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1. 发明授权

US06306634B1 Esterase gene and its use 失效
标题翻译：酯酶基因及其用途
公开(公告)号：US06306634B1
公开(公告)日：2001-10-23
申请号：US08979170
申请日：1997-11-26
申请人： Takeshi Ishii , Satoshi Mitsuda
发明人： Takeshi Ishii , Satoshi Mitsuda
IPC分类号： C12N918
CPC分类号： C12P7/26 , C12N9/18 , C12P7/38 , C12P41/004
摘要： An isolated esterase gene coding for an esterase capable of causing asymmetric hydrolysis of an organic carboxylic acid ester of a cyclopentenolone of formula I; wherein R1 is C1-C10 alkyl, C2-C10 alkenyl, C2-C10 alkynyl or C1-C4 haloalkyl, to produce the cyclopentenolone of formula I in (S)-form, and hybridizing to the base sequence of SEQ ID NO:1, is useful for the industrially favorable production of optically active cyclopentenolones of formula I which serve as the intermediates of drugs, agricultural chemicals or other active products.
摘要翻译：编码能够引起式I的环戊烯醇酮的有机羧酸酯的不对称水解的酯酶的分离的酯酶基因;其中R1是C1-C10烷基，C2-C10链烯基，C2-C10炔基或C1-C4卤代烷基，产生（S） - 型的式I的环戊烯醇酮，并与SEQ ID NO：1的碱基序列杂交，可用于工业上有利地生产作为药物中间体的式I的光学活性的环戊烯醇酮，农药或其他活性产品。

2. 发明授权

US06184008B2 Production of optically active sphingoid compound 失效
标题翻译：光学活性鞘氨醇化合物的制备
公开(公告)号：US06184008B2
公开(公告)日：2001-02-06
申请号：US09336601
申请日：1999-06-21
申请人： Hiromichi Ohta , Takeshi Sugai , Takeshi Ishii , Satoshi Mitsuda
发明人： Hiromichi Ohta , Takeshi Sugai , Takeshi Ishii , Satoshi Mitsuda
IPC分类号： C12P1302
CPC分类号： C07C233/17 , C12N9/18 , C12P13/02 , C12P41/004
摘要： An industrially advantageous production method of an optically active alcohol useful for cosmetics and medical supplies or production intermediates thereof using an esterase having an ability to selectively hydrolyze an optically active sphingoid compound.
摘要翻译：可用于化妆品和医疗用途的光学活性醇的工业上有利的生产方法或其使用具有选择性水解旋光性类鞘氨醇化合物的能力的酯酶的生产中间体。

3. 发明授权

US6087145A Esterase gene and its use 失效
标题翻译：酯酶基因及其用途
公开(公告)号：US6087145A
公开(公告)日：2000-07-11
申请号：US978589
申请日：1997-11-26
申请人： Takeshi Ishii , Satoshi Mitsuda
发明人： Takeshi Ishii , Satoshi Mitsuda
IPC分类号： C12N15/09 , C07H21/04 , C12N1/21 , C12N9/16 , C12N9/18 , C12N15/00 , C12N15/55 , C12P7/38 , C12P41/00 , C12R1/01 , C12R1/19 , C12N1/00 , C12N5/10 , C12N15/63
CPC分类号： C12P7/38 , C12N9/18 , C12P41/004
摘要： An isolated esterase gene coding for an esterase capable of causing asymmetric hydrolysis of an organic carboxylic acid ester of a cyclopentenolone of formula I: ##STR1## wherein R.sub.1 is hydrogen or methyl, and R.sub.2 is C.sub.1 -C.sub.10 alkyl, C.sub.2 -C.sub.10 alkenyl, C.sub.2 -C.sub.10 alkynyl, C.sub.1 -C.sub.4 haloalkyl, a C.sub.5 -C.sub.9 aliphatic hydrocarbon moiety which may be optionally protected on the terminal hydroxyl group thereof, or a C.sub.5 -C.sub.9 fatty acid residue which may be optionally protected on the terminal carboxyl group thereof, to produce the cyclopentenolone of formula I in (R)-form, and hybridizing to the base sequence of SEQ ID NO:1, is useful for the industrially favorable production of optically active cyclopentenolones of formula I which serve as the intermediates of drugs, agricultural chemicals or other active products.
摘要翻译：编码能够导致式I的环戊烯醇酮的有机羧酸酯不对称水解的酯酶的分离的酯酶基因：其中R1是氢或甲基，R2是C1-C10烷基，C2-C10链烯基，C2-C10炔基，C 1 -C 4卤代烷基，可以在其末端羟基上任意保护的C 5 -C 9脂族烃部分或可以任选地保护在其末端羧基上的C5-C9脂肪酸残基，以制备环戊烯醇酮（R）形式的式I化合物和与SEQ ID NO：1的碱基序列杂交可用于工业上有利地生产作为药物，农药或其它活性产物的中间体的式I的光学活性环戊烯酮。

4. 发明授权

US06960460B2 Esterase gene and its use 失效
标题翻译：酯酶基因及其用途
公开(公告)号：US06960460B2
公开(公告)日：2005-11-01
申请号：US10147467
申请日：2002-05-17
申请人： Takeshi Ishii , Satoshi Mitsuda
发明人： Takeshi Ishii , Satoshi Mitsuda
IPC分类号： C12N1/21 , C12N9/18 , C12P7/38 , C12P41/00
CPC分类号： C12P7/38 , C12N9/18 , C12P41/004
摘要： An isolated esterase gene coding for an esterase capable of causing asymmetric hydrolysis of an organic carboxylic acid ester of a cyclopentenolone of formula I: wherein R1 is hydrogen or methyl, and R2 is C1-C10 alkyl, C2-C10 alkenyl, C2-C10 alkynyl, C1-C4 haloalkyl, a C5-C9 aliphatic hydrocarbon moiety which may be optionally protected on the terminal hydroxyl group thereof, or a C5-C9 fatty acid residue which may be optionally protected on the terminal carboxyl group thereof, to produce the cyclopentenolone of formula I in (R)-form, and hybridizing to the base sequence of SEQ ID NO:1, is useful for the industrially favorable production of optically active cyclopentenolones of formula I which serve as the intermediates of drugs, agricultural chemicals or other active products.
摘要翻译：编码能够引起式I的环戊烯醇酮的有机羧酸酯的不对称水解的酯酶的分离的酯酶基因：其中R 1是氢或甲基，R 2是是C 1 -C 10烷基，C 2 -C 10链烯基，C 2 - C 1 -C 10炔基，C 1 -C 4卤代烷基，C 5 -C 3亚烷基可以任选地保护其末端羟基或可以任选保护的C 5 -C 9脂肪酸残基的脂族烃部分在其末端羧基上制备（R） - 型的式I的环戊烯醇酮，并与SEQ ID NO：1的碱基序列杂交，可用于工业上有利地生产式I的光学活性的环戊烯醇酮，其用于作为药物，农药或其他活性成分的中间体。

5. 发明授权

US06472189B1 Esterase gene and its use 失效
标题翻译：酯酶基因及其用途
公开(公告)号：US06472189B1
公开(公告)日：2002-10-29
申请号：US09219120
申请日：1998-12-23
申请人： Takeshi Ishii , Satoshi Mitsuda
发明人： Takeshi Ishii , Satoshi Mitsuda
IPC分类号： C12P726
CPC分类号： C12P7/38 , C12N9/18 , C12P41/004
摘要： An isolated esterase gene coding for an esterase capable of causing asymmetric hydrolysis of an organic carboxylic acid ester of a cyclopentenolone of formula I: wherein R1 is hydrogen or methyl, and R2 is C1-C10 alkyl, C2-C10 alkenyl, C2-C10 alkynyl, C1-C4 haloalkyl, a C5-C9 aliphatic hydrocarbon moiety which may be optionally protected on the terminal hydroxyl group thereof, or a C5-C9 fatty acid residue which may be optionally protected on the terminal carboxyl group thereof, to produce the cyclopentenolone of formula I in (R)-form, and hybridizing to the base sequence of SEQ ID NO:1, is useful for the industrially favorable production of optically active cyclopentenolones of formula I which serve as the intermediates of drugs, agricultural chemicals or other active products.
摘要翻译：编码能够导致式I的环戊烯醇酮的有机羧酸酯不对称水解的酯酶的分离的酯酶基因：其中R1是氢或甲基，R2是C1-C10烷基，C2-C10链烯基，C2-C10炔基，C 1 -C 4卤代烷基，可以在其末端羟基上任意保护的C 5 -C 9脂族烃部分或可以任选地保护在其末端羧基上的C5-C9脂肪酸残基，以制备环戊烯醇酮（R）形式的式I化合物和与SEQ ID NO：1的碱基序列杂交可用于工业上有利地生产作为药物，农药或其它活性产物的中间体的式I的光学活性环戊烯酮。

6. 发明授权

US06514740B1 Esterase gene and its use 失效
标题翻译：酯酶基因及其用途
公开(公告)号：US06514740B1
公开(公告)日：2003-02-04
申请号：US09842898
申请日：2001-04-27
申请人： Takeshi Ishii , Satoshi Mitsuda
发明人： Takeshi Ishii , Satoshi Mitsuda
IPC分类号： C12N918
CPC分类号： C12P7/26 , C12N9/18 , C12P7/38 , C12P41/004
摘要： An isolated esterase gene coding for an esterase capable of causing asymmetric hydrolysis of an organic carboxylic acid ester of a cyclopentenolone of formula I: wherein R1 is C1-C10 alkyl, C2-C10 alkenyl, C2-C10 alkynyl or C1-C4 haloalky, to produce the cyclopentenolone of formula I in (S)-form, and hybridizing to the base sequence of SEQ ID NO:1, is useful for the industrially favorable production of optically active cyclopentenolones of formula I which serve as the intermediates of drugs, agricultural chemicals or other active products.
摘要翻译：编码能够使式I的环戊烯醇酮的有机羧酸酯不对称水解的酯酶的分离的酯酶基因：其中R1是C1-C10烷基，C2-C10链烯基，C2-C10炔基或C1-C4卤代烷基，产生（S） - 型的式I的环戊烯醇酮，并与SEQ ID NO：1的碱基序列杂交，可用于工业上有利地生产作为药物中间体的式I的光学活性的环戊烯醇酮，农药或其他活性产品。

7. 发明授权

US6127152A Process for producing nucleoside derivatives 失效
标题翻译：制备核苷衍生物的方法
公开(公告)号：US6127152A
公开(公告)日：2000-10-03
申请号：US127124
申请日：1998-07-30
申请人： Hiromichi Ohta , Takeshi Sugai , Takeshi Ishii , Satoshi Mitsuda
发明人： Hiromichi Ohta , Takeshi Sugai , Takeshi Ishii , Satoshi Mitsuda
IPC分类号： C12N9/16 , C07H19/06 , C07H19/16 , C12N9/18 , C12N15/09 , C12P19/38 , C12P19/40
CPC分类号： C12P19/385 , C12N9/18 , C12P19/40
摘要： There is disclosed a process for producing a nucleoside derivative of the formula [I]: ##STR1## characterized by contacting 2',3',5'-O-triacylribonucleoside derivative of the formula [II]: ##STR2## with an ester hydrolase: (i) capable of regio-selectively deacylating the acyl group at 5'-O-position in the formula [II] above, and(ii) having an amino acid sequence encoded by a gene which hybridizes to a nucleotide sequence encoding an amino acid sequence of SEQ ID NO:1.
摘要翻译：公开了具有式[I]的核苷衍生物的方法：其特征在于使式[II]的2'，3'，5'-O-三酰基核糖核苷衍生物与酯水解酶接触：（i）能够选择性地使上述式[II]中的5'-O-位的酰基取代酰基，和（ii）具有与编码SEQ ID NO的氨基酸序列的核苷酸序列杂交的基因编码的氨基酸序列：1。

8. 发明授权

US5432067A Process for production of biotin using bacteria belonging to the genus sphingomonas 失效
标题翻译：使用属于鞘氨醇单胞菌属的细菌生产生物素的方法
公开(公告)号：US5432067A
公开(公告)日：1995-07-11
申请号：US111440
申请日：1993-08-25
申请人： Kazuo Kumagai , Misao Miki , Emiko Kawano , Satoshi Mitsuda
发明人： Kazuo Kumagai , Misao Miki , Emiko Kawano , Satoshi Mitsuda
IPC分类号： C12N1/20 , C12P17/18 , C12R1/01 , C12P1/04 , C12N1/12 , C12N11/18
CPC分类号： C12R1/01 , C12P17/186 , Y10S435/822
摘要： There is disclosed a process for the production of biotin, in which a culture of a microorganism of the genus Sphingomonas, having an ability to produce biotin, is prepared in a medium, and biotin produced and accumulated in the medium is collected. Also disclosed are microorganisms of the genus Sphingomonas, having an ability to produce biotin, which are useful for this production process of the present invention.
摘要翻译：公开了生产生物素的方法，其中在培养基中制备具有生产生物素能力的鞘氨醇单胞菌属微生物的培养物，收集培养基中产生和积累的生物素。还公开了具有生产生物素能力的鞘氨醇单胞菌属微生物，其可用于本发明的该生产方法。

9. 发明授权

US4571436A Process for producing optically active cyclopentenolones 失效
标题翻译：光学活性环戊烯酮的制备方法
公开(公告)号：US4571436A
公开(公告)日：1986-02-18
申请号：US612122
申请日：1984-05-21
申请人： Takeaki Umemura , Ayumu Inoue , Satoshi Mitsuda
发明人： Takeaki Umemura , Ayumu Inoue , Satoshi Mitsuda
IPC分类号： C07C45/64 , C07C45/67 , C07C49/707 , C07C49/743 , C07C203/08 , C12P7/26 , C12P41/00 , C07C45/65
CPC分类号： C12P41/004 , C07B53/00 , C07C201/02 , C07C303/28 , C07C45/64 , C07C45/673 , C07C49/707 , C07C49/743 , C12P7/26 , C07C2101/10
摘要： Optically active cyclopentenolones, which are useful as an intermediate of pyrethroid insecticides, are produced from racemic cyclopentenolones according to the following procedures; (1) asymmetric hydrolysis of racemic carboxylate esters of the cyclopentenolones, (2) nitrate- or sulfonate-esterification of the asymmetrical hydrolysis products, and (3) hydrolysis of the esterification products.
摘要翻译：可用作拟除虫菊酯类杀虫剂中间体的光学活性环戊烯醇酮根据以下程序由外消旋环戊烯醇酮制备; （1）环戊烯酮的外消旋羧酸酯的不对称水解，（2）不对称水解产物的硝酸酯或磺酸酯化，和（3）酯化产物的水解。

10. 发明授权

US5965432A Method for improving optical purity of an amine compound 失效
标题翻译：提高胺化合物的光学纯度的方法
公开(公告)号：US5965432A
公开(公告)日：1999-10-12
申请号：US990087
申请日：1997-12-12
申请人： Yuko Kobayashi , Satoshi Mitsuda , Ryohei Komaki
发明人： Yuko Kobayashi , Satoshi Mitsuda , Ryohei Komaki
IPC分类号： C12P13/00 , C12P41/00 , C12R1/06
CPC分类号： C12P13/001 , C12P41/001 , Y10S435/83
摘要： There is provided a method for improving optical purity of an amine compound of the formula I: ##STR1## wherein R.sup.1 indicates a phenyl group which may be substituted or an aralkyl group having 7 to 10 carbon atoms which may be substituted, and R.sup.2 indicates an alkyl group having 1 to 6 carbon atoms, which is characterized by contacting a cutlture of a microorganism belonging to Arthrobacter having an ability to preferentially metabolize one optical isomer based on an asymmetric carbon atom to which an amino group bonds in the amine compound of the formula I or a treated product thereof with the amine compound of the formula I.
摘要翻译：提供了提高式I的胺化合物的光学纯度的方法：其中R1表示可被取代的苯基或可被取代的具有7〜10个碳原子的芳烷基，R2表示具有 1至6个碳原子，其特征在于使属于节杆菌的微生物的切片与基于在式I的胺化合物中的氨基键合的不对称碳原子优先代谢一种光学异构体的能力接触，或其处理产物与式I的胺化合物反应。

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