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11. 发明授权

US09527795B2 Methylene beta-ketoester monomers, methods for making methylene beta-ketoester monomers, polymerizable compositions and products formed therefrom 有权
标题翻译：亚甲基β-酮酯单体，制备亚甲基β-酮酯单体的方法，可聚合组合物和由其形成的产物
公开(公告)号：US09527795B2
公开(公告)日：2016-12-27
申请号：US14352406
申请日：2012-10-18
申请人： Sirrus, Inc.
发明人： Bernard M. Malofsky , Adam G. Malofsky , Tanmoy Dey , Jeffrey M. Sullivan
IPC分类号： C07C69/604 , C07D333/24 , C07C69/738 , C07D307/54 , C07C49/794 , C07C49/80 , C07C49/798 , C07C67/03 , C09J133/06 , C07C45/75 , C07C49/796 , C07D307/46 , C07D333/22 , C08F116/36 , C08F128/06 , C09D129/12 , C09D141/00 , C07C67/30 , C08F20/28 , C08F20/68 , C08F24/00 , C08F28/06 , C08F222/14 , C08F222/10
CPC分类号： C08F20/28 , C07C45/75 , C07C49/794 , C07C49/796 , C07C49/798 , C07C49/80 , C07C67/03 , C07C67/30 , C07C69/604 , C07C69/738 , C07D307/46 , C07D307/54 , C07D333/22 , C07D333/24 , C08F20/14 , C08F20/30 , C08F20/38 , C08F20/68 , C08F22/20 , C08F24/00 , C08F28/06 , C08F116/36 , C08F128/06 , C08F222/1006 , C08F222/14 , C08K3/013 , C08K5/0008 , C08L21/00 , C08L33/14 , C08L33/16 , C08L35/02 , C09D4/00 , C09D129/12 , C09D133/14 , C09D133/16 , C09D135/02 , C09D141/00 , C09J133/06 , C09J133/14 , C09J133/16 , C09J135/02 , Y02P20/127
摘要： The present invention provides methylene beta-ketoester monomers, methods for producing the same, and compositions and products formed therefrom. In the method for producing the methylene beta-ketoesters of the invention, a beta-ketoester is reacted with a source of formaldehyde in a modified Knoevenagel reaction optionally in the presence of an acidic or basic catalyst, and optionally in the presence of an acidic or non-acidic solvent, to form reaction complex. The reaction complex may be an oligomeric complex. The reaction complex is subjected to further processing, which may be vaporization by contact with an energy transfer means in order to isolate the beta-ketoester monomer. The present invention further compositions and products formed from methylene beta-ketoester monomers of the invention, including monomer-based products (e.g., inks, adhesives, coatings, sealants or reactive molding) and polymer-based products (e.g., fibers, films, sheets, medical polymers, composite polymers and surfactants).
摘要翻译：本发明提供亚甲基β-酮酯单体，其制备方法，以及由其形成的组合物和产品。在制备本发明的亚甲基β-酮酯的方法中，β-酮酯与改性的Knoevenagel反应中的甲醛源反应，任选地在酸性或碱性催化剂存在下，任选地在酸性或碱性非酸性溶剂，形成反应络合物。反应络合物可以是低聚物。将反应复合物进行进一步处理，其可以通过与能量转移装置接触而蒸发，以分离β-酮酯单体。本发明还包括由本发明的亚甲基β-酮酯单体形成的组合物和产品，包括基于单体的产品（例如油墨，粘合剂，涂料，密封剂或反应性模塑）和基于聚合物的产品（例如纤维，薄膜，片材，医用聚合物，复合聚合物和表面活性剂）。

12. 发明申请

US20160138804A1 RECIRCULATION AND DISPOSAL OF AQUEOUS CATALYST SOLUTIONS IN AMINE CATALYTIC PROCESSES 有权
标题翻译：氨催化工艺中水性催化剂溶液的回收和处理
公开(公告)号：US20160138804A1
公开(公告)日：2016-05-19
申请号：US14904898
申请日：2014-07-15
申请人： EVONIK RÖHM GMBH
发明人： Steffen KRILL , Torsten BALDUF , Rudolf BURGHARDT , Gerhard KOELBL , Reed ZHAO
IPC分类号： F23G7/00 , C07C45/75
CPC分类号： F23G7/008 , C07C45/75 , C07C45/82 , F23G5/14 , F23G7/001 , F23G7/065 , C07C47/22
摘要： The present invention relates to the oxidative combustion of amine-containing wastewaters, especially in a process for preparing methacrolein. Methacrolein is used in chemical synthesis particularly as an intermediate for preparation of methacrylic acid, methyl methacrylate, or else of active ingredients, odorants or flavorings. More particularly, the present invention relates to an oxidative combustion of the amine-containing wastewaters with only low nitrogen oxide formation.
摘要翻译：本发明涉及含胺废水的氧化燃烧，特别是在制备异丁烯醛的方法中。甲基丙烯醛用于化学合成，特别是作为制备甲基丙烯酸，甲基丙烯酸甲酯或其他活性成分，气味剂或调味剂的中间体。更具体地，本发明涉及仅含低氮氧化物形成的含胺废水的氧化燃烧。

13. 发明申请

US20160068618A1 METHYLENE BETA-DIKETONE MONOMERS, METHODS FOR MAKING METHYLENE BETA-DIKETONE MONOMERS, POLYMERIZABLE COMPOSITIONS AND PRODUCTS FORMED THEREFROM 有权
标题翻译：甲基β-二酮单体，制备甲基β-二酮单体的方法，可聚合组合物和形成的产物
公开(公告)号：US20160068618A1
公开(公告)日：2016-03-10
申请号：US14868795
申请日：2015-09-29
申请人： Sirrus, Inc.
发明人： Jeffrey M. Sullivan , Adam G. Malofsky , Bernard M. Malofsky , Tanmoy Dey
IPC分类号： C08F16/36 , C07C45/75 , C07C49/203 , C07C49/794 , C07C49/84 , C07D333/22 , C07C49/557 , C07C49/227 , C07D307/46 , C07C49/80 , C08F28/06 , C07C49/796
CPC分类号： C07C49/84 , C07C45/75 , C07C49/203 , C07C49/227 , C07C49/557 , C07C49/794 , C07C49/796 , C07C49/80 , C07C2601/14 , C07D307/46 , C07D333/22
摘要： The present teachings are directed at 1,1-disubstituted alkene monomers (e.g., methylene beta-diketone monomers), methods for producing the same, and compositions and products formed therefrom. In the method for producing the monomer, a beta-diketone is preferably reacted with a source of formaldehyde in a modified Knoevenagel reaction optionally in the presence of an acidic or basic catalyst, and optionally in the presence of an acidic or non-acidic solvent, to form reaction complex. The reaction complex may be an oligomeric complex. The reaction complex is subjected to vaporization in order to isolate the monomer. The monomer(s) may be employed in compositions and products, including monomer-based products (e.g., inks, adhesives, coatings, sealants or reactive molding) and polymer-based products (e.g., fibers, films, sheets, medical polymers, composite polymers and surfactants).
摘要翻译：本教导涉及1,1-二取代的烯烃单体（例如亚甲基β-二酮单体），其制备方法，以及由其形成的组合物和产物。在制备单体的方法中，β-二酮优选在任选地在酸性或碱性催化剂存在下，任选地在酸性或非酸性溶剂的存在下，在改性的Knoevenagel反应中与甲醛源反应，形成反应复合物。反应络合物可以是低聚物。使反应复合物进行蒸发以分离单体。单体可用于组合物和产品，包括基于单体的产品（例如油墨，粘合剂，涂料，密封剂或反应性模塑）和基于聚合物的产品（例如纤维，薄膜，片材，医用聚合物，复合材料聚合物和表面活性剂）。

14. 发明申请

US20050222248A1 Isoflavone metabolites 审中-公开
标题翻译：异黄酮代谢物
公开(公告)号：US20050222248A1
公开(公告)日：2005-10-06
申请号：US11132025
申请日：2005-05-18
申请人： George Joannou
发明人： George Joannou
IPC分类号： A23L33/105 , A23L33/11 , A61K31/352 , A61K31/353 , A61P35/00 , C07C45/46 , C07C45/62 , C07C45/67 , C07C45/75 , C07C49/245 , C07C49/248 , C07C49/747 , C07C49/83 , C07C49/835 , C07D311/36 , C07D311/38 , C07D311/58 , C12N1/00
CPC分类号： C07C45/673 , A23L33/105 , A23L33/11 , A61K31/352 , C07C45/46 , C07C45/62 , C07C45/75 , C07C49/747 , C07C49/83 , C07C49/835 , C07C49/84 , C07D311/38 , C07D311/58
摘要： There are disclosed compounds of formulae (I) or (II) in which A is selected from the group consisting of (1), (2), (3) and (4);OH, and one of R1 and R2 is selected from H, OH and OCH3, and the other of R1 and R2 is selected from OH and OCH3; one of R3 and R4 is selected from H, OH and OCH3, and the other of R3 and R4 is selected from OH and OCH3; provided that at least one of the pairs R1, R2 and R3, R4 are both OH; R5 is selected from OH and OCH3; and ------ denotes a single or double bond; and pharmaceutically acceptable salts and prodrugs thereof. The compounds of the invention are useful for the treatment of hormone-dependent conditions and cancers.
摘要翻译：公开了式（I）或（II）的化合物，其中A选自（1），（2），（3）和（4）; OH和R 1， R 2和R 2选自H，OH和OCH 3，R 1和R 2中的另一个选自H， / SUB>选自OH和OCH 3; R 3和R 4中的一个选自H，OH和OCH 3，并且R 3和R 4中的另一个选自OH和OCH 3; 条件是对R 1，R 2和R 3，R 4中的至少一个都是OH ; R 5选自OH和OCH 3; - <表示单键或双键; 及其药学上可接受的盐和前药。本发明的化合物可用于治疗激素依赖性病症和癌症。

15. 发明授权

US5801292A Aldehyde process 失效
标题翻译：醛过程
公开(公告)号：US5801292A
公开(公告)日：1998-09-01
申请号：US623072
申请日：1996-03-28
申请人： Thomas J. Kwok , Windell C. Watkins
发明人： Thomas J. Kwok , Windell C. Watkins
IPC分类号： B01J21/10 , C07B61/00 , C07C29/141 , C07C45/72 , C07C45/74 , C07C45/75 , C07C47/19 , C07C45/45
CPC分类号： C07C29/141 , C07C45/72 , C07C45/74 , C07C45/75
摘要： A process for condensing aldehydes where an aldehyde having an a hydrogen and having the formula R.sub.1 CHO, wherein R.sub.1 is selected from alkyl having one to twelve carbon atoms and aralkyl having one to fourteen carbon atoms, is combined with hydrated MgO to form a reaction product comprising an aldol of said aldehyde, the unsaturated aldehyde derived by dehydration of said aldol, or mixtures thereof. In a second embodiment, a first composition selected from aldehydes containing an a hydrogen and having the formula R.sub.1 CHO, wherein R.sub.1 is as defined above, is combined with a second composition selected from aldehydes having the formula R.sub.2 CHO, wherein R.sub.2 is selected from H, alkyl having one to twelve carbon atoms, and aralkyl having one to fourteen carbon atoms, and with hydrated MgO, to form a reaction product mixture comprising an aldol of said aldehyde, the unsaturated aldehyde derived by dehydration of said aldol, or mixtures thereof. The aldol or aldehyde formed may be separated from the reaction product mixture, and recovered or treated as desired, or the reaction product mixture may be further directly treated, such as by hydrogenation, to produce a desired product admixture.
摘要翻译：一种用于冷凝醛的方法，其中具有氢且具有式R 1 CHO的醛，其中R 1选自具有1至12个碳原子的烷基和具有1至14个碳原子的芳烷基的醛与水合MgO组合以形成反应产物，所述醛的醛醇，由所述醛醇脱水衍生的不饱和醛，或其混合物。在第二个实施方案中，选自含有氢并具有式R 1 CHO（其中R 1如上定义）的第一组合物与选自具有式R 2 CHO的醛的第二组合物组合，其中R 2选自H，烷基具有1至12个碳原子的烷基和具有1至14个碳原子的芳烷基和与水合MgO反应，形成包含醛的醛醇的反应产物混合物，通过所述醛醇的脱水得到的不饱和醛或其混合物。形成的醛醇醛或醛可以与反应产物混合物分离，并根据需要进行回收或处理，或者可以例如通过氢化进一步直接处理反应产物混合物以产生所需的产物混合物。

16. 发明授权

US5705706A Process for the production of 2-(alkoxymethyl)acrolein 失效
标题翻译：制备2-（烷氧基甲基）丙烯醛的方法
公开(公告)号：US5705706A
公开(公告)日：1998-01-06
申请号：US681509
申请日：1996-07-23
申请人： Mathias Hoepp , Klaus Koehler , Dietrich Arntz
发明人： Mathias Hoepp , Klaus Koehler , Dietrich Arntz
IPC分类号： B01J31/02 , C07B61/00 , C07C45/75 , C07C47/277 , C07C45/61
CPC分类号： C07C45/75
摘要： 2-(Alkoxymethyl)acrolein of the formula ##STR1## is produced from acrolein, an alcohol ROH and formaldehyde, in one step, with a good yield being obtained. The acrolein is reacted with a substantially equimolar quantity of a source of formaldehyde in the presence of at least an equimolar quantity of the alcohol ROH and a catalytic quantity of a catalyst system based on a secondary amine and a mineral acid at a pH value of the reaction mixture in the range of 1 to less than 7.
摘要翻译：式（IMAGE）的2-（烷氧基甲基）丙烯醛由丙烯醛，醇ROH和甲醛一步制备，得到良好的收率。在至少等摩尔量的ROH和催化量的基于仲胺和无机酸的催化剂体系的存在下，丙烯醛与基本上等摩尔量的甲醛源反应，pH值为反应混合物的范围为1至小于7。

17. 发明授权

US5703270A Method for preparing a vinyl compound having a hydroxy group 失效
标题翻译：制备具有羟基的乙烯基化合物的方法
公开(公告)号：US5703270A
公开(公告)日：1997-12-30
申请号：US394013
申请日：1995-02-22
申请人： Koichi Nakagawa , Mitsuaki Makino , Yuichi Kita
发明人： Koichi Nakagawa , Mitsuaki Makino , Yuichi Kita
IPC分类号： C07C45/72 , C07C45/75 , C07C67/343 , C07C253/30 , C07C69/732
CPC分类号： C07C253/30 , C07C45/72 , C07C45/75 , C07C67/343
摘要： A vinyl compound having a hydroxy group of the formula (1) ##STR1## wherein R is a hydrogen atom or an organic residue, X is a --CN group, a --COR.sub.0 group or a --COOR.sub.0 group and R.sub.0 is a hydrogen atom or an organic residue, is prepared by reacting a vinyl compound of the formula (2) ##STR2## wherein X is a --CN group, a --COR.sub.0 group or a --COOR.sub.0 group and R.sub.0 is a hydrogen atom or an organic residue, with an aldehyde series compound in the presence of a tertiary amine compound, and water in a sufficient amount for forming an aqueous phase upon the completion of the reaction. In this method, since the aqueous phase is formed upon the completion of the reaction, the organic phase including the vinyl compound having a hydroxy group and the aqueous phase including the tertiary amine compound can be easily separated.
摘要翻译：具有式（1）的羟基的乙烯基化合物（1）其中R是氢原子或有机残基，X是-CN基，-COR0基或-COOR0基，R0是氢原子或有机残基通过使式（2）的乙烯基化合物（2）其中X是-CN基，-COR0基或-COOR0基，R0是氢原子或在叔胺化合物存在下与醛系化合物反应的有机残基，以及在反应完成时形成水相的足够量的水。在该方法中，由于在反应完成后形成水相，因此可以容易地分离包含具有羟基的乙烯基化合物和包含叔胺化合物的水相的有机相。

18. 发明授权

US5585496A Catalytic preparation of condensation products of formaldehyde 失效
标题翻译：催化制备甲醛缩合产物
公开(公告)号：US5585496A
公开(公告)日：1996-12-17
申请号：US570557
申请日：1995-12-11
申请人： Joaquim H. Teles , Johann-Peter Melder , Eugen Gehrer , Wolfgang Harder , Klaus Ebel , Carsten Groening , Regina Meyer
发明人： Joaquim H. Teles , Johann-Peter Melder , Eugen Gehrer , Wolfgang Harder , Klaus Ebel , Carsten Groening , Regina Meyer
IPC分类号： B01J31/02 , C07B61/00 , C07C45/75 , C07C47/19 , C07C49/17 , C07D249/08 , C07D249/10 , C07D249/12 , C07D249/14 , C07D471/06
CPC分类号： C07C45/75
摘要： A process for the catalytical preparation of condensation products of formaldehyde, in which formaldehyde or a formaldehyde-forming compound is caused to undergo reaction using a catalyst which has been produced, in the presence of an auxiliary base, from a triazolium salt of formula I ##STR1## in which R.sup.1 and R.sup.3 are the same or different and stand for aliphatic groups having from 1 to 30 carbon atoms, optionally substituted aryl groups, optionally substituted aralkyl groups, and/or optionally substituted heteroaryl groups,R.sup.2 represents hydrogen, the hydroxymethylene group --CH.sub.2 OH or the hydroxy-hydroxymethylene-methylidyne group --CH(OH)(CH.sub.2 OH), andR.sup.4 denotes hydrogen, a halogen atom, a nitro or cyano group, an aliphatic group having from 1 to 30 carbon atoms, an optionally substituted aryl group, an optionally substituted aralkyl group, an optionally substituted heteroaryl group, an alkoxy group --OR.sup.5, a thioether group --SR.sup.6, an amino group --NR.sup.7 R.sup.8, an acyl group--COR.sup.9 or an ester group --COOR.sup.10, where R.sup.5, R.sup.6, R.sup.7, R.sup.8, and R.sup.9 stand for radicals such as those stated above for R.sup.1, and R.sup.10 is a C.sub.1 -C.sub.10 alkyl group or an optionally substituted aryl or aralkyl group, orR.sup.3 and R.sup.4 together form a C.sub.3 -C.sub.5 alkylene or C.sub.3 -C.sub.5 alkenylene group or a C.sub.6 -C.sub.14 alkylene group, or a C.sub.7 -C.sub.14 aralkylene or C.sub.8 -C.sub.14 aralkenylene bridging member, andA is the equivalent of an anion having one or more negative charges for electrical neutralization of the charge on the triazolium cation.
摘要翻译：催化制备甲醛缩合产物的方法，其中使甲醛或形成甲醛的化合物在辅助碱存在下由式I的三唑鎓盐生产的催化剂进行反应，（I）其中R1和R3相同或不同，代表具有1至30个碳原子的脂族基团，任选取代的芳基，任选取代的芳烷基和/或任选取代的杂芳基，R 2表示氢，羟基亚甲基-CH 2 OH或羟基 - 羟基亚甲基 - 亚甲基基团-CH（OH）（CH 2 OH），R 4表示氢，卤素原子，硝基或氰基，具有1至30个碳原子的脂族基团，取代的芳基，任选取代的芳烷基，任选取代的杂芳基，烷氧基-OR 5，硫醚基-SR 6，氨基-NR 7 R 8，酰基-C COR 9或酯gr 其中R 5，R 6，R 7，R 8和R 9分别代表上述R 1的基团，R 10是C 1 -C 10烷基或任意取代的芳基或芳烷基，或者R 3和R 4一起形成 C3-C5亚烷基或C3-C5亚烯基或C6-C14亚烷基，或C7-C14亚芳基或C8-C14芳亚烷基桥连元件，A相当于具有一个或多个负电荷用于电中和的阴离子的三唑鎓阳离子的电荷。

19. 发明授权

US5235118A Continuous process for the preparation of 2-ethyl-2-(hydroxymethyl)hexanal and 2-butyl-2-ethyl-1, 3-propanediol 失效
标题翻译：用于制备2-乙基-2-（羟甲基）己醛和2-丁基-2-乙基-1,3-丙二醇的连续方法
公开(公告)号：US5235118A
公开(公告)日：1993-08-10
申请号：US937039
申请日：1992-08-31
申请人： Don L. Morris , William A. Beavers , William E. Choate
发明人： Don L. Morris , William A. Beavers , William E. Choate
IPC分类号： C07C31/20 , C07C45/75
CPC分类号： C07C31/20 , C07C45/75
摘要： Disclosed is a continuous process for the manufacture of 2-ethyl-2-(hydroxymethyl)hexanal wherein 2-ethylhexanal, formaldehyde and a tertiary amine are continuously fed to a reaction zone and crude product comprising an aqueous phase and an organic phase containing 2-ethyl-2-(hydroxymethyl)hexanal and 2-ethylhexanal is continuously removed from the reaction zone Also disclosed are processes for (1) the azeotropic distillation of the organic phase of the crude product whereby unreacted 2-ethylhexanal is recovered and (2) the catalytic hydrogenation of the refined, organic phase of the crude product to produce 2-butyl-2-ethyl-1,3-propanediol.
摘要翻译：公开了用于制备2-乙基-2-（羟甲基）己醛的连续方法，其中将2-乙基己醛，甲醛和叔胺连续加入到反应区中，粗产物包含水相和含2- 乙基-2-（羟甲基）己醛和2-乙基己醛从反应区连续除去。还公开了（1）粗产物的有机相的共沸蒸馏的方法，从而回收未反应的2-乙基己醛，（2）催化氢化粗产物的精制有机相，生成2-丁基-2-乙基-1,3-丙二醇。

20. 发明授权

US5210314A Preparation of canthaxanthin and astaxanthin 失效
标题翻译：甘氨酸和阿司匹林的制备
公开(公告)号：US5210314A
公开(公告)日：1993-05-11
申请号：US695336
申请日：1991-04-29
申请人： Hansgeorg Ernst , Joachim Paust , Werner Hoffmann
发明人： Hansgeorg Ernst , Joachim Paust , Werner Hoffmann
IPC分类号： C07C45/75 , C07C49/653 , C07C49/743 , C07C69/63 , C07C403/12 , C07C403/24 , C07F9/54
CPC分类号： C07C403/24 , C07C403/12 , C07F9/54 , C07F9/5435 , C07C2101/16
摘要： A process for preparing canthaxanthin (Ia) and astaxanthin (Ib) of the formula I ##STR1##where R is H (a) or OH (b), comprises reacting a tertiary alcohol of the formula II ##STR2##where R is H (a) or OH (b), with trifluoroacetic acid, reacting the resulting novel trifluoroacetate of the formula III ##STR3##with triphenylphosphine, and reacting the resulting novel triphenylphosphonium trifluoroacetate of the formula IV ##STR4## with 2,7-dimethyl-2,4,6-octatriene-1,8-dial under the conditions of a Wittig synthesis. The present invention also relates to the novel trifluoroacetates of the formula III and the corresponding triphenylphosphonium trifluoroacetates of the formula IV.
摘要翻译：制备式I的角黄素（Ia）和虾青素（Ib）的方法，其中R是H（a）或OH（b））包括使式II的叔醇（II）与R （III）的三氟乙酸盐与三苯基膦反应，并使得到的式IV的三氟化三苯基鏻（Ⅳ）与式（Ⅳ）化合物反应，得到新的三氟乙酸盐，在Wittig合成条件下用2,7-二甲基-2,4,6-辛二烯-1,8-表盘。本发明还涉及式III的新型三氟乙酸盐和式Ⅳ相应的三苯基三氟乙酸盐。

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