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1. 发明申请

US20040265932A1 Reagents and methods useful for detecting diseases of the breast 审中-公开
标题翻译：用于检测乳腺疾病的试剂和方法
公开(公告)号：US20040265932A1
公开(公告)日：2004-12-30
申请号：US10816326
申请日：2004-04-01
发明人： Jerry Henslee , Paul N. Friedman
IPC分类号： G01N033/574 , C12Q001/68
CPC分类号： C07K14/47 , A01K2217/05 , A61K38/00 , A61K39/00 , A61K2039/505 , A61K2039/51 , C07K14/4721 , C07K14/4748 , C07K16/18 , C07K16/3015 , C07K2319/00 , C12Q1/6886 , C12Q2600/136 , G01N33/57415 , G01N2333/4713
摘要： This invention relates to the use of two or more breast specific markers for the detection of breast cancer in a patient.
摘要翻译：本发明涉及两种或多种乳房特异性标记物用于检测患者乳腺癌的用途。

2. 发明申请

US20040265931A1 HAUSP-Mdm2 interaction and uses thereof 失效
标题翻译： HAUSP-Mdm2相互作用及其用途
公开(公告)号：US20040265931A1
公开(公告)日：2004-12-30
申请号：US10813177
申请日：2004-03-29
发明人： Wei Gu , Muyang Li
IPC分类号： G01N033/574
CPC分类号： A61K38/1709 , C12Q1/6886 , C12Q2600/136 , G01N33/57426 , G01N33/57484
摘要： The present invention provides methods for diagnosing neoplasia, assessing the efficacy of therapy to treat neoplasia, assessing the prognosis of a subject who has neoplasia, and treating neoplasia. The present invention also provides a kit for use in detecting neoplasia. The present invention further provides methods for deubiquitinating and/or stabilizing Mdm2 in a cell, and for modulating deubiquitination and/or stability of p53 in a cell. Additionally, the present invention provides a method for identifying a modulator of Mdm2-HAUSP interaction. Also provided is a modulator identified by this method, a pharmaceutical composition comprising the modulator, and use of the modulator in a method of treating neoplasia. The present invention further provides methods for identifying an agent that is reactive with Mdm2 and an agent that is reactive with HAUSP. Also provided are agents identified by these methods. Finally, the present invention provides a complex comprising Mdm2 and HAUSP.
摘要翻译：本发明提供了用于诊断肿瘤的方法，评估治疗瘤形成的疗效，评估具有瘤形成的受试者的预后以及治疗瘤形成的方法。本发明还提供了用于检测瘤形成的试剂盒。本发明还提供了在细胞中去泛素化和/或稳定Mdm2的方法，并且用于调节细胞中p53的去泛素化和/或稳定性的方法。另外，本发明提供了鉴定Mdm2-HAUSP相互作用的调节剂的方法。还提供了通过该方法鉴定的调节剂，包含调节剂的药物组合物，以及在治疗瘤形成的方法中调节剂的用途。本发明还提供用于鉴定与Mdm2反应的试剂和与HAUSP反应的试剂的方法。还提供了通过这些方法鉴定的药剂。最后，本发明提供了包含Mdm2和HAUSP的复合物。

3. 发明申请

US20040265928A1 Polynucleotides differentially expressed in adenocarcinomas, polypeptides encoded thereby, and methods of use thereof 审中-公开
标题翻译：在腺癌中差异表达的多核苷酸，由此编码的多肽及其使用方法
公开(公告)号：US20040265928A1
公开(公告)日：2004-12-30
申请号：US10763692
申请日：2004-01-22
发明人： Giulia C. Kennedy
IPC分类号： C12Q001/68 , G01N033/574 , C07H021/04 , C12N009/64
CPC分类号： C07K14/47 , A01K2217/05 , A01K2217/075
摘要： The present invention features human HX2004-6 polypeptide and nucleotide sequences encoding HX2004-6 polypeptides. In a particular aspect, the polynucleotide is the nucleotide sequence of SEQ ID NO: 1. In related aspects the invention features expression vectors and host cells comprising polynucleotides that encode a human HX2004-6 polypeptide. The present invention also relates to antibodies that bind specifically to a human HX2004-6 polypeptide. Further provided are diagnostic and screening methods using HX2004-6 polynucleotides and antibodies specific for HX2004-6 polypeptides.
摘要翻译：本发明的特征在于人HX2004-6多肽和编码HX2004-6多肽的核苷酸序列。在一个特定方面，多核苷酸是SEQ ID NO：1的核苷酸序列。在相关方面，本发明的特征在于包含编码人HX2004-6多肽的多核苷酸的表达载体和宿主细胞。本发明还涉及与人HX2004-6多肽特异性结合的抗体。还提供了使用HX2004-6多核苷酸和HX2004-6多肽特异性抗体的诊断和筛选方法。

4. 发明申请

US20040253652A1 Method and system for detecting electrophysiological changes in pre-cancerous and cancerous breast tissue and epithelium 失效
标题翻译：检测前癌和癌性乳腺组织和上皮细胞电生理变化的方法和系统
公开(公告)号：US20040253652A1
公开(公告)日：2004-12-16
申请号：US10717074
申请日：2003-11-19
发明人： Richard J. Davies
IPC分类号： G01N033/574
CPC分类号： A61B5/0531 , A61B5/04002 , A61B5/04082 , A61B5/4312 , A61B5/4839
摘要： A method and system are provided for determining a condition of a selected region of epithelial and stromal tissue in the human breast. A plurality of measuring electrodes are used to measure the tissue and transepithelial electropotential of breast tissue. Surface electropotential and impedance are also measured at one or more locations. An agent may be introduced into the region of tissue to enhance electrophysiological characteristics. The condition of the tissue is determined based on the electropotential and impedance profile at different depths of the epithelium, stroma, tissue, or organ, together with an estimate of the functional changes in the epithelium due to altered ion transport and electrophysiological properties of the tissue. Devices for practicing the disclosed methods are also provided.
摘要翻译：提供了用于确定人乳腺中上皮和基质组织的选定区域的状况的方法和系统。多个测量电极用于测量乳腺组织的组织和跨上皮电穿孔。在一个或多个位置也测量表面电位和阻抗。可以将药剂引入组织区域以增强电生理特征。基于上皮，基质，组织或器官的不同深度处的电位和阻抗分布来确定组织的状况，以及由于组织的离子迁移和电生理学性质的上皮的功能变化的估计。还提供了用于实践所公开方法的设备。

5. 发明申请

US20040248218A1 Gene SCC-112 and diagnostic and therapeutic uses thereof 失效
标题翻译：基因SCC-112及其诊断和治疗用途
公开(公告)号：US20040248218A1
公开(公告)日：2004-12-09
申请号：US10679580
申请日：2003-10-06
申请人： Georgetown University , NeoPharm, Inc.
发明人： Usha Kasid , Deepak Kumar , Imran Ahmad
IPC分类号： G01N033/574 , C12N009/64 , C07H021/04
CPC分类号： C07K14/82 , A61K38/00 , G01N33/574
摘要： A gene that is a modulator of tumor growth and metastasis in certain cancer types is provided. SCC-112 (about 150 kDa) and/or a mutant form of SCC-112 (about 65 kDa) is a tumor suppressor molecule. This gene and corresponding polypeptide have diagnostic and therapeutic application for detecting and treating cancers that involve expression of SCC-112 such as breast and kidney cancers.
摘要翻译：提供了一种在某些癌症类型中是肿瘤生长和转移的调节剂的基因。 SCC-112（约150kDa）和/或突变形式的SCC-112（约65kDa）是肿瘤抑制分子。该基因和相应的多肽具有用于检测和治疗涉及表达SCC-112（例如乳腺和肾癌）的癌症的诊断和治疗应用。

6. 发明申请

US20040248216A1 Method of examining cancer by assaying autoantibody against mdm2 and reagent therefor 审中-公开
标题翻译：通过测定针对mdm2的自身抗体及其试剂检测癌症的方法
公开(公告)号：US20040248216A1
公开(公告)日：2004-12-09
申请号：US10240231
申请日：2002-09-27
发明人： Yuko Seino
IPC分类号： G01N033/567 , G01N033/574
CPC分类号： C07K14/47 , G01N33/57407 , G01N33/57423 , G01N33/57484
摘要： The present invention relates to a novel method for detecting a cancer by measuring an autoantibody to MDM2 in blood, a reagent therefor, and a kit therefor. For example, a MDM peptide fragment is used as an antigen, and an anti-MDM2 antibody produced by use of said antigen, or the labeled product thereof is used as an antibody for measuring the above autoantibody, to detect the cancer by an immunoassay.
摘要翻译：本发明涉及通过测量血液中MDM2的自身抗体，其试剂及其试剂盒来检测癌症的新方法。例如，使用MDM肽片段作为抗原，使用通过使用所述抗原产生的抗MDM2抗体或其标记产物作为测定上述自身抗体的抗体，通过免疫测定法检测癌症。

7. 发明申请

US20040248151A1 Method for predicting the response to HER2-directed therapy 审中-公开
标题翻译：预测HER2导向治疗反应的方法
公开(公告)号：US20040248151A1
公开(公告)日：2004-12-09
申请号：US10735118
申请日：2003-12-11
申请人： Ventana Medical Systems, Inc. , Cell Signaling Technology
发明人： Sarah S. Bacus , Bradley L. Smith
IPC分类号： C12Q001/68 , G01N033/574
CPC分类号： G01N33/57415 , C07K16/2863 , C07K16/40 , C07K2317/24 , G01N33/5041 , G01N33/574 , G01N33/6893 , G01N2333/4703 , G01N2333/4756 , G01N2333/71 , G01N2333/912 , G01N2333/9121 , G01N2440/14 , G01N2800/52
摘要： This invention provides methods for determining or predicting response to HER2-directed therapy in an individual.
摘要翻译：本发明提供了确定或预测个体对HER2定向治疗的反应的方法。

8. 发明申请

US20040241653A1 Methods for identifying marker genes for cancer 审中-公开
标题翻译：识别癌症标志物基因的方法
公开(公告)号：US20040241653A1
公开(公告)日：2004-12-02
申请号：US10335053
申请日：2002-12-31
发明人： Elena Feinstein , Andrei V. Gudkov
IPC分类号： C12Q001/68 , G01N033/574
CPC分类号： G01N33/5748 , C12Q1/6886 , C12Q2600/136 , G01N33/574 , G01N2500/00 , G01N2500/10
摘要： The invention describes a method of identifying tissue-specific tumor markers, and diagnostic and therapeutic methods and compositions of using the same. More specifically, the invention presents a method for a rational search of diagnostic and prognostic cancer markers and therapeutic targets among the genes negatively regulated by tumor suppressor genes.
摘要翻译：本发明描述了鉴定组织特异性肿瘤标志物的方法，以及使用其的诊断和治疗方法和组合物。更具体地，本发明提供了一种在由肿瘤抑制基因负调控的基因中合理搜索诊断和预后癌症标志物和治疗靶标的方法。

9. 发明申请

US20040235073A1 Kruppel-like transcriptional factor KLF4/GKLF and uses thereof 失效
标题翻译： Kruppel样转录因子KLF4 / GKLF及其用途
公开(公告)号：US20040235073A1
公开(公告)日：2004-11-25
申请号：US10776133
申请日：2004-02-11
发明人： J. Michael Ruppert , Jeffrey Allen Engler
IPC分类号： G01N033/574
CPC分类号： C12Q1/6886 , A61K38/00 , C07H21/00 , C07K14/82 , C12N2799/025 , C12Q2600/106 , C12Q2600/112 , C12Q2600/118 , C12Q2600/136 , G01N33/5017 , G01N2500/10 , G01N2800/52
摘要： The present invention proivdes methods of identifying new carcinoma oncogenes or analyzing functions of known carcinoma oncogenes by transformation of RK3E cells. Also provided are methods of using nuclear localization of Krnullppel-like factor 4 (KLF4, or termed Gut-Enriched Krnullppel-Like Factor, GKLF) as a marker and prognostic factor for aggressive early-stage breast carcinoma.
摘要翻译：本发明通过转化RK3E细胞来产生鉴定新的致癌基因或分析已知致癌基因的功能的方法。还提供了使用Krüppel样因子4（KLF4或称为富含Gückel样因子，GKLF）的核定位作为侵袭性早期乳腺癌的标志物和预后因子的方法。

10. 发明申请

US20040235071A1 Methods and compositions for treating cancer using 15986, 2188, 20743, 9148, 9151, 9791, 44252, 14184, 42461, 8204, 7970, 25552, 21657, 26492, 2411, 15088, 1905, 28899, 63380, 33935, 10480, 12686, 25501, 17694, 15701, 53062, 49908, 21612, 38949, 6216, 46863, 9235, 2201, 6985, 9883, 12238, 18057, 21617, 39228, 49928, 54476, 62113, 64316, 12264, 32362, 58198, 2887, 3205, 8557, 9600, 9693, 44867, 53058, 55556, 57658, 2208, 10252, 10302, 14218, 33877, 10317, 10485, 25964, 14815, 1363, 1397, 14827, 21708, 3801, 64698, 2179 or 13249 审中-公开
公开(公告)号：US20040235071A1
公开(公告)日：2004-11-25
申请号：US10737450
申请日：2003-12-16
申请人： Millennium Pharmaceuticals, Inc.
发明人： Eric S. Lightcap , Jeffrey A. Ecsedy , John J. Hunter , Kyle J. MacBeth , Michelle Tighe Nestor
IPC分类号： G01N033/574
CPC分类号： G01N33/574
摘要： The present invention relates to methods for the diagnosis and treatment of a cancer or cancer. Specifically, the present invention identifies the differential expression of 15986, 2188, 20743, 9148, 9151, 9791, 44252, 14184, 42461, 8204, 7970, 25552, 21657, 26492, 2411, 15088, 1905, 28899, 63380, 33935, 10480, 12686, 25501, 17694, 15701, 53062, 49908, 21612, 38949, 6216, 46863, 9235, 2201, 6985, 9883, 12238, 18057, 21617, 39228, 49928, 54476, 62113, 64316, 12264, 32362, 58198, 2887, 3205, 8557, 9600, 9693, 44867, 53058, 55556, 57658, 2208, 10252, 10302, 14218, 33877, 10317, 10485, 25964, 14815, 1363, 1397, 14827, 21708, 3801, 64698, 2179 and 13249 genes in tissues relating to cancer, relative to their expression in normal, or non-cancer disease states, and/or in response to manipulations relevant to a cancer. The present invention describes methods for the diagnostic evaluation and prognosis of various cancers, and for the identification of subjects exhibiting a predisposition to such conditions. The invention also provides methods for identifying a compound capable of modulating a cancer or cancer. The present invention also provides methods for the identification and therapeutic use of compounds as treatments of cancer.

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