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11. 发明申请

US20200299737A1 IMPROVEMENTS IN OR RELATING TO ORGANIC COMPOUNDS 审中-公开
公开(公告)号：US20200299737A1
公开(公告)日：2020-09-24
申请号：US16765649
申请日：2018-11-21
申请人： Givaudan SA
发明人： Andreas GOEKE , Julie CHARPENTIER , Boris SCHILLING , Fridtjof SCHRÖDER
IPC分类号： C12P7/38 , C07C45/27 , C12N9/88 , A23L27/10 , A23L27/20
摘要： A process for producing rotundone from α-guaiene, in particular by oxidation of the C(3) position, wherein the α-guaiene is produced from a precursor by a sesquiterpene synthase. The sesquiterpene synthase is produced in a microorganism.

12. 发明申请

US20200095619A1 NEW ENZYMATIC PROCESS FOR PRODUCTION OF MODIFIED HOP PRODUCTS 审中-公开
公开(公告)号：US20200095619A1
公开(公告)日：2020-03-26
申请号：US16584058
申请日：2019-09-26
申请人： KALAMAZOO HOLDINGS, INC .
发明人： Katie WHALEN , Donald Richard BERDAHL , Brian Patrick BUFFIN , Matthew Blake JONES , Katrina WILLIAMS
IPC分类号： C12P7/38 , C12C3/12 , C12N11/16
摘要： The present invention relates to a process for producing a beer bittering agent via enzyme catalyzed bioconversion of hop-derived isoalpha acids to dihydro-(rho)-isoalpha acids and to the novel enzyme catalysts which may be employed in such a process.

13. 发明申请

US20090061471A1 Methods and systems for selective fluorination of organic molecules 有权
标题翻译：选择性氟化有机分子的方法和系统
公开(公告)号：US20090061471A1
公开(公告)日：2009-03-05
申请号：US11890218
申请日：2007-08-04
申请人： Rudi Fasan , Frances H. Arnold
发明人： Rudi Fasan , Frances H. Arnold
IPC分类号： C12Q1/26 , C12P7/62 , C12P7/38 , C12P17/04 , C12P17/14 , C12P19/44
CPC分类号： C07B39/00 , C07C17/16 , C07C45/63 , C07C49/687 , C07H5/02 , C12P7/00 , C12P7/42 , C12P7/62 , C07C23/20
摘要： A method and system for selectively fluorinating organic molecules on a target site wherein the target site is activated and then fluorinated are shown together with a method and system for identifying a molecule having a biological activity.
摘要翻译：在目标部位选择性氟化有机分子的方法和系统，其中靶位点被活化然后被氟化，以及用于鉴定具有生物活性的分子的方法和系统。

14. 发明授权

US6087145A Esterase gene and its use 失效
标题翻译：酯酶基因及其用途
公开(公告)号：US6087145A
公开(公告)日：2000-07-11
申请号：US978589
申请日：1997-11-26
申请人： Takeshi Ishii , Satoshi Mitsuda
发明人： Takeshi Ishii , Satoshi Mitsuda
IPC分类号： C12N15/09 , C07H21/04 , C12N1/21 , C12N9/16 , C12N9/18 , C12N15/00 , C12N15/55 , C12P7/38 , C12P41/00 , C12R1/01 , C12R1/19 , C12N1/00 , C12N5/10 , C12N15/63
CPC分类号： C12P7/38 , C12N9/18 , C12P41/004
摘要： An isolated esterase gene coding for an esterase capable of causing asymmetric hydrolysis of an organic carboxylic acid ester of a cyclopentenolone of formula I: ##STR1## wherein R.sub.1 is hydrogen or methyl, and R.sub.2 is C.sub.1 -C.sub.10 alkyl, C.sub.2 -C.sub.10 alkenyl, C.sub.2 -C.sub.10 alkynyl, C.sub.1 -C.sub.4 haloalkyl, a C.sub.5 -C.sub.9 aliphatic hydrocarbon moiety which may be optionally protected on the terminal hydroxyl group thereof, or a C.sub.5 -C.sub.9 fatty acid residue which may be optionally protected on the terminal carboxyl group thereof, to produce the cyclopentenolone of formula I in (R)-form, and hybridizing to the base sequence of SEQ ID NO:1, is useful for the industrially favorable production of optically active cyclopentenolones of formula I which serve as the intermediates of drugs, agricultural chemicals or other active products.
摘要翻译：编码能够导致式I的环戊烯醇酮的有机羧酸酯不对称水解的酯酶的分离的酯酶基因：其中R1是氢或甲基，R2是C1-C10烷基，C2-C10链烯基，C2-C10炔基，C 1 -C 4卤代烷基，可以在其末端羟基上任意保护的C 5 -C 9脂族烃部分或可以任选地保护在其末端羧基上的C5-C9脂肪酸残基，以制备环戊烯醇酮（R）形式的式I化合物和与SEQ ID NO：1的碱基序列杂交可用于工业上有利地生产作为药物，农药或其它活性产物的中间体的式I的光学活性环戊烯酮。

15. 发明授权

US5300437A Enantiomeric enrichment and stereoselective synthesis of chiral amines 失效
标题翻译：手性胺的对映体富集和立体选择性合成
公开(公告)号：US5300437A
公开(公告)日：1994-04-05
申请号：US959147
申请日：1992-10-09
申请人： David I. Stirling , George W. Matcham , Andrew L. Zeitlin
发明人： David I. Stirling , George W. Matcham , Andrew L. Zeitlin
IPC分类号： C12N9/10 , C12P7/26 , C12P41/00 , C12P13/02 , C12P7/38
CPC分类号： C12N9/1096 , C12P41/006 , C12P7/26
摘要： Amines in which the amino group is on a secondary carbon atom which is chirally substituted can be enantiomerically enriched by the action of an omega-amino acid transaminase which has the property of preferentially converting one of the two chiral forms to a ketone. The process also can be used to stereoselectively synthesize one chiral form from ketones substantially to the exclusion of the other.
摘要翻译：其中氨基在手性取代的仲碳原子上的胺可通过ω-氨基酸转氨酶的作用而被对映体富集，该氨基酸转氨酶具有优先将两种手性形式之一转化为酮的性质。该方法还可以用于立体选择性地从酮中合成一种手性形式，基本上排除另一种。

16. 发明授权

US3415716A Preparation of hydroxycyclopentenones 失效
标题翻译：羟基环戊烯酮的制备
公开(公告)号：US3415716A
公开(公告)日：1968-12-10
申请号：US55059966
申请日：1966-05-17
申请人： HOFFMANN LA ROCHE
发明人： JULIUS BERGER , WIGHTMAN KIERSTEAD RICHARD , ANDREW LEMAHIEU RONALD , BENJAMIN TABENKIN
IPC分类号： C12P7/26 , C12P7/38
CPC分类号： C12P7/38 , C12P7/26 , Y10S435/822 , Y10S435/832 , Y10S435/881 , Y10S435/886 , Y10S435/889 , Y10S435/896 , Y10S435/897 , Y10S435/911 , Y10S435/917 , Y10S435/918 , Y10S435/931 , Y10S435/933 , Y10S435/939

17. 发明公开

US20240150308A1 PROCESSES AND INTERMEDIATES FOR THE PREPARATIONS OF BENZOPROSTACYCLIN ANALOGUES AND BENZOPROSTACYCLIN ANALOGUES PREPARED THEREFROM 审中-公开
公开(公告)号：US20240150308A1
公开(公告)日：2024-05-09
申请号：US18532307
申请日：2023-12-07
申请人： CHIROGATE INTERNATIONAL INC.
发明人： CHUN-YU LIN , TZYH-MANN WEI , SHIH-YI WEI
IPC分类号： C07D307/93 , C07C45/65 , C07C49/573 , C07C67/24 , C07C67/317 , C07C69/157 , C07C69/734 , C07D307/42 , C07F7/18 , C12P7/38
CPC分类号： C07D307/93 , C07C45/65 , C07C49/573 , C07C67/24 , C07C67/317 , C07C69/157 , C07C69/734 , C07D307/42 , C07F7/1892 , C12P7/38 , C07C2601/08 , C07C2601/10 , C07C2601/16
摘要： The invention relates to processes for preparing benzoprostacyclin analogues and intermediates prepared from the process, and the benzoprostacyclin analogues prepared therefrom. The invention also relates to cyclopentenone intermediates in racemic or optically active form.

18. 发明授权

US11821020B2 Enzymatic process for production of modified hop products 有权
公开(公告)号：US11821020B2
公开(公告)日：2023-11-21
申请号：US17362070
申请日：2021-06-29
申请人： KALAMAZOO HOLDINGS, INC.
发明人： Katie Whalen , Donald Richard Berdahl , Brian Patrick Buffin , Matthew Blake Jones , Katrina Williams
IPC分类号： C12P7/38 , C12C3/12 , C12N11/16
CPC分类号： C12P7/38 , C12C3/12 , C12N11/16 , C12Y101/01086
摘要： The present invention relates to a process for producing a beer tittering agent via enzyme catalyzed bioconversion of hop-derived isoalpha acids to dihydro-(rho)-isoalpha acids and to the novel enzyme catalysts which may be employed in such a process.

19. 发明申请

US20230040990A1 PRODUCTION OF GUAIENE AND ROTUNDONE 有权
公开(公告)号：US20230040990A1
公开(公告)日：2023-02-09
申请号：US17936072
申请日：2022-09-28
申请人： Givaudan SA
发明人： Andreas GOEKE , Julie CHARPENTIER , Boris SCHILLING , Fridtjof SCHRÖDER
IPC分类号： C12P7/38 , A23L27/20 , A23L27/10 , C07C45/27 , C12N9/88
摘要： A process for producing rotundone from α-guaiene, in particular by oxidation of the C(3) position, wherein the α-guaiene is produced from a precursor by a sesquiterpene synthase. The sesquiterpene synthase is produced in a microorganism.

20. 发明授权

US08742161B2 Process for producing optically active bicyclo [3.1.0] hexane derivative using enzyme 有权
标题翻译：使用酶制备光学双环[3.1.0]己烷衍生物的方法
公开(公告)号：US08742161B2
公开(公告)日：2014-06-03
申请号：US13510375
申请日：2010-11-18
申请人： Joji Sasaki
发明人： Joji Sasaki
IPC分类号： C07C69/74 , C12P7/38
CPC分类号： C07C69/757 , C07B53/00 , C07B57/00 , C07C67/303 , C07C67/313 , C07C67/327 , C07C2602/18 , C12P7/62 , C12Y301/01003
摘要： There is provided a process for producing a bicyclo [3.1.0] hexane derivative represented by the formula (I) and a salt thereof including; causing an enzyme to act on an optically inactive compound represented by the formula (II) causing an asymmetric acylation reaction and a highly-stereoselective conversion to an optically active compound represented by the formula (III); and converting the compound represented by the formula (III) to the compound represented by the formula (I) or a salt thereof.
摘要翻译：提供了制备由式（I）表示的双环[3.1.0]己烷衍生物及其盐的方法，所述方法包括：导致酶作用于由式（II）表示的光学惰性化合物，引起不对称酰化反应和高度立体选择性转化为由式（III）表示的光学活性化合物; 并将由式（III）表示的化合物转化成由式（I）表示的化合物或其盐。

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