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1. 发明授权

US09081736B2 Modeling of mPGES-1 three-dimensional structures: applications in drug design and discovery 有权
标题翻译： mPGES-1三维结构的建模：药物设计和发现中的应用
公开(公告)号：US09081736B2
公开(公告)日：2015-07-14
申请号：US13064594
申请日：2011-04-01
申请人： Chang-Guo Zhan , Xiaoqin Huang , Adel Hamza
发明人： Chang-Guo Zhan , Xiaoqin Huang , Adel Hamza
IPC分类号： G06G7/48 , G06F19/16 , C07K1/00 , C12N9/90 , G06F19/22
CPC分类号： G06F19/16 , C07K1/00 , C12N9/90 , C12Y503/99003 , G06F19/22
摘要： This invention relates to representations of prostaglandin synthase three-dimensional structures. Such representations are suitable for designing agents that modulate the activity of the enzyme by binding to the substrate binding domain.
摘要翻译：本发明涉及前列腺素合酶三维结构的表示。这种表征适用于设计通过结合底物结合结构域来调节酶的活性的试剂。

2. 发明授权

US08318156B2 Anti-cocaine compositions and treatment 有权
标题翻译：抗可卡因组合物和治疗
公开(公告)号：US08318156B2
公开(公告)日：2012-11-27
申请号：US12373510
申请日：2007-07-10
申请人： Donald W Landry , Joanne MacDonald , Shi-Xian Deng , Chang-Guo Zhan , Daquan Gao , James H. Woods , Roger K. Sunahara , Diwahar L. Narasimhan , Victor Yang , Mei-Chuan Holden Ko , John J. Tesmer , Tien-Yi Lee , Young Min Kwon
发明人： Donald W Landry , Joanne MacDonald , Shi-Xian Deng , Chang-Guo Zhan , Daquan Gao , James H. Woods , Roger K. Sunahara , Diwahar L. Narasimhan , Victor Yang , Mei-Chuan Holden Ko , John J. Tesmer , Tien-Yi Lee , Young Min Kwon
IPC分类号： A61K38/46 , A61K38/43 , C12N9/16 , C12N9/14 , C12P21/06 , C12P19/34 , C07H21/04
CPC分类号： C12N9/18 , A61K38/00 , A61K38/465 , C12Y301/01084
摘要： Embodiments of the invention disclosed herein generally relate to anti-cocaine therapeutics. Specifically, some embodiments of the invention relate to highly efficient, thermostable, and long-lasting cocaine esterase (CocE) mutants that can protect against the toxic and reinforcing effects of cocaine in subjects. Provided herein are mutant CocE polypeptides displaying thermostable esterase activity. Also provided are methods of treating cocaine-induced conditions in a subject in need via administration of mutant CocE as well as methods for high-throughput screening of candidate esterase polypeptides.
摘要翻译：本文公开的本发明的实施方案通常涉及抗可卡因治疗剂。具体地，本发明的一些实施方案涉及可以防止可卡因在受试者中的有毒和增强作用的高效，耐热和持久的可卡因酯酶（CocE）突变体。本文提供显示耐热酯酶活性的突变型CocE多肽。还提供了通过施用突变体CocE处理需要的受试者中可卡因诱导的病症的方法以及候选酯酶多肽的高通量筛选方法。

3. 发明授权

US08193327B1 High-activity mutants of butyrylcholinesterase for cocaine hydrolysis and method of generating the same 有权
标题翻译：用于可卡因水解的丁酰胆碱酯酶的高活性突变体及其产生方法
公开(公告)号：US08193327B1
公开(公告)日：2012-06-05
申请号：US13018641
申请日：2011-02-01
申请人： Chang-Guo Zhan , Hoon Cho , Hsin-Hsiung Tai
发明人： Chang-Guo Zhan , Hoon Cho , Hsin-Hsiung Tai
IPC分类号： C07H21/04 , C12N9/18
CPC分类号： C12N9/18 , A61K38/00 , C12Y301/01008
摘要： A novel computational method and generation of mutant butyrylcholinesterase for cocaine hydrolysis is provided. The method includes molecular modeling a possible BChE mutant and conducting molecular dynamics simulations and hybrid quantum mechanical/molecular mechanical calculations thereby providing a screening method of possible BChE mutants by predicting which mutant will lead to a more stable transition state for a rate determining step. Site-directed mutagenesis, protein expression, and protein activity is conducted for mutants determined computationally as being good candidates for possible BChE mutants, i.e., ones predicted to have higher catalytic efficiency as compared with wild-type BChE. In addition, mutants A199S/A328W/Y332G, A199S/F227A/A328W/Y332G, A199S/S287G/A328W/Y332G, A199S/F227A/S287G/A328W/Y332G, and A199S/F227A/S287G/A328W/E441D all have enhanced catalytic efficiency for (−)-cocaine compared with wild-type BChE.
摘要翻译：提供了一种新颖的计算方法和用于可卡因水解的突变丁酰胆碱酯酶的产生。该方法包括对可能的BChE突变体进行分子建模，并进行分子动力学模拟和混合量子力学/分子机械计算，从而通过预测哪个突变体将导致速率确定步骤的更稳定的过渡状态来提供可能的BChE突变体的筛选方法。对于可能的BChE突变体，即与野生型BChE相比预测具有更高催化效率的突变体，对计算确定的突变体进行定点诱变，蛋白质表达和蛋白质活性。此外，突变体A199S / A328W / Y332G，A199S / F227A / A328W / Y332G，A199S / S287G / A328W / Y332G，A199S / F227A / S287G / A328W / Y332G和A199S / F227A / S287G / A328W / E441D都具有增强的催化（ - ） - 可卡因与野生型BChE相比有效。

4. 发明授权

US08066883B2 Removing aluminum from solution using chelating compounds and immobilized tethered chelators 有权
标题翻译：使用螯合化合物和固定的束缚螯合剂从溶液中除去铝
公开(公告)号：US08066883B2
公开(公告)日：2011-11-29
申请号：US13052477
申请日：2011-03-21
申请人： Robert A. Yokel , Wesley R. Harris , Christopher D. Spilling , Chang-Guo Zhan
发明人： Robert A. Yokel , Wesley R. Harris , Christopher D. Spilling , Chang-Guo Zhan
IPC分类号： C02F1/42
CPC分类号： C07C259/06 , B01D15/3828 , B01J20/3204 , B01J20/321 , B01J20/3212 , B01J20/3219 , B01J20/3251 , B01J20/3253 , C02F2101/20 , C07C217/28 , C07C255/13 , C07C311/17 , C08F8/28 , C08F8/30 , C08F12/30 , C08F212/08 , C08F212/36 , C08F212/14 , C08F8/36
摘要： Methods are described for removing aluminum from a solution using novel di- and tripodal compounds as chelators.
摘要翻译：描述了使用新的二 - 和三峰化合物作为螯合剂从溶液中除去铝的方法。

5. 发明授权

US5798753A Color format conversion in a parallel processor 失效
标题翻译：并行处理器中的颜色格式转换
公开(公告)号：US5798753A
公开(公告)日：1998-08-25
申请号：US398111
申请日：1995-03-03
申请人： Chang-Guo Zhou , Daniel S. Rice
发明人： Chang-Guo Zhou , Daniel S. Rice
IPC分类号： H04N9/67 , G06T1/20 , H04N9/64 , G06F15/00
CPC分类号： H04N9/641
摘要： A pixel of a color video image is converted from one color format having luminance and chrominance signals, e.g., YUV format, to a destination format, e.g., RGB or CMY formats, by forming luminance and chrominance component words which include partitioned words representing various color components of the luminance and chrominance signals. The luminance and chrominance component words are summed using a partitioned addition operation to thereby accumulate the various color components of the luminance and chrominance signals simultaneously and in parallel. Formation of the luminance and chrominance component words is, in some instances, done by a load and store unit of a central processing unit while a graphics execution unit simultaneously sums the luminance and chrominance components using the partitioned addition operation. By using this technique, conversion of pixels of a color motion image from YUV format to a different format, e.g., RGB format, is reduced from approximately 20 instruction cycles per pixel to generally less than 2.5 instruction cycles per pixel. Such a reduction in processing requirements has enabled full real-time rendering, e.g., thirty frames per second, of full-sized, digital NTSC, MPEG-compressed, motion video images using only a central processing unit and appropriately configured computer software. No additional, special-purpose hardware components were needed.
摘要翻译：通过形成包括表示各种颜色的分割字的亮度和色度分量字，将彩色视频图像的像素从具有亮度和色度信号（例如YUV格式）的一种颜色格式转换为目的地格式，例如RGB或CMY格式亮度和色度信号的分量。亮度和色度分量词使用分割加法运算相加，从而同时和并行地累积亮度和色度信号的各种颜色分量。在一些情况下，亮度和色度分量词的形成由中央处理单元的加载和存储单元完成，而图形执行单元使用分区加法运算来同时对亮度和色度分量求和。通过使用这种技术，从YUV格式的颜色运动图像的像素到不同格式（例如，RGB格式）的转换从每像素的大约20个指令周期减少到每个像素通常小于2.5个指令周期。这样的处理要求的降低使得仅使用中央处理单元和适当配置的计算机软件的全尺寸，数字NTSC，MPEG压缩，运动视频图像的全实时渲染，例如，每秒30帧。不需要额外的专用硬件组件。

6. 发明申请

US20110288844A1 Modeling of mPGES-1 three-dimensional structures: applications in drug design and discovery 审中-公开
标题翻译： mPGES-1三维结构的建模：药物设计和发现中的应用
公开(公告)号：US20110288844A1
公开(公告)日：2011-11-24
申请号：US13064594
申请日：2011-04-01
申请人： Chang-Guo Zhan , Xiaoqin Huang , Adel Hamza
发明人： Chang-Guo Zhan , Xiaoqin Huang , Adel Hamza
IPC分类号： G06G7/48
CPC分类号： G06F19/16 , C07K1/00 , C12N9/90 , C12Y503/99003 , G06F19/22
摘要： This invention relates to representations of prostaglandin synthase three-dimensional structures. Such representations are suitable for designing agents that modulate the activity of the enzyme by binding to the substrate binding domain.
摘要翻译：本发明涉及前列腺素合酶三维结构的表示。这种表征适用于设计通过结合底物结合结构域来调节酶的活性的试剂。

7. 发明授权

US07919082B1 High-activity mutants of butyrylcholinesterase for cocaine hydrolysis and method of generating the same 有权
标题翻译：用于可卡因水解的丁酰胆碱酯酶的高活性突变体及其产生方法
公开(公告)号：US07919082B1
公开(公告)日：2011-04-05
申请号：US12752920
申请日：2010-04-01
申请人： Chang-Guo Zhan , Hoon Cho , Hsin-Hsiung Tai
发明人： Chang-Guo Zhan , Hoon Cho , Hsin-Hsiung Tai
IPC分类号： A61K38/46 , C12N9/16
CPC分类号： C12N9/18 , A61K38/00 , C12Y301/01008
摘要： A novel computational method and generation of mutant butyrylcholinesterase for cocaine hydrolysis is provided. The method includes molecular modeling a possible BChE mutant and conducting molecular dynamics simulations and hybrid quantum mechanical/molecular mechanical calculations thereby providing a screening method of possible BChE mutants by predicting which mutant will lead to a more stable transition state for a rate determining step. Site-directed mutagenesis, protein expression, and protein activity is conducted for mutants determined computationally as being good candidates for possible BChE mutants, i.e., ones predicted to have higher catalytic efficiency as compared with wild-type BChE. In addition, mutants A199S/A328W/Y332G, A199S/F227A/A328W/Y332G, A199S/S287G/A328W/Y332G, A199S/F227A/S287G/A328W/Y332G, and A199S/F227A/S287G/A328W/E441D all have enhanced catalytic efficiency for (−)-cocaine compared with wild-type BChE.
摘要翻译：提供了一种新颖的计算方法和用于可卡因水解的突变丁酰胆碱酯酶的产生。该方法包括对可能的BChE突变体进行分子建模，并进行分子动力学模拟和混合量子力学/分子机械计算，从而通过预测哪个突变体将导致速率确定步骤的更稳定的过渡状态来提供可能的BChE突变体的筛选方法。对于可能的BChE突变体，即与野生型BChE相比预测具有更高催化效率的突变体，对计算确定的突变体进行定点诱变，蛋白质表达和蛋白质活性。此外，突变体A199S / A328W / Y332G，A199S / F227A / A328W / Y332G，A199S / S287G / A328W / Y332G，A199S / F227A / S287G / A328W / Y332G和A199S / F227A / S287G / A328W / E441D都具有增强的催化（ - ） - 可卡因与野生型BChE相比有效。

8. 发明授权

US07731957B1 High-activity mutants of butyrylcholinesterase for cocaine hydrolysis and method of generating the same 有权
标题翻译：用于可卡因水解的丁酰胆碱酯酶的高活性突变体及其产生方法
公开(公告)号：US07731957B1
公开(公告)日：2010-06-08
申请号：US12192394
申请日：2008-08-15
申请人： Chang-Guo Zhan , Hoon Cho , Hsin-Hsiung Tai
发明人： Chang-Guo Zhan , Hoon Cho , Hsin-Hsiung Tai
IPC分类号： A61K38/46 , C12N9/16
CPC分类号： C12N9/18 , A61K38/00 , C12Y301/01008
摘要： A novel computational method and generation of mutant butyrylcholinesterase for cocaine hydrolysis is provided. The method includes molecular modeling a possible BChE mutant and conducting molecular dynamics simulations and hybrid quantum mechanical/molecular mechanical calculations thereby providing a screening method of possible BChE mutants by predicting which mutant will lead to a more stable transition state for a rate determining step. Site-directed mutagenesis, protein expression, and protein activity is conducted for mutants determined computationally as being good candidates for possible BChE mutants, i.e., ones predicted to have higher catalytic efficiency as compared with wild-type BChE. In addition, mutants A199S/A328W/Y332G, A199S/F227A/A328W/Y332G, A199S/S287G/A328W/Y332G, A199S/F227A/S287G/A328W/Y332G, and A199S/F227A/S287G/A328W/E441D all have enhanced catalytic efficiency for (−)-cocaine compared with wild-type BChE.
摘要翻译：提供了一种新颖的计算方法和用于可卡因水解的突变丁酰胆碱酯酶的产生。该方法包括对可能的BChE突变体进行分子建模，并进行分子动力学模拟和混合量子力学/分子机械计算，从而通过预测哪个突变体将导致速率确定步骤的更稳定的过渡状态来提供可能的BChE突变体的筛选方法。对于可能的BChE突变体，即与野生型BChE相比预测具有更高催化效率的突变体，对计算确定的突变体进行定点诱变，蛋白质表达和蛋白质活性。此外，突变体A199S / A328W / Y332G，A199S / F227A / A328W / Y332G，A199S / S287G / A328W / Y332G，A199S / F227A / S287G / A328W / Y332G和A199S / F227A / S287G / A328W / E441D都具有增强的催化（ - ） - 可卡因与野生型BChE相比有效。

9. 发明授权

US08846887B1 High activity mutants of butyrylcholinesterase for cocaine hydrolysis 有权
标题翻译：用于可卡因水解的丁酰胆碱酯酶的高活性突变体
公开(公告)号：US08846887B1
公开(公告)日：2014-09-30
申请号：US13479899
申请日：2012-05-24
申请人： Chang-Guo Zhan , Fang Zheng , Wenchao Yang
发明人： Chang-Guo Zhan , Fang Zheng , Wenchao Yang
IPC分类号： C07H21/04
CPC分类号： A61K38/465 , A61K38/00 , C12N9/18 , C12Y301/01008
摘要： Butyrylcholinesterase (BChE) polypeptide variants of the presently-disclosed subject matter have enhanced catalytic efficiency for (−)-cocaine, as compared to wild-type BChE. Pharmaceutical compositions of the presently-disclosed subject matter include a BChE polypeptide variant having an enhanced catalytic efficiency for (−)-cocaine. A method of the presently-disclosed subject matter for treating a cocaine-induced condition includes administering to an individual an effective amount of a BChE polypeptide variant, as disclosed herein, to lower blood cocaine concentration.
摘要翻译：与野生型BChE相比，目前公开的主题的丁酰胆碱酯酶（BChE）多肽变体具有增强（ - ） - 可卡因的催化效率。目前公开的主题的药物组合物包括对（ - ） - 可卡因具有增强的催化效率的BChE多肽变体。用于治疗可卡因诱导病症的目前公开的主题的方法包括向个体施用有效量的如本文公开的BChE多肽变体以降低可卡因浓度。

10. 发明申请

US20130289456A1 GARMENT BASED AIRWAY CLEARANCE SYSTEMS AND METHODS 审中-公开
标题翻译：基于服装的空中交通系统和方法
公开(公告)号：US20130289456A1
公开(公告)日：2013-10-31
申请号：US13852520
申请日：2013-03-28
申请人： Mike Yang Chang Guo , Boon Khai Ang , Beng Leong Toh
发明人： Mike Yang Chang Guo , Boon Khai Ang , Beng Leong Toh
IPC分类号： A61H9/00
CPC分类号： A61H9/0007 , A61H9/0078 , A61H2201/0157 , A61H2201/0184 , A61H2201/1207 , A61H2201/1238 , A61H2201/1621 , A61H2201/165 , A61H2201/5007 , A61H2201/501 , A61H2201/5012 , A61H2201/5035 , A61H2201/5038 , A61H2201/5071 , A61H2201/5082 , A61H2201/5097 , A61H2205/084 , A61H2230/065 , A61H2230/085 , A61H2230/305 , A61H2230/505
摘要： A garment based airway clearance system for mobilizing secretions in a patient's airway and related methods are disclosed. The garment based airway clearance system comprises a therapy chamber mounted substantially around the circumference of the garment such that inflation of the therapy chamber causing a compressive force to be applied on the thorax or chest of the wearer of the garment.
摘要翻译：公开了一种用于在患者气道中调动分泌物的基于衣服的气道清除系统及相关方法。基于衣服的气道清除系统包括基本上围绕衣服的圆周安装的治疗室，使得治疗室的膨胀导致施加在衣服的穿着者的胸部或胸部的压缩力。

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