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11. 发明授权

US09568468B2 In vivo cellular screening methods and compositions for modeling and treating nervous system dysfunction 有权
标题翻译：用于建模和治疗神经系统功能障碍的体内细胞筛选方法和组合物
公开(公告)号：US09568468B2
公开(公告)日：2017-02-14
申请号：US14212999
申请日：2014-03-14
申请人： WISCONSIN ALUMNI RESEARCH FOUNDATION
发明人： Barry Ganetzky , Daniel L. Miller , Shannon L. Ballard
IPC分类号： G01N33/00 , A01K67/00 , G01N33/50 , G01N33/68
CPC分类号： G01N33/5058 , G01N33/5085 , G01N33/6896 , G01N2333/43573 , G01N2800/2821
摘要： Described herein are methods and composition for identifying agents that modulate nerve regeneration in vivo in extended third instar (ETI) Drosophila larvae. The methods include the use of ETI Drosophila larvae having a structural or functional disruption in one or more neurons (e.g., motor neurons) to evaluate a nerve regeneration phenotype over an extended developmental time period in the presence or absence of a test agent.
摘要翻译：本文描述了用于鉴定在延长的三龄（ETI）果蝇幼虫中调节体内神经再生的试剂的方法和组合物。所述方法包括使用在一种或多种神经元（例如，运动神经元）中具有结构或功能性破坏的ETI果蝇幼虫，以在存在或不存在测试试剂的情况下在延长的发育时间段内评估神经再生表型。

12. 发明申请

US20170006871A1 METHODS OF IDENTIFYING INSECT-TRPA1 MODULATORS 有权
标题翻译：识别INS-TRPA1调节剂的方法
公开(公告)号：US20170006871A1
公开(公告)日：2017-01-12
申请号：US15276682
申请日：2016-09-26
申请人： BRANDEIS UNIVERSITY
发明人： PAUL GARRITY , KYEONGJIN KANG
IPC分类号： A01N47/48 , G01N33/68 , G01N33/50 , A01N35/02 , A01N43/36
CPC分类号： A01N47/48 , A01N35/02 , A01N43/36 , A23K50/90 , G01N33/5008 , G01N33/5085 , G01N33/6872 , G01N35/10 , G01N2333/43552 , G01N2333/43573 , G01N2333/705 , G01N2500/02
摘要： The invention provides a screening method for identifying an insect-specific TRPA1 modulator by comparing modulation of an insect TRPA1 and a mammalian TRPA1. The invention further provides method of insect control by applying to an insect a insect-specific TRPA1 modulator identified by the screening method.
摘要翻译：本发明提供了通过比较昆虫TRPA1和哺乳动物TRPA1的调节来鉴定昆虫特异性TRPA1调节剂的筛选方法。本发明还通过将昆虫特异性TRPA1调节剂应用于通过筛选方法鉴定的昆虫特异性TRPA1调节剂，进一步提供了昆虫防治方法。

13. 发明申请

US20150377897A1 METHODS FOR IDENTIFYING ARTHROPOD REPELLENTS BASED ON MODULATION OF SPECIFIC IONOTROPIC RECEPTORS, AND COMPOUNDS AND COMPOSITIONS IDENTIFIED BY SUCH METHODS 有权
标题翻译：用于鉴别特异性离子受体调节性神经递质的方法，以及通过这些方法鉴定的化合物和组合物
公开(公告)号：US20150377897A1
公开(公告)日：2015-12-31
申请号：US14853710
申请日：2015-09-14
申请人： THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
发明人： Anandasankar RAY , Pinky KAIN , Christine PHAM
IPC分类号： G01N33/68
CPC分类号： G01N33/68 , G01N2333/43573 , G01N2333/705 , G01N2500/04
摘要： Provided herein are screening methods for identifying arthropod repellent compounds based on modulation of ionotropic receptors, including an Ir40a receptor, an Ir93a receptor and an Ir25a receptor. Further provided are screening systems related to these methods. Such systems may include a sample that has one or more of the ionotropic receptors; and one or more compounds that each is a repellent for at least one arthropod species, wherein the one or more compound each modulates the activity of such ionotropic receptor(s). Further provided are one or more compounds identified using the screening methods described herein, and compositions containing such compounds.
摘要翻译：本文提供了基于离子型受体（包括Ir40a受体，Ir93a受体和Ir25a受体）的调节来鉴定节肢动物驱避化合物的筛选方法。进一步提供与这些方法相关的筛选系统。这样的系统可以包括具有一种或多种离子型受体的样品; 和一种或多种化合物，其各自为至少一种节肢动物物种的驱避剂，其中所述一种或多种化合物各自调节这种离子型受体的活性。进一步提供使用本文所述的筛选方法鉴定的一种或多种化合物，和含有这些化合物的组合物。

14. 发明授权

US08071733B2 Antibodies that specifically bind hedgehog-derived polypeptides 失效
标题翻译：特异性结合刺猬蛋白衍生多肽的抗体
公开(公告)号：US08071733B2
公开(公告)日：2011-12-06
申请号：US12790611
申请日：2010-05-28
申请人： Philip A. Beachy , Jeffrey A. Porter , Randall T. Moon
发明人： Philip A. Beachy , Jeffrey A. Porter , Randall T. Moon
IPC分类号： C07K16/00 , C07K16/18
CPC分类号： G01N33/5005 , A01K67/0339 , A01K2217/05 , A01K2227/706 , A01K2267/03 , A61K38/00 , C07K14/43581 , C07K14/46 , C07K14/47 , C07K2319/00 , C07K2319/21 , C07K2319/23 , C07K2319/50 , C12N15/62 , G01N33/5008 , G01N33/5011 , G01N33/502 , G01N33/5058 , G01N33/68 , G01N33/92 , G01N2333/43573 , G01N2333/4603 , G01N2333/4606 , G01N2333/465 , G01N2333/47 , G01N2500/10
摘要： The present invention provides two novel polypeptides, referred to as the “N” and “C” fragments of hedgehog, or N-terminal and C-terminal fragments, respectively, which are derived after specific cleavage at a G′CF site recognized by the autoproteolytic domain in the native protein. Also included are sterol-modified hedgehog polypeptides and functional fragments thereof. Methods of identifying compositions which affect hedgehog activity based on inhibition of cholesterol modification of hedgehog protein are described.
摘要翻译：本发明提供了两种新的多肽，分别被称为刺猬蛋白的“N”和“C”片段，或N末端和C末端片段，其在由G'CF识别的G'CF位点上的特异性切割后衍生天然蛋白质中的自体蛋白水解结构域。还包括固醇修饰的刺猬蛋白多肽及其功能片段。描述了基于对刺猬蛋白胆固醇修饰的抑制影响刺猬蛋白活性的组合物的方法。

15. 发明授权

US07741451B2 Antibodies that specifically bind hedgehog-derived polypeptides 失效
标题翻译：特异性结合刺猬蛋白衍生多肽的抗体
公开(公告)号：US07741451B2
公开(公告)日：2010-06-22
申请号：US11804733
申请日：2007-05-18
申请人： Philip A. Beachy , Jeffrey A. Porter
发明人： Philip A. Beachy , Jeffrey A. Porter
IPC分类号： C07K16/00 , C07K16/18
CPC分类号： G01N33/5005 , A01K67/0339 , A01K2217/05 , A01K2227/706 , A01K2267/03 , A61K38/00 , C07K14/43581 , C07K14/46 , C07K14/47 , C07K2319/00 , C07K2319/21 , C07K2319/23 , C07K2319/50 , C12N15/62 , G01N33/5008 , G01N33/5011 , G01N33/502 , G01N33/5058 , G01N33/68 , G01N33/92 , G01N2333/43573 , G01N2333/4603 , G01N2333/4606 , G01N2333/465 , G01N2333/47 , G01N2500/10
摘要： The present invention provides two novel polypeptides, referred to as the “N” and “C” fragments of hedgehog, or N-terminal and C-terminal fragments, respectively, which are derived after specific cleavage at a G′CF site recognized by the autoproteolytic domain in the native protein. Also included are sterol-modified hedgehog polypeptides and functional fragments thereof. Methods of identifying compositions which affect hedgehog activity based on inhibition of cholesterol modification of hedgehog protein are described.
摘要翻译：本发明提供了两种新的多肽，分别被称为刺猬蛋白的“N”和“C”片段，或N末端和C末端片段，其在由G'CF识别的G'CF位点上的特异性切割后衍生天然蛋白质中的自体蛋白水解结构域。还包括固醇修饰的刺猬蛋白多肽及其功能片段。描述了基于对刺猬蛋白胆固醇修饰的抑制影响刺猬蛋白活性的组合物的方法。

16. 发明申请

US20060156421A1 High throughput screening methods for anti-metastatic compounds 审中-公开
标题翻译：抗转移性化合物的高通量筛选方法
公开(公告)号：US20060156421A1
公开(公告)日：2006-07-13
申请号：US11323151
申请日：2005-12-30
申请人： Ross Cagan
发明人： Ross Cagan
IPC分类号： A01K67/033
CPC分类号： C12N15/8509 , A01K67/0339 , A01K2217/05 , A01K2217/058 , A01K2227/706 , A01K2267/0331 , C07K14/82 , G01N33/5085 , G01N2333/43573
摘要： High throughput methods for screening of anti-cancer compounds using Drosophila are described. The methods involve modifying the expression of dCsk and observing the effect of putative anti-cancer candidate compounds on resulting expressed characteristics in the Drosophila. Related animal models and apparatus are also provided.
摘要翻译：描述了使用果蝇筛选抗癌化合物的高通量方法。该方法涉及修饰dCsk的表达，并观察推测的抗癌候选化合物对果蝇表达特征的影响。还提供了相关的动物模型和装置。

17. 发明申请

US20050202401A1 Nucleic acid sequences found in Drosophilia melanogaster that encode proteins essential for viability and method of use 有权
标题翻译：在果蝇中发现的核酸序列，其编码对生存力和使用方法至关重要的蛋白质
公开(公告)号：US20050202401A1
公开(公告)日：2005-09-15
申请号：US10842130
申请日：2004-05-10
申请人： Alan Christensen , Douglas Dorer
发明人： Alan Christensen , Douglas Dorer
IPC分类号： A01N63/00 , C12Q1/00
CPC分类号： G01N33/5085 , A01N63/00 , G01N2333/43573
摘要： Within the unique Triplo-lethal region (Tpl) of the Drosophila melanogaster genome we have found a cluster of 20 genes encoding a novel family of proteins. This family is also present in the Anopheles gambiae genome and displays remarkable synteny and sequence conservation with the Drosophila cluster. The family is also present in the sequenced genome of Drosophila pseudoobscura, and homologs have been found in Aedes aegyptii mosquitoes and the honeybee (Apis mellifera), but it is not present in the sequenced genome of any non-insect species. Phylogenetic analysis suggests that the cluster evolved prior to the divergence of Drosophila and Anopheles (250MYA) and has been highly conserved since. The ratio of synonymous to nonsynonymous substitutions and the high codon bias suggest that there has been selection on this family both for expression level and function. We suggest that this gene family is Tpl, name it the Osiris family, and suggest possible functions. We also suggest that this family of proteins, due to the unique dosage sensitivity, and the lack of homologs in non-insect species, would be a good target for genetic engineering or novel insecticides. The proteins also present an excellent means to test compounds for use as possible insecticides.
摘要翻译：在果蝇黑腹果蝇基因组的独特的Triplo致死区域（Tpl）中，我们发现了一组编码新型蛋白质家族的20个基因。这个家庭也存在于冈比亚按摩基因组中，并与果蝇簇显示出显着的合成和序列保守性。该家族也存在于果蝇假芽孢杆菌的测序基因组中，并且已经在艾滋病艾滋病蚊子和蜜蜂（Apis mellifera）中发现了同源物，但是它不存在于任何非昆虫物种的测序基因组中。系统发育分析表明，集群在果蝇和按蚊（250MYA）发散之前发展，自从以来一直保持高度保守。非同义替代的代名词和高密码子偏倚的比例表明，该家族在表达水平和功能方面都有选择。我们建议这个基因家族是Tpl，将其命名为Osiris家族，并提出可能的功能。我们还建议，由于独特的剂量敏感性和非昆虫物种缺乏同系物，这种蛋白质家族将是基因工程或新型杀虫剂的良好靶标。蛋白质也是测试化合物用作可能的杀虫剂的极好手段。

18. 发明申请

US20020142288A1 Auto-sampler for treatment or pretreatment of sample multicellular organisms for a large particle sorting flow cytometer 审中-公开
标题翻译：自动采样器用于大颗粒分选流式细胞仪的样品多细胞生物体的治疗或预处理
公开(公告)号：US20020142288A1
公开(公告)日：2002-10-03
申请号：US10077561
申请日：2002-02-15
发明人： Peter E. Kaultkiewicz , John E. Memmott
IPC分类号： C12Q001/00
CPC分类号： G01N15/14 , G01N33/5082 , G01N33/537 , G01N2333/43573
摘要： A system and method for analyzing the effects of a test drug on a multicellular organism is provided. The organisms which may include embryos are labeled with a cytohistochemical reagent and sorted into wells of a microtiter plate using fluorescence activated cell sorting. To each well is added a test drug. The organisms in each well are then analyzed using a auto-sampler device to determine the effect of the test drug. The organism can then be re-sorted into a fresh titer plate.
摘要翻译：提供了一种用于分析试验药物对多细胞生物体的作用的系统和方法。可以包括胚胎的生物体用细胞组织化学试剂标记，并使用荧光激活细胞分选将其分选到微量滴定板的孔中。每口加入试药。然后使用自动取样装置分析每个孔中的生物体以确定试验药物的效果。然后可以将生物体重新分选成新鲜的滴定板。

19. 发明授权

US06270984B1 Modulating robo: ligand interactions 失效
标题翻译：调节robo：配体相互作用
公开(公告)号：US06270984B1
公开(公告)日：2001-08-07
申请号：US09540245
申请日：2000-03-31
申请人： Corey S. Goodman , Thomas Kidd , Katja Brose , Marc Tessier-Lavigne
发明人： Corey S. Goodman , Thomas Kidd , Katja Brose , Marc Tessier-Lavigne
IPC分类号： G01N3383
CPC分类号： C07K14/70503 , A61K38/00 , C07K14/4702 , G01N33/566 , G01N33/68 , G01N2333/43573 , G01N2500/02
摘要： Disclosed are methods and compositions for identifying agents which modulate the interaction of Robo and a Robo ligand and for modulating the interaction of Robo and a Robo ligand. The methods for identifying Robo:ligand modulators find particular application in commercial drug screens. These methods generally comprise (1) combining a Robo polypeptide, a Slit polypeptide and a candidate agent under conditions whereby, but for the presence of the agent, the Robo and Slit polypeptides engage in a first interaction, and (2) determining a second interaction of the Robo and Slit polypeptides in the presence of the agent, wherein a difference between the first and second interactions indicates that the agent modulates the interaction of the Robo and Slit polypeptides. The subject methods of modulating the interaction of Robo and a Robo ligand involve combining a Robo polypeptide, a Slit polypeptide and a modulator under conditions whereby, but for the presence of the modulator, the Robo and Slit polypeptides engage in a first interaction, whereby the Robo and Slit polypeptides engage in a second interaction different from the first interaction. In a particular embodiment, the modulator is dominant negative form of the Robo or Slit polypeptide.
摘要翻译：公开了用于鉴定调节Robo和Robo配体的相互作用并调节Robo和Robo配体的相互作用的试剂的方法和组合物。用于鉴定Robo：配体调节剂的方法在商业药物筛选中发现具体应用。这些方法通常包括（1）在条件下组合Robo多肽，狭缝多肽和候选试剂，但是对于所述试剂的存在，所述Robo和狭缝多肽参与第一相互作用，和（2）确定第二相互作用的Robo和Slit多肽，其中所述第一和第二相互作用之间的差异指示所述试剂调节所述Robo和Slit多肽的相互作用。调节Robo和Robo配体的相互作用的主题方法包括在条件下组合Robo多肽，狭缝多肽和调节剂，但是对于调节剂的存在，Robo和Slit多肽参与第一相互作用，由此 Robo和Slit多肽参与与第一相互作用不同的第二相互作用。在一个具体实施方案中，调节剂是Robo或Slit多肽的显性阴性形式。

20. 发明授权

US6046015A Modulating Robo: ligand interactions 失效
标题翻译：调制Robo：配体相互作用
公开(公告)号：US6046015A
公开(公告)日：2000-04-04
申请号：US191647
申请日：1998-11-13
申请人： Corey S. Goodman , Thomas Kidd , Katja Brose , Marc Tessier-Lavigne
发明人： Corey S. Goodman , Thomas Kidd , Katja Brose , Marc Tessier-Lavigne
IPC分类号： C12N15/09 , A61K38/00 , A61K38/17 , A61P43/00 , C07K14/47 , C07K14/705 , C07K16/18 , C12N15/12 , G01N33/15 , G01N33/50 , G01N33/566 , G01N33/68 , G01N33/53 , C07K7/08 , C12N5/02
CPC分类号： C07K14/70503 , C07K14/4702 , G01N33/566 , G01N33/68 , A61K38/00 , G01N2333/43573 , G01N2500/02
摘要： Disclosed are methods and compositions for identifing agents which modulate the interaction of Robo and a Robo ligand and for modulating the interaction of Robo and a Robo ligand. The methods for identifying Robo:ligand modulators find particular application in commercial drug screens. These methods generally comprise (1) combining a Robo polypeptide, a Slit polypeptide and a candidate agent under conditions whereby, but for the presence of the agent, the Robo and Slit polypeptides engage in a first interaction, and (2) determining a second interaction of the Robo and Slit polypeptides in the presence of the agent, wherein a difference between the first and second interactions indicates that the agent modulates the interaction of the Robo and Slit polypeptides. The subject methods of modulating the interaction of Robo and a Robo ligand involve combining a Robo polypeptide, a Slit polypeptide and a modulator under conditions whereby, but for the presence of the modulator, the Robo and Slit polypeptides engage in a first interaction, whereby the Robo and Slit polypeptides engage in a second interaction different from the first interaction. In a particular embodiment, the modulator is dominant negative form of the Robo or Slit polypeptide.
摘要翻译：公开了用于调节Robo和Robo配体的相互作用并用于调节Robo和Robo配体的相互作用的识别剂的方法和组合物。用于鉴定Robo：配体调节剂的方法在商业药物筛选中发现具体应用。这些方法通常包括（1）在条件下组合Robo多肽，狭缝多肽和候选试剂，但是对于所述试剂的存在，所述Robo和狭缝多肽参与第一相互作用，和（2）确定第二相互作用的Robo和Slit多肽，其中所述第一和第二相互作用之间的差异指示所述试剂调节所述Robo和Slit多肽的相互作用。调节Robo和Robo配体的相互作用的主题方法包括在条件下组合Robo多肽，狭缝多肽和调节剂，但是对于调节剂的存在，Robo和Slit多肽参与第一相互作用，由此 Robo和Slit多肽参与与第一相互作用不同的第二相互作用。在一个具体实施方案中，调节剂是Robo或Slit多肽的显性阴性形式。

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