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1. 发明授权

US10463612B2 Method for manufacturing medicated chewing gum without cooling 有权
公开(公告)号：US10463612B2
公开(公告)日：2019-11-05
申请号：US15622632
申请日：2017-06-14
申请人： MastiX, LLC
发明人： Lisa Bachmann , Robert Estey
IPC分类号： A61K9/68 , A23G4/10 , A23G4/08 , A61K31/352 , A61K31/05 , A23G4/06 , A23G4/12 , A61K31/522 , A61K31/722 , A61K36/185 , A23G4/18
摘要： An improved method for manufacture of chewing gums containing active ingredient(s) that preserves the efficacy of the active ingredient(s) by avoiding exposure to high heat and extreme cold during milling that can otherwise degrade the active's efficacy. A chewing gum base is used, along with one or more therapeutically-active ingredients, one or more sweeteners (alcohol-based and/or natural), and one or more flavorings and optional flavor modifiers. The method generally comprises heating the gum base in ovens to melt the gum base. Separately, the active ingredient(s), sweeteners and flavorings are combined in a mixer. The melted gum base is added to the mixer and cools to produce a particulate mixture. As mixing continues the mass cools to room temperature and forms granular pieces. The granular pieces are ground into a powder at room temperature, mixed at room temperature with tableting excipients, and tableted. Several variations on the foregoing are also described.

2. 发明申请

US20170368020A1 Oral compositions delivering therapeutically effective amounts of cannabinoids 审中-公开
公开(公告)号：US20170368020A1
公开(公告)日：2017-12-28
申请号：US15615521
申请日：2017-06-06
申请人： MastiX, LLC
发明人： Robert Estey , William O. Brisben
IPC分类号： A61K31/352 , A61K47/24 , A61K47/10 , A61K31/70 , A61K9/20 , A61K47/36 , A61K9/68
摘要： Oral compositions provide delivery of cannabinoids to a subject. The oral compare chewable, fast- or slow-dissolving once placed in the mouth of a subject.

3. 发明申请

US20170273902A1 Method for manufacturing medicated chewing gum without cooling 审中-公开
公开(公告)号：US20170273902A1
公开(公告)日：2017-09-28
申请号：US15622584
申请日：2017-06-14
申请人： MastiX, LLC
发明人： Lisa Bachmann , Robert Estey
IPC分类号： A61K9/68 , A23G4/08 , A61K31/05 , A23G4/12 , A23G4/06
CPC分类号： A61K9/0058 , A23G4/066 , A23G4/068 , A23G4/08 , A23G4/10 , A23G4/12 , A23G4/18 , A23V2002/00 , A61K31/05 , A61K31/352 , A61K31/522 , A61K31/722 , A61K36/185
摘要： An improved method for manufacture of chewing gums containing active ingredient(s) that preserves the efficacy of the active ingredient(s) by avoiding exposure to high heat and extreme cold during milling that can otherwise degrade the active's efficacy. A chewing gum base is used, along with one or more therapeutically-active ingredients, one or more sweeteners (alcohol-based and/or natural), and one or more flavorings and optional flavor modifiers. The method generally comprises heating the gum base in ovens to melt the gum base. Separately, the active ingredient(s), sweeteners and flavorings are combined in a mixer. The melted gum base is added to the mixer and cools to produce a particulate mixture. As mixing continues the mass cools to room temperature and forms granular pieces. The granular pieces are ground into a powder at room temperature, mixed at room temperature with tableting excipients, and tableted. Several variations on the foregoing are also described.

4. 发明授权

US10765658B2 Oral compositions delivering therapeutically effective amounts of cannabinoids 有权
公开(公告)号：US10765658B2
公开(公告)日：2020-09-08
申请号：US15615521
申请日：2017-06-06
申请人： MastiX, LLC
发明人： Robert Estey , William O. Brisben
IPC分类号： A61K31/352 , A61K31/05 , A61K36/185 , A61K9/20 , A61K9/00 , A61K9/68 , A61K31/70 , A61K47/10 , A61K47/24 , A61K47/36
摘要： Oral compositions provide delivery of cannabinoids to a subject. The oral compare chewable, fast- or slow-dissolving once placed in the mouth of a subject.

5. 发明申请

US20160354310A1 METHOD FOR MANUFACTURING MEDICATED CHEWING GUM WITHOUT COOLING 有权
标题翻译：用于制造没有冷却的医用柚子胶的方法
公开(公告)号：US20160354310A1
公开(公告)日：2016-12-08
申请号：US14732072
申请日：2015-06-05
申请人： Mastix LLC
发明人： Lisa Bachmann , Robert Estey
IPC分类号： A61K9/68 , A23G4/18 , A61K31/05 , A23G4/06 , A61K31/352 , A23G4/10 , A23G4/08
CPC分类号： A61K9/0058 , A23G4/066 , A23G4/068 , A23G4/08 , A23G4/10 , A23G4/12 , A23G4/18 , A23V2002/00 , A61K31/05 , A61K31/352 , A61K31/522 , A61K31/722 , A61K36/185
摘要： An improved method for manufacture of chewing gums containing active ingredient(s) that preserves the efficacy of the active ingredient(s) by avoiding exposure to high heat and extreme cold during milling that can otherwise degrade the active's efficacy. A chewing gum base is used, along with one or more therapeutically-active ingredients, one or more sweeteners (alcohol-based and/or natural), and one or more flavorings and optional flavor modifiers. The method generally comprises heating the gum base in ovens to melt the gum base. Separately, the active ingredient(s), sweeteners and flavorings are combined in a mixer. The melted gum base is added to the mixer and cools to produce a particulate mixture. As mixing continues the mass cools to room temperature and forms granular pieces. The granular pieces are ground into a powder at room temperature, mixed at room temperature with tableting excipients, and tableted. Several variations on the foregoing are also described.
摘要翻译：一种用于制造包含活性成分的口香糖的改进方法，其通过避免在研磨过程中暴露于高热和极冷而保持活性成分的功效，否则会降低活性成分的功效。使用口香糖基料以及一种或多种治疗活性成分，一种或多种甜味剂（基于醇和/或天然）和一种或多种调味剂和任选的调味剂。该方法通常包括在烘箱中加热胶基以熔化胶基。另外，将活性成分，甜味剂和调味剂混合在混合器中。将熔融的胶基添加到混合器中并冷却以产生颗粒混合物。随着混合继续，质量冷却至室温并形成颗粒状碎片。将颗粒状物在室温下粉碎成粉末，在室温下与压片赋形剂混合并压片。还描述了前述的几个变型。

6. 发明申请

US20170281539A1 Method for manufacturing medicated chewing gum without cooling 审中-公开
公开(公告)号：US20170281539A1
公开(公告)日：2017-10-05
申请号：US15622632
申请日：2017-06-14
申请人： MastiX, LLC
发明人： Lisa Bachmann , Robert Estey
IPC分类号： A61K9/68 , A23G4/10
CPC分类号： A61K9/0058 , A23G4/066 , A23G4/068 , A23G4/08 , A23G4/10 , A23G4/12 , A23G4/18 , A23V2002/00 , A61K31/05 , A61K31/352 , A61K31/522 , A61K31/722 , A61K36/185
摘要： An improved method for manufacture of chewing gums containing active ingredient(s) that preserves the efficacy of the active ingredient(s) by avoiding exposure to high heat and extreme cold during milling that can otherwise degrade the active's efficacy. A chewing gum base is used, along with one or more therapeutically-active ingredients, one or more sweeteners (alcohol-based and/or natural), and one or more flavorings and optional flavor modifiers. The method generally comprises heating the gum base in ovens to melt the gum base. Separately, the active ingredient(s), sweeteners and flavorings are combined in a mixer. The melted gum base is added to the mixer and cools to produce a particulate mixture. As mixing continues the mass cools to room temperature and forms granular pieces. The granular pieces are ground into a powder at room temperature, mixed at room temperature with tableting excipients, and tableted. Several variations on the foregoing are also described.

7. 发明申请

US20170273903A1 Method for manufacturing medicated chewing gum without cooling 审中-公开
公开(公告)号：US20170273903A1
公开(公告)日：2017-09-28
申请号：US15622676
申请日：2017-06-14
申请人： MastiX, LLC
发明人： Lisa Bachmann , Robert Estey
IPC分类号： A61K9/68 , A23G4/08 , A61K31/05 , A23G4/12 , A23G4/06
CPC分类号： A61K9/0058 , A23G4/066 , A23G4/068 , A23G4/08 , A23G4/10 , A23G4/12 , A23G4/18 , A23V2002/00 , A61K31/05 , A61K31/352 , A61K31/522 , A61K31/722 , A61K36/185
摘要： An improved method for manufacture of chewing gums containing active ingredient(s) that preserves the efficacy of the active ingredient(s) by avoiding exposure to high heat and extreme cold during milling that can otherwise degrade the active's efficacy. A chewing gum base is used, along with one or more therapeutically-active ingredients, one or more sweeteners (alcohol-based and/or natural), and one or more flavorings and optional flavor modifiers. The method generally comprises heating the gum base in ovens to melt the gum base. Separately, the active ingredient(s), sweeteners and flavorings are combined in a mixer. The melted gum base is added to the mixer and cools to produce a particulate mixture. As mixing continues the mass cools to room temperature and forms granular pieces. The granular pieces are ground into a powder at room temperature, mixed at room temperature with tableting excipients, and tableted. Several variations on the foregoing are also described.

8. 发明授权

US09744128B2 Method for manufacturing medicated chewing gum without cooling 有权
公开(公告)号：US09744128B2
公开(公告)日：2017-08-29
申请号：US14732072
申请日：2015-06-05
申请人： Mastix LLC
发明人： Lisa Bachmann , Robert Estey
IPC分类号： A61K31/352 , A61K31/05 , A23G4/06 , A23G4/08 , A23G4/18 , A23G4/10 , A61K9/68 , A23G4/12
CPC分类号： A61K9/0058 , A23G4/066 , A23G4/068 , A23G4/08 , A23G4/10 , A23G4/12 , A23G4/18 , A23V2002/00 , A61K31/05 , A61K31/352 , A61K31/522 , A61K31/722 , A61K36/185
摘要： An improved method for manufacture of chewing gums containing active ingredient(s) that preserves the efficacy of the active ingredient(s) by avoiding exposure to high heat and extreme cold during milling that can otherwise degrade the active's efficacy. A chewing gum base is used, along with one or more therapeutically-active ingredients, one or more sweeteners (alcohol-based and/or natural), and one or more flavorings and optional flavor modifiers. The method generally comprises heating the gum base in ovens to melt the gum base. Separately, the active ingredient(s), sweeteners and flavorings are combined in a mixer. The melted gum base is added to the mixer and cools to produce a particulate mixture. As mixing continues the mass cools to room temperature and forms granular pieces. The granular pieces are ground into a powder at room temperature, mixed at room temperature with tableting excipients, and tableted. Several variations on the foregoing are also described.

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