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11. 发明申请

US20050137334A1 Composite nanospheres and their conjugates with biomolecules 有权
公开(公告)号：US20050137334A1
公开(公告)日：2005-06-23
申请号：US11022885
申请日：2004-12-28
申请人： Olivier Mondain-Monval , Abdelhamid Elaissari , Eric Bosc , Christian Pichot , Bernard Mandrand , Jerome Bibette
发明人： Olivier Mondain-Monval , Abdelhamid Elaissari , Eric Bosc , Christian Pichot , Bernard Mandrand , Jerome Bibette
IPC分类号： G01N33/545 , A61K9/51 , A61K31/7088 , A61K45/00 , A61K47/02 , A61K47/04 , A61K47/32 , A61K47/48 , A61K48/00 , A61P43/00 , C09D11/00 , G01N33/543 , C08L51/04
CPC分类号： G01N33/5434 , G01N2446/20 , G01N2446/64 , G01N2446/66 , Y10T428/2982 , Y10T428/2984 , Y10T428/2985 , Y10T428/2987
摘要： The invention concerns composite nanospheres having a diameter ranging between about 50 and 1000 nm plus or minus 5%, preferably between about 100 and 500 nm plus or minus 5% and advantageously between 100 and 200 nm plus or minus 5%, and comprising an essentially liquid core consisting of an organic phase and inorganic nanoparticles, distributed inside the organic phase, and a skin consisting of at least a hydrophilic polymer derived from the polymerisation of at least one water soluble monomer, in particular N-alkylacrylamide or a N-N-dialkylacrylamide; conjugates derived from said nanospheres; their preparation methods and their uses.

12. 发明授权

US5232782A Magnetizable "core-shell" microspheres based on a cross-linked organopolysiloxane and a process for their preparation 失效
标题翻译：基于交联的有机聚硅氧烷的可磁化“核壳”微晶及其制备方法
公开(公告)号：US5232782A
公开(公告)日：1993-08-03
申请号：US634910
申请日：1990-12-27
申请人： Dominique Charmot
发明人： Dominique Charmot
IPC分类号： C08G77/04 , A61K9/50 , B01J13/02 , B01J13/18 , C08J3/12 , C08K9/06 , C08L83/02 , C08L83/04 , C12N11/08 , G01N33/553 , H01F1/34
CPC分类号： B01J13/18 , A61K9/5031 , A61K9/5094 , G01N2446/20 , G01N2446/30 , G01N2446/64 , G01N2446/66 , Y10T428/2995 , Y10T428/2998
摘要： Magnetizable "core-shell" microspheres comprising a core of a magnetizable filler and a shell of crosslinked organopolysiloxane obtained by dispersing an aqueous suspension of a magnetizable filler, not coated with a dispersing agent, in an organic solvent, dissolving an organopolysiloxane and an organohydrogenpolysiloxane in the organic phase, crosslinking, removing water, separating and, if appropriate, redispersing the magnetizable microspheres in water.
摘要翻译：可磁化的“核 - 壳”微球，其包含可磁化填料的芯和通过将未涂覆有分散剂的可磁化填料的水悬浮液分散在有机溶剂中而获得的交联的有机聚硅氧烷的壳，将有机聚硅氧烷和有机氢聚硅氧烷溶解在有机相，交联，除去水分离，如果合适的话，将可磁化的微球再分散在水中。

13. 发明授权

US4358388A Magnetic polymer latex and preparation process 失效
标题翻译：磁性聚合物胶乳及其制备方法
公开(公告)号：US4358388A
公开(公告)日：1982-11-09
申请号：US254778
申请日：1981-04-16
申请人： Jean-Claude Daniel , Jean-Luc Schuppiser , Marc Tricot, deceased
发明人： Jean-Claude Daniel , Jean-Luc Schuppiser , Marc Tricot, deceased
IPC分类号： H01F1/00 , C08F2/00 , C08F2/44 , C08F12/00 , C08F12/02 , C08F12/06 , C08F20/00 , C08F20/06 , C08F212/00 , C08F220/10 , C08K3/22 , G01N33/543 , G11B5/702 , H01F1/44 , H01F1/26
CPC分类号： G01N33/5434 , C08F12/02 , C08F2/44 , G11B5/7023 , G01N2446/20 , G01N2446/40 , G01N2446/64
摘要： Magnetic-polymer latex having a concentration of less than 65% by weight of hydrophobic vinyl aromatic polymer particles. The polymer particles have diameters from 0.03 to 5 microns and also have dispersed therein a magnetically-charged material in an amount of from 0.5 to 50% by weight with respect to the polymer portion of the polymer particles.A process for preparing magnetic-polymer latices. Magnetically charged particles are dispersed in an organic phase comprising an organically soluble initiator and an organic monomeric component selected from the group consisting of a single vinyl aromatic monomer and a combination of a single vinyl aromatic monomer and a copolymerizing monomer. The dispersion so obtained is mixed with an aqueous solution containing an emulsifying agent and the mixture is homogenized. Polymerization is then effected to form a magnetic-polymer latex containing hydrophobic vinyl aromatic polymer particle. More organic monomer component may be added immediately prior to or during polymerization. Alternatively, the magnetically-charged material may be dispersed into an organic phase comprising an organically soluble initiator and a water-soluble organic compound. An organic monomeric component is added to the aqueous-organic phase mixture after homogenization and prior to or during polymerization, which is effected to form a magnetic-polymer latex containing hydrophobic polymer particles. The magnetic-polymer latices obtained are useful in paints, magnetic tapes, recordings, and biological applications.
摘要翻译：具有小于65重量％的疏水性乙烯基芳族聚合物颗粒的磁性聚合物胶乳。聚合物颗粒的直径为0.03至5微米，并且其中分散有相对于聚合物颗粒的聚合物部分为0.5至50重量％的充磁材料。制备磁性聚合物胶乳的方法。磁性带电粒子分散在包含有机溶解引发剂和选自单一乙烯基芳族单体和单一乙烯基芳族单体和共聚单体的组合的有机单体组分的有机相中。将如此获得的分散体与含有乳化剂的水溶液混合，将混合物均化。然后进行聚合以形成含有疏水性乙烯基芳族聚合物颗粒的磁性聚合物胶乳。可以在聚合之前或期间立即加入更多的有机单体组分。或者，带电荷的材料可以分散到包含有机溶解引发剂和水溶性有机化合物的有机相中。在均化之后和在聚合之前或期间，将有机单体组分加入到水 - 有机相混合物中，其进行以形成含有疏水聚合物颗粒的磁性聚合物胶乳。获得的磁性聚合物胶乳可用于油漆，磁带，记录和生物应用。

14. 发明授权

US08486720B2 Arrays of magnetic particles 有权
标题翻译：磁性粒子阵列
公开(公告)号：US08486720B2
公开(公告)日：2013-07-16
申请号：US10910460
申请日：2004-08-03
申请人： Sukanta Banerjee , Michael Seul , Alice X. Li
发明人： Sukanta Banerjee , Michael Seul , Alice X. Li
IPC分类号： G01N33/553
CPC分类号： C12Q1/6813 , B01J19/0046 , B01J2219/00286 , B01J2219/00315 , B01J2219/00497 , B01J2219/005 , B01J2219/00527 , B01J2219/00545 , B01J2219/00576 , B01J2219/00585 , B01J2219/00596 , B01J2219/00644 , B01J2219/00648 , B01J2219/00653 , B01J2219/00722 , B01J2219/00725 , C12Q1/6837 , C12Q1/6876 , G01N27/745 , G01N33/5434 , G01N33/54346 , G01N33/587 , G01N2035/00564 , G01N2035/00762 , G01N2446/20 , G01N2446/64 , Y10T436/11 , C12Q2565/513 , C12Q2563/143 , C12Q2563/107 , C12Q2563/155
摘要： The present invention provides a method for the generation of novel libraries of encoded magnetic particles from sub-libraries of by the generation of novel sub-libraries of magnetic nanoparticles and encoded particles. The sub-libraries are functionalized on demand are useful in the formation of arrays. The present invention is especially useful for performing multiplexed (parallel) assays for qualitative and/or quantitative analysis of binding interactions of a number of analyte molecules in a sample.
摘要翻译：本发明提供了一种通过产生磁性纳米颗粒和编码颗粒的新型亚文库从子文库生成新的编码磁性颗粒文库的方法。子库根据需要进行功能化在数组的形成中是有用的。本发明特别可用于进行多个（并行）测定以定性和/或定量分析样品中许多分析物分子的结合相互作用。

15. 发明授权

US07892854B2 Multianalyte molecular analysis using application-specific random particle arrays 有权
标题翻译：使用应用特异性随机粒子阵列进行多分析分析
公开(公告)号：US07892854B2
公开(公告)日：2011-02-22
申请号：US10204799
申请日：2001-06-21
申请人： Sukanta Banerjee , Michael Seul , Alice X. Li , Kairali Podual , Chiu W. Chau
发明人： Sukanta Banerjee , Michael Seul , Alice X. Li , Kairali Podual , Chiu W. Chau
IPC分类号： G01N33/553 , C12Q1/68
CPC分类号： C12Q1/6813 , B01J19/0046 , B01J2219/00286 , B01J2219/00315 , B01J2219/00497 , B01J2219/005 , B01J2219/00527 , B01J2219/00545 , B01J2219/00576 , B01J2219/00585 , B01J2219/00596 , B01J2219/00644 , B01J2219/00648 , B01J2219/00653 , B01J2219/00722 , B01J2219/00725 , C12Q1/6837 , C12Q1/6876 , G01N27/745 , G01N33/5434 , G01N33/54346 , G01N33/587 , G01N2035/00564 , G01N2035/00762 , G01N2446/20 , G01N2446/64 , Y10T436/11 , C12Q2565/513 , C12Q2563/143 , C12Q2563/107 , C12Q2563/155
摘要： The present invention provides methods and apparatus for the application of a particle array in bioassay format to perform qualitative and/or quantitative molecular interaction analysis between two classes of molecules (an analyte and a binding agent). The methods and apparatus disclosed herein permit the determination of the presence or absence of association, the strength of association, and/or the rate of association and dissociation governing the binding interactions between the binding agents and the analyte molecules. The present invention is especially useful for performing multiplexed (parallel) assays for qualitative and/or quantitative analysis of binding interactions of a number of analyte molecules in a sample.
摘要翻译：本发明提供了用于以生物测定形式应用颗粒阵列以在两类分子（分析物和结合剂）之间进行定性和/或定量分子相互作用分析的方法和装置。本文公开的方法和装置允许确定结合剂和分析物分子之间的结合相互作用的存在或不存在，缔合的强度，和/或缔合速率和解离速率。本发明特别可用于进行多个（并行）测定以定性和/或定量分析样品中许多分析物分子的结合相互作用。

16. 发明授权

US06866838B1 Composite nanospheres and their conjugates with biomolecules 有权
标题翻译：复合纳米球及其与生物分子的共轭物
公开(公告)号：US06866838B1
公开(公告)日：2005-03-15
申请号：US10129141
申请日：2000-11-06
申请人： Olivier Mondain-Monval , Abdelhamid Elaissari , Eric Bosc , Christian Pichot , Bernard Mandrand , Jérôme Bibette
发明人： Olivier Mondain-Monval , Abdelhamid Elaissari , Eric Bosc , Christian Pichot , Bernard Mandrand , Jérôme Bibette
IPC分类号： G01N33/545 , A61K9/51 , A61K31/7088 , A61K45/00 , A61K47/02 , A61K47/04 , A61K47/32 , A61K47/48 , A61K48/00 , A61P43/00 , C09D11/00 , G01N33/543 , A61B8/00 , A61K9/14 , B01J13/02
CPC分类号： G01N33/5434 , G01N2446/20 , G01N2446/64 , G01N2446/66 , Y10T428/2982 , Y10T428/2984 , Y10T428/2985 , Y10T428/2987
摘要： The invention concerns composite nanospheres having a diameter ranging between about 50 and 1000 nm plus or minus 5%, preferably between about 100 and 500 nm plus or minus 5% and advantageously between 100 and 200 nm plus or minus 5%, and comprising an essentially liquid core consisting of an organic phase and inorganic nanoparticles, distributed inside the organic phase, and a skin consisting of at least a hydrophilic polymer derived from the polymerisation of at least one water soluble monomer, in particular N-alkylacrylamide or a N—N-dialkylacrylamide; conjugates derived from said nanospheres; their preparation methods and their uses.
摘要翻译：本发明涉及直径范围在约50和1000nm之间的复合纳米球，加上或减少5％，优选在约100和500nm之间加上或减少5％，并且有利地在100和200nm之间加上或减少5％，并且包括基本上分布在有机相内部的有机相和无机纳米颗粒组成的液体芯，以及至少由至少一种水溶性单体，特别是N-烷基丙烯酰胺或NN-二烷基丙烯酰胺的聚合衍生的亲水性聚合物组成的皮肤; 源自所述纳米球的共轭物; 其制备方法及其用途。

17. 发明申请

US20040132122A1 Multianalyte molecular analysis using application-specific random particle arrays 有权
标题翻译：使用应用特异性随机粒子阵列进行多分析分析
公开(公告)号：US20040132122A1
公开(公告)日：2004-07-08
申请号：US10204799
申请日：2003-02-19
发明人： Sukanta Banerjee , Michael Seul , Alice X. Li , Kairali Podual , Chiu W. Chau
IPC分类号： G01N033/53
CPC分类号： C12Q1/6813 , B01J19/0046 , B01J2219/00286 , B01J2219/00315 , B01J2219/00497 , B01J2219/005 , B01J2219/00527 , B01J2219/00545 , B01J2219/00576 , B01J2219/00585 , B01J2219/00596 , B01J2219/00644 , B01J2219/00648 , B01J2219/00653 , B01J2219/00722 , B01J2219/00725 , C12Q1/6837 , C12Q1/6876 , G01N27/745 , G01N33/5434 , G01N33/54346 , G01N33/587 , G01N2035/00564 , G01N2035/00762 , G01N2446/20 , G01N2446/64 , Y10T436/11 , C12Q2565/513 , C12Q2563/143 , C12Q2563/107 , C12Q2563/155
摘要： The present invention provides methods and apparatus for the application of a particle array in bioassay format to perform qualitative and/or quantitative molecular interaction analysis between two classes of molecules (an analyte and a binding agent). The methods and apparatus disclosed herein permit the determination of the presence or absence of association, the strength of association, and/or the rate of association and dissociation governing the binding interactions between the binding agents and the analyte molecules. The present invention is especially useful for performing multiplexed (parallel) assays for qualitative and/or quantitative analysis of binding interactions of a number of analyte molecules in a sample.
摘要翻译：本发明提供了用于以生物测定形式应用颗粒阵列以在两类分子（分析物和结合剂）之间进行定性和/或定量分子相互作用分析的方法和装置。本文公开的方法和装置允许确定结合剂和分析物分子之间的结合相互作用的存在或不存在，缔合的强度，和/或缔合速率和解离速率。本发明特别可用于进行多个（并行）测定以定性和/或定量分析样品中许多分析物分子的结合相互作用。

18. 发明授权

US5356713A Magnetizable composite microspheres of hydrophobic crosslinked polymer, process for preparing them and their application in biology 失效
标题翻译：疏水交联聚合物的可磁化复合微球，制备方法及其在生物学中的应用
公开(公告)号：US5356713A
公开(公告)日：1994-10-18
申请号：US70053
申请日：1993-06-01
申请人： Dominique Charmot , Christine Vidil
发明人： Dominique Charmot , Christine Vidil
IPC分类号： G01N33/545 , A61K39/00 , A61L31/00 , B22F1/02 , C01G49/00 , C08F2/44 , C08F12/00 , C08F292/00 , C08K9/04 , C08K9/10 , C08L25/00 , C08L25/04 , G01N33/543 , G01N33/553 , H01F1/44 , B32B5/16
CPC分类号： G01N33/5434 , C08F292/00 , C08K9/10 , G01N2446/20 , G01N2446/30 , G01N2446/64 , G01N2446/66 , G01N2446/84 , Y10T428/2991 , Y10T428/2998
摘要： Magnetizable composite microspheres approximately from 0.05 to 10 .mu.m in diameter, comprising a core of magnetizable particles and a shell of a hydrophobic crosslinked copolymer formed from a vinylaromatic monomer and a crosslinking emulsifying polymer. The microspheres are obtained by the pre-emulsification in water of a magnetic fluid composed of magnetizable particles dispersed in a vinylaromatic monomer and in a crosslinking emulsifying polymer, polymerization, separation of the magnetizable microspheres and optional redispersion in water. The microspheres are useful in biological applications.
摘要翻译：直径约为0.05-10μm的可磁化复合微球，包含可磁化颗粒的芯和由乙烯基芳族单体和交联乳化聚合物形成的疏水性交联共聚物的壳。微球是通过在水中预先乳化在由可分散在乙烯基芳族单体中的可磁化颗粒和交联乳化聚合物，聚合，可磁化微球分离和任选的再分散在水中的磁性流体获得的。微球可用于生物应用。

19. 发明授权

US5178947A Magnetizable composite microspheres based on a crosslinked organosilicon polymer 失效
标题翻译：基于交联有机硅聚合物的可磁化复合微结构
公开(公告)号：US5178947A
公开(公告)日：1993-01-12
申请号：US634909
申请日：1990-12-27
申请人： Dominique Charmot , Andre Thibon
发明人： Dominique Charmot , Andre Thibon
IPC分类号： C08G77/12 , A61K9/50 , C08G77/20 , C08G77/22 , C08J3/12 , C08K9/06 , C08L83/05 , C08L83/07 , C12N11/08 , C12N11/14 , G01N33/553 , H01F1/34 , H01F1/44
CPC分类号： C08J3/12 , A61K9/5094 , C08J3/126 , C12N11/14 , H01F1/44 , C08J2383/04 , C08J2483/02 , G01N2446/20 , G01N2446/30 , G01N2446/64 , G01N2446/66 , Y10T428/2995
摘要： Magnetizable composite microspheres comprising a core of a magnetizable filler distributed uniformly in a network of a polysilsesquioxane SiVi containing double bonds and a shell of a crosslinked organosilicon polymer derived from the hydrosilylation of an organohydrogenopolysiloxane SiH with the ethylenically unsaturated groups of the polysilsesquioxane. The magnetizable composite microspheres are obtained by dispersing an aqueous suspension of a magnetizable filler, not coated with a dispersing agent, in a solvent, dissolving an alkoxysilane or an alkoxysiloxane containing double bonds, polycondensing to a SiVi group-containing polysilsesquioxane SiVi, removing water, dissolving the organohydrogenopolysiloxane SiH polymer in the organic phase, crosslinking the mixture of polymers, removing water, separating the microspheres and, if appropriate, redispersing the microspheres in water. The magnetizable composite microspheres are preferably used as an active supports in biology.
摘要翻译：可磁化的复合微球，其包含均匀分布在含有双键的聚倍半硅氧烷SiVi的网络中的可磁化填料的芯和衍生自有机氢聚硅氧烷SiH与聚倍半硅氧烷的烯键式不饱和基团的氢化硅烷化的交联的有机硅聚合物的壳。可磁化复合微球是通过将未涂覆分散剂的可磁化填料的水性悬浮液分散在溶剂中，将含有双键的烷氧基硅烷或烷氧基硅氧烷，缩聚反应分散在含SiVi的聚倍半硅氧烷SiVi中，除去水，将有机氢聚硅氧烷SiH聚合物溶解在有机相中，交联聚合物的混合物，除去水，分离微球体，如果合适的话，将微球体再分散在水中。可磁化复合微球优选用作生物学中的活性载体。

20. 发明授权

US5034145A Process for the preparation of magnetizable microspheres based on polysiloxane and their biological application 失效
标题翻译：基于聚硅氧烷制备可磁化微球的方法及其生物应用
公开(公告)号：US5034145A
公开(公告)日：1991-07-23
申请号：US537879
申请日：1990-06-13
申请人： Frederic Leising , Bernard Chauvel , Ghislaine Torres
发明人： Frederic Leising , Bernard Chauvel , Ghislaine Torres
IPC分类号： C12N11/02 , A61K9/50 , A61K47/30 , B01J13/00 , B01J13/02 , B01J13/12 , C08K3/00 , C08L83/04 , C10M173/00 , C10N10/04 , C10N10/12 , C10N10/14 , C10N10/16 , C10N40/14 , C12N5/00 , C12N5/06 , G01N33/543 , H01F1/34
CPC分类号： B01J13/125 , A61K9/5094 , C12N5/0075 , G01N33/5434 , C12N2533/30 , G01N2446/20 , G01N2446/30 , G01N2446/64 , Y10T428/2991 , Y10T428/2995
摘要： Magnetizable microspheres, optionally in aqueous dispersion, consisting of a matrix of at least one organopolysiloxane optionally bearing Si-vinyl groups or reactive and/or ionic units and magnetizable particles less than 300 angstroms in diameter encapsulated in the matrix. The magnetizable microspheres are prepared by homogenizing a solution of the organopolysiloxane and a magnetic fluid in the presence of water and a surfactant, removing the solvent for the organopolysiloxane and the carrier liquid of the magnetic fluid, and at least partially removing the water. The magnetizable microspheres are useful in biological applications as active supports.
摘要翻译：可任选地在水分散体中的可磁化微球由至少一种有机聚硅氧烷的基体组成，所述基质任选地含有Si-乙烯基或反应性和/或离子单元以及直径小于300埃的可磁化的颗粒，其包封在基质中。可磁化的微球体是通过在水和表面活性剂的存在下均化有机聚硅氧烷和磁性流体的溶液，除去有机聚硅氧烷和磁性流体的载体液体的溶剂，并且至少部分地除去水来制备的。可磁化微球体在生物应用中可用作活性载体。

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