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11. 发明授权

US07061606B2 Near infrared chemical imaging microscope 有权
公开(公告)号：US07061606B2
公开(公告)日：2006-06-13
申请号：US10773077
申请日：2004-02-05
申请人： Patrick J. Treado , Matthew Nelson , Scott Keitzer
发明人： Patrick J. Treado , Matthew Nelson , Scott Keitzer
IPC分类号： G01J3/44 , G01J3/28
CPC分类号： G01N21/359 , G01J3/2823 , G02B21/0016 , G02B21/06
摘要： A chemical imaging system is provided which uses a near infrared radiation microscope. The system includes an illumination source which illuminates an area of a sample using light in the near infrared radiation wavelength and light in the visible wavelength. A multitude of spatially resolved spectra of transmitted, reflected, emitted or scattered near infrared wavelength radiation light from the illuminated area of the sample is collected and a collimated beam is produced therefrom. A near infrared imaging spectrometer is provided for selecting a near infrared radiation image of the collimated beam. The filtered images are collected by a detector for further processing. The visible wavelength light from the illuminated area of the sample is simultaneously detected providing for the simultaneous visible and near infrared chemical imaging analysis of the sample. Two efficient means for performing three dimensional near infrared chemical imaging microscopy are provided.

12. 发明授权

US07859753B2 Optical birefringence filters with interleaved absorptive and zero degree reflective polarizers 有权
标题翻译：具有交错吸收和零度反射偏振器的光学双折射滤光片
公开(公告)号：US07859753B2
公开(公告)日：2010-12-28
申请号：US11611924
申请日：2006-12-18
申请人： Xinghua Wang
发明人： Xinghua Wang
IPC分类号： G02B5/30
CPC分类号： G02B5/3083 , G02B27/281
摘要： A wavelength discriminating optical filter has birefringent retarders stacked between polarizing filters, in relative rotational orientations causing passband wavelengths to emerge in a polarization state aligned to a second such polarizing filter, for transmission, whereas wavelengths at orthogonal polarization states are blocked. The second polarizing filter can be a wiregrid type that reflects the blocked orthogonal component backwards along the light signal propagation path. Internal reflections are minimized while obtaining a high transmission ratio and high discrimination for the passband wavelengths, by pairing a zero-degree reflective polarizer as the second or selection polarizer, with a preceding non-zero-degree reflective polarizer. The non-zero-degree reflective polarizer can absorb the blocked orthogonal polarization components, for example using an oriented dichroic material, or a polarizing cube or the like can be provided to divert the blocked polarization component.
摘要翻译：波长鉴别滤光器具有堆叠在偏振滤光器之间的双折射延迟器，以相对旋转取向使得通带波长以与第二偏振滤光器对准的偏振态出现，用于透射，而正交偏振状态下的波长被阻挡。第二偏振滤光器可以是沿着光信号传播路径向后反射阻挡的正交分量的线栅型。通过将零度反射偏振器与第二或选择偏振器配对，与先前的非零度反射偏振器配对，可以获得高透射率和通带宽度的高辨别性，从而最小化内部反射。非零度反射偏振器可以例如使用定向二色性材料吸收阻挡的正交偏振分量，或者可以提供偏振立方体等来转移被阻挡的偏振分量。

13. 发明授权

US07379179B2 Raman spectroscopic methods for component particle analysis 有权
标题翻译：拉曼光谱分析方法
公开(公告)号：US07379179B2
公开(公告)日：2008-05-27
申请号：US11000778
申请日：2004-11-30
申请人： Matthew P. Nelson , Patrick J. Treado , Jason Attanucci
发明人： Matthew P. Nelson , Patrick J. Treado , Jason Attanucci
IPC分类号： G01N21/44
CPC分类号： G01N15/1475 , G01N21/65 , G01N2015/1493
摘要： The invention relates to methods of assessing one or more geometric properties of a particle of a substance using a Raman spectroscopic property of the substance. The method is useful, for example, for assessing particle sizes and size distributions in mixtures containing both particles of the substance and other materials.
摘要翻译：本发明涉及使用该物质的拉曼光谱性质评估物质颗粒的一种或多种几何性质的方法。该方法例如用于评估含有物质颗粒和其它材料的混合物的粒度和尺寸分布是有用的。

14. 发明授权

US07330746B2 Non-invasive biochemical analysis 有权
标题翻译：非侵入性生化分析
公开(公告)号：US07330746B2
公开(公告)日：2008-02-12
申请号：US11146458
申请日：2005-06-07
申请人： Joseph E. Demuth , Patrick J. Treado , John S. Maier , Jeffrey K. Cohen
发明人： Joseph E. Demuth , Patrick J. Treado , John S. Maier , Jeffrey K. Cohen
IPC分类号： A61B5/00
CPC分类号： A61B5/14546 , A61B5/14532 , A61B5/1455 , A61B5/415 , A61B5/418
摘要： The invention relates to methods and devices for assessing one or more blood components in an animal. The present invention permits non-invasive assessment of blood components in a body structure containing blood and other tissue types by assessing multiple regions of a tissue surface for an optical characteristic of blood and separately assessing one or more optical (e.g., Raman or NIR) characteristics of the blood component for one or more regions that exhibit the optical characteristic of blood.
摘要翻译：本发明涉及用于评估动物体内一种或多种血液成分的方法和装置。本发明通过评估血液的光学特性的组织表面的多个区域并分别评估一种或多种光学（例如，拉曼或NIR）特征，允许对包含血液和其它组织类型的体内结构中的血液成分进行非侵入性评估的血液成分用于表现出血液光学特性的一个或多个区域。

15. 发明申请

US20060268267A1 System and method for dynamic chemical imaging 有权
标题翻译：动态化学成像系统和方法
公开(公告)号：US20060268267A1
公开(公告)日：2006-11-30
申请号：US11399032
申请日：2006-04-06
申请人： Thomas Voigt , David Tuschel , John Maier
发明人： Thomas Voigt , David Tuschel , John Maier
IPC分类号： G01J3/44
CPC分类号： G01N21/6456 , G01J3/12 , G01J3/1256 , G01J3/2823 , G01J3/32 , G01J3/44 , G01J2003/1269 , G01N21/3563 , G01N21/3577 , G01N21/65
摘要： A system and method for detecting dynamic changes that occur in a sample between a first time interval and a second time interval using a series of at least first and second sequential chemical images of the sample. During the first time interval: (i) the sample is illuminated with a plurality of photons to thereby produce photons scattered or emitted by the sample; (ii) a two-dimensional array of detection elements is used to simultaneously detect scattered or emitted photons in a first predetermined wavelength band from different locations on or within the sample; and (iii) the two-dimensional array of detection elements is thereafter used one or more further times to simultaneously detect scattered or emitted photons in one or more further predetermined wavelength band(s) from different locations on or within the sample. The outputs of the two-dimensional array of detection elements during the first time interval are then combined to generate the first chemical image of the sample. The process is repeated during the second time interval to generate the second chemical image of the sample. Dynamic changes occurring in the sample between the first time interval and the second time interval are detected based on one or more differences between the first and second chemical images.
摘要翻译：一种系统和方法，用于使用所述样本的至少第一和第二顺序化学图像的一系列来检测在第一时间间隔和第二时间间隔之间在样本中发生的动态变化。在第一时间间隔期间：（i）样品用多个光子照射，从而产生样品散射或发射的光子; （ii）检测元件的二维阵列用于同时从样品上或样品内的不同位置检测来自第一预定波长带的散射或发射的光子; 然后，（iii）检测元件的二维阵列此后再被使用一次或多次，以同时检测来自样品上或样品内的不同位置的一个或多个另外的预定波长带中的散射或发射的光子。然后组合在第一时间间隔期间检测元件的二维阵列的输出以产生样本的第一化学图像。该过程在第二时间间隔期间重复以产生样品的第二化学图像。基于第一和第二化学图像之间的一个或多个差异来检测在第一时间间隔和第二时间间隔之间在样本中发生的动态变化。

16. 发明申请

US20060164640A1 Near infrared chemical imaging microscope 有权
公开(公告)号：US20060164640A1
公开(公告)日：2006-07-27
申请号：US11366762
申请日：2006-03-02
申请人： Patrick Treado , Matthew Nelson , Scott Keitzer
发明人： Patrick Treado , Matthew Nelson , Scott Keitzer
IPC分类号： G01J3/28
CPC分类号： G01N21/359 , G01J3/2823 , G02B21/0016 , G02B21/06
摘要： A chemical imaging system is provided which uses a near infrared radiation microscope. The system includes an illumination source which illuminates an area of a sample using light in the near infrared radiation wavelength and light in the visible wavelength. A multitude of spatially resolved spectra of transmitted, reflected, emitted or scattered near infrared wavelength radiation light from the illuminated area of the sample is collected and a collimated beam is produced therefrom. A near infrared imaging spectrometer is provided for selecting a near infrared radiation image of the collimated beam. The filtered images are collected by a detector for further processing. The visible wavelength light from the illuminated area of the sample is simultaneously detected providing for the simultaneous visible and near infrared chemical imaging analysis of the sample. Two efficient means for performing three dimensional near infrared chemical imaging microscopy are provided.

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