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1. 发明申请

US20060157652A1 Near infrared chemical imaging microscope 有权
公开(公告)号：US20060157652A1
公开(公告)日：2006-07-20
申请号：US11366887
申请日：2006-03-02
申请人： Patrick Treado , Matthew Nelson , Scott Keitzer
发明人： Patrick Treado , Matthew Nelson , Scott Keitzer
IPC分类号： G01N21/35
CPC分类号： G01N21/359 , G01J3/2823 , G02B21/0016 , G02B21/06
摘要： A chemical imaging system is provided which uses a near infrared radiation microscope. The system includes an illumination source which illuminates an area of a sample using light in the near infrared radiation wavelength and light in the visible wavelength. A multitude of spatially resolved spectra of transmitted, reflected, emitted or scattered near infrared wavelength radiation light from the illuminated area of the sample is collected and a collimated beam is produced therefrom. A near infrared imaging spectrometer is provided for selecting a near infrared radiation image of the collimated beam. The filtered images are collected by a detector for further processing. The visible wavelength light from the illuminated area of the sample is simultaneously detected providing for the simultaneous visible and near infrared chemical imaging analysis of the sample. Two efficient means for performing three dimensional near infrared chemical imaging microscopy are provided.

2. 发明申请

US20070263290A1 CHEMICAL IMAGING FIBERSCOPE 有权
标题翻译：化学成像FIBERSCOPE
公开(公告)号：US20070263290A1
公开(公告)日：2007-11-15
申请号：US11744797
申请日：2007-05-04
申请人： Patrick Treado , Matthew Nelson , Scott Keitzer , Ryan Smith
发明人： Patrick Treado , Matthew Nelson , Scott Keitzer , Ryan Smith
IPC分类号： G02B5/04 , G02B3/00 , G02B5/22
CPC分类号： G02B6/06 , A61B1/00165 , A61B1/043 , A61B1/063 , A61B1/0638 , A61B1/0646 , A61B1/07 , A61B5/0075 , A61B5/0084 , G01J3/02 , G01J3/0208 , G01J3/0218 , G01J3/0227 , G01J3/024 , G01J3/0256 , G01J3/0262 , G01J3/0286 , G01J3/44 , G01J2003/1213
摘要： A fiberscope device is disclosed which is suitable for video imaging, laser Raman spectroscopy and laser Raman spectroscopic (i.e. chemical) imaging. The fiberscope design minimizes fiber background interference arising from the laser delivery fiber optic and the coherent fiber optic light gathering bundle while maintaining high light throughput efficiency through the use of integrated spectral filters. In the fiberscope design, the laser delivery fiber optic is offset from the coherent fiber optic light gathering bundle. The laser delivery field is captured entirely by the light gathering field of view of the coherent fiber bundle. The fiberscope incorporates spectral filter optical elements that provide environmental insensitivity, particularly to temperature and moisture. The fiberscope is suited to the analysis of a wide range of condensed phase materials (solids and liquids), including the analysis of biological materials such as breast tissue lesions and arterial plaques, in such a manner to delineate abnormal from normal tissues.
摘要翻译：公开了适用于视频成像，激光拉曼光谱和激光拉曼光谱（即化学）成像的纤维内窥镜装置。纤维镜设计可以最大限度地减少激光传输光纤和相干光纤采集光束产生的光纤背景干扰，同时通过使用集成光谱滤波器保持高光通量效率。在纤维镜设计中，激光传输光纤与相干光纤聚光束偏移。激光输送场完全由相干光纤束的聚光场捕获。纤维镜包含光谱滤光器光学元件，其提供环境不敏感性，特别是对温度和湿度。纤维内窥镜适用于分析各种凝聚相材料（固体和液体），包括分析生物材料如乳房组织损伤和动脉斑块，以便从正常组织中描绘异常。

3. 发明申请

US20060192956A1 NEAR INFRARED CHEMICAL IMAGING MICROSCOPE 有权
标题翻译：近红外化学成像显微镜
公开(公告)号：US20060192956A1
公开(公告)日：2006-08-31
申请号：US11257219
申请日：2005-10-24
申请人： Patrick Treado , Matthew Nelson , Scott Keitzer
发明人： Patrick Treado , Matthew Nelson , Scott Keitzer
IPC分类号： G01J3/28
CPC分类号： G01N21/359 , G01J3/2823 , G02B21/0016 , G02B21/06
摘要： A chemical imaging system is provided which uses a near infrared radiation microscope. The system includes an illumination source which illuminates an area of a sample using light in the near infrared radiation wavelength and light in the visible wavelength. A multitude of spatially resolved spectra of transmitted, reflected, emitted or scattered near infrared wavelength radiation light from the illuminated area of the sample is collected and a collimated beam is produced therefrom. A near infrared imaging spectrometer is provided for selecting a near infrared radiation image of the collimated beam. The filtered images are collected by a detector for further processing. The visible wavelength light from the illuminated area of the sample is simultaneously detected providing for the simultaneous visible and near infrared chemical imaging analysis of the sample. Two efficient means for performing three dimensional near infrared chemical imaging microscopy are provided.
摘要翻译：提供使用近红外辐射显微镜的化学成像系统。该系统包括使用近红外辐射波长的光和可见波长的光来照射样品的区域的照明源。收集来自样品的照射区域的透射，反射，发射或散射的近红外波长辐射光的多个空间解析光谱，并从其中产生准直光束。提供近红外成像光谱仪用于选择准直光束的近红外辐射图像。滤波后的图像由检测器收集以进一步处理。同时检测来自样品的照射区域的可见波长的光，提供样品的同时可见和近红外化学成像分析。提供了三维近红外化学成像显微镜的两种有效手段。

4. 发明申请

US20060151702A1 Near infrared chemical imaging microscope 有权
公开(公告)号：US20060151702A1
公开(公告)日：2006-07-13
申请号：US11366129
申请日：2006-03-02
申请人： Patrick Treado , Matthew Nelson , Scott Keitzer
发明人： Patrick Treado , Matthew Nelson , Scott Keitzer
IPC分类号： G01N21/35
CPC分类号： G01N21/359 , G01J3/2823 , G02B21/0016 , G02B21/06
摘要： A chemical imaging system is provided which uses a near infrared radiation microscope. The system includes an illumination source which illuminates an area of a sample using light in the near infrared radiation wavelength and light in the visible wavelength. A multitude of spatially resolved spectra of transmitted, reflected, emitted or scattered near infrared wavelength radiation light from the illuminated area of the sample is collected and a collimated beam is produced therefrom. A near infrared imaging spectrometer is provided for selecting a near infrared radiation image of the collimated beam. The filtered images are collected by a detector for further processing. The visible wavelength light from the illuminated area of the sample is simultaneously detected providing for the simultaneous visible and near infrared chemical imaging analysis of the sample. Two efficient means for performing three dimensional near infrared chemical imaging microscopy are provided.

5. 发明申请

US20060049354A1 Near infrared chemical imaging microscope 有权
公开(公告)号：US20060049354A1
公开(公告)日：2006-03-09
申请号：US11257139
申请日：2005-10-24
申请人： Patrick Treado , Matthew Nelson , Scott Keitzer
发明人： Patrick Treado , Matthew Nelson , Scott Keitzer
IPC分类号： G01J5/02
CPC分类号： G01N21/359 , G01J3/2823 , G02B21/0016 , G02B21/06
摘要： A chemical imaging system is provided which uses a near infrared radiation microscope. The system includes an illumination source which illuminates an area of a sample using light in the near infrared radiation wavelength and light in the visible wavelength. A multitude of spatially resolved spectra of transmitted, reflected, emitted or scattered near infrared wavelength radiation light from the illuminated area of the sample is collected and a collimated beam is produced therefrom. A near infrared imaging spectrometer is provided for selecting a near infrared radiation image of the collimated beam. The filtered images are collected by a detector for further processing. The visible wavelength light from the illuminated area of the sample is simultaneously detected providing for the simultaneous visible and near infrared chemical imaging analysis of the sample. Two efficient means for performing three dimensional near infrared chemical imaging microscopy are provided.

6. 发明申请

US20060164640A1 Near infrared chemical imaging microscope 有权
公开(公告)号：US20060164640A1
公开(公告)日：2006-07-27
申请号：US11366762
申请日：2006-03-02
申请人： Patrick Treado , Matthew Nelson , Scott Keitzer
发明人： Patrick Treado , Matthew Nelson , Scott Keitzer
IPC分类号： G01J3/28
CPC分类号： G01N21/359 , G01J3/2823 , G02B21/0016 , G02B21/06
摘要： A chemical imaging system is provided which uses a near infrared radiation microscope. The system includes an illumination source which illuminates an area of a sample using light in the near infrared radiation wavelength and light in the visible wavelength. A multitude of spatially resolved spectra of transmitted, reflected, emitted or scattered near infrared wavelength radiation light from the illuminated area of the sample is collected and a collimated beam is produced therefrom. A near infrared imaging spectrometer is provided for selecting a near infrared radiation image of the collimated beam. The filtered images are collected by a detector for further processing. The visible wavelength light from the illuminated area of the sample is simultaneously detected providing for the simultaneous visible and near infrared chemical imaging analysis of the sample. Two efficient means for performing three dimensional near infrared chemical imaging microscopy are provided.

7. 发明申请

US20060091311A1 Near infrared chemical imaging microscope 有权
公开(公告)号：US20060091311A1
公开(公告)日：2006-05-04
申请号：US11257222
申请日：2005-10-24
申请人： Patrick Treado , Matthew Nelson , Scott Keitzer
发明人： Patrick Treado , Matthew Nelson , Scott Keitzer
IPC分类号： G01J5/02
CPC分类号： G01N21/359 , G01J3/2823 , G02B21/0016 , G02B21/06
摘要： A chemical imaging system is provided which uses a near infrared radiation microscope. The system includes an illumination source which illuminates an area of a sample using light in the near infrared radiation wavelength and light in the visible wavelength. A multitude of spatially resolved spectra of transmitted, reflected, emitted or scattered near infrared wavelength radiation light from the illuminated area of the sample is collected and a collimated beam is produced therefrom. A near infrared imaging spectrometer is provided for selecting a near infrared radiation image of the collimated beam. The filtered images are collected by a detector for further processing. The visible wavelength light from the illuminated area of the sample is simultaneously detected providing for the simultaneous visible and near infrared chemical imaging analysis of the sample. Two efficient means for performing three dimensional near infrared chemical imaging microscopy are provided.

8. 发明申请

US20060033026A1 Near infrared chemical imaging microscope 失效
公开(公告)号：US20060033026A1
公开(公告)日：2006-02-16
申请号：US11256889
申请日：2005-10-24
申请人： Patrick Treado , Matthew Nelson , Scott Keitzer
发明人： Patrick Treado , Matthew Nelson , Scott Keitzer
IPC分类号： G01N21/35
CPC分类号： G01N21/359 , G01J3/2823 , G02B21/0016 , G02B21/06
摘要： A chemical imaging system is provided which uses a near infrared radiation microscope. The system includes an illumination source which illuminates an area of a sample using light in the near infrared radiation wavelength and light in the visible wavelength. A multitude of spatially resolved spectra of transmitted, reflected, emitted or scattered near infrared wavelength radiation light from the illuminated area of the sample is collected and a collimated beam is produced therefrom. A near infrared imaging spectrometer is provided for selecting a near infrared radiation image of the collimated beam. The filtered images are collected by a detector for further processing. The visible wavelength light from the illuminated area of the sample is simultaneously detected providing for the simultaneous visible and near infrared chemical imaging analysis of the sample. Two efficient means for performing three dimensional near infrared chemical imaging microscopy are provided.

9. 发明授权

US08440959B2 Method and apparatus for automated spectral calibration 有权
标题翻译：用于自动光谱校准的方法和装置
公开(公告)号：US08440959B2
公开(公告)日：2013-05-14
申请号：US12897376
申请日：2010-10-04
申请人： Matthew Nelson , Patrick Treado
发明人： Matthew Nelson , Patrick Treado
IPC分类号： G01D18/00
CPC分类号： A61B5/0059 , A61B2560/0223 , G01J3/28 , G01J3/42
摘要： A method and apparatus for automated spectral calibration of a spectroscopy device. A method for simultaneous calibration and spectral imaging of a sample by: simultaneously illuminating the sample and a calibrant with a plurality of illuminating photons; receiving, at the spectrometer, a first plurality of photons collected from the sample and a second plurality of photons collected from the calibrant; forming a calibrant spectrum from the first plurality of collected photons and a sample spectrum from the second plurality of collected photons; comparing the calibrant spectrum with a reference spectrum of the calibrant to determine a wavelength-shift in the calibrant spectrum; applying the wavelength-shift to the sample spectrum to obtain a calibrated sample spectrum.
摘要翻译：一种用于光谱装置的自动光谱校准的方法和装置。一种通过以下步骤同时校准和光谱成像的方法：同时用多个照明光子照射样品和校准物; 在光谱仪处接收从样品收集的第一组多个光子和从校准物收集的第二组多个光子; 从所述第一多个收集的光子形成校准谱，以及来自所述第二多个收集的光子的样品光谱; 将校准谱与校准物的参考光谱进行比较，以确定校准谱中的波长漂移; 将波长偏移应用于样本光谱以获得校准的样本光谱。

10. 发明授权

US08289513B2 System and method for component discrimination enhancement based on multispectral addition imaging 有权
标题翻译：基于多光谱加法成像的组件鉴别增强的系统和方法
公开(公告)号：US08289513B2
公开(公告)日：2012-10-16
申请号：US12799779
申请日：2010-04-30
申请人： Matthew Nelson , Patrick Treado , Charles W. Gardner, Jr.
发明人： Matthew Nelson , Patrick Treado , Charles W. Gardner, Jr.
IPC分类号： G01J3/28
CPC分类号： G01J3/02 , G01J3/0224 , G01J3/32 , G01J3/44 , G01N21/314 , G01N21/33 , G01N21/35 , G01N21/3581 , G01N21/359 , G01N21/65 , G02B21/16 , G02B21/361
摘要： A system and method for performing multispectral color addition imaging. An optical image is obtained for a sample scene comprising one or more target materials. Spectroscopic data is obtained for one or more target materials. A first and second waveband of interest are obtained for one or more target materials. A ratio of the first and second wavebands of interest is obtained and compared to one or more ranges of threshold values. Based on this comparison, a result is displayed wherein this result comprises a pseudo color overlay on said optical image. The pseudo color image may comprise one or more pseudo colors assigned to one or more target materials so as to differentiate and identify the target materials present in the sample scene.
摘要翻译：用于执行多光谱彩色加成成像的系统和方法。获得包含一个或多个目标材料的样本场景的光学图像。获得一种或多种目标材料的光谱数据。获得针对一种或多种目标材料的第一和第二感兴趣波段。获得感兴趣的第一和第二波段的比率并将其与一个或多个阈值范围进行比较。基于该比较，显示结果，其中该结果包括所述光学图像上的伪颜色覆盖。伪彩色图像可以包括分配给一个或多个目标材料的一种或多种伪颜色，以便区分和识别存在于样本场景中的目标材料。

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