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21. 发明授权

US09856214B2 EBNA1 inhibitors and their method of use 有权
公开(公告)号：US09856214B2
公开(公告)日：2018-01-02
申请号：US15036211
申请日：2014-11-14
申请人： THE WISTAR INSTITUTE OF ANATOMY AND BIOLOGY
发明人： Troy E. Messick , Garry R. Smith , Allen B. Reitz , Paul M. Lieberman , Mark E. McDonnell , Yan Zhang , Venkata Velvadapu
IPC分类号： A61K31/405 , A61K31/41 , A61K31/42 , C07D209/42 , C07D401/00 , C07D403/00 , C07D207/327 , C07C229/56 , C07C255/54 , C07C255/55 , C07C211/27 , C07C217/84 , C07C233/11 , C07C233/64 , C07C233/65 , C07C235/58 , C07C311/08 , C07C311/16 , C07C311/17 , C07C317/14 , C07D235/06 , C07D403/10 , C07D239/26 , C07D409/10 , C07D417/10 , C07D471/04 , C07D487/04 , C07D209/08 , C07D295/155 , C07D213/55 , C07C53/18 , C07C63/66 , C07C65/19 , C07C65/28 , C07C229/64 , C07C317/44 , C07D207/08 , C07D207/12 , C07D207/14 , C07D207/16 , C07D211/70 , C07D213/64 , C07D213/74 , C07D215/14 , C07D231/12 , C07D249/06 , C07D277/30 , C07D307/79 , C07D333/54 , C07D401/04 , C07D401/10
CPC分类号： C07D207/327 , C07C53/18 , C07C63/66 , C07C65/19 , C07C65/28 , C07C211/27 , C07C217/84 , C07C229/56 , C07C229/64 , C07C233/11 , C07C233/64 , C07C233/65 , C07C235/58 , C07C255/54 , C07C255/55 , C07C311/08 , C07C311/16 , C07C311/17 , C07C317/14 , C07C317/44 , C07C2601/02 , C07D207/08 , C07D207/12 , C07D207/14 , C07D207/16 , C07D209/08 , C07D211/70 , C07D213/55 , C07D213/64 , C07D213/74 , C07D215/14 , C07D231/12 , C07D235/06 , C07D239/26 , C07D249/06 , C07D277/30 , C07D295/155 , C07D307/79 , C07D333/54 , C07D401/04 , C07D401/10 , C07D403/10 , C07D409/10 , C07D417/10 , C07D471/04 , C07D487/04
摘要： The invention provides EBNA1 inhibitors, and pharmaceutical compositions comprising the same, that are useful for the treatment of diseases caused by EBNA1 activity such as, but not limited to, cancer, infectious mononucleosis, chronic fatigue syndrome, multiple sclerosis, systemic lupus erythematosus and/or rheumatoid arthritis. The compounds and compositions of the invention are further useful for the treatment of diseases caused by latent Epstein-Barr Virus (EBV) infection. The compounds and compositions of the invention are further useful for the treatment of diseases caused by lytic EBV infection.

22. 发明申请

US20140274794A1 Methods and Compositions for Diagnosis of Ovarian Cancer 审中-公开
公开(公告)号：US20140274794A1
公开(公告)日：2014-09-18
申请号：US14342646
申请日：2012-09-07
申请人： David W. Speicher , Hsin-Yao Tang , Lynn A. Beer
发明人： David W. Speicher , Hsin-Yao Tang , Lynn A. Beer
IPC分类号： C12Q1/68 , G01N33/574
CPC分类号： C12Q1/6886 , C07K14/4748 , G01N33/57449 , G01N2800/50 , G01N2800/54 , G01N2800/56
摘要： Methods and compositions are provided for diagnosing ovarian cancer in a mammalian subject, preferably in a serum or plasma sample of a human subject. The methods and compositions enable the detection or measurement in the sample or from a protein level profile generated from the sample, the protein level of one or more specified biomarkers. Comparing the protein level(s) of the biomarker(s) in the subject's sample or from protein abundance profile of multiple biomarkers, with the level of the same biomarker(s) or profile in a reference standard, permits the determination of a diagnosis of ovarian cancer, or the identification of a risk of developing ovarian cancer, or enables the monitoring of the status of progression or remission of ovarian cancer in the subject followed during a therapeutic protocol.

23. 发明申请

US20140241983A1 Methods and Compositions for Enhancing the Therapeutic Effect of Anti-Tumor T Cells 有权
标题翻译：用于增强抗肿瘤T细胞治疗作用的方法和组合
公开(公告)号：US20140241983A1
公开(公告)日：2014-08-28
申请号：US14350588
申请日：2012-10-24
申请人： The Wistar Institute of Anatomy and Biology
发明人： Hui Hu , Jose R. Conejo-Garcia , Tom-Li Stephen
IPC分类号： C12N15/113 , A61K45/06 , A61K39/395 , A61K31/713 , A61K35/14 , A61K38/20
CPC分类号： C12N15/113 , A61K31/713 , A61K35/17 , A61K38/2046 , A61K39/0011 , A61K39/3955 , A61K45/06 , A61K47/595 , A61K48/005 , A61K2039/5156 , A61K2039/5158 , A61N5/10 , C12N2310/14 , C12N2310/531 , C12N2330/50 , C12N2740/16043
摘要： Compositions, e.g., therapeutic agents, and methods are provided for modulating gene and protein expression of Forkhead Box protein 1 (Foxp1). The therapeutic agents include short nucleic acid molecules that modulate gene and protein expression of Forkhead Box protein 1 (Foxp1) expression, viral vectors containing such molecules, T cells transduced with these viruses for adoptive therapies, and any small molecules that bind to and inactivate Foxp1. These compounds and methods have applications in cancer therapy either alone or in combination with other therapies that stimulate the endogenous immune system in the environment of the cancer, e.g., tumor.
摘要翻译：提供组合物，例如治疗剂和方法用于调节Forkhead Box蛋白1（Foxp1）的基因和蛋白质表达。治疗剂包括调节Forkhead Box蛋白1（Foxp1）表达的基因和蛋白质表达的短核酸分子，含有这种分子的病毒载体，用这些病毒转导用于过继疗法的T细胞以及结合和失活Foxp1的任何小分子。这些化合物和方法单独使用或与刺激癌症环境（例如肿瘤）中的内源性免疫系统的其它治疗组合的癌症治疗中有应用。

24. 发明申请

US20140099340A1 Compositions and Methods for Targeting Stromal Cells for the Treatment of Cancer 有权
标题翻译：靶向基质细胞治疗癌症的组合物和方法
公开(公告)号：US20140099340A1
公开(公告)日：2014-04-10
申请号：US14042306
申请日：2013-09-30
申请人： The Wistar Institute of Anatomy and Biology , The Trustees of the University of Pennsylvania
发明人： Carl H. June , Ellen Pure , Liang-Chuan Wang , Steven Albelda , John Scholler
IPC分类号： C07K16/18 , A61K35/14 , A61K39/00
CPC分类号： C07K16/40 , A61K35/17 , A61K39/0011 , C07K14/7051 , C07K14/70517 , C07K14/70521 , C07K14/70578 , C07K16/18 , C07K16/30 , C07K2317/24 , C07K2317/51 , C07K2317/515 , C07K2317/622 , C07K2317/73 , C07K2319/02 , C07K2319/03 , C07K2319/30 , C07K2319/70 , C12N2710/10343
摘要： The present invention provides compositions and methods for treating cancer in a human. The invention relates to targeting the stromal cell population in a tumor microenvironment. For example, in one embodiment, the invention provides a composition that is targeted to fibroblast activation protein (FAP). The invention includes a chimeric antigen receptor (CAR) which comprises an anti-FAP domain, a transmembrane domain, and a CD3zeta signaling domain.
摘要翻译：本发明提供了治疗人类癌症的组合物和方法。本发明涉及在肿瘤微环境中靶向基质细胞群。例如，在一个实施方案中，本发明提供靶向成纤维细胞活化蛋白（FAP）的组合物。本发明包括嵌合抗原受体（CAR），其包含抗FAP结构域，跨膜结构域和CD3zeta信号结构域。

25. 发明授权

US07015309B1 Pyrrhocoricin-derived peptides, and methods of use thereof 有权
标题翻译：来自吡啶维生素的肽，及其使用方法
公开(公告)号：US07015309B1
公开(公告)日：2006-03-21
申请号：US09980804
申请日：2000-06-21
申请人： Laszlo Otvos
发明人： Laszlo Otvos
IPC分类号： C07K1/00
CPC分类号： C07K7/08 , C07K14/43563
摘要： Modifications of the peptide pyrrhocoricin permit the production of a variety of anti-bacterial or anti-fungal peptides having general formula R1-Asp-Lys-Gly-X-Y-Leu-Pro-Arg-Pro-Thr-Pro-Pro-Arg-Pro-Ile-Tyr-X′-Y′-R2 SEQ ID NO: 1 or multimeric compositions containing more than a single peptide of that formula. These peptides may be straight chain or cyclic peptides, and may contain one or more non-cleavable bonds. These peptides are characterized by anti-bacterial or anti-fungal activity and metabolic stability in mammalian serum. These peptides are useful in anti-bacterial or anti-fungal pharmaceutical compositions and for further drug development or identification of other antibiotic or anti-fungal compounds.
摘要翻译：肽吡啶维生素的修饰允许制备各种具有通式R 1 -Asp-Lys-Gly-XY-Leu-Pro-Arg-Pro-Thr的抗细菌或抗真菌肽 -Pro-Pro-Arg-Pro-Ile-Tyr-X'-Y'-R 2 SEQ ID NO：1或含有多于该式的单一肽的多聚体组合物。这些肽可以是直链或环状肽，并且可以含有一个或多个不可裂解的键。这些肽的特征在于哺乳动物血清中的抗细菌或抗真菌活性和代谢稳定性。这些肽可用于抗细菌或抗真菌药物组合物和用于进一步药物开发或鉴定其它抗生素或抗真菌化合物。

26. 发明申请

US20060003938A1 Novel pyrrhocoricin-derived peptides and methods of use thereof 审中-公开
标题翻译：新型吡啶维生素衍生肽及其使用方法
公开(公告)号：US20060003938A1
公开(公告)日：2006-01-05
申请号：US11220439
申请日：2005-09-07
申请人： Laszlo Otvos
发明人： Laszlo Otvos
IPC分类号： A61K38/16 , C07K7/08 , C12P21/06
CPC分类号： C07K7/08 , A61K38/00 , C07K9/00 , C07K14/43563
摘要： Modifications of the peptide pyrrhocoricin permit the production of a variety of anti-bacterial or anti-fungal peptides having the general formula R1-Asp-Lys-Gly-X-Y-Leu-Pro-Arg-Pro-Thr-Pro-Pro-Arg-Pro-Ile-Tyr-X′-Y′-R2 [SEQ ID NO: 1] or multimeric compositions containing more than a single peptide of that formula. These peptides may be straight chain or cyclic peptides, and may contain one or more non-cleavable bonds. These peptides are characterized by anti-bacterial or anti-fungal activity and metabolic stability in mammalian serum. These peptides are useful in anti-bacterial or anti-fungal pharmaceutical compositions and for further drug development or identification of other antibiotic or anti-fungal compounds.
摘要翻译：肽吡啶维生素的修饰允许产生具有通式R 1 -Asp-Lys-Gly-XY-Leu-Pro-Arg-Pro-1的各种抗细菌或抗真菌肽， Thr-Pro-Pro-Arg-Pro-Ile-Tyr-X'-Y'-R 2 [SEQ ID NO：1]或含有多于该式的单一肽的多聚体组合物。这些肽可以是直链或环状肽，并且可以含有一个或多个不可裂解的键。这些肽的特征在于哺乳动物血清中的抗细菌或抗真菌活性和代谢稳定性。这些肽可用于抗细菌或抗真菌药物组合物和用于进一步药物开发或鉴定其它抗生素或抗真菌化合物。

27. 发明申请

US20030219435A9 Method of reducing an immune response to a recombinant virus 审中-公开
公开(公告)号：US20030219435A9
公开(公告)日：2003-11-27
申请号：US09994965
申请日：2001-11-27
申请人： The Trustees of the University of Pennsylvania , The Wistar Institute of Anatomy and Biology
发明人： James M. Wilson , Yiping Yang , Giorgio Trinchieri
IPC分类号： A61K048/00 , A61K039/395 , A61K038/20
CPC分类号： C12N15/86 , A61K39/39541 , A61K48/00 , A61K2039/505 , C07K16/2812 , C07K16/2875 , C12N2710/10343 , A61K2300/00
摘要： A method of reducing immune response during gene therapy is provided which involves co-administration of the viral vector bearing a therapeutic transgene and a selected immune modulator capable of inhibiting the formation of neutralizing antibodies and/or CTL elimination of the vectors upon repeated administration.

28. 发明申请

US20030166021A1 Box-dependent Myc-interacting protein (BIN1) compositions and uses therefor 审中-公开
标题翻译：盒依赖性Myc相互作用蛋白（BIN1）组合物及其用途
公开(公告)号：US20030166021A1
公开(公告)日：2003-09-04
申请号：US10123807
申请日：2002-04-16
申请人： The Wistar Institute of Anatomy and Biology
发明人： George C. Prendergast , Daitoku Sakamuro
IPC分类号： G01N033/574 , C07K016/40 , C07K016/30
CPC分类号： C07K16/18 , A61K38/00 , A61K48/00 , C07K14/4702 , C07K14/4703 , C07K14/4747
摘要： The present invention provides Bin1 genomic sequences and proteins encoded thereby. Also provided are compositions and methods utilizing these sequences and proteins in the diagnosis and treatment of cancers and hyperplastic disease states. Further provided are oligonucleotides derived from sequences encoding Bin1, as well as compositions and methods utilizing same for diagnostic and therapeutic purposes.
摘要翻译：本发明提供了Bin1基因组序列和由此编码的蛋白质。还提供了利用这些序列和蛋白质在癌症和增生性疾病状态的诊断和治疗中的组合物和方法。还提供了衍生自编码Bin1的序列的寡核苷酸，以及用于诊断和治疗目的的组合物和方法。

29. 发明申请

US20030108957A1 Biocidal molecules, macromolecular targets and methods of production and use 审中-公开
标题翻译：杀生物分子，大分子靶标和生产和使用方法
公开(公告)号：US20030108957A1
公开(公告)日：2003-06-12
申请号：US10181654
申请日：2002-07-19
申请人： The Wistar Institute of Anatomy and Biology
发明人： Laszlo Otvos , Magdalena Blaszczyk-Thurin
IPC分类号： A01N061/00 , G01N033/567 , G06F019/00 , G01N033/48 , G01N033/50
CPC分类号： A01N37/46 , A01N61/00 , A61K38/1709 , C07K14/4713 , C12Q1/18 , G01N33/5011 , G01N33/5695 , G01N33/6875 , G01N2333/195 , G01N2333/35 , G01N2333/37 , G01N2333/43552 , G01N2333/47 , G01N2500/04
摘要： A method for identifying a compound that has a biocidal effect against a selected organism involves screening from among known or unknown peptide or non-peptide molecules, a test molecule that binds selectively to a target sequence of a multi-helical lid of a heat shock protein of the organism. The binding of the test compound inhibits the protein folding activity of the protein. A specific embodiment of such a method is useful for identifying or designing a pharmaceutical or veterinary biocidal or antibiotic compound, preferably a pathogen and/or strain-specific compound. For this purpose, the compound does not bind to a heat shock protein that is homologous to the mammalian subject to be treated with the compound. Screening methods can encompass direct binding or competitive assays. Molecules or compounds identified by these methods are employed as biocides for pharmaceutical, veterinary, pesticide, insecticide and rodenticide uses, among others.
摘要翻译：用于鉴定对所选生物具有杀生物作用的化合物的方法涉及从已知或未知的肽或非肽分子中筛选，所述测试分子选择性地结合热休克蛋白多螺旋盖的靶序列的生物体。测试化合物的结合抑制蛋白质的蛋白质折叠活性。这种方法的具体实施方案可用于鉴定或设计药用或兽用杀生物剂或抗生素化合物，优选病原体和/或菌株特异性化合物。为此，该化合物不结合与用该化合物处理的哺乳动物受试者同源的热休克蛋白。筛选方法可以包括直接结合或竞争性测定。通过这些方法鉴定的分子或化合物被用作药物，兽医，农药，杀虫剂和杀鼠剂用途的杀生物剂等。

30. 发明授权

US6159710A Method and compositions for stabilizing unstable gene transcripts 有权
标题翻译：用于稳定不稳定基因转录物的方法和组合物
公开(公告)号：US6159710A
公开(公告)日：2000-12-12
申请号：US403267
申请日：1999-10-15
申请人： Nigel W. Fraser , Janice M. Zabolotny , Claude F. Krummenacher
发明人： Nigel W. Fraser , Janice M. Zabolotny , Claude F. Krummenacher
IPC分类号： A61K48/00 , C07K14/035 , C07K14/82 , C12N15/63 , C12N15/869 , C12P21/02
CPC分类号： C12N15/86 , A61K48/00 , C07K14/005 , C07K14/82 , C07K2319/00 , C12N15/63 , C12N2710/16622 , C12N2710/16643 , C12N2830/00 , C12N2830/003 , C12N2840/44
摘要： A polynucleotide molecule useful for stably producing a gene product includes a polynucleotide sequence encoding the gene product (or alternatively a gene transcript) flanked by a 5' sequence and a 3' of an intron. Methods and compositions using this molecule permit enhanced recombinant expression of the gene product and are particularly useful in stabilizing unstable mRNA transcripts, permitting the stable production of desirable genes encoded thereby. Vectors and host cells containing this molecule are useful in the methods.
摘要翻译： PCT No.PCT / US98 / 07691 Sec。 371 1999年10月15日第 102（e）1999年10月15日PCT PCT 1998年4月17日PCT公布。第WO98 / 48004号公报 1998年10月29日的日期可用于稳定产生基因产物的多核苷酸分子包括编码侧翼为内含子的5'序列和3'的基因产物（或基因转录物）的多核苷酸序列。使用该分子的方法和组合物可以增强基因产物的重组表达，并且特别可用于稳定不稳定的mRNA转录物，从而稳定地产生由其编码的所需基因。含有该分子的载体和宿主细胞在该方法中是有用的。

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