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21. 发明授权

US10145841B2 Method for detecting antigen, and apparatus using same 有权
公开(公告)号：US10145841B2
公开(公告)日：2018-12-04
申请号：US14379664
申请日：2013-02-20
申请人： NANOENTEK, INC.
发明人： Chan Il Chung , Chang Seop Lee , Jeoung Ku Hwang , Jong Sik Jeong
IPC分类号： G01N33/543 , G01N33/53
摘要： The present invention provides a method for detecting an antigen in an analysis sample, the method including: (a) contacting an analysis sample with a detection antibody with which a marker generating a detectable signal is combined and which specifically binds to the antigen; (b) contacting a capture antibody with the resultant product of step (a), the capture antibody specifically binding to an antigen to be detected; (c) contacting the detection antibody, with which the marker generating a detectable signal is combined, with a reference substance which is bound to a surface of a solid substrate and which includes an epitope to which the detection antibody specifically binds; (d) measuring signals generated from the markers of the resultant product of step (b) and the resultant product of step (c); and (e) analyzing the measured signals to determine the presence or absence and amount of the antigen in the analysis sample. The method for detecting an antigen of the present invention can control the flow and the reaction time of an analysis sample, thereby improving sensitivity and minimizing the influences by the concentration of the analysis sample or the temperature of the detection reaction, and thus improving stability, reliability, and reproducibility of data, when compared with the conventional method for detecting an antigen. Accordingly, the method and apparatus for detecting an antigen of the present invention can be easily operated without specialized skills, thereby instantly obtaining the presence or absence and amount of detection antigen in the analysis sample through on-site diagnosis.

22. 发明申请

US20150253561A1 MICROSCOPE AND METHOD FOR CONTROLLING SAME 审中-公开
标题翻译：显微镜及其控制方法
公开(公告)号：US20150253561A1
公开(公告)日：2015-09-10
申请号：US14425333
申请日：2013-09-05
申请人： NANOENTEK, INC.
发明人： Jae-Hwa Lee , Sang-Hwa Ahn
IPC分类号： G02B21/36 , G02B21/04 , G02B21/08
CPC分类号： G02B21/365 , G02B21/04 , G02B21/08 , G02B21/24 , G02B21/361
摘要： Disclosed is a microscope and a method of controlling the same. According to the one or more of the embodiments of the present inventions relating to the microscope, an optical module for observing cells may be separated from a control module to be disposed in a narrow space such as the inside of an incubator or the inside of a clean bench, and is capable of observing cells while measuring a distribution of the cells (confluence) in a predetermined cycle.
摘要翻译：公开了一种显微镜及其控制方法。根据与显微镜相关的本发明的一个或多个实施例，用于观察细胞的光学模块可以与控制模块分离以设置在诸如孵化器内部或内部的狭窄空间中并且能够在以预定的周期测量细胞分布（汇合）的同时观察细胞。

23. 发明申请

US20150101422A1 SAMPLE ANALYZING CHIP 有权
标题翻译：样品分析芯片
公开(公告)号：US20150101422A1
公开(公告)日：2015-04-16
申请号：US14401140
申请日：2013-05-14
申请人： NANOENTEK, INC.
发明人： Dae Sung Hur , Jae Jeong Kim , Yu Rae Kim
IPC分类号： G01N1/00 , G01N33/48
CPC分类号： G01N1/00 , B01L3/502715 , B01L3/502723 , B01L3/502746 , B01L2200/027 , B01L2200/0684 , B01L2300/0816 , B01L2300/089 , B01L2400/086 , G01N33/48 , G01N35/08 , G01N2001/002
摘要： The present invention relates to a sample analyzing chip. The chip can prevent upper and lower substrates of a channel from being attached to each other due to deflection on a micro channel and can solve the problem of the sample drying up within a measuring time of a target. Also, the chip can prevent bubbles from being generated in a central portion of the micro channel.
摘要翻译：本发明涉及一种样品分析芯片。该芯片可以防止通道上的上下基板由于微通道上的偏转而彼此附接，并且可以在目标的测量时间内解决样品干燥的问题。此外，芯片可以防止在微通道的中心部分产生气泡。

24. 发明申请

US20140370620A1 MULTIMER TYPE DISCRIMINATION AND DETECTION METHOD FOR MULTIMER-FORMING POLYPEPTIDE 审中-公开
标题翻译：用于多形成多肽的多种类型的鉴别和检测方法
公开(公告)号：US20140370620A1
公开(公告)日：2014-12-18
申请号：US14369896
申请日：2013-01-03
申请人： NANOENTEK, INC.
发明人： Chan Il Chung , Dae Sung Hur , Ho Young Kim , Jason Sung Kim
IPC分类号： G01N33/68
CPC分类号： G01N33/6896 , G01N33/536 , G01N33/54346 , G01N2333/47
摘要： The present invention relates to a method for selectively detecting a multimer type multimer-forming polypeptide in a biological sample, the method comprising: (a) bringing the biological sample into contact with an agglutination reaction inducing agent to induce the formation of an aggregate in an analysis target, the agglutination reaction inducing agent being a particle in which a specific antibody is surface-bonded with the multimer-forming polypeptide; (b) obtaining an image with respect to the aggregate of step (a); and (c) analyzing a size or a shape of the aggregate by using the image. Step (a), step (b), or steps (a) and (b) are performed on a microchip having a microchannel. The image analysis is performed using a coefficient according to the size of the aggregate in a predetermined volume provided by the microchannel. In the case where the multimer type of multimer-forming polypeptide is present in the biological sample, the size of the aggregate is larger than the size of an aggregate of a monomer type control group. According to the present invention, unlike in a detection method using chemiluminescence immunoanalysis of the related art, an image with respect to an agglutination reaction target is obtained and then a size or a shape of an aggregate is analyzed so as to determine whether or not an analysis target is present in a biological sample and to determine the quantity of the analysis target. Also, it is possible to detect a multimer type multimer-forming polypeptide by just analyzing an image acquired from the sample so that the detection process is made more convenient and quick.
摘要翻译：本发明涉及在生物样品中选择性检测多聚体型多聚体形成多肽的方法，该方法包括：（a）使生物样品与凝集反应诱导剂接触以诱导聚集体形成分析对象，凝集反应诱导剂是其中特异性抗体与多聚体形成多肽表面键合的颗粒; （b）获得关于步骤（a）的总计的图像; 和（c）通过使用图像来分析聚集体的尺寸或形状。在具有微通道的微芯片上执行步骤（a），步骤（b）或步骤（a）和（b）。使用根据由微通道提供的预定体积中的聚集体的尺寸的系数执行图像分析。在生物样品中存在多聚体形式的多聚体形成多肽的情况下，聚集体的尺寸大于单体型对照组的聚集体的尺寸。根据本发明，与使用现有技术的化学发光免疫分析的检测方法不同，可以获得相对于凝集反应靶的图像，然后分析聚集体的尺寸或形状，以确定是否分析目标存在于生物样本中并确定分析目标的数量。此外，通过仅仅分析从样品获取的图像，使得检测过程更方便快捷，可以检测多聚体型多聚体形成多肽。

25. 发明授权

US10495633B2 Method for detecting detection object in sample, and detection kit using same 有权
公开(公告)号：US10495633B2
公开(公告)日：2019-12-03
申请号：US15313382
申请日：2015-05-22
申请人： NANOENTEK, INC.
发明人： Joon Seok Seo , Kyu Hwan Shim
IPC分类号： C12Q1/68 , G01N33/53 , G01N33/533 , G01N33/74 , G01N33/543
CPC分类号： G01N33/533 , C12Q1/68 , G01N33/53 , G01N33/54306 , G01N33/74
摘要： The present invention relates to a novel method for detecting a detection object in a sample, and a detection device using the same. The detecting method of the present invention uses a “bridge composite” in which gold nanoparticles and an antibody specific to a detection object are coupled in order to induce a sufficient coupling reaction between the antibody and the detection object, thereby improving reactivity. Accordingly, since excellent resolution is provided, the method of the present invention has advantages of enabling accurate concentration measurement of a detection object in a sample, and amplifying a measurement signal. In addition, the method of the present invention can effectively detect small molecules such as hormones, vitamins, etc. having a small molecular weight.

26. 发明授权

US09176035B2 Sampler 有权
标题翻译：取样器
公开(公告)号：US09176035B2
公开(公告)日：2015-11-03
申请号：US14349368
申请日：2012-05-15
申请人： Dae Sung Hur
发明人： Dae Sung Hur
IPC分类号： G01N1/28 , G01N1/34 , G01N33/49 , A61B5/15 , B01L3/00
CPC分类号： G01N1/34 , A61B5/1405 , A61B5/150022 , A61B5/150343 , A61B5/150755 , B01L3/502753 , B01L2300/0681 , B01L2300/0809 , B01L2300/0832 , B01L2400/0406 , B01L2400/0478 , G01N33/491
摘要： The present invention relates to a sampler which is capable of rapidly and easily separating blood corpuscles from blood, being operated conveniently, and directly using extracted plasma. According to one embodiment of the present invention, a sampler includes a chamber and a membrane guide. Here, the chamber includes an insertion unit having an insertion hole on one side, wherein the other side is opened, and an inner side includes a receiving space for receiving a sample. Additionally, one side of the membrane guide is combined to the membrane, and the membrane guide includes a channel wherein filtered materials, which are filtered through the membrane among the samples received in the receiving space, are moved in a gravitational direction.
摘要翻译：本发明涉及一种能够快速，容易地将血液从血液中分离并且操作方便，并直接使用提取的等离子体的取样器。根据本发明的一个实施例，采样器包括腔室和膜引导件。这里，腔室包括在一侧具有插入孔的插入单元，其中另一侧被打开，并且内侧包括用于接收样品的容纳空间。此外，膜引导件的一侧与膜组合，并且膜引导件包括通道，其中在接收空间中接收的样品中通过膜过滤的过滤材料在重力方向上移动。

27. 发明授权

US08900531B2 Method for bonding plastic micro chip 有权
标题翻译：粘合塑料微芯片的方法
公开(公告)号：US08900531B2
公开(公告)日：2014-12-02
申请号：US12916098
申请日：2010-10-29
申请人： Jun Keun Chang , Dae Sung Hur , Chanil Chung , Jun Ha Park , Han Sang Jo
发明人： Jun Keun Chang , Dae Sung Hur , Chanil Chung , Jun Ha Park , Han Sang Jo
IPC分类号： B01L99/00 , H01L25/04 , B29C65/08 , B29C65/54 , B29C65/00 , B01L3/00 , B29C59/14 , B29C65/02 , B29C65/14 , B29C65/16 , B29C65/48 , B29K23/00 , B29K25/00 , B29K33/00 , B29K69/00 , B29L31/00
CPC分类号： B29C65/4895 , B01L3/5027 , B01L3/502707 , B01L2200/12 , B01L2300/0816 , B01L2300/0825 , B01L2300/0887 , B29C59/14 , B29C65/02 , B29C65/08 , B29C65/14 , B29C65/16 , B29C65/48 , B29C65/54 , B29C65/548 , B29C66/02 , B29C66/028 , B29C66/1122 , B29C66/3022 , B29C66/53461 , B29C66/54 , B29C66/542 , B29C66/71 , B29C66/73161 , B29C66/8322 , B29K2023/06 , B29K2023/12 , B29K2025/00 , B29K2033/12 , B29K2069/00 , B29K2101/12 , B29K2995/0026 , B29L2031/756 , H01L25/046 , H01L2924/0002 , Y10T156/1064 , B29C59/16 , B29C65/00 , H01L2924/00 , B29K2067/003 , B29K2025/06
摘要： Disclosed is a method of bonding upper and lower substrates for manufacturing a plastic micro chip comprising the upper substrate, the lower substrate and a sample filling space having a predetermined height for filling a sample between the upper and lower substrates. According to the method, the upper and lower substrates are bonded by introducing an organic solvent between the upper and lower substrates. In addition, the invention provides a method of manufacturing a micro chip using the method and a micro chip manufactured according to the method. According to the invention, it is possible to easily and precisely bond the upper and lower substrates of the plastic micro chip.
摘要翻译：公开了一种用于制造塑料微芯片的上基板和下基板的方法，其包括上基板，下基板和具有预定高度的样品填充空间，用于在上基板和下基板之间填充样品。根据该方法，通过在上基板和下基板之间引入有机溶剂来粘合上基板和下基板。另外，本发明提供使用该方法制造微芯片的方法和根据该方法制造的微芯片。根据本发明，可以容易且精确地粘合塑料微芯片的上下基板。

28. 发明授权

US08834813B2 Chip for analyzing fluids 有权
标题翻译：用于分析流体的芯片
公开(公告)号：US08834813B2
公开(公告)日：2014-09-16
申请号：US12729583
申请日：2010-03-23
申请人： Jun Ha Park , Chan Il Chung , Jun Keun Chang , Dae Sung Hur , Ji Young Park
发明人： Jun Ha Park , Chan Il Chung , Jun Keun Chang , Dae Sung Hur , Ji Young Park
IPC分类号： B01L99/00 , B01L3/00
CPC分类号： B01L3/5027 , B01L3/502723 , B01L2300/0816 , B01L2300/0851 , B01L2300/0858 , B01L2300/089 , B01L2400/0406 , B01L2400/086
摘要： A fluid analysis chip includes a channel formed within the chip. The chip includes a sample inlet and a sample outlet communicating with an outside of the chip, where the sample inlet and the sample outlet communicate with each other through the closed channel. An expanding part of the channel is formed in a longitudinal direction of the channel in such a manner that a pair of inner walls of the channel define an inner surface of the expanding part, and the expanding part has a larger sectional area than the channel.
摘要翻译：流体分析芯片包括形成在芯片内的通道。芯片包括与芯片外部连通的样品入口和样品出口，其中样品入口和样品出口通过封闭通道彼此连通。通道的扩展部分沿通道的纵向方向形成，使得通道的一对内壁限定扩张部分的内表面，并且扩张部分具有比通道更大的截面面积。

29. 发明授权

US08794450B2 Channel filter having surface topology for filtering micro particles and method for manufacturing same 有权
标题翻译：具有用于过滤微粒子的表面拓扑的通道过滤器及其制造方法
公开(公告)号：US08794450B2
公开(公告)日：2014-08-05
申请号：US12513189
申请日：2007-11-02
申请人： Dae-Sung Hur , Jun-Ha Park , Chan-Il Chung , Jun-Keun Chang
发明人： Dae-Sung Hur , Jun-Ha Park , Chan-Il Chung , Jun-Keun Chang
IPC分类号： B01D35/28 , B01D67/00 , G01N30/90 , B01L3/00
CPC分类号： B01D67/0062 , B01D35/28 , B01L3/502753 , G01N30/90
摘要： Disclosed is a channel filter for separating microparticles, and more particularly to a channel filter which can easily separate a sample having various sized microparticles by using a surface topology. In the disclosed channel filter, a topology having an upward/downward reference height from a sample inlet to an outlet is continuously or discontinuously formed, and thus it is possible to efficiently separate microparticles from a sample liquid.
摘要翻译：公开了一种用于分离微粒的通道过滤器，更具体地说，涉及通过使用表面拓扑结构容易地分离具有各种尺寸的微粒的样品的通道过滤器。在所公开的通道过滤器中，连续地或不连续地形成具有从样品入口到出口的向上/向下参考高度的拓扑，因此可以有效地从样品液体中分离微粒。

30. 发明申请

US20120282625A1 MICROFLUIDIC DEVICE COMPRISING MICROCHANNEL WHERE PROTRUSIONS ARE FORMED ON BOTTOM SURFACE 审中-公开
标题翻译：包含微波通道的微流控器件在底部表面形成
公开(公告)号：US20120282625A1
公开(公告)日：2012-11-08
申请号：US13512319
申请日：2010-11-26
申请人： Dae Sung Hur , Jong Hyun Oh , Jae Jeong Kim , Eun Hee Park
发明人： Dae Sung Hur , Jong Hyun Oh , Jae Jeong Kim , Eun Hee Park
IPC分类号： G01N21/64 , G01N33/53 , G01N33/566
CPC分类号： G01N21/05 , B01L3/502715 , B01L2400/086 , G01N21/0303 , G01N2021/0346
摘要： Disclosed is a microfluidic device comprising a microchannel through which fluid can flow. Protrusions are formed on the bottom surface of the microchannel. The microfluidic device increases detection sensitivity by improving optical characteristics and enhances the reactivity of biochemical reaction by slowing down the velocity of fluid flowing inside the microchannel.
摘要翻译：公开了一种微流体装置，其包括流体可以流过的微通道。突起形成在微通道的底表面上。微流体装置通过改善光学特性来提高检测灵敏度，并通过减缓在微通道内流动的流体的速度来提高生化反应的反应性。

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