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11. 发明授权

US09586907B2 Isothiocyanate compounds, pharmaceutical compositions, and uses thereof 有权
标题翻译：异硫氰酸酯化合物，药物组合物及其用途
公开(公告)号：US09586907B2
公开(公告)日：2017-03-07
申请号：US14512884
申请日：2014-10-13
申请人： Rutgers, The State University of New Jersey
发明人： Arkady Mustaev , Natalia Kurepina
IPC分类号： A61K31/26 , C07C331/00 , A61K31/21 , C07D233/64 , C07C331/20 , C07C331/22 , C07C331/30 , C07C331/28 , C07D209/14 , C07D213/24
CPC分类号： C07D233/64 , C07C331/20 , C07C331/22 , C07C331/28 , C07C331/30 , C07C2603/20 , C07C2603/50 , C07C2603/74 , C07D209/14 , C07D213/24
摘要： Provided herein are compositions of matter and pharmaceutical compositions thereof, for use in inhibiting the growth of various microbial pathogens, including bacteria, fungi, protozoa, and viral pathogens. Also provided herein are methods of treating microbial diseases/infections and cancer with the compositions. The compositions are additionally useful in wood preservation and food preservation by inhibition of microbial growth.
摘要翻译：本文提供了用于抑制各种微生物病原体（包括细菌，真菌，原生动物和病毒病原体）的生长的物质及其药物组合物的组合物。本文还提供了用组合物治疗微生物疾病/感染和癌症的方法。通过抑制微生物生长，组合物另外可用于木材保存和食品保存。

12. 发明授权

US6069255A Preparation of vinyl isothiocyanates 失效
标题翻译：异硫氰酸乙烯酯的制备
公开(公告)号：US6069255A
公开(公告)日：2000-05-30
申请号：US88836
申请日：1998-06-02
申请人： James Ian Grayson , Graham Heyes , Arthur Jackson , James Orrock Macgregor , Brian John Somerville
发明人： James Ian Grayson , Graham Heyes , Arthur Jackson , James Orrock Macgregor , Brian John Somerville
IPC分类号： C07C331/22 , C07D277/20
CPC分类号： C07C331/22
摘要： A process for preparing a vinyl isothiocyanate comprises contacting a halogen-substituted allyl thiocyanate, in solution and at an elevated temperature, with an acidic material which is either an acid or a halide or oxyhalide of an inorganic acid. The halogen-substituted allyl thiocyanate may be prepared from a dihalogenated alkene. The vinyl isothiocyanate may subsequently be converted to a thiazole.
摘要翻译：制备异硫氰酸乙烯酯的方法包括在溶液中和升高的温度下将卤素取代的烯丙基硫氰酸酯与无机酸的酸或卤化物或卤氧化物的酸性物质接触。卤素取代的硫氰酸烯丙酯可以由二卤代烯烃制备。随后将异硫氰酸乙烯酯转化成噻唑。

14. 发明授权

US4910263A Oil additives containing a thiocarbamyl moiety 失效
标题翻译：含有硫代氨基甲酰部分的油添加剂
公开(公告)号：US4910263A
公开(公告)日：1990-03-20
申请号：US252942
申请日：1988-10-03
申请人： Stanley J. Brois , Antonio Gutierrez
发明人： Stanley J. Brois , Antonio Gutierrez
IPC分类号： C07C331/22 , C07C335/12 , C07D257/02 , C07D295/13 , C10L1/24 , C10M135/14
CPC分类号： C07D295/13 , C07C331/22 , C07C335/12 , C07D257/02 , C10L1/24 , C10M135/14 , C10M2205/00 , C10M2205/026 , C10M2207/024 , C10M2209/084 , C10M2209/086 , C10M2215/065 , C10M2219/06 , C10M2219/062 , C10M2219/064 , C10M2219/066 , C10M2219/082 , C10M2219/087 , C10M2219/088 , C10M2219/089 , C10M2219/09 , C10M2219/10 , C10M2219/102 , C10M2219/104 , C10M2219/106 , C10M2221/00 , C10M2221/04 , C10M2221/041 , C10M2223/045 , C10M2223/12 , C10M2225/04 , C10M2229/02 , C10M2229/05 , C10N2210/02 , C10N2240/06 , C10N2240/08 , C10N2270/02
摘要： An oil-soluble additive for lubricating oil applications is provided by the formation of an adduct of thiocyanogen halide and polyalkene, removal of the hydrogen halide from said adduct and thermal rearrangement of the product to provide a polyalkenyl isothiocyanate which can be subsequently derivitized to provide a thiocarbamyl moiety containing product having excellent sludge dispersement properties.
摘要翻译：用于润滑油应用的油溶性添加剂通过形成硫氰化物卤化物和聚烯烃的加合物，从所述加合物中除去卤化氢和产物的热重排来提供一种聚链烯基异硫氰酸酯，其可随后被衍生以提供一种硫代氨基甲酰基部分含有极好的污泥分散性。

15. 发明授权

US4717754A Oil additives containing a thiocarbamyl moiety 失效
公开(公告)号：US4717754A
公开(公告)日：1988-01-05
申请号：US908786
申请日：1986-09-18
申请人： Stanley J. Brois , Antonio Gutierrez
发明人： Stanley J. Brois , Antonio Gutierrez
IPC分类号： C07C331/22 , C07C335/12 , C07D257/02 , C07D295/13 , C10L1/24 , C10M135/00 , C10M135/14 , C08F8/34
CPC分类号： C07D295/13 , C07C331/22 , C07C335/12 , C07D257/02 , C10L1/24 , C10M135/00 , C10M135/14 , C10M2205/00 , C10M2205/026 , C10M2207/024 , C10M2209/084 , C10M2209/086 , C10M2215/065 , C10M2219/06 , C10M2219/062 , C10M2219/064 , C10M2219/066 , C10M2219/082 , C10M2219/087 , C10M2219/088 , C10M2219/089 , C10M2219/09 , C10M2219/10 , C10M2219/102 , C10M2219/104 , C10M2219/106 , C10M2221/00 , C10M2221/04 , C10M2221/041 , C10M2223/045 , C10M2223/12 , C10M2225/04 , C10M2229/02 , C10M2229/05 , C10N2210/02 , C10N2240/06 , C10N2240/08 , C10N2270/02
摘要： An oil-soluble additive for lubricating oil applications is provided by the formation of an adduct of thiocyanogen halide and polyalkene, removal of the hydrogen halide from said adduct and thermal rearrangement of the product to provide a polyalkenyl isothiocyanate which can be subsequently derivitized to provide a thiocarbamyl moiety containing product having excellent sludge dispersement properties.

16. 发明申请

US20190233371A1 Isothiocyanate Production Method, Composition for Transporting and Storing N-Substituted O-Substituted Thiocarbamate, and Isothiocyanate Composition 审中-公开
公开(公告)号：US20190233371A1
公开(公告)日：2019-08-01
申请号：US16382738
申请日：2019-04-12
申请人： Asahi Kasei Kabushiki Kaisha
发明人： Masaaki Shinohata , Yuji Kosugi , Nobuhisa Miyake
IPC分类号： C07C331/30 , C07C331/20 , C07C335/16 , C07C335/10 , C07C329/04 , C07C331/22 , C07C333/04 , C07C335/14 , C07C335/08 , C07C333/08 , C07C333/06
CPC分类号： C07C331/30 , C07C329/04 , C07C331/20 , C07C331/22 , C07C333/04 , C07C333/06 , C07C333/08 , C07C333/20 , C07C333/22 , C07C333/24 , C07C335/08 , C07C335/10 , C07C335/14 , C07C335/16 , C07C2601/14
摘要： The present invention relates to an isothiocyanate production method using an organic primary amine and thiourea as starting materials; to a composition for transporting and storing an N-substituted O-substituted thiocarbamate that includes an N-substituted O-substituted thiocarbamate and a hydroxy compound, the equivalent weight ratio of hydroxy groups of the hydroxy compound with respect to the carbamate groups of the N-substituted O-substituted thiocarbamate being in the range of 1 to 100; to a composition for transporting and storing a compound with a thioureido group that includes a compound with a thioureido group and a hydroxy compound, the equivalent weight ratio of hydroxy groups of the hydroxy compound with respect to the thioureido groups of the compound with a thioureido group being in the range of 1 to 100; and to an isothiocyanate composition containing an isothiocyanate and a compound with a specific functional group.

17. 发明授权

US5726338A Process for producing isothiocyanate derivatives 失效
标题翻译：异硫氰酸酯衍生物的制备方法
公开(公告)号：US5726338A
公开(公告)日：1998-03-10
申请号：US712838
申请日：1996-09-12
申请人： Hideki Uneme , Yasuo Kamiya
发明人： Hideki Uneme , Yasuo Kamiya
IPC分类号： C07C331/22
CPC分类号： C07C331/22
摘要： A process for producing 2-halogenoallyl isothiocyanate �I! represented by the formula: ##STR1## wherein X.sup.1 is a halogen atom, is disclosed. The process comprises reacting a compound represented by the formula: ##STR2## wherein X.sup.1 is a halogen atom and X.sup.2 is a leaving group, with a thiocyanate represented by the formula; M(SCN)n wherein M is a metal or an ammonium group and n is a valence number of M, in the presence of water under heating. According to the process for producing of the present invention, 2-halogenoallyl isothiocyanata �I!, which has an insecticidal effect as such and is useful as an intermediate for a medicine, an agricultural chemical and the like, can be produced on an industrially large scale in a good yield.
摘要翻译：公开了由下式表示的2-卤代烯丙基异硫氰酸酯[I]的方法，其中X1是卤素原子。该方法包括使下式表示的化合物与下式所示的硫氰酸酯反应：其中X1是卤素原子，X2是离去基团; M（SCN）n，其中M是金属或铵基，n是价数为M，在加热的水存在下。根据本发明的制造方法，具有杀虫作用的2-卤代烯丙基异硫氰酸酯[I]可用作药物，农药等的中间体，可以在工业上大规模良好。

18. 发明授权

US5354777A Cyanoalkene derivatives, process for their preparation, and their use as microbicide for the protection of materials 失效
标题翻译：氰基烯烃衍生物，其制备方法，以及作为杀微生物剂用于保护材料的用途
公开(公告)号：US5354777A
公开(公告)日：1994-10-11
申请号：US21407
申请日：1993-02-23
申请人： Peter Wachtler , Wilfried Paulus , Georg-Wilhelm Ludwig
发明人： Peter Wachtler , Wilfried Paulus , Georg-Wilhelm Ludwig
IPC分类号： A01N37/34 , A01N41/10 , A01N43/50 , A01N47/46 , A01N47/48 , C07C255/09 , C07C255/30 , C07C255/31 , C07C323/54 , C07C331/12 , C07C331/14 , C07C331/22 , C07D233/54 , C07D233/61 , C07D249/08 , C07D265/30 , C07D295/14 , C07D295/145 , C07D317/44 , C07D317/60 , C07D333/24
CPC分类号： C07D233/64 , A01N47/48 , C07C255/30 , C07C331/12 , C07C331/14 , C07D295/145 , C07D317/60
摘要： New cyanoalkene derivatives of the formula (I) ##STR1## are described, in which R and R.sup.1 have the meaning given in the description, and a process for their preparation.The new cyanoalkene derivatives are used for combating microorganisms for the protection of industrial materials.
摘要翻译：描述了式（I）的新的氰基烯烃衍生物（I），其中R和R 1具有说明书中给出的含义及其制备方法。新的氰基烯烃衍生物用于防治微生物以保护工业材料。

19. 发明授权

US4952580A Pesticidal polyhaloalkene derivatives 失效
标题翻译：杀虫多卤代烯烃衍生物
公开(公告)号：US4952580A
公开(公告)日：1990-08-28
申请号：US270903
申请日：1988-11-09
申请人： Anthony J. Martinez , Thomas G. Cullen
发明人： Anthony J. Martinez , Thomas G. Cullen
IPC分类号： A01N31/02 , A01N37/02 , A01N37/06 , A01N37/10 , A01N37/32 , A01N43/06 , A01N43/36 , A01N43/78 , A01N43/80 , C07C33/42 , C07C323/52 , C07C331/22 , C07D207/34 , C07D207/40 , C07D207/404 , C07D271/06 , C07D271/07 , C07D271/10 , C07D271/113 , C07D275/06 , C07D277/16 , C07D277/36 , C07D285/08 , C07D285/12 , C07D285/125 , C07D285/135 , C07D307/71 , C07D333/34 , C07D333/38 , C07D333/54
CPC分类号： C07D207/404 , A01N31/02 , A01N37/02 , A01N37/06 , A01N37/10 , A01N37/32 , A01N43/06 , A01N43/36 , A01N43/78 , A01N43/80 , C07C323/52 , C07C33/423 , C07C331/22 , C07C69/63 , C07C69/76 , C07D207/34 , C07D271/07 , C07D271/113 , C07D275/06 , C07D277/16 , C07D277/36 , C07D285/08 , C07D285/125 , C07D285/135 , C07D307/71 , C07D333/34 , C07D333/38 , C07D333/54
摘要： Polyhaloalkene compounds of the formula: ##STR1## wherein X is sulfur, oxygen, or nitrogen, Y.sup.1 and Y.sup.2 are fluorine, Z is hydrogen or the same as Y.sup.1 and Y.sup.2, and n is 1-4; provided that:(A) when X is sulfur, Z is fluorine and R is thienyl or substituted thienyl, thianaphthyl or substituted thianaphthyl, thiazolinyl or substituted thiazolinyl, oxadiazolyl or substituted oxadiazolyl, 3,4,4-trifluoro-3-butenyloxycarbonylmethyl, thiadiazolyl substituted by halogen or R.sup.2 S, wherein R.sup.2 is 3,4,4-trifluoro-3-butenyl or R.sup.2 is phenylmethyl or phenylthiomethyl each optionally substituted by halogen or nitro; or R is thiadiazolyl substituted by R.sup.3, wherein R.sup.3 is substituted aryl, arylalkyl, aryloxyalkyl, alkylthio, haloalkylthio, haloarylthio, cyanoalkylthio, arylalkylthio, aryloxyalkylthio, arylthioalkylthio, heterocycloalkylthio, alkenylthio, haloalkenylthio, halocycloalkylalkenylthio, wherein said aryl or heterocyclic groups of R.sup.3 may be mono-, di-, tri-, tetra-, or penta-substituted; or R.sup.3 is an amino group mono- or di- substituted with members independently selected from alkyl, alkylcarbonyl, haloalkylcarbonyl, aryl, arylaminocarbonyl, arylalkylcarbonyl, arylalkoxycarbonyl, and 3-(2,2-dichloroethenyl)-2,2-dimethylcyclopropanecarbonyl;(B) when X is oxygen, Z is fluorine and R is C(O)R.sup.1, wherein R.sup.1 is perfluoralkyl, phenyl or substituted phenyl, thienyl or substituted thienyl, furanyl or substituted furanyl, pyrollyl or substituted pyrollyl, or dihydrothiazolylthiomethyl; and(C) when X is nitrogen, R taken with the nitrogen is an isothiocyanate, succinimide, or saccharine group.The compounds exhibit activity against plant nematodes and helminths that are indicators of animal anthelmintic activity and therefore are useful in agriculture and veterinary practice.
摘要翻译：下式的多卤烯化合物：其中X是硫，氧或氮，Y1和Y2是氟，Z是氢或与Y1和Y2相同，n是1-4; 条件是：（A）当X是硫时，Z是氟，R是噻吩基或取代的噻吩基，噻萘基或取代的噻萘基，噻唑啉基或取代的噻唑啉基，恶二唑基或取代的恶二唑基，3,4,4-三氟-3-丁烯氧基羰基甲基，噻二唑基被卤素或R 2S取代，其中R 2是3,4,4-三氟-3-丁烯基或R 2是各自任选被卤素或硝基取代的苯基甲基或苯硫基甲基; 或R是被R 3取代的噻二唑基，其中R 3是取代的芳基，芳烷基，芳氧基烷基，烷硫基，卤代烷硫基，卤代芳硫基，氰基烷硫基，芳烷硫基，芳氧基烷硫基，芳硫基烷硫基，杂环烷硫基，烯硫基，卤代链烯硫基，卤代环烷基烯基硫基，其中R3的芳基或杂环基可以单，二，三，四或五取代; 或R 3是独立地选自烷基，烷基羰基，卤代烷基羰基，芳基，芳基氨基羰基，芳基烷基羰基，芳基烷氧基羰基和3-（2,2-二氯乙烯基）-2,2-二甲基环丙烷羰基中的一个或二者取代的氨基。（B）当X是氧时，Z是氟，R是C（O）R 1，其中R 1是全氟烷基，苯基或取代的苯基，噻吩基或取代的噻吩基，呋喃基或取代的呋喃基，吡咯基或取代的吡咯基或二氢噻唑硫基甲基; 和（C）当X是氮时，用氮取代的R是异硫氰酸酯，琥珀酰亚胺或糖精组。该化合物表现出对作为动物驱虫活性指标的植物线虫和蠕虫的活性，因此可用于农业和兽医实践。

20. 发明授权

US3031486A Polyhalogen containing 1-isothiocyanomethyl bicyclo(2. 2. 1)-1, 4-heptadienes 失效
标题翻译：含有1-异硫氰基甲基双环（2.2.1）-1,4-庚二烯的多卤素
公开(公告)号：US3031486A
公开(公告)日：1962-04-24
申请号：US76054258
申请日：1958-09-12
申请人： VELSICOL CHEMICAL CORP
发明人： RICHTER SIDNEY B
IPC分类号： C07C331/22
CPC分类号： C07C331/22

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