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11. 发明申请

US20070244556A1 Annuloplasty Device Having a Helical Anchor and Methods for its Use 审中-公开
公开(公告)号：US20070244556A1
公开(公告)日：2007-10-18
申请号：US11734566
申请日：2007-04-12
申请人： Nasser Rafiee , Nareak Douk , Eliot Bloom , Michael Finney , Morgan House , Rany Huynh , Stuart Mac Donald , Juan-Pablo Mas , David Barone
发明人： Nasser Rafiee , Nareak Douk , Eliot Bloom , Michael Finney , Morgan House , Rany Huynh , Stuart Mac Donald , Juan-Pablo Mas , David Barone
IPC分类号： A61F2/24
摘要： A system for modifying a heart valve annulus includes a helically helical anchored annuloplasty device delivered to the annulus via an elongated delivery member. The helical anchors of the devices disclosed herein are rotated into the valve annulus along an anchor guide by using a driver that is movably disposed in the delivery member. A tether is disposed within an inner channel of the helical anchor and a locking device is used to secure the annuloplasty device after the valve annulus has been modified. The annuloplasty device can be delivered to the annulus using, traditional surgical approach or a minimally invasive or catheter based methods.

12. 发明申请

US20070051377A1 Cardiac valve annulus reduction system 有权
标题翻译：心脏瓣膜减压系统
公开(公告)号：US20070051377A1
公开(公告)日：2007-03-08
申请号：US10531819
申请日：2004-11-12
申请人： Nareak Douk , Nasser Rafiee , Eliot Bloom , Douglas Fogg , Rany Huynh , David Barone
发明人： Nareak Douk , Nasser Rafiee , Eliot Bloom , Douglas Fogg , Rany Huynh , David Barone
IPC分类号： A61B19/00
CPC分类号： A61F2/2445 , A61B17/00234 , A61B17/0401 , A61B2017/00243 , A61B2017/00783 , A61B2017/0414 , A61B2017/0496 , A61B2017/06052 , A61B2017/06176 , A61F2002/30545 , A61F2220/0016 , A61F2250/001
摘要： A catheter-based, annulus reduction device and system for cardiac valve repair and method of using the same. The system is usable for treating mitral valve regurgitation and comprises a catheter, a reduction ring carried within the catheter, the reduction ring including a plurality of exit ports formed in a side wall of the reduction ring and filament received in the reduction ring. The filament includes a plurality of radially extendible barbs corresponding to the sidewall openings. The reduction ring carrying the filament is deployed adjacent a mitral valve annulus and the filament is translated relative to the reduction ring to deploy the barbs through the exit ports and into the annulus and to further translate the reduction ring with deployed barbs to reshape the annulus.
摘要翻译：一种基于导管的减压装置和心脏瓣膜修复系统及其使用方法。该系统可用于治疗二尖瓣反流，并且包括导管，在导管内承载的还原环，所述还原环包括形成在所述还原环的侧壁中的多个出口和容纳在所述还原环中的细丝。灯丝包括对应于侧壁开口的多个可径向延伸的倒钩。承载细丝的还原环被布置在二尖瓣环附近，并且细丝相对于还原环平移，以将倒钩布置在出口端口并进入环形空间中，并且进一步将还原环用展开的倒钩重新平整以环形环。

13. 发明申请

US20060167474A1 Apparatus and method for elongation of a papillary muscle 审中-公开
标题翻译：用于乳头肌伸长的装置和方法
公开(公告)号：US20060167474A1
公开(公告)日：2006-07-27
申请号：US10531832
申请日：2004-09-15
申请人： Eliot Bloom , Nasser Rafiee , Nareak Douk
发明人： Eliot Bloom , Nasser Rafiee , Nareak Douk
IPC分类号： A61B17/122 , A61B17/128 , A61F2/24
CPC分类号： A61F2/2466 , A61B90/02 , A61B2017/00243 , A61B2017/088 , A61F2/2457
摘要： A system and method for treating a dilated heart valve by elongating a papillary muscle. The system comprises a delivery catheter 110 and a holding catheter 130. The system further comprises a muscle elongation device 200 including at least two clamping rings 210, 215 slidably connected by at least one connecting rod 220. The muscle elongation device 200 is delivered to a papillary muscle 560 associated with the dilated heart valve, where it is released from the delivery catheter 110 and the clamping rings 210, 215 wrap about and engage the papillary muscle. The muscle tissue is cut between the clamping rings 210, 215, which then move away from each other to a predetermined position, thus permitting the papillary muscle to elongate.
摘要翻译：一种通过延长乳头肌来治疗扩张型心脏瓣膜的系统和方法。该系统包括输送导管110和保持导管130。系统还包括肌肉伸长装置200，其包括至少两个由至少一个连杆220可滑动地连接的夹紧环210,215。肌肉伸长装置200被输送到与扩张的心脏瓣膜相关联的乳头肌560，其中它从输送导管110释放，并且夹紧环210,215包裹并接合乳头肌。在夹紧环210,215之间切割肌肉组织，然后夹紧环210,215彼此远离移动到预定位置，从而允许乳头肌细长。

14. 发明申请

US20060074308A1 Catheter with curved distal section having reinforcing strip and method of making same 有权
标题翻译：具有弯曲远端部分的导管具有加强条及其制造方法
公开(公告)号：US20060074308A1
公开(公告)日：2006-04-06
申请号：US10952996
申请日：2004-09-28
申请人： Nasser Rafiee , Nareak Douk , Peter Strickler , Matthew Poole
发明人： Nasser Rafiee , Nareak Douk , Peter Strickler , Matthew Poole
IPC分类号： A61M25/00
CPC分类号： A61M25/0054 , A61M25/0041 , A61M25/0045
摘要： A catheter having an elongate hollow shaft with a curved distal section having at least one pre-curved reinforcing strip embedded therein. The pre-curved reinforcing strip comprises a relatively stiff material that is unaffected by the process of thermoforming a final curve in the catheter. Methods of making the catheter are also described.
摘要翻译：具有细长空心轴的导管，其具有弯曲的远侧部分，其具有嵌入其中的至少一个预弯曲加强条。预弯曲的加强条包括相对刚硬的材料，其不受热成型导管中的最终曲线的过程的影响。还描述了制造导管的方法。

15. 发明申请

US20050124876A1 Low-profile distal protection device 有权
标题翻译：薄型远端保护装置
公开(公告)号：US20050124876A1
公开(公告)日：2005-06-09
申请号：US10718638
申请日：2003-11-24
申请人： Nareak Douk , Nasser Rafiee , Albert Dunfee
发明人： Nareak Douk , Nasser Rafiee , Albert Dunfee
IPC分类号： A61B17/22 , A61F2/01 , A61B6/00
CPC分类号： A61F2/013 , A61B17/221 , A61F2002/018 , A61F2230/0006 , A61F2230/0069 , A61F2230/0097 , A61F2250/0036 , Y10T29/49801
摘要： A distal protection device captures debris during vascular procedures. In order to reduce the profile of the device, the thickness of the distal protection element is reduced in one or both of the end regions, either by reducing the thickness of filaments which form the distal protection element, or by removing portions of those filaments altogether. Various methods of reducing the thickness of the end regions and different profiles that can be created by the reduction are disclosed.
摘要翻译：远端保护装置在血管手术过程中捕获碎屑。为了减小装置的轮廓，通过减小形成远端保护元件的长丝的厚度，或者通过一起去除这些细丝的一部分，在一个或两个端部区域中减小远侧保护元件的厚度。公开了减少可以产生的端部区域的厚度和不同的轮廓的各种方法。

16. 发明授权

US06866677B2 Temporary intraluminal filter guidewire and methods of use 失效
标题翻译：临时管腔内过滤器导丝及使用方法
公开(公告)号：US06866677B2
公开(公告)日：2005-03-15
申请号：US09824832
申请日：2001-04-03
申请人： Nareak Douk , Nasser Rafiee , David S. Brin , Peter G. Strickler
发明人： Nareak Douk , Nasser Rafiee , David S. Brin , Peter G. Strickler
IPC分类号： A61B17/00 , A61B17/22 , A61F2/01 , A61F2/82 , A61M25/00 , A61M29/00
CPC分类号： A61F2/013 , A61B2017/1205 , A61B2017/12095 , A61F2002/015 , A61F2002/018 , A61F2230/0006 , A61F2230/0069 , A61F2230/0071 , A61F2230/008
摘要： The present invention is a temporary intraluminal filter guidewire for use during interventional procedures, such as angioplasty or stent deployment. A braided filter is mounted near the distal end of a steerable guidewire, which guides a therapeutic catheter. An actuator rod slides over the guidewire and is removably connected to the filter. The rod controls relative displacement of the filter ends, causing transformation of the filter between a deployed configuration and a collapsed configuration. Wire having enhanced radiopacity is included in the filter to provide visualization under fluoroscopy.
摘要翻译：本发明是在介入手术期间使用的临时管腔内过滤器导丝，例如血管成形术或支架展开。编织过滤器安装在引导治疗导管的可导向导丝的远端附近。致动器杆在导丝上滑动并且可移除地连接到过滤器。杆控制过滤器端部的相对位移，导致过滤器在部署配置和折叠配置之间的转换。具有增强的射线不透性的线被包括在过滤器中以在荧光透视下提供可视化。

17. 发明授权

US06273850B1 Device for positioning a radiation source at a stenosis treatment site 失效
标题翻译：用于在狭窄治疗部位定位辐射源的装置
公开(公告)号：US06273850B1
公开(公告)日：2001-08-14
申请号：US08960375
申请日：1997-10-29
申请人： Richard A. Gambale , James Stewart Hunter , Nareak Douk
发明人： Richard A. Gambale , James Stewart Hunter , Nareak Douk
IPC分类号： A61N500
CPC分类号： A61N5/1007 , A61N5/1002 , A61N2005/1008
摘要： An apparatus is described for irradiating a stenosed region of an artery by use of a sliding or floating radiation source inserted into or onto a catheter or onto a guide wire within a catheter, delivered to the treatment site by a mechanical or hydraulic fluid and housed at the site for the irradiation procedure.
摘要翻译：描述了一种用于通过使用插入在导管中或导管上或导管内的滑动或浮动辐射源来照射动脉狭窄区域的装置，其通过机械或液压流体输送到治疗部位并且容纳在照射程序的地点。

18. 发明授权

US08801776B2 Infundibular reducer devices 有权
标题翻译：漏斗式减速器装置
公开(公告)号：US08801776B2
公开(公告)日：2014-08-12
申请号：US12391330
申请日：2009-02-24
申请人： Morgan House , Philipp Bonhoeffer , Nasser Rafiee , Rany Huynh Busold , Nareak Douk , Juan-Pablo Mas , Stuart MacDonald , Michael Finney
发明人： Morgan House , Philipp Bonhoeffer , Nasser Rafiee , Rany Huynh Busold , Nareak Douk , Juan-Pablo Mas , Stuart MacDonald , Michael Finney
IPC分类号： A61F2/06
CPC分类号： A61F2/2418 , A61F2230/0054 , A61F2230/0078 , A61F2230/008 , A61F2250/0023 , A61F2250/0039 , A61F2250/0048
摘要： Described is a prosthetic valve assembly comprising: a radially self-expandable stent configured to expand to bear against a wall of a native body lumen; and an implantable prosthetic valve, having a diameter, the valve being mounted inside the stent; wherein the diameter of the stent is greater than the diameter of the prosthetic valve.
摘要翻译：描述了一种假体瓣膜组件，其包括：径向自扩张支架，其构造成膨胀以抵靠本体体腔的壁; 以及具有直径的植入式假体瓣膜，所述瓣膜安装在所述支架内; 其中支架的直径大于人工瓣膜的直径。

19. 发明授权

US08057537B2 Compliant venous graft 有权
标题翻译：合并静脉移植
公开(公告)号：US08057537B2
公开(公告)日：2011-11-15
申请号：US10834360
申请日：2004-04-28
申请人： Peter P. Zilla , Nasser Rafiee , Deon Bezuidenhout , Thomas Franz , Mark Yeoman , Hellmut Bowles , Nareak Douk , Michael F. Wolf
发明人： Peter P. Zilla , Nasser Rafiee , Deon Bezuidenhout , Thomas Franz , Mark Yeoman , Hellmut Bowles , Nareak Douk , Michael F. Wolf
IPC分类号： A61F2/90
CPC分类号： A61F2/06 , A61F2/90 , A61L27/14 , A61L27/3625
摘要： A venous graft for replacement of a section of an artery and methods of making the graft. The graft comprises a flexible, resilient, generally tubular external support and a vein segment carried within and having an ablumenal surface in contact with and supported by the tubular support, the venous graft being capable of resilient radial expansion in a manner mimicking the radial compliance properties of an artery.
摘要翻译：用于替换动脉的一部分的静脉移植物和制造移植物的方法。移植物包括柔性的，弹性的，大体上管状的外部支撑件和承载在管状支撑件内并具有与管状支撑件接触并由其支撑的缩小表面的静脉段，静脉移植物能够以模拟径向顺应性的方式弹性径向膨胀的动脉。

20. 发明授权

US07955384B2 Coronary sinus approach for repair of mitral valve regurgitation 有权
标题翻译：冠状窦方法修复二尖瓣关闭不全
公开(公告)号：US07955384B2
公开(公告)日：2011-06-07
申请号：US10531833
申请日：2004-11-11
申请人： Nasser Rafiee , Nareak Douk , James F. Crittenden
发明人： Nasser Rafiee , Nareak Douk , James F. Crittenden
IPC分类号： A61F2/24
CPC分类号： A61F2/2451
摘要： A device and method for treating cardiac valve regurgitation. The device includes a tubular member including a lumen there through and a locking mechanism and a compression device carried on the tubular member. The compression device is transformable to a compression configuration in response to axial displacement and is locked in the compression configuration by the locking mechanism. The method includes positioning the compression device adjacent a cardiac valve and applying an axial displacement to the compression device to transform the compression device into a compression configuration and locking the compression device in the compression configuration to apply a compressive force to the cardiac valve.
摘要翻译：一种用于治疗心脏瓣膜反流的装置和方法。该装置包括管状构件，其包括其中的内腔和锁定机构以及承载在管状构件上的压缩装置。压缩装置可以响应于轴向位移而变形成压缩构型，并且通过锁定机构锁定在压缩构造中。该方法包括将压缩装置定位在心脏瓣膜附近并向压缩装置施加轴向位移，以将压缩装置转换成压缩构型并将压缩装置锁定在压缩构型中以向心脏瓣膜施加压缩力。

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