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11. 发明申请

US20090287106A1 ISCHEMIA DETECTION USING A HEART SOUND SENSOR 有权
标题翻译：使用心音传感器进行ISCHEMIA检测
公开(公告)号：US20090287106A1
公开(公告)日：2009-11-19
申请号：US12510962
申请日：2009-07-28
申请人： Yi Zhang , Richard Fogoros , Carlos Haro , Yousufali Dalal , Marina Brockway , Krzysztof Z. Siejko
发明人： Yi Zhang , Richard Fogoros , Carlos Haro , Yousufali Dalal , Marina Brockway , Krzysztof Z. Siejko
IPC分类号： A61B5/02
CPC分类号： A61N1/3627 , A61B5/0031 , A61B5/024 , A61B5/0452 , A61B5/0456 , A61B7/04 , A61N1/36578 , A61N1/395
摘要： A system comprising an implantable medical device (IMD) includes an implantable heart sound sensor to produce an electrical signal representative of at least one heart sound. The heart sound is associated with mechanical activity of a patient's heart. Additionally, the IMD includes a heart sound sensor interface circuit coupled to the heart sound sensor to produce a heart sound signal, and a signal analyzer circuit coupled to the heart sound sensor interface circuit. The signal analyzer circuit measures a baseline heart sound signal, and deems that an ischemic event has occurred using, among other things, a measured subsequent change in the heart sound signal from the established baseline heart sound signal.
摘要翻译：包括可植入医疗装置（IMD）的系统包括可植入心音传感器，以产生代表至少一个心音的电信号。心脏声音与患者心脏的机械活动有关。另外，IMD包括耦合到心脏声音传感器以产生心脏声音信号的心脏声音传感器接口电路，以及耦合到心脏声音传感器接口电路的信号分析器电路。信号分析器电路测量基线心音信号，并且认为已经发生了缺血事件，其中使用来自已建立的基线心音信号的心音信号的测量后续变化。

12. 发明申请

US20080139951A1 Detection of Stenosis 审中-公开
标题翻译：狭窄检测
公开(公告)号：US20080139951A1
公开(公告)日：2008-06-12
申请号：US11608578
申请日：2006-12-08
申请人： Abhilash Patangay , Marina Brockway , Jeffrey E. Stahmann , Yi Zhang , Gerrard M. Carlson
发明人： Abhilash Patangay , Marina Brockway , Jeffrey E. Stahmann , Yi Zhang , Gerrard M. Carlson
IPC分类号： A61B5/026 , A61F2/82
CPC分类号： A61B5/411 , A61B5/0031 , A61B5/02007 , A61B5/02158 , A61B5/026 , A61B5/0402 , A61B5/076 , A61B2562/0204 , A61B2562/0219 , A61F2/02 , A61F2/91 , A61F2250/0002
摘要： A system for detecting stenosis in a patient. The system includes an implantable sensing unit having a turbulence sensor and a communication device for transmitting a signal from the turbulence sensor. The system also includes a cardiac sensor for generating a signal corresponding to cardiac activity and a processing device configured to receive signals from the sensing unit and from the cardiac sensor. The processing device is configured to determine a time window corresponding to cardiac activity, to determine a turbulence level from the turbulence signal within the time window, and to detect the presence of stenosis from the turbulence level.
摘要翻译：一种用于检测患者狭窄的系统。该系统包括具有湍流传感器的可植入感测单元和用于从湍流传感器发送信号的通信装置。该系统还包括用于产生对应于心脏活动的信号的心脏传感器和被配置为从感测单元和心脏传感器接收信号的处理装置。处理装置被配置为确定对应于心脏活动的时间窗口，以确定在时间窗口内的湍流信号的湍流水平，并且从湍流水平检测狭窄的存在。

13. 发明申请

US20060282000A1 Ischemia detection using a heart sound sensor 有权
标题翻译：使用心脏声音传感器进行缺血检测
公开(公告)号：US20060282000A1
公开(公告)日：2006-12-14
申请号：US11148107
申请日：2005-06-08
申请人： Yi Zhang , Richard Fogoros , Carlos Haro , Yousufali Dalal , Marina Brockway , Krzysztof Siejko
发明人： Yi Zhang , Richard Fogoros , Carlos Haro , Yousufali Dalal , Marina Brockway , Krzysztof Siejko
IPC分类号： A61B5/02
CPC分类号： A61N1/3627 , A61B5/0031 , A61B5/024 , A61B5/0452 , A61B5/0456 , A61B7/04 , A61N1/36578 , A61N1/395
摘要： A system comprising an implantable medical device (IMD) includes an implantable heart sound sensor to produce an electrical signal representative of at least one heart sound. The heart sound is associated with mechanical activity of a patient's heart. Additionally, the IMD includes a heart sound sensor interface circuit coupled to the heart sound sensor to produce a heart sound signal, and a signal analyzer circuit coupled to the heart sound sensor interface circuit. The signal analyzer circuit measures a baseline heart sound signal, and deems that an ischemic event has occurred using, among other things, a measured subsequent change in the heart sound signal from the established baseline heart sound signal.
摘要翻译：包括可植入医疗装置（IMD）的系统包括可植入心音传感器，以产生代表至少一个心音的电信号。心脏声音与患者心脏的机械活动有关。另外，IMD包括耦合到心脏声音传感器以产生心脏声音信号的心脏声音传感器接口电路，以及耦合到心脏声音传感器接口电路的信号分析器电路。信号分析器电路测量基线心音信号，并且认为已经发生了缺血事件，其中使用来自已建立的基线心音信号的心音信号的测量后续变化。

14. 发明申请

US20060116593A1 Cardiac activation sequence monitoring for ischemia detection 有权
标题翻译：心脏激活序列监测缺血检测
公开(公告)号：US20060116593A1
公开(公告)日：2006-06-01
申请号：US11079744
申请日：2005-03-14
申请人： Yi Zhang , Scott Meyer , Jeffrey Stahmann , Carlos Ricci , Marina Brockway , Aaron McCabe , Yinghong Yu , Donald Hopper
发明人： Yi Zhang , Scott Meyer , Jeffrey Stahmann , Carlos Ricci , Marina Brockway , Aaron McCabe , Yinghong Yu , Donald Hopper
IPC分类号： A61B5/04
CPC分类号： A61N1/3702 , A61B5/0452 , A61B5/7203
摘要： Cardiac monitoring and/or stimulation methods and systems that provide one or more of monitoring, diagnosing, defibrillation, and pacing. Cardiac signal separation is employed to detect, monitor, track and/or trend ischemia using cardiac activation sequence information. Ischemia detection may involve sensing composite cardiac signals using implantable electrodes, and performing a signal separation that produces one or more cardiac activation signal vectors associated with one or more cardiac activation sequences. A change in the signal vector may be detected using subsequent separations. The change may be an elevation or depression of the ST segment of a cardiac cycle or other change indicative of myocardial ischemia, myocardial infarction, or other pathological change. The change may be used to predict, quantify, and/or qualify an event such as an arrhythmia, a myocardial infarction, or other pathologic change. Information associated with the vectors may be stored and used to track the vectors.
摘要翻译：提供一种或多种监测，诊断，除颤和起搏的心脏监测和/或刺激方法和系统。使用心脏信号分离来使用心脏激活序列信息来检测，监测，跟踪和/或趋势性缺血。缺血检测可以涉及使用可植入电极感测复合心脏信号，并且执行产生与一个或多个心脏激活序列相关联的一个或多个心脏激活信号载体的信号分离。可以使用后续分离来检测信号矢量的变化。该变化可以是心脏周期的ST段的升高或抑制或指示心肌缺血，心肌梗死或其他病理变化的其它变化。该变化可用于预测，量化和/或限定诸如心律失常，心肌梗死或其它病理变化的事件。与矢量相关联的信息可以被存储并用于跟踪矢量。

15. 发明申请

US20050288600A1 Automatic orientation determination for ECG measurements using multiple electrodes 有权
标题翻译：使用多个电极的ECG测量的自动取向确定
公开(公告)号：US20050288600A1
公开(公告)日：2005-12-29
申请号：US10876008
申请日：2004-06-24
申请人： Yi Zhang , Marina Brockway , Carlos Ricci , Ron Heil , Douglas Daum , Robert Sweeney , Aaron McCabe
发明人： Yi Zhang , Marina Brockway , Carlos Ricci , Ron Heil , Douglas Daum , Robert Sweeney , Aaron McCabe
IPC分类号： A61B5/00 , A61B5/04 , A61B5/0402 , A61B5/042 , A61N1/365 , A61N1/375 , G06K9/62
CPC分类号： A61B5/0006 , A61B5/0031 , A61B5/04011 , A61B5/0422 , A61B5/7207 , A61B5/7217 , A61N1/3756 , G06K9/624
摘要： Cardiac monitoring and/or stimulation methods and systems provide monitoring, defibrillation and/or pacing therapies. A signal processor receives a plurality of composite signals associated with a plurality of sources, separates a signal using a source separation algorithm, and identifies a cardiac signal using a selected vector. The signal processor may iteratively separate signals from the plurality of composite signals until the cardiac signal is identified. The selected vector may be updated if desired or necessary. A method of signal separation involves detecting a plurality of composite signals at a plurality of locations, separating a signal using source separation, and selecting a vector that provides a cardiac signal. The separation may include a principal component analysis and/or an independent component analysis. Vectors may be selected and updated based on changes of position and/or orientation of implanted components and changes in patient parameters such as patient condition, cardiac signal-to-noise ratio, and disease progression.
摘要翻译：心脏监测和/或刺激方法和系统提供监测，除颤和/或起搏治疗。信号处理器接收与多个源相关联的多个复合信号，使用源分离算法分离信号，并使用所选择的向量来识别心脏信号。信号处理器可以迭代地分离来自多个复合信号的信号，直到识别出心脏信号。如果需要或必要，可以更新所选择的向量。信号分离的方法包括在多个位置检测多个复合信号，使用源分离分离信号，以及选择提供心脏信号的向量。分离可以包括主成分分析和/或独立成分分析。可以基于植入组件的位置和/或取向的改变以及患者参数（例如患者状况，心脏信噪比和疾病进展）的变化来选择和更新载体。

16. 发明申请

US20070129643A1 Method and system for heart failure status evaluation based on a disordered breathing index 有权
标题翻译：基于无序呼吸指数的心衰状态评估方法和系统
公开(公告)号：US20070129643A1
公开(公告)日：2007-06-07
申请号：US11291525
申请日：2005-12-01
申请人： Jonathan Kwok , Marina Brockway , Kent Lee , Quan Ni , Yachuan Pu , Jeffrey Stahmann , Yi Zhang , Jesse Hartley
发明人： Jonathan Kwok , Marina Brockway , Kent Lee , Quan Ni , Yachuan Pu , Jeffrey Stahmann , Yi Zhang , Jesse Hartley
IPC分类号： A61B5/08 , A61B5/02
CPC分类号： A61B5/091 , A61B5/0031 , A61B5/0809 , A61B5/0816 , A61B5/113 , A61B5/4818 , A61N1/3627 , A61N1/36521 , A61N1/36535
摘要： An evaluation of heart failure status is provided based on a disordered breathing index. Patient respiration is sensed and a respiration signal is generated. Disordered breathing episodes are detected based on the respiration signal. A disordered breathing index is determined based on the disordered breathing episodes. The disordered breathing index is trended and used to evaluate heart failure status. The disordered breathing index may be combined with additional information and/or may take into account patient activity, posture, sleep stage, or other patient information.
摘要翻译：基于无序呼吸指数提供心力衰竭状态评估。感测患者呼吸并产生呼吸信号。基于呼吸信号检测到无序呼吸事件。基于无序呼吸发作确定无序呼吸指数。无序呼吸指数趋向并用于评估心力衰竭状态。无序呼吸指数可以与附加信息组合和/或可以考虑患者活动，姿势，睡眠阶段或其他患者信息。

17. 发明授权

US07993280B2 Rapid shallow breathing detection for use in congestive heart failure status determination 有权
标题翻译：快速浅呼吸检测用于充血性心力衰竭状态测定
公开(公告)号：US07993280B2
公开(公告)日：2011-08-09
申请号：US12847645
申请日：2010-07-30
申请人： Yi Zhang , John D. Hatlestad , Yousufali H. Dalal , Marina Brockway
发明人： Yi Zhang , John D. Hatlestad , Yousufali H. Dalal , Marina Brockway
IPC分类号： A61B5/08
CPC分类号： A61B5/091 , A61B5/053 , A61B5/0816 , A61B5/411 , A61B2562/0219 , A61N1/3627 , A61N1/36521
摘要： Systems and methods involve use of a medical device comprising sensing circuitry. One or more respiratory parameters are detected using the device. Patient baseline weight is provided, and an output signal indicative of a patient's congestive heart failure status is generated based on a change in the one or more respiratory parameters and a change in the patient's measured weight or predicted weight relative to the patient baseline weight. The respiratory parameters may include one or more of respiration rate, relative tidal volume, an index indicative of rapid shallow breathing by the patient, an index derived by computing a respiration rate and a tidal volume for each patient breath, and an index indicative of dyspnea, for example.
摘要翻译：系统和方法涉及使用包括感测电路的医疗装置。使用该装置检测一个或多个呼吸参数。提供患者基线重量，并且基于一个或多个呼吸参数的变化和患者相对于患者基线重量的测量重量或预测体重的变化来生成指示患者充血性心力衰竭状态的输出信号。呼吸参数可以包括呼吸速率，相对潮气量，指示患者快速浅呼吸的指标，通过计算呼吸速率导出的指数和每个患者呼吸的潮气量以及指示呼吸困难的指数中的一个或多个，例如。

18. 发明授权

US07766840B2 Method and system for heart failure status evaluation based on a disordered breathing index 有权
标题翻译：基于无序呼吸指数的心衰状态评估方法和系统
公开(公告)号：US07766840B2
公开(公告)日：2010-08-03
申请号：US11291525
申请日：2005-12-01
申请人： Jonathan Kwok , Marina Brockway , Kent Lee , Quan Ni , Yachuan Pu , Jeffrey Stahmann , Yi Zhang , Jesse Hartley
发明人： Jonathan Kwok , Marina Brockway , Kent Lee , Quan Ni , Yachuan Pu , Jeffrey Stahmann , Yi Zhang , Jesse Hartley
IPC分类号： A61B5/08 , A61B5/02
CPC分类号： A61B5/091 , A61B5/0031 , A61B5/0809 , A61B5/0816 , A61B5/113 , A61B5/4818 , A61N1/3627 , A61N1/36521 , A61N1/36535
摘要： An evaluation of heart failure status is provided based on a disordered breathing index. Patient respiration is sensed and a respiration signal is generated. Disordered breathing episodes are detected based on the respiration signal. A disordered breathing index is determined based on the disordered breathing episodes. The disordered breathing index is trended and used to evaluate heart failure status. The disordered breathing index may be combined with additional information and/or may take into account patient activity, posture, sleep stage, or other patient information.
摘要翻译：基于无序呼吸指数提供心力衰竭状态评估。感测患者呼吸并产生呼吸信号。基于呼吸信号检测到无序呼吸事件。基于无序呼吸发作确定无序呼吸指数。无序呼吸指数趋向并用于评估心力衰竭状态。无序呼吸指数可以与附加信息组合和/或可以考虑患者活动，姿势，睡眠阶段或其他患者信息。

19. 发明授权

US07775983B2 Rapid shallow breathing detection for use in congestive heart failure status determination 有权
标题翻译：快速浅呼吸检测用于充血性心力衰竭状态测定
公开(公告)号：US07775983B2
公开(公告)日：2010-08-17
申请号：US11229316
申请日：2005-09-16
申请人： Yi Zhang , John D. Hatlestad , Yousufali H. Dalal , Marina Brockway
发明人： Yi Zhang , John D. Hatlestad , Yousufali H. Dalal , Marina Brockway
IPC分类号： A61B5/02 , A61B5/08
CPC分类号： A61B5/091 , A61B5/053 , A61B5/0816 , A61B5/411 , A61B2562/0219 , A61N1/3627 , A61N1/36521
摘要： Systems and methods involve use of a medical device comprising sensing circuitry. One or more respiratory parameters are detected using the device. Patient baseline weight is provided, and an output signal indicative of a patient's congestive heart failure status is generated based on a change in the one or more respiratory parameters and a change in the patient's measured weight or predicted weight relative to the patient baseline weight. The respiratory parameters may include one or more of respiration rate, relative tidal volume, an index indicative of rapid shallow breathing by the patient, an index derived by computing a respiration rate and a tidal volume for each patient breath, and an index indicative of dyspnea, for example.
摘要翻译：系统和方法涉及使用包括感测电路的医疗装置。使用该装置检测一个或多个呼吸参数。提供患者基线重量，并且基于一个或多个呼吸参数的变化和患者相对于患者基线重量的测量重量或预测体重的变化来生成指示患者充血性心力衰竭状态的输出信号。呼吸参数可以包括呼吸速率，相对潮气量，指示患者快速浅呼吸的指标，通过计算呼吸速率导出的指数和每个患者呼吸的潮气量以及指示呼吸困难的指数中的一个或多个，例如。

20. 发明授权

US07668594B2 Method and apparatus for delivering chronic and post-ischemia cardiac therapies 失效
标题翻译：用于递送慢性和缺血后心脏治疗的方法和装置
公开(公告)号：US07668594B2
公开(公告)日：2010-02-23
申请号：US11207251
申请日：2005-08-19
申请人： Marina Brockway , Joseph M. Pastore , Yi Zhang , Carlos Ricci , Allan Shuros , Rodney W. Salo
发明人： Marina Brockway , Joseph M. Pastore , Yi Zhang , Carlos Ricci , Allan Shuros , Rodney W. Salo
IPC分类号： A61N1/368 , A61N1/08
CPC分类号： A61N1/36585 , A61N1/056 , A61N1/36114 , A61N1/3627 , A61N1/36521 , A61N1/36557
摘要： An implantable cardiac rhythm management (CRM) device delivers a chronic therapy while detecting an ischemic state. When the ischemic state indicates the occurrence of an ischemic event, the implantable CRM device delivers a post-ischemia therapy. The post-ischemia therapy and the chronic therapy are adjusted using feedback control with the ischemic state and parameters indicative of the effectiveness of the post-ischemic therapy and the effectiveness of the chronic therapy as inputs.
摘要翻译：植入式心律管理（CRM）装置在检测缺血状态时进行慢性治疗。当缺血状态表明发生缺血事件时，可植入的CRM装置传递缺血后的治疗。使用具有缺血状态的反馈控制和指示缺血后治疗的有效性和作为输入的慢性治疗的有效性的参数来调整局部后缺血治疗和慢性治疗。

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