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11. 发明申请

US20140107397A1 METHODS AND DEVICES FOR TREATING PRIMARY HEADACHE 有权
公开(公告)号：US20140107397A1
公开(公告)日：2014-04-17
申请号：US14028200
申请日：2013-09-16
申请人： ElectroCore, LLC
发明人： Bruce J. Simon , Joseph P. Errico , John T. Raffle
IPC分类号： A61N1/04 , A61N2/00
CPC分类号： A61N1/36021 , A61N1/0456 , A61N1/36075 , A61N1/40 , A61N2/006 , A61N2/008 , A61N2/02
摘要： Non-invasive electrical nerve stimulation devices and magnetic stimulation devices are disclosed, along with methods of treating medical disorders using energy that is delivered noninvasively by such devices. The disorders comprise migraine and other primary headaches such as cluster headaches, including sinus symptoms that resemble an immune-mediated response (“sinus” headaches), irrespective of whether those symptoms arise from an allergy that is co-morbid with the headache. The disclosed methods may also be used to treat other disorders that may be co-morbid with migraine headaches, such as anxiety disorders. In preferred embodiments of the disclosed methods, one or both of the patient's vagus nerves are stimulated non-invasively. In other embodiments, parts of the sympathetic nervous system and/or the adrenal glands are stimulated.

12. 发明授权

US08676330B2 Electrical and magnetic stimulators used to treat migraine/sinus headache and comorbid disorders 有权
标题翻译：用于治疗偏头痛/窦性头痛和并发症的电磁刺激剂
公开(公告)号：US08676330B2
公开(公告)日：2014-03-18
申请号：US13109250
申请日：2011-05-17
申请人： Bruce J. Simon , Joseph P. Errico , John T. Raffle
发明人： Bruce J. Simon , Joseph P. Errico , John T. Raffle
IPC分类号： A61N1/36
CPC分类号： A61N1/36021 , A61N1/0456 , A61N1/36075 , A61N1/40 , A61N2/006 , A61N2/008 , A61N2/02
摘要： Non-invasive electrical nerve stimulation devices and magnetic stimulation devices are disclosed, along with methods of treating medical disorders using energy that is delivered noninvasively by such devices. The disorders comprise migraine and other primary headaches such as cluster headaches, including sinus symptoms that resemble an immune-mediated response (“sinus” headaches), irrespective of whether those symptoms arise from an allergy that is co-morbid with the headache. The disclosed methods may also be used to treat other disorders that may be co-morbid with migraine headaches, such as anxiety disorders. In preferred embodiments of the disclosed methods, one or both of the patient's vagus nerves are stimulated non-invasively. In other embodiments, parts of the sympathetic nervous system and/or the adrenal glands are stimulated.
摘要翻译：公开了非侵入性电神经刺激装置和磁刺激装置，以及使用由这种装置非侵入性地输送的能量来治疗医学病症的方法。这些疾病包括偏头痛和其他原发性头痛，例如丛集性头痛，包括类似于免疫介导的反应（“窦”头痛）的窦性症状，而不管这些症状是否由与头痛并发的过敏引起。所公开的方法还可以用于治疗可能与偏头痛如焦虑症一起并发的其它疾病。在所公开的方法的优选实施例中，患者的迷走神经中的一个或两个被非侵入性地刺激。在其它实施方案中，刺激部分交感神经系统和/或肾上腺。

13. 发明授权

US08666496B2 Methods and apparatus for electrical treatment using balloon and electrode 有权
标题翻译：使用气球和电极进行电处理的方法和装置
公开(公告)号：US08666496B2
公开(公告)日：2014-03-04
申请号：US13769366
申请日：2013-02-17
申请人： Bruce Simon , Steven Mendez , Hecheng Hu , Richard P. Dickerson , James R. Pastena , Puyun Guo
发明人： Bruce Simon , Steven Mendez , Hecheng Hu , Richard P. Dickerson , James R. Pastena , Puyun Guo
IPC分类号： A61N1/00
CPC分类号： A61N1/05 , A61M2025/105 , A61N1/0517 , A61N1/0519 , A61N1/0551 , A61N1/36007 , A61N1/3605 , A61N1/375 , A61N1/40
摘要： The present invention provides systems, apparatus and methods for selectively applying electrical energy to body tissue. A device is provided with an electrode positioned within the interior of an enclosure and a fluid passage coupled to the enclosure for delivery of an electrically conductive fluid such that the electrically conductive fluid. The conductive fluid allows for the passage of electrical energy from the electrode through the fluid and the outer wall of the enclosure for treatment of tissue on or in a patient. The electrode does not directly contact the tissue of the patient, which reduces the potential for collateral tissue damage or necrosis and/or excessive electric fields in the tissue.
摘要翻译：本发明提供了用于选择性地向身体组织施加电能的系统，装置和方法。设备设置有位于外壳内部的电极和耦合到外壳的流体通道，用于传送导电流体，使得导电流体。导电流体允许来自电极的电能通过外壳的流体和外壁，用于治疗患者身上或患者中的组织。电极不直接接触患者的组织，这降低了组织中附带组织损伤或坏死和/或过度电场的可能性。

14. 发明授权

US08612004B2 Electrical stimulation treatment of hypotension 有权
公开(公告)号：US08612004B2
公开(公告)日：2013-12-17
申请号：US13537547
申请日：2012-06-29
申请人： Joseph P. Errico , Bruce J. Simon , Steven Mendez
发明人： Joseph P. Errico , Bruce J. Simon , Steven Mendez
IPC分类号： A61N1/00
CPC分类号： A61N1/36114 , A61N1/0456 , A61N1/05 , A61N1/0517 , A61N1/0519 , A61N1/36014 , A61N1/36053 , A61N1/36117 , A61N1/36153 , A61N1/36171 , A61N1/36175
摘要： The present invention includes methods and devices for treating hypotension, such as in cases of shock, including septic shock, anaphylactic shock and hypovolemia. The method includes the step of applying at least one electrical impulse to at least one selected region of a parasympathetic nervous system of the patient. The electrical impulse is sufficient to modulate one or more nerves of the parasympathetic nervous system to increase the ratio of blood pressure to heart rate and relieve the condition and/or extend the patient's life.

15. 发明申请

US20130245486A1 DEVICES AND METHODS FOR MONITORING NON-INVASIVE VAGUS NERVE STIMULATION 有权
标题翻译：用于监测非侵入性VAGUS神经刺激的装置和方法
公开(公告)号：US20130245486A1
公开(公告)日：2013-09-19
申请号：US13872116
申请日：2013-04-28
申请人： Bruce J. Simon , Joseph P. Errico
发明人： Bruce J. Simon , Joseph P. Errico
IPC分类号： A61N1/36
CPC分类号： A61N1/36014 , A61B5/02405 , A61B5/04886 , A61B5/4035 , A61B5/4041 , A61B5/4803 , A61B5/4836 , A61B5/687 , A61B5/7264 , A61B5/7267 , A61B2090/3941 , A61N1/36021 , A61N1/40
摘要： Devices and methods are disclosed that treat a medical condition, such as migraine headache, by electrically stimulating a nerve noninvasively, which may be a vagus nerve situated within a patient's neck. Preferred embodiments allow a patient to self-treat his or her condition. Disclosed methods assure that the device is being positioned correctly on the neck and that the amplitude and other parameters of the stimulation actually stimulate the vagus nerve with a therapeutic waveform. Those methods comprise measuring properties of the patient's larynx, pupil diameters, blood flow within an eye, electrodermal activity and/or heart rate variability.
摘要翻译：公开了通过非侵入性地刺激神经（其可以是位于患者颈部内的迷走神经）来治疗诸如偏头痛头痛的医疗状况的装置和方法。优选实施例允许患者自我治疗他或她的病情。公开的方法确保装置正确地定位在颈部上，并且刺激的振幅和其它参数实际上以治疗波形刺激迷走神经。这些方法包括测量患者的喉部的性质，瞳孔直径，眼睛内的血流量，电皮肤活动和/或心率变异性。

16. 发明申请

US20130204334A1 METHODS AND APPARATUS FOR ELECTRICAL TREATMENT USING BALLOON AND ELECTRODE 有权
标题翻译：使用气泡和电极进行电解处理的方法和装置
公开(公告)号：US20130204334A1
公开(公告)日：2013-08-08
申请号：US13769366
申请日：2013-02-17
申请人： Bruce Simon , Steven Mendez , Hecheng Hu , Richard P. , James R. Pastena , Puyun Guo
发明人： Bruce Simon , Steven Mendez , Hecheng Hu , Richard P. , James R. Pastena , Puyun Guo
IPC分类号： A61N1/05
CPC分类号： A61N1/05 , A61M2025/105 , A61N1/0517 , A61N1/0519 , A61N1/0551 , A61N1/36007 , A61N1/3605 , A61N1/375 , A61N1/40
摘要： The present invention provides systems, apparatus and methods for selectively applying electrical energy to body tissue. A device is provided with an electrode positioned within the interior of an enclosure and a fluid passage coupled to the enclosure for delivery of an electrically conductive fluid such that the electrically conductive fluid. The conductive fluid allows for the passage of electrical energy from the electrode through the fluid and the outer wall of the enclosure for treatment of tissue on or in a patient. The electrode does not directly contact the tissue of the patient, which reduces the potential for collateral tissue damage or necrosis and/or excessive electric fields in the tissue.
摘要翻译：本发明提供了用于选择性地向身体组织施加电能的系统，装置和方法。设备设置有位于外壳内部的电极和耦合到外壳的流体通道，用于传送导电流体，使得导电流体。导电流体允许来自电极的电能通过外壳的流体和外壁，用于治疗患者身上或患者中的组织。电极不直接接触患者的组织，这降低了组织中附带组织损伤或坏死和/或过度电场的可能性。

17. 发明申请

US20130131753A1 NON-INVASIVE MAGNETIC OR ELECTRICAL NERVE STIMULATION TO TREAT GASTROPARESIS, FUNCTIONAL DYSPEPSIA, AND OTHER FUNCTIONAL GASTROINTESTINAL DISORDERS 有权
标题翻译：非侵入性磁性或电刺激治疗胃肠道功能性功能障碍和其他功能性胃肠疾病
公开(公告)号：US20130131753A1
公开(公告)日：2013-05-23
申请号：US13731035
申请日：2012-12-30
申请人： Bruce J. Simon , Joseph P. Errico , John T. Raffle
发明人： Bruce J. Simon , Joseph P. Errico , John T. Raffle
IPC分类号： A61N1/36
CPC分类号： A61N1/36007 , A61N1/0456 , A61N1/205 , A61N1/36 , A61N1/36014 , A61N1/40 , A61N2/006 , A61N2/02
摘要： Devices, systems and methods are disclosed for treating or preventing gastroparesis, functional dyspepsia, and other functional gastrointestinal disorders. The methods comprise transmitting impulses of energy non-invasively to selected nerve fibers, particularly those in a vagus nerve. The methods provide damaged interstitial cells of Cajal (ICC) with trophic factors via vagal afferent nerve fibers, thereby reversing ICC damage, and as a consequence improving gastric motility. The methods also increase levels of inhibitory neurotransmitters in the brain so as to decrease neural activity within the area postrema, or they deactivate a resting state neural network containing parts of the anterior insula and anterior cingulate cortex, which will thereby reduce abnormal interoception and visceral hypersensitivity.
摘要翻译：公开了用于治疗或预防胃轻瘫，功能性消化不良和其它功能性胃肠道疾病的装置，系统和方法。所述方法包括非侵入性地将能量的脉冲传送到所选择的神经纤维，特别是迷走神经中的神经纤维。该方法通过迷走神经传入神经纤维向营养因子提供Cajal（ICC）受损的间质细胞，从而逆转ICC损伤，从而改善胃动力。这些方法还增加了大脑中抑制性神经递质的含量，从而减少了后期区域的神经活动，或者它们使含有前岛和前扣带皮层部分的静息状态神经网络失活，从而减少异常的接受和内脏超敏反应。

18. 发明申请

US20130066395A1 NERVE STIMULATION METHODS FOR AVERTING IMMINENT ONSET OR EPISODE OF A DISEASE 审中-公开
标题翻译：用于平均静脉注射或感染疾病的神经刺激方法
公开(公告)号：US20130066395A1
公开(公告)日：2013-03-14
申请号：US13655716
申请日：2012-10-19
申请人： Bruce J. Simon , Joseph P. Errico , John T. Raffle
发明人： Bruce J. Simon , Joseph P. Errico , John T. Raffle
IPC分类号： A61N1/36 , A61N1/40
CPC分类号： A61N1/36053 , A61B5/0476 , A61B5/4094 , A61B5/4833 , A61B5/4836 , A61N1/36003 , A61N1/36014 , A61N1/3756 , A61N1/40 , A61N2/006 , A61N2/02
摘要： Transcutaneous electrical and magnetic nerve stimulation devices are disclosed, along with methods of averting imminent medical attacks using energy that is delivered noninvasively by the devices. The attacks comprise asthma attack, epileptic seizure, attacks of migraine headache, transient ischemic attack or stroke, onset of atrial fibrillation, myocardial infarction, onset of ventricular fibrillation or tachycardia, panic attack, and attacks of acute depression. The imminence of an attack is forecasted using grey-box or black-box models as used in control theory. In preferred embodiments of the disclosed methods, a vagus nerve in the neck of a patient is stimulated noninvasively to avert the attack.
摘要翻译：公开了经皮电磁神经刺激装置，以及使用由装置非侵入性地传送的能量来避免即将发生的医疗攻击的方法。袭击包括哮喘发作，癫痫发作，偏头痛，短暂性脑缺血发作或中风发作，心房颤动发作，心肌梗塞，心室颤动或心动过速发作，恐慌发作和急性抑郁症发作。使用控制理论中使用的灰盒或黑盒模型预测攻击的即将发生。在所公开的方法的优选实施例中，患者颈部的迷走神经被非侵入性地刺激以避免攻击。

19. 发明申请

US20120265280A1 Electrical Stimulation Treatment of Hypotension 有权
标题翻译：低血压的电刺激治疗
公开(公告)号：US20120265280A1
公开(公告)日：2012-10-18
申请号：US13537547
申请日：2012-06-29
申请人： JP Errico , Bruce Simon , Steven Mendez
发明人： JP Errico , Bruce Simon , Steven Mendez
IPC分类号： A61N1/05
CPC分类号： A61N1/36114 , A61N1/0456 , A61N1/05 , A61N1/0517 , A61N1/0519 , A61N1/36014 , A61N1/36053 , A61N1/36117 , A61N1/36153 , A61N1/36171 , A61N1/36175
摘要： The present invention includes methods and devices for treating hypotension, such as in cases of shock, including septic shock, anaphylactic shock and hypovolemia. The method includes the step of applying at least one electrical impulse to at least one selected region of a parasympathetic nervous system of the patient. The electrical impulse is sufficient to modulate one or more nerves of the parasympathetic nervous system to increase the ratio of blood pressure to heart rate and relieve the condition and/or extend the patient's life.
摘要翻译：本发明包括用于治疗低血压的方法和装置，例如在休克的情况下，包括败血性休克，过敏性休克和血容量不足。该方法包括对患者的副交感神经系统的至少一个选定区域施加至少一个电脉冲的步骤。电脉冲足以调节副交感神经系统的一个或多个神经，以增加血压与心率的比例，并缓解病情和/或延长患者的生命。

20. 发明授权

US08204598B2 Methods and apparatus for treating bronchial restriction using electrical modulation 有权
标题翻译：使用电调制治疗支气管阻塞的方法和装置
公开(公告)号：US08204598B2
公开(公告)日：2012-06-19
申请号：US13303627
申请日：2011-11-23
申请人： Joseph P. Errico , Steven Mendez
发明人： Joseph P. Errico , Steven Mendez
IPC分类号： A61N1/00
CPC分类号： A61N1/36114 , A61N1/0551 , A61N1/36014 , A61N1/36053 , A61N1/36153 , A61N1/36171 , A61N1/36175
摘要： Methods and devices for treating anaphylaxis, anaphylactic shock, bronchial constriction, and/or asthma include providing an electrical impulse to a selected region of the vagus nerve of a patient suffering from anaphylaxis to block and/or modulate nerve signals that would regulate the function of, for example, myocardial tissue, vasodilation/constriction and/or pulmonary tissue.
摘要翻译：用于治疗过敏反应，过敏性休克，支气管收缩和/或哮喘的方法和装置包括向患有过敏反应的患者的迷走神经的选定区域提供电脉冲以阻断和/或调节调节神经信号功能的神经信号，例如心肌组织，血管扩张/收缩和/或肺组织。

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