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    • 20. 发明申请
    • MULTIBRANCHED POLYOXYALKYLENE DERIVATIVE
    • 多分支聚氧乙烯衍生物
    • US20100029899A1
    • 2010-02-04
    • US12529043
    • 2008-02-28
    • Kenji SakanoueHiroki YoshiokaTomohiro Shirosaki
    • Kenji SakanoueHiroki YoshiokaTomohiro Shirosaki
    • C08G67/00
    • C08G65/2609A61K47/60C08G65/327C08G65/3317C08G65/3318C08G65/33337C08G65/33372C08G65/33396C08L2203/02
    • An object of the present invention is to provide a novel multibranched polyoxyalkylene derivative, and an intermediate for the production thereof. Specifically, the object is to provide a multibranched polyoxyalkylene derivative which can keep a high activity of a bio-related substance modified with the multibranched polyoxyalkylene derivative and which can easily produce the modified substance; an intermediate thereof; and a bio-related substance to which the multibranched polyoxyalkylene derivative is bonded.The novel multibranched polyoxyalkylene derivative according to the invention is a polyoxyalkylene derivative (1) having a functional group reactive with a bio-related substance and the bio-related substance according to the invention has a structure modified with the above polyoxyalkylene derivative (1) by a reaction. Furthermore, the intermediate for the production of the novel multibranched polyoxyalkylene derivative according to the invention is a polyoxyalkylene derivative (A). wherein A1O and A2O independently represent an oxyalkylene group having 2 to 4 carbon atoms, m represents 20 to 500, n represents 15 to 700, R represents a hydrogen atom or a hydrocarbon group having 1 to 20 carbon atoms, X represents a functional group reactive with a bio-related substance, and X1 represents a hydroxyl group which may be protected.
    • 本发明的目的是提供一种新型的多分支聚氧化烯衍生物及其生产用中间体。 具体地说,本发明提供一种能够保持由多支化聚氧化烯衍生物改性的生物相关物质的高活性的多分支聚氧化烯衍生物,能够容易地生成改性物质。 其中间体; 和多支链聚氧化烯衍生物所结合的生物相关物质。 根据本发明的新型多支链聚氧化烯衍生物是具有与生物相关物质反应的官能团的聚氧化烯衍生物(1),根据本发明的生物相关物质具有通过上述聚氧化烯衍生物(1)改性的结构 一个反应。 此外,用于生产根据本发明的新型多支链聚氧化烯衍生物的中间体是聚氧化烯衍生物(A)。 其中,AlO和A2O独立地表示碳原子数2〜4的氧化烯基,m表示20〜500,n表示15〜700,R表示氢原子或碳原子数1〜20的烃基,X表示官能团的反应性 与生物相关物质,X1表示可被保护的羟基。