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11. 发明公开

US20230271793A1 MULTILAYER HYDRODYNAMIC SHEATH FLOW STRUCTURE 审中-公开
公开(公告)号：US20230271793A1
公开(公告)日：2023-08-31
申请号：US18136126
申请日：2023-04-18
申请人： CYTONOME/ST, LLC
发明人： John R. Gilbert , Manish Deshpande , Bernard Bunner
IPC分类号： B65G51/08 , B01L3/00 , G01N15/14 , B07C5/00 , B07C5/34 , B01F33/301
CPC分类号： B65G51/08 , B01L3/502776 , G01N15/1404 , G01N15/1484 , B07C5/00 , B07C5/34 , B01F33/3017 , B01J2219/00822 , B01J2219/00831 , B01J2219/00833 , B01J2219/0086 , B01J2219/00891 , B01L2200/0636 , B01L2300/0816 , B01L2300/0887 , B01L2400/0487 , B65G51/00
摘要： A microfabricated sheath flow structure for producing a sheath flow includes a primary sheath flow channel for conveying a sheath fluid, a sample inlet for injecting a sample into the sheath fluid in the primary sheath flow channel, a primary focusing region for focusing the sample within the sheath fluid and a secondary focusing region for providing additional focusing of the sample within the sheath fluid. The secondary focusing region may be formed by a flow channel intersecting the primary sheath flow channel to inject additional sheath fluid into the primary sheath flow channel from a selected direction. A sheath flow system may comprise a plurality of sheath flow structures operating in parallel on a microfluidic chip.

12. 发明公开

US20230249180A1 A multifunctional microfluidic detection chip 审中-公开
公开(公告)号：US20230249180A1
公开(公告)日：2023-08-10
申请号：US18012653
申请日：2021-11-01
申请人： LANSION BIOTECHNOLOGY CO., LTD.
发明人： Xingshang Xu , Jeffery Chen
IPC分类号： B01L3/00 , B01F33/301 , B01F23/451 , B01F23/40 , B01F35/83
CPC分类号： B01L3/502723 , B01F33/3017 , B01F23/451 , B01F23/483 , B01F35/83 , B01F2101/23
摘要： The invention discloses a multifunctional microfluidic detection chip. The detection chip comprises a chip body, on which a sample injection chamber, a sample quantitative chamber, a sample overflow chamber, a diluent storage chamber, a diluent quantitative chamber, a diluent overflow chamber, a quantitative mixing chamber, a reaction chamber and vent holes are disposed; a sample to be detected is injected into the sample injection chamber, and enters the sample quantitative chamber through a microfluidic channel, and the excess reaction sample enters the sample overflow chamber, a diluent in the diluent storage chamber enters the diluent quantitative chamber through a microfluidic channel, and the excess diluent enters the diluent overflow chamber; the reaction chamber includes one or more reaction cavities and a sample blank cavity; after the sample in the sample quantitative chamber is mixed with the diluent in the diluent quantitative chamber uniformly in the quantitative mixing chamber, mixed liquid enters the reaction cavities through microfluidic channels and reacts with a reaction reagent for detection, and enters the sample blank cavity at the same time as a sample blank for detection. The invention can effectively reduce the sample consumption, improve the accuracy of the detection results, and simultaneously detect multiple indicators.

13. 发明授权

US11982602B2 Fluidic device, system, and mixing method 有权
公开(公告)号：US11982602B2
公开(公告)日：2024-05-14
申请号：US17256151
申请日：2018-06-29
申请人： NIKON CORPORATION
发明人： Ryo Kobayashi , Hirofumi Shiono
IPC分类号： G01N1/38 , B01F33/301 , G01N35/08
CPC分类号： G01N1/38 , B01F33/3017 , G01N35/085 , G01N2001/383
摘要： The present invention provides a fluidic device in which solutions of different concentrations can be easily obtained. The fluidic device includes: a first substrate and a second substrate which are stacked in a thickness direction; an undiluted solution introduction flow path which has an undiluted solution introduction port and which is constituted of a groove part provided on at least one of the first substrate and the second substrate; a first circulation flow path which is constituted of a groove part having an annular shape and having a shared part that shares part of a flow path with the undiluted solution introduction flow path and a non-shared part which is not shared with the undiluted solution introduction flow path and which is connected to a diluting solution introduction port; a second circulation flow path which is provided independently of the first circulation flow path and which is constituted of a groove part having an annular shape and having a shared part that shares some flow path with the undiluted solution introduction flow path and a non-shared part which is not shared with the undiluted solution introduction flow path and which is connected to a diluting solution introduction port; and/or a third circulation flow path which is constituted of a groove part having an annular shape and having a shared flow path that shares part of a flow path with the first circulation flow path and a non-shared flow path which is not shared with the first circulation flow path and which is connected to a diluting solution introduction port, wherein the undiluted solution introduction flow path includes a valve at both ends of the shared part.

14. 发明授权

US11969480B2 Processes of preparing mRNA-loaded lipid nanoparticles 有权
公开(公告)号：US11969480B2
公开(公告)日：2024-04-30
申请号：US17185587
申请日：2021-02-25
申请人： Translate Bio, Inc.
发明人： Shrirang Karve , Ashish Sarode , Frank DeRosa
IPC分类号： C07H21/02 , A61K9/51 , A61K47/60 , A61K47/69 , A61K48/00 , B01F23/451 , B01F33/301 , B01J13/20 , B01F101/22
CPC分类号： A61K48/0091 , A61K9/5123 , A61K47/60 , A61K47/6925 , A61K48/0033 , B01F23/451 , B01F33/3017 , B01J13/203 , B01F2101/22
摘要： The present invention provides an improved process for lipid nanoparticle formulation and mRNA encapsulation. In some embodiments, the present invention provides a process of encapsulating messenger RNA (mRNA) in lipid nanoparticles comprising a step of mixing a suspension of preformed lipid nanoparticles and mRNA.

15. 发明公开

US20230356221A1 MIXING AND MICROFLUIDIC APPARATUSES RELATED THERETO 审中-公开
公开(公告)号：US20230356221A1
公开(公告)日：2023-11-09
申请号：US18199521
申请日：2023-05-19
申请人： Nutcracker Therapeutics, Inc.
发明人： Benjamin Eldridge , Ximiao Wen
IPC分类号： B01L3/00 , A61K31/7105 , B01F23/40 , B01F33/301
CPC分类号： B01L3/50273 , B01L3/502738 , A61K31/7105 , B01F23/405 , B01F33/3017 , B01L2300/0854 , B01L2300/0858 , B01L2300/0867 , B01L2300/0877 , B01L2300/0883 , B01L2400/0478 , B01L2400/0487 , B01L2400/06 , B01F2215/0472 , B01F2101/22
摘要： The application relates to microfluidic apparatus and methods of use thereof. Provided in one example is a microfluidic device comprising: a first fluidic input and a second fluidic input; and a fluidic intersection channel to receive fluid from the first fluidic input and the second fluidic input, wherein the fluidic intersection channel opens into a first mixing chamber on an upper region of a first side of the first mixing chamber, wherein the first mixing chamber has a length, a width, and a depth, wherein the depth is greater than about 1.5 times a depth of the fluidic intersection channel; an outlet channel on an upper region of a second side of the first mixing chamber, wherein the outlet channel has a depth that is less than the depth of the first mixing chamber, and wherein an opening of the outlet channel is offset along a width of the second side of the first mixing chamber relative to the fluidic intersection.

16. 发明公开

US20230285312A1 LIPID NANOPARTICLES MANUFACTURING CHIP, LIPID NANOPARTICLES MANUFACTURING SYSTEM HAVING THE SAME, AND LIPID NANOPARTICLES MANUFACTURING METHOD 审中-公开
公开(公告)号：US20230285312A1
公开(公告)日：2023-09-14
申请号：US18024743
申请日：2022-05-11
申请人： Inventage Lab Inc.
发明人： Euidon HAN , Chan Hee CHON , Dong Hoon KIM , Ju Hee KIM
IPC分类号： A61K9/51 , B01F33/301 , B01F23/41 , B01F23/451 , B01F23/40 , B01F23/80 , C12N15/88 , B01L3/00
CPC分类号： A61K9/5192 , A61K9/5123 , B01F23/4143 , B01F23/4145 , B01F23/451 , B01F23/483 , B01F23/49 , B01F23/808 , B01F33/3017 , B01L3/502753 , C12N15/88 , B01F2101/22
摘要： A lipid nanoparticles manufacturing chip includes a mixer unit for forming a mixed solution by mixing a first raw material containing an active ingredient and a second raw material containing a lipid, a dilution unit that is connected to the mixer unit and dilutes the mixed solution using a diluent solution to make a diluted mixed solution, and a concentration unit connected to the dilution unit and for obtaining a concentrated solution by concentrating lipid nanoparticles (LNP) from the diluted mixed solution.

17. 发明授权

US11724257B2 Mixing and microfluidic apparatuses related thereto 有权
公开(公告)号：US11724257B2
公开(公告)日：2023-08-15
申请号：US17727937
申请日：2022-04-25
申请人： Nutcracker Therapeutics, Inc.
发明人： Benjamin Eldridge , Ximiao Wen
IPC分类号： B01L3/00 , A61K31/7105 , B01F23/40 , B01F33/301 , B01F101/22
CPC分类号： B01L3/50273 , A61K31/7105 , B01F23/405 , B01F33/3017 , B01L3/502738 , B01F2101/22 , B01F2215/0472 , B01L2300/0854 , B01L2300/0858 , B01L2300/0867 , B01L2300/0877 , B01L2300/0883 , B01L2400/0478 , B01L2400/0487 , B01L2400/06
摘要： The application relates to microfluidic apparatus and methods of use thereof. Provided in one example is a microfluidic device comprising: a first fluidic input and a second fluidic input; and a fluidic intersection channel to receive fluid from the first fluidic input and the second fluidic input, wherein the fluidic intersection channel opens into a first mixing chamber on an upper region of a first side of the first mixing chamber, wherein the first mixing chamber has a length, a width, and a depth, wherein the depth is greater than about 1.5 times a depth of the fluidic intersection channel; an outlet channel on an upper region of a second side of the first mixing chamber, wherein the outlet channel has a depth that is less than the depth of the first mixing chamber, and wherein an opening of the outlet channel is offset along a width of the second side of the first mixing chamber relative to the fluidic intersection.

18. 发明公开

US20230249183A1 SAMPLE EXTRACTION DEVICE AND METHODS OF USING THE SAME 审中-公开
公开(公告)号：US20230249183A1
公开(公告)日：2023-08-10
申请号：US18136632
申请日：2023-04-19
申请人： NOVEL MICRODEVICES, INC.
发明人： Andrea Maria Dominic Pais , Rohan Joseph Alexander Pais , Chelsea Qinjie Zhou
IPC分类号： B01L3/00 , G01N33/487 , B01L3/02 , B01L7/00 , G01N1/38 , B01F31/441 , B01F33/30 , B01F33/452 , B01F33/301 , G01N1/10
CPC分类号： B01L3/50273 , B01F31/441 , B01F33/30 , B01F33/452 , B01F33/3017 , B01L3/0293 , B01L3/502738 , B01L7/00 , B01L7/52 , G01N1/10 , G01N1/38 , G01N33/487 , B01L2200/16 , B01L2300/0816 , B01L2300/0867 , B01L2400/0481 , B01L2400/0683 , G01N2035/00128
摘要： The presently disclosed subject matter provides devices and methods for sample extraction from a swab during biological sample processing. In particular embodiments, the devices and methods are configured for use in conjunction with microfluidic devices for sample processing.

19. 发明授权

US11648555B2 Domino capillary microfluidic circuit 有权
公开(公告)号：US11648555B2
公开(公告)日：2023-05-16
申请号：US16757915
申请日：2018-10-19
申请人： THE ROYAL INSTITUTION FOR THE ADVANCEMENT OF LEARNING/MCGILL UNIVERSITY
发明人： David Juncker , Ayokunle Olanrewaju , Mohamed Yafia Okba Salem
IPC分类号： B01L3/00 , B01F23/45 , B01F23/40 , B01F25/433 , B01F33/301 , B01F101/23
CPC分类号： B01L3/50273 , B01F23/45 , B01F23/49 , B01F25/4331 , B01F33/3017 , B01L3/502738 , B01F2101/23 , B01L2300/0816 , B01L2300/0864 , B01L2300/12 , B01L2300/161 , B01L2400/0406 , B01L2400/0487 , B01L2400/0688
摘要： There is disclosed a capillary microfluidic circuit including a main channel communicating with a flow inducing element. The main channel has intermediary inlets. Reservoirs for containing one or more liquids prior to being drawn into the main channel. The reservoirs include a first reservoir and at least a second reservoir. Each of the reservoirs has an upstream end connectable to vents for filling the reservoirs with the one or more liquids and a downstream end. The downstream end of each of the reservoirs is connected to the intermediary inlets of the main channel A conduit is disposed between the first reservoir and the a least a second reservoir. The conduit links the downstream end of the first reservoir with the upstream end of the at least a second reservoir.

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