基于所提取的控制部分执行与所述消息相关的操作。根据实施例，如果由移动电话接收到的控制部分包括通知模式控制命令，则移动电话根据通知模式控制命令发出消息通知，而不考虑在移动电话上预先配置的消息通知模式。因此，可以满足发件人个性化消息服务的要求。

30. 发明授权

US5768429A Apparatus and method for accelerating digital video decompression by performing operations in parallel 失效
标题翻译：通过并行执行操作来加速数字视频解压缩的装置和方法
公开(公告)号：US5768429A
公开(公告)日：1998-06-16
申请号：US562674
申请日：1995-11-27
申请人： Amandeep S. Jabbi , Chang-Guo Zhou
发明人： Amandeep S. Jabbi , Chang-Guo Zhou
IPC分类号： G06T9/00 , G06K9/36
CPC分类号： G06T9/007
摘要： A method and apparatus for fast and cost-effective digital video decompression is disclosed. The invention implements the inverse quantization, inverse discrete cosine transform and motion compensation functions for an MPEG decoder in a pipelined parallel processor. The IDCT and motion compensation functions are implemented to maximize parallelization by using partitioned arithmetic and logic operations in a superscalar microprocessor. This approach drastically reduces the total number of instruction cycles required to perform the IDCT and motion compensation functions.
摘要翻译：公开了一种用于快速且具有成本效益的数字视频解压缩的方法和装置。本发明为流水线并行处理器中的MPEG解码器实现逆量化，逆离散余弦变换和运动补偿功能。实现IDCT和运动补偿功能以通过在超标量微处理器中使用分区算术和逻辑运算来最大化并行化。这种方法大大减少了执行IDCT和运动补偿功能所需的指令周期总数。

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