专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

US20050202401A1 Nucleic acid sequences found in Drosophilia melanogaster that encode proteins essential for viability and method of use 有权
标题翻译：在果蝇中发现的核酸序列，其编码对生存力和使用方法至关重要的蛋白质
公开(公告)号：US20050202401A1
公开(公告)日：2005-09-15
申请号：US10842130
申请日：2004-05-10
申请人： Alan Christensen , Douglas Dorer
发明人： Alan Christensen , Douglas Dorer
IPC分类号： A01N63/00 , C12Q1/00
CPC分类号： G01N33/5085 , A01N63/00 , G01N2333/43573
摘要： Within the unique Triplo-lethal region (Tpl) of the Drosophila melanogaster genome we have found a cluster of 20 genes encoding a novel family of proteins. This family is also present in the Anopheles gambiae genome and displays remarkable synteny and sequence conservation with the Drosophila cluster. The family is also present in the sequenced genome of Drosophila pseudoobscura, and homologs have been found in Aedes aegyptii mosquitoes and the honeybee (Apis mellifera), but it is not present in the sequenced genome of any non-insect species. Phylogenetic analysis suggests that the cluster evolved prior to the divergence of Drosophila and Anopheles (250MYA) and has been highly conserved since. The ratio of synonymous to nonsynonymous substitutions and the high codon bias suggest that there has been selection on this family both for expression level and function. We suggest that this gene family is Tpl, name it the Osiris family, and suggest possible functions. We also suggest that this family of proteins, due to the unique dosage sensitivity, and the lack of homologs in non-insect species, would be a good target for genetic engineering or novel insecticides. The proteins also present an excellent means to test compounds for use as possible insecticides.
摘要翻译：在果蝇黑腹果蝇基因组的独特的Triplo致死区域（Tpl）中，我们发现了一组编码新型蛋白质家族的20个基因。这个家庭也存在于冈比亚按摩基因组中，并与果蝇簇显示出显着的合成和序列保守性。该家族也存在于果蝇假芽孢杆菌的测序基因组中，并且已经在艾滋病艾滋病蚊子和蜜蜂（Apis mellifera）中发现了同源物，但是它不存在于任何非昆虫物种的测序基因组中。系统发育分析表明，集群在果蝇和按蚊（250MYA）发散之前发展，自从以来一直保持高度保守。非同义替代的代名词和高密码子偏倚的比例表明，该家族在表达水平和功能方面都有选择。我们建议这个基因家族是Tpl，将其命名为Osiris家族，并提出可能的功能。我们还建议，由于独特的剂量敏感性和非昆虫物种缺乏同系物，这种蛋白质家族将是基因工程或新型杀虫剂的良好靶标。蛋白质也是测试化合物用作可能的杀虫剂的极好手段。

IPRDB

热门服务

关于我们

友情链接

联系方式