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    • 11. 发明申请
    • METHOD FOR MANUFACTURING MEDICATED CHEWING GUM WITHOUT COOLING
    • 用于制造没有冷却的医用柚子胶的方法
    • US20160354310A1
    • 2016-12-08
    • US14732072
    • 2015-06-05
    • Mastix LLC
    • Lisa BachmannRobert Estey
    • A61K9/68A23G4/18A61K31/05A23G4/06A61K31/352A23G4/10A23G4/08
    • A61K9/0058A23G4/066A23G4/068A23G4/08A23G4/10A23G4/12A23G4/18A23V2002/00A61K31/05A61K31/352A61K31/522A61K31/722A61K36/185
    • An improved method for manufacture of chewing gums containing active ingredient(s) that preserves the efficacy of the active ingredient(s) by avoiding exposure to high heat and extreme cold during milling that can otherwise degrade the active's efficacy. A chewing gum base is used, along with one or more therapeutically-active ingredients, one or more sweeteners (alcohol-based and/or natural), and one or more flavorings and optional flavor modifiers. The method generally comprises heating the gum base in ovens to melt the gum base. Separately, the active ingredient(s), sweeteners and flavorings are combined in a mixer. The melted gum base is added to the mixer and cools to produce a particulate mixture. As mixing continues the mass cools to room temperature and forms granular pieces. The granular pieces are ground into a powder at room temperature, mixed at room temperature with tableting excipients, and tableted. Several variations on the foregoing are also described.
    • 一种用于制造包含活性成分的口香糖的改进方法,其通过避免在研磨过程中暴露于高热和极冷而保持活性成分的功效,否则会降低活性成分的功效。 使用口香糖基料以及一种或多种治疗活性成分,一种或多种甜味剂(基于醇和/或天然)和一种或多种调味剂和任选的调味剂。 该方法通常包括在烘箱中加热胶基以熔化胶基。 另外,将活性成分,甜味剂和调味剂混合在混合器中。 将熔融的胶基添加到混合器中并冷却以产生颗粒混合物。 随着混合继续,质量冷却至室温并形成颗粒状碎片。 将颗粒状物在室温下粉碎成粉末,在室温下与压片赋形剂混合并压片。 还描述了前述的几个变型。
    • 19. 发明授权
    • Compressed chewing gum tablet
    • 压缩口香糖片
    • US08734763B2
    • 2014-05-27
    • US11631801
    • 2004-07-06
    • Vibeke Nissen
    • Vibeke Nissen
    • A61K9/68A61K36/48
    • A23G4/20A23G4/068A23G4/08A23G4/12A23P10/28A23P20/10A24B15/16A24B15/18B30B11/085
    • The invention relates to a chewing gum tablet (20) comprising at least two cohered chewing gum modules (21, 22, 23), said tableted chewing gum being formed by compression of chewing gum granules, at least one of said chewing gum modules comprising gum base granules, said gum base granules comprising an elastomer system, said chewing gum tablet comprising an elastomer system in an amount of at least 10% by weight of the tablet. According to the invention, a compressed chewing gum tablet has been obtained featuring extremely impressing abilities of incorporating well-defined amounts of chewing gum ingredients combined with acceptable rheological properties of the compete tablet.
    • 本发明涉及包含至少两个粘结的口香糖模块(21,22,23)的口香糖片(20),所述压片口香糖通过压缩口香糖颗粒形成,所述口香糖模块中的至少一种包含口香糖 所述胶基颗粒包含弹性体系统,所述口香糖片剂包含至少10重量%片剂的量的弹性体体系。 根据本发明,已经获得了一种压缩口香糖片,具有极好的吸引力,其能够将明确量的口香糖成分与竞争片剂的可接受的流变学特性相结合。